Ingabe uzizwa ukhathele ngaso sonke isikhathi ngoba unesifo somfutho wegazi ophansi? Ake sixoxe nge-Erythropoietin!

Ingabe ngezinye izikhathi uzizwa ukhathele futhi ungenampilo? Esinye isizathu salokhu ukwehla kwenani lamaseli abomvu egazi emzimbeni. Umzimba wethu une-hormone ebaluleke kakhulu esiza ekukhiqizweni kwala maseli abomvu egazi. Leyo yi-hormone esizokhuluma ngayo namuhla. Igama layo yi-Erythropoietin, noma i-EPO ngamafuphi.

Kuyini i-Erythropoietin?

Kalula nje, i-Erythropoietin iyi-hormone ekhiqizwa kakhulu yizinso zethu. Yebo, ukuzwile kahle, uma sicabanga ngezinso, sicabanga kuphela ngokukhiqizwa komchamo, kodwa izinso zenza okuningi emizimbeni yethu. Omunye umsebenzi obaluleke kangaka ukukhiqiza le-hormone (EPO). Le hormone (EPO) isiza ukugcina inani elinempilo lamaseli abomvu egazi, okungukuthi, ama-erythrocyte, emizimbeni yethu.

Ngezinye izikhathi, odokotela basebenzisa uhlobo lokwenziwa lwe-erythropoietin ukwelapha i-anemia , ikakhulukazi ezimweni ezifana nesifo sezinso esingamahlalakhona. Futhi, abanye abasubathi basebenzisa kabi lo muthi ukuze bathuthukise ukusebenza kwabo. Ngoba i-EPO ikhulisa inani lomoya-mpilo ofinyelela emisipheni yabo. Ingabe lokho akuvumelekile? Kulungile?

Amanye amagama ale erythropoietin afaka phakathi i-erythropoietin, i-hematopoietin, kanye ne-hemopoietin. Kodwa-ke, wonke asho into efanayo.

Iyiphi insizakalo enikezwa yi-erythropoietin (EPO) emizimbeni yethu?

Kulungile, manje ake sibone ukuthi yini ngempela eyenziwa yi-EPO. Umsebenzi oyinhloko we-EPO ukusiza ekwakheni amangqamuzana abomvu egazi. Lawa mangqamuzana abomvu egazi yiwo athwala umoya-mpilo ezicutshini zomzimba wethu. Umoya-mpilo uguqulwa ube amandla, bese kukhishwa i-carbon dioxide ezicutshini zethu. Uma uphefumula, lawa mangqamuzana abomvu egazi afanayo asiza ekususeni lowo moya-mpilo.

Yilokhu okuvame ukwenzeka: Uma uhlobo oluthile lweseli ezinso zethu luthola ukuthi izinga lomoya-mpilo egazini lethu liphansi, lwandisa ukukhiqizwa kwalo kwe-(EPO). Le hormone (EPO) ibe isitshela ingxenye ethambile yamathambo ethu, umnkantsha wamathambo, ukuthi yenze amangqamuzana egazi abomvu engeziwe. Cabanga ngakho njengokunikeza i-oda efektri.

Uma amaseli ezinso ezwa ukuthi kunomoya-mpilo owanele egazini, anciphisa ukukhiqizwa kwe-erythropoietin. Lena inqubo eyinkimbinkimbi kakhulu, kodwa elawulwa kahle.

Kodwa-ke, ezinye izimo zezokwelapha zingathinta inani le-EPO elikhiqizwa yizinso. Zingakhiqiza kakhulu noma zingakhiqizi ngokwanele. Lokhu kungabangela izinkinga ngamaseli abomvu egazi amaningi kakhulu noma ambalwa kakhulu.

Kwenzekani uma amazinga e-erythropoietin (EPO) ekhuphuka?

Uma amazinga e-EPO enyuka ngokungafanele, okungukuthi, uma umzimba une-EPO eningi kunalokho okudingayo, inani lamaseli abomvu egazi linganda ngokungadingekile. Lokhu sikubiza ngokuthi i-polycythemia. Kufana nokuminyana kwezimoto emgwaqweni, lapho kunamaseli abomvu egazi amaningi kakhulu, ukuhamba kwegazi kungavinjelwa.

Yiziphi izizathu zokwanda okungaka kwamazinga e-EPO?

Kungaba nezizathu eziningana zokuthi kungani amazinga e-EPO engaba phezulu ngokungadingekile.

• Ukuchayeka isikhathi eside emazingeni aphansi omoya-mpilo: Lokhu kungenzeka kubantu ababhemayo noma abahlala ezindaweni ezinezintaba, eziphakeme ngaphezu kolwandle. Lokhu kungenxa yokuthi umoya uqukethe umoya-mpilo omncane njengoba ukhuphuka. Kodwa-ke, kuvamile ukuthi umuntu ohlala endaweni enezintaba abe namazinga aphezulu e-EPO, okuyindlela umzimba okwazi ukuzivumelanisa nezimo ngayo.
• I-anemia ayibangelwa yisifo sezinso: Ngezinye izikhathi i-anemia ayibangelwa inkinga yezinso. Kodwa-ke, lapho izinso zizwa ukuthi umzimba awunawo amangqamuzana abomvu egazi, zikhiqiza i-EPO eyengeziwe ukusiza ekwakheni amangqamuzana abomvu egazi. Lokhu futhi ukwanda okuvamile nokudingekile kwe-EPO.
• Umdlavuza ongavamile: Akuvamile kakhulu ukuthi ezinye izinhlobo zomdlavuza zingabangela izinso ukuthi zikhiqize i-EPO eningi kakhulu ngendlela engafanele.

Yiziphi izimbangela zamazinga aphansi e-erythropoietin (EPO)?

Imbangela eyinhloko nevame kakhulu yamazinga aphansi e-EPO yisifo sezinso esingamahlalakhona ( CKD ). Uma izinso zonakele, azikwazi ukukhiqiza i-EPO eyanele. Lokhu kubangela amazinga aphansi e-EPO. Lesi simo, kanye namazinga aphansi e-EPO, singaholela ekulahlekelweni kwegazi. Ungabona ukuthi zingaki izinkinga ezingavela uma izinso zingasebenzi kahle, akunjalo?

Futhi, isimo esibizwa ngokuthi i-Polycythemia Vera singabangela amazinga aphansi e-EPO. Lolu uhlobo lomdlavuza wegazi. Kulokhu, ukuguquka kwezakhi zofuzo kubangela ukuthi umongo wethu wamathambo ukhiqize amangqamuzana egazi abomvu amaningi kakhulu. Ngemuva kwalokho, izinso zizwa ukuthi kunamangqamuzana egazi abomvu amaningi kakhulu emzimbeni, bese zinciphisa ukukhiqizwa kwazo kwe-EPO.

Aphathwa kanjani amazinga aphansi e-erythropoietin (EPO)?

Uma izinga lakho le-EPO liphansi, into yokuqala okufanele uyenze lapho uyelapha ukuthola imbangela eyisisekelo bese uyelapha.

Indlela eyinhloko yokwelapha i-anemia ebangelwa amazinga aphansi e-EPO iwukufaka i-erythropoietin ephinde ihlanganiswe. Lawa abizwa nangokuthi ama-erythropoietin-stimulating agents noma ama-ESA. Lawa angama-hormone e-EPO emvelo kanye nohlobo lwe-EPO oluyi-synthetic, noma olwenziwe elebhu. Odokotela bakopisha, noma bakopishe, i-EPO gene bese bekunika yona njengomjovo wokukhuthaza ukukhiqizwa kwamaseli egazi abomvu engeziwe.

Le mithi yokugomela (i-ESA) isetshenziswa kakhulu ukwelapha isifo sezinso esingamahlalakhona.Yelapha i-anemia ebangelwa ukwehluleka kwezinso okungapheli. Inikezwa nabantu abanezinhlobo ezithile zomdlavuza ezingavamile.

Kodwa-ke, le mithi yokugomela (i-ESA) ingabangela imiphumela emibi. Akuwona wonke umuntu oyitholayo, kodwa abanye abantu bangase:

• Umfutho wegazi ophakeme
• Imfiva
• Isiyezi
• Isicanucanu
• Ubuhlungu endaweni yokujova

Ngaphambi kokuqala lolu hlobo lokwelashwa, kubaluleke kakhulu ukuxoxa ngakho konke lokhu nodokotela wakho bese ubuza noma yimiphi imibuzo ongase ube nayo.

Odokotela balinganisa kanjani amazinga e-erythropoietin (EPO)?

Udokotela wakho angalinganisa amazinga akho e-EPO ngokuhlolwa kwegazi. Lokhu kuhlolwa kwegazi kungasiza ekunqumeni ukuthi izinguquko kumaseli akho egazi, njenge-polycythemia, i-anemia, noma ezinye izimo zomnkantsha wamathambo, zithinta yini ukukhiqizwa kwe-EPO.

Nakhu okwenzayo uma uthatha igazi:

1. Okokuqala, hlanza isikhumba esizungeze umthambo engalweni yakho ngento efana ne-iodine noma i-isopropyl alcohol.

2. Bese kuthi, kusetshenziswa inaliti encane (ngokuvamile engu-21 gauge, encane kancane kunesigxobo esivamile sendlebe), kuthathwe igazi elincane emthanjeni osengalweni yakho.

3. Isampula yegazi ithunyelwa elabhorethri ukuze ihlolwe.

Uma ilabhorethri isiqedile ukuhlola isampula yegazi lakho, udokotela wakho uzokufonela ukuze axoxe ngemiphumela yokuhlolwa futhi aphendule noma yimiphi imibuzo ongase ube nayo. Ngezinye izikhathi, noma amazinga akho e-EPO engaphakathi kwesilinganiso esijwayelekile, ungadinga ezinye izindlela zokwelapha. Lokhu kuzonqunywa udokotela wakho.

Kufanele libe lingakanani izinga elijwayelekile le-erythropoietin (EPO)?

Odokotela balinganisa i-EPO ngama-milliyunithi nge-milliliter (mU/mL). Izinga le-EPO lomuntu ophilile lingasukela ku-4 kuya ku-26 mU/mL.

Kodwa khumbula, imiphumela yakho yokuhlolwa (i-EPO) ingahluka kancane kuye ngezici eziningana. Isibonelo:

• iminyaka yakho
• Ubulili bakho bemvelo
• Isimo sakho sempilo iyonke

Ngakho-ke, udokotela wakho ozohlaziya imiphumela yakho ngokunembile futhi akutshele ukuthi amazinga akho (e-EPO) aphilile noma cha. Ungabheki nje izinombolo bese ufinyelela iziphetho ngokushesha, kulungile?

Yiziphi izindlela zokwandisa amazinga e-erythropoietin (EPO) ngokwemvelo?

Uma unesifo sezinso esingamahlalakhona (CKD), noma uma une-anemia enamazinga aphansi e-EPO, ezinye izinguquko zokudla nendlela yokuphila zingasiza ekwandiseni amazinga akho e-EPO kancane. Kodwa-ke, lokhu kufanele kwenziwe kuphela ngeseluleko sezokwelapha.

• Ukuzivocavoca: Ucwaningo lukhombisile ukuthi uma uvivinya umzimba njalo, ngamandla aphakathi (ukuzivocavoca okunamandla), umzimba wakho usebenzisa umoya-mpilo owengeziwe. Ubuchopho bakho bube sebutshela umzimba wakho ukuthi wenze i-EPO eyengeziwe. Izibonelo zalolu hlobo lokuzivocavoca ukugibela ibhayisikili, ukugijima, nokubhukuda.
• Insimbi yokudla: Insimbi iyisakhi esiyinhloko se-hemoglobin. Le hemoglobin isiza ukuthutha umoya-mpilo uye emangqamuzaneni emizimba yethu. Ukudla okucebile ngensimbi kufaka phakathi inyama ebomvu, izikhupha zamaqanda, isibindi, i-tofu, kanye nokudla okuqiniswe ngensimbi (isb., okusanhlamvu okuthile, isinkwa, ne-pasta).

Kodwa lezi zinto zodwa zingase zingabi nomthelela omkhulu, ikakhulukazi uma isimo esiyisisekelo sibi kakhulu. Ngakho -ke kubalulekile ukulandela iseluleko sikadokotela wakho.

Izinto okufanele uzikhumbule kukho konke lokhu (Umyalezo Wokuya Ekhaya)

I-Erythropoietin iyi-hormone ebaluleke kakhulu nebalulekile etshela umnkantsha wethu ukuthi “wenze amangqamuzana egazi abomvu engeziwe.” Kodwa-ke, ngezinye izikhathi imizimba yethu yenza amangqamuzana egazi abomvu amaningi ngendlela engafanele, noma inganele. Zombili lezi zingabangela izinkinga zempilo.

Uma uhlala uzizwa ukhathele futhi ukhathele, ungakushayi indiva lokho. Ungabonana nodokotela bese uhlolwa amazinga egazi lakho (i-EPO). Udokotela angabe esencoma ukwelashwa okufanele kakhulu kuwe. Khumbula, ibhalansi yala ma-hormone ibaluleke kakhulu empilweni enempilo.