Wake wazibuza ukuthi ubuchopho bethu bumatasa kangakanani? Kufana neColombo Town, lapho kwenzeka izinto eziningi ngesikhathi esisodwa. Imiyalezo iyahamba iye phambili naphambili, kwenziwa izinqumo, imizwa iyalawulwa... konke lokhu kwenzeka ngenethiwekhi yezithunywa ezincane zamakhemikhali. Ngakho-ke, kwenzekani lapho konke kuhamba ngendlela exakile endaweni exakile kangaka? Konke kuba yisiphithiphithi, akunjalo? Kukhona othile engqondweni yethu ovimba leyo siphithiphithi, athulise yonke into, futhi ayilawule. Namuhla sizokhuluma ngaleyo ngelosi ebalulekile, okungukuthi, 'ibhuleki' yemvelo ebuchosheni bethu. Leyo yiGABA.
Iyini ngempela i-GABA?
Kalula nje, i-GABA , eyisifinyezo se -gamma-aminobutyric acid, iyisithunywa samakhemikhali ebuchosheni bethu. Kwezokwelapha, sibiza lawa ma-neurotransmitter. Njengabathumeli beposi, athwala imiyalezo esuka kwelinye iseli lezinzwa ebuchosheni iye kwelinye.
Kodwa umyalezo ophethwe yi-GABA ukhethekile kancane. Akusiwo umyalezo othi "Shesha, gijima." Kungumyalezo othi "Kulungile, kulungile, sekwanele manje. Yehlisa ijubane kancane, yehlisa ijubane." Okusho ukuthi, i-GABA ilawula kancane umsebenzi wesimiso sethu sezinzwa esiyinhloko - okungukuthi, ubuchopho kanye nomgogodla. Ivimba amangqamuzana ezinzwa ukuthi angashukunyiswa ngokungadingekile.
Yingakho sikholelwa ukuthi i-GABA idlala indima ebalulekile ekuthuliseni izingqondo zethu nasekulawuleni izinto ezifana nokucindezeleka, ukwesaba, nokukhathazeka. Kufana nokupholisa ingqondo yethu ngokwemvelo.
Ake sibheke kabanzi ukuthi i-GABA isebenza kanjani.
Ukuze uqonde lokhu, cabanga ukuthi amangqamuzana ezinzwa ebuchosheni bakho ayakhuluma. Kodwa awaxhumene. Kukhona isikhala esincane phakathi kweseli elilodwa nelinye. Sikubiza ngokuthi i-synapse. Uma umyalezo udinga ukuthunyelwa, i-neurotransmitter iyakhishwa kusuka kwelinye iseli, ibhukude idlule leso sikhala, bese ibopha i-receptor ekhethekile kuseli elilandelayo.
Kufana nesihluthulelo nokukhiya. Akuwona wonke amakhiye angavula yonke ingidi. Futhi, akuwona wonke ama-'Neurotransmitter' angaxhuma ku-'Receptor' ngayinye. I-'key' ebizwa nge-GABA ingavula kuphela ama-'locks' abizwa ngama-GABA receptors.
Uma i-GABA ihamba futhi ibopha 'ku-receptor' yayo, umlayezo otholwa yiseli lemizwa elilandelayo "ukunciphisa umsebenzi wakho." Okusho ukuthi, ikhono lalelo seli lokwamukela imiyalezo evela kwamanye amaseli, ukwenza imiyalezo emisha, noma ukuthumela imiyalezo kwamanye amaseli liyancishiswa. Ngale ndlela, umsebenzi wobuchopho uwonke uyazola. Njengalapho isibani sethrafikhi siba bomvu emgwaqweni omatasa, izimoto ziyama bese ithrafikhi ilawulwa kancane.
I-GABA ne-Glutamate - ukushintshana okubili 'kokuvula' kanye 'nokuvala' ebuchosheni
Ukuze ubuchopho bethu busebenze kahle, ibhalansi ibaluleke kakhulu. Uma sikhuluma nge-GABA, sidinga futhi ukukhuluma ngokuphambene nayo, okuyi -Glutamate .
I-GABA ne-glutamate zisebenza njengezinkinobho ezimbili ze-'On' kanye ne-'Off'.
- I-GABA iyindlela eyinhloko yokushintsha ingqondo. Okusho ukuthi, i-neurotransmitter eyinhloko eyeka ukusebenza futhi ikuthulise.
- I-Glutamate iyi -switch eyinhloko yobuchopho ethi 'On' . Okusho ukuthi, 'iyi-neurotransmitter' evuselela amangqamuzana ezinzwa futhi yandise umsebenzi wawo.
Cabanga ngakho njenge-accelerator kanye ne-brake emotweni. Uma ufuna ukushayela imoto kahle, udinga ukuzisebenzisa zombili kahle nangesikhathi esifanele. Ukuba ne-accelerator eyodwa kuphela ngeke kusebenze. Uma une-accelerator kuphela, uzophahlazeka yonke indawo. Uma une-brake kuphela, awukwazi ukuqhubekela phambili. Ngokufanayo, ukuze ubuchopho bethu busebenze kahle futhi ngempumelelo, kudingeka kube nokulinganisela okubucayi phakathi kwemiphumela yokuzola ye-GABA kanye nemiphumela evuselelayo ye-glutamate.
Ngokumangalisayo, lesi sithako esizolisayo esibizwa nge-GABA sikhiqizwa ngesikhuthazi esifanayo, i-glutamate. I-Glutamate iguqulwa ibe yi-GABA ngesenzo se-enzyme ekhethekile.
Kwenzekani uma amazinga e-GABA engalingani?
Uma ibhalansi esikhulume ngayo ilahlekile, ikakhulukazi uma umsebenzi we-GABA wehla, 'amabhuleki' obuchopho ngeke asebenze kahle. Khona-ke umsebenzi wobuchopho uzokwanda ngokungadingekile, futhi kungavela inkinga ngemva kwenye. Ake sibheke ezinye zezimo zezokwelapha okucatshangwa ukuthi zihlobene nokwehla komsebenzi we-GABA ngezansi.
| Isimo sezokwelapha | Incazelo elula |
|---|---|
| Ukukhathazeka Nokuphazamiseka Kwemizwelo | Uma i-GABA inganele ukuzola ingqondo, ukwesaba okungadingekile, imicabango ephazamisayo, kanye nesimo sengqondo sokungaphumuli kungavela. |
| I-Schizophrenia | Isifo sengqondo esiyinkimbinkimbi esithinta imicabango, imizwa, kanye nokuziphatha. Kunobufakazi bokuthi ukungalingani kwe-GABA kungaba nomthelela kulokhu. |
| Isifo se-Autism Spectrum | Isimo sokuthuthukiswa esithinta ubudlelwano bomphakathi kanye nokuxhumana. Singabonakala ezinguqukweni ohlelweni lwe-GABA. |
| Ukucindezeleka | Ukudabuka isikhathi eside nokulahlekelwa isithakazelo ezintweni. Lokhu kungase kuhlobane namazinga aphansi e-GABA. |
| Isithuthwane / Ukuquleka | Ukwanda okungazelelwe, okungalawuleki komsebenzi kagesi ebuchosheni. Isizathu esiyinhloko salokhu ubuthakathaka benqubo 'yokubhuleka' ye-GABA. |
| Isifo sikaHuntington | Isifo esizuzwe njengefa esibhubhisa kancane kancane amangqamuzana obuchopho. |
| I-Hypersomnia | Ukulala ngokweqile emini noma ukulala isikhathi eside kungabangelwa ukusebenza ngokweqile kohlelo lwe-GABA. |
Ingabe ikhona imithi ehlose i-GABA?
Yebo. Ngenxa yokuthi i-GABA idlala indima ebaluleke kangaka ebuchosheni bethu, abakhiqizi bemithi bathuthukise imithi eminingana ehlose uhlelo lwe-GABA. Le mithi isebenza ngokuthuthukisa imiphumela yemvelo yokuzola ye-GABA noma ngokwenza njenge-GABA.
Okubalulekile: Imithi elandelayo iyizibonelo kuphela. Ungayisebenzisi noma uyeke ukuyisebenzisa nganoma yisiphi isizathu ngaphandle kweseluleko neseluleko sikadokotela. Eminye yale mithi ingaba umlutha futhi ingabangela imiphumela emibi.
| Isigaba/igama lezidakamizwa | Isetshenziselwani? (Isibonelo) |
|---|---|
| Ama-Benzodiazepines - isibonelo i-Diazepam (Valium®), i-Alprazolam (Xanax®) | Ukunciphisa ukukhathazeka, ukulawula ukuxhuzula, ukulawula izimpawu zokuyeka utshwala, kanye nokukhulula imisipha. |
| Ama-Barbiturates | Lezi futhi ziwuhlobo lomuthi wokudambisa. Zisetshenziselwa ukuxhuzula kanye nokubulala izinzwa. |
| I-Valproic Acid | Inikezwa ukulawula ukuxhuzula kanye nokuqinisa imizwa. |
| I-Zolpidem (i-Zolpidem - i-Ambien®) | Iphilisi lokulala elisetshenziselwa ukwelapha ukungakwazi ukulala. |
| I-Propofol | Umuthi onamandla osetshenziselwa ukubulala izinzwa okuvamile ngesikhathi sokuhlinzwa. |
| I-Baclofen | Umuthi onikezwa ukunciphisa ukuqina kwemisipha okungafuneki (ukuqaqamba). |
Iqiniso noma amanga mayelana nezithako zokudla ze-GABA
Cishe uke wabona "ama-GABA Supplements" ethengiswa emakhemisi noma ku-inthanethi. Athi ayakusiza uphumule, ulale, futhi unciphise ukucindezeleka. Kodwa kunenkinga.
Ubuchopho bethu buyindawo ephephile kakhulu. Abuvumeli lutho nje ukuthi lungene. Kukhona uhlelo olukhethekile lokuphepha oluzungeze ubuchopho olubizwa ngokuthi i-Blood-Brain Barrier . Lufana nomsele ozungeze inqaba. Yizinto ezibalulekile ebuchosheni kuphela ezivunyelwe ukudlula kulolu hlelo lokuphepha.
Abacwaningi abaningi bakholelwa ukuthi ikhono lezithasiselo ze-GABA esizithatha ngaphandle ukuze sidlule umgoqo wegazi nobuchopho liphansi kakhulu. Ngakho-ke, ukuthi zithinta kanjani ubuchopho akukacaci. Abanye abantu bathi bazizwa bezolile uma bethatha lezi zithasiselo. Akukacaci ukuthi isayensi ivumelana ngokuthi lokhu kuyi-GABA efinyelela ubuchopho ngempela, noma ukuthi kuyi-placebo effect.
Ngakho-ke, qiniseka ukuthi ukhuluma nodokotela wakho ngaphambi kokuthatha isithasiselo se-GABA. Ungumuntu ongcono kakhulu wokunquma ukuthi siyafaneleka yini esimweni sakho noma cha.
Ingabe ikhona i-GABA ekudleni?
Yebo, i-GABA ikhona ngokwemvelo kwezinye ukudla, ikakhulukazi ukudla okubilisiwe.
- UKimchi
- I-Miso
- I-Tempeh
Ngaphezu kwalokho, amatiye aluhlaza, amnyama, kanye ne-oolong nawo aqukethe i-GABA. Futhi, kunenkolelo yokuthi ukudla okufana nelayisi elinsundu, i-soy, i-broccoli, isipinashi, utamatisi, kanye ne-cauliflower kusiza ekwandiseni ukukhiqizwa kwe-GABA emizimbeni yethu.
Kodwa njengakwezithasiselo, abukho ubufakazi obanele bokukhombisa ukuthi i-GABA evela kulokhu kudla ifinyelela kangakanani ebuchosheni. Kodwa ukudla ukudla okunempilo nokulinganiselayo kuhle emzimbeni ngazo zonke izindlela.
Umlayezo Wokuya Nawe Ekhaya
- I-GABA iyisithunywa samakhemikhali esiyinhloko 'esizolisayo' ebuchosheni bethu. Isebenza 'njengebhuleki' ebuchosheni bethu.
- Ukulinganisela phakathi kwe-glutamate, okwandisa umsebenzi wobuchopho, kanye ne-GABA, okunciphisa umsebenzi, kubalulekile engqondweni enempilo.
- Amazinga aphansi e-GABA angahlotshaniswa nezimo eziningana zezokwelapha, njengokukhathazeka, ukucindezeleka, kanye nesifo sokuwa.
- Imithi eminingi ebalulekile esetshenziswa kwezokwelapha ihlose uhlelo lwe-GABA. Le mithi kufanele isetshenziswe kuphela ngaphansi kokuqondisa kwezokwelapha.
- Kusenobufakazi obuncane besayensi mayelana nokusebenza kahle kwezithasiselo ze-GABA emakethe, futhi kuyangabazeka ukuthi ziyangena yini ebuchosheni.
- Uma unenkinga yokukhathazeka, ukucindezeleka, noma ukuqwasha, kubaluleke kakhulu ukubonana nodokotela oqeqeshiwe bese ucela iseluleko , kunokuthembela kuphela ezithasiselo noma ekudleni.
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