Ingabe unenani elandayo lama-eosinophils, uhlobo lweseli elimhlophe legazi, emzimbeni wakho? Ake sixoxe nge-Hypereosinophilic Syndrome!

Ingabe ngezinye izikhathi uzizwa sengathi kukhona okungahambi kahle emzimbeni wakho, ukuthi uhlala unezinkinga, kodwa awukwazi ukuthola ukuthi kuyini ngempela? Kunezifo ezithile ezingavamile kakhulu futhi eziyinkimbinkimbi kancane. Namuhla sizokhuluma ngesifo esisodwa esinjalo. Kulokhu, kukhona ukwanda okukhulu kwenani lama -eosinophil, uhlobo olukhethekile lweseli elimhlophe legazi emzimbeni wethu.

Iyini i-Hypereosinophilic Syndrome?

Kalula nje, i-Hypereosinophilic Syndrome (HES) yisimo esingavamile esibangelwa ukwanda ngokweqile kwenani lama-eosinophils , uhlobo lweseli elimhlophe legazi emzimbeni wethu. Manje ungase uzibuze ukuthi ayini lawa ma-eosinophils.

Cabanga ngakho njengenqaba. Kunezinhlobo ezahlukene zamasosha okuvikela le nqaba. Ngokufanayo, kunezinhlobo ezahlukene zamangqamuzana amhlophe egazini lethu alwa namagciwane futhi asivikele ezifweni. Ama-eosinophil angomunye wamasosha akhethekile. Indima yawo eyinhloko ukulwa nezinambuzane ezingena emizimbeni yethu nokusabela ekuguleni komzimba.

Ngokuvamile, ama-eosinophil akha u-5% kuya ku-7% wamangqamuzana amhlophe egazi aphelele egazini lomuntu ophilile. Lokho kusho ukuthi kune-eosinophil ephakathi kuka-100 no-500 nge-microliter ngayinye yegazi. Kodwa-ke, uma unento efana nokungezwani komzimba, lawa ma-eosinophil anganda kancane. Sibiza leso simo ngokuthi i-eosinophilia .

Kodwa-ke, ku-hypereosinophilic syndrome (HES), lesi simo esibizwa ngokuthi i-eosinophilia siba sibi kakhulu, futhi ukukhiqizwa kwe-eosinophil kwenzeka ngesivinini esikhulu, okubangela ukuthi la maseli aqoqeke kakhulu egazini nasezicutshini ezahlukahlukene zomzimba. Lapho ama-eosinophil anda ngale ndlela, la maseli aqala ukulimaza izitho ezibalulekile njengenhliziyo yethu, amaphaphu, isikhumba, kanye nesimiso sezinzwa. Uma singelashwa kahle, lesi simo singasongela impilo. Kodwa izindaba ezinhle ukuthi uma lesi sifo sitholakala kusenesikhathi futhi kuqaliswa ukwelashwa okufanele, abantu abangaphezu kuka-80% abane-HES baphila kahle ngisho neminyaka emihlanu ngemva kokuxilongwa.

Ubani othola i-hypereosinophilic syndrome (HES)?

Lesi simo esibizwa ngokuthi i-HES empeleni asivamile . Ngakho-ke kunzima kodokotela ukusho ngqo ukuthi bangaki abantu abanalesi sifo. Nakuba noma ubani angasithola lesi sifo, sivame kakhulu kubantu abaneminyaka ephakathi kuka-20 no-50 .

Yini ebangela i-hypereosinophilic syndrome (HES)?

Eqinisweni, ezimweni eziningi ze-HES, abacwaningi abakakatholi ukuthi yini ngempela ebangela lokhu kwanda okungazelelwe kwenani lama-eosinophil. Kodwa-ke, bathole ezinye izimo noma izici ezingase zibe nomthelela kulokhu:

• Izifo ze-Myeloproliferative: Lezi yiqembu lezifo ezibonakala ngokukhiqizwa ngokweqile kwamaseli egazi emnkantsheni wethu wamathambo. Kalula nje, kufana nokuthi umnkantshe usebenza kanzima kakhulu.
• Amazinga aphezulu e-Interleukin-5: Lena yiprotheni ekhiqizwa amangqamuzana ethu amhlophe egazi. Uma lokhu kwanda, ukukhiqizwa kwama-eosinophil kuyakhuthazwa.
• Ukukhubazeka kwezakhi zofuzo okusheshisa ukukhula kwamaseli: Ngezinye izikhathi, la maseli angakhula ngokungalawuleki ngenxa yezinguquko ezakhiweni zofuzo.

Ziyini izimpawu ze-HES?

Uphawu oluvame kakhulu lwe-HES ukuqubuka kwesikhumba noma ukuqubuka. Ezinye izimpawu zincike ekutheni amazinga e-eosinophil aphakeme kangakanani emzimbeni.

Cabanga ngakho ngale ndlela:

• Uma inhliziyo ithintekile: Ungase ube nezimpawu ezifana nokwehluleka kwenhliziyo okubangelwa yi-Congestive Heart (isimo esifana nokwehluleka kwenhliziyo), i-Cardiomyopathy (ukuba buthaka kwemisipha yenhliziyo), i-Myocarditis (ukuvuvukala kwemisipha yenhliziyo), noma i-Pericardial Effusion (ukunqwabelana koketshezi oluzungeze inhliziyo).
• Uma amaphaphu ethintekile: Ungase ube nezifo zokuphefumula ezivame ukwenzeka, njengomkhuhlane kanye nomkhuhlane, ukukhwehlela, kanye nobunzima bokuphefumula.

Ngaphezu kwalokho, izimpawu ezivamile ezifana nokukhathala, umkhuhlane, izinhlungu zomzimba, kanye nokwehla kwesisindo nazo zingabonakala.

Odokotela bayixilonga kanjani i-hypereosinophilic syndrome (HES)?

Ukuxilonga i-HES kungaba inqubo eyinkimbinkimbi. Odokotela bavame ukusebenzisa "inqubo yokuqeda," okusho ukuqinisekisa ukuthi azikho ezinye izimo ezingayibangela.

Isibonelo, uma unezilonda zesikhumba ezihlala ziluma, udokotela wakho angase aqale ahlole izimo ezithile zesikhumba bese ekunikeza ukwelashwa.

Uma izimpawu zakho ziqhubeka ngemva kwalokhu kwelashwa, udokotela wakho angase enze ukuhlolwa kwegazi ukuze ahlole amazinga aphezulu e-eosinophil egazini lakho. Uma izimpawu zakho zibonakala zihlobene nenkinga yesibindi, futhi ngemva kokukhipha ezinye izimbangela, udokotela wakho angase enze nokuhlolwa kwegazi lokusebenza kwesibindi . Ngezinye izikhathi, kungadingeka i-biopsy (ukuthatha ucezu lwezicubu) ukuqinisekisa ukuxilongwa kwe-HES.

Ngenxa yokuthi lesi sifo sithatha isikhathi ukuxilonga, ungase ugule izinyanga, ukhathele, futhi ungakwazi ukuthola ukuthi kwenzekani ngempela. Kodwa kubalulekile ukuba nesineke.

Odokotela baphatha kanjani i-hypereosinophilic syndrome (HES)?

Umgomo oyinhloko wodokotela ukunciphisa amazinga aphezulu ama-eosinophil egazini nasezicutshini zakho. Izindlela zokwelapha ezivame kakhulu ezisetshenziswa ukufeza lokhu yilezi:

• Ama-Corticosteroids: Lezi izidakamizwa ezinamandla zokulwa nokuvuvukala.
• Imithi yokwelapha ngamakhemikhali: Imithi enikezwa ukubulala amangqamuzana omdlavuza. Le mithi isetshenziswa futhi ngemithamo ephansi ukulawula amangqamuzana e-eosinophil.

Ngaphezu kwalokho, ngezinye izikhathi kusetshenziswa izindlela zokwelapha eziqondiwe njenge- Imatinib kanye nezindlela zokwelapha ze-antibody ze-monoclonal .

Ingabe i-hypereosinophilic syndrome (HES) ingavinjelwa?

Ngeshwa, njengoba imbangela eqondile yamacala amaningi e-HES ingaziwa, kunzima ukusho noma yini eqondile mayelana nendlela yokuyivimbela.

Uma ngine-hypereosinophilic syndrome (HES), yini okufanele ngiyilindele? (Intuthuko yesifo)

Inkambo yesikhathi esizayo yesifo sakho, noma "ukubikezela," incike esimweni sakho esithile. Isibonelo, uma i-HES yakho ibangelwa yinto ethile, njengesifo somnkantsha wamathambo, udokotela wakho cishe uzokunikeza ukwelashwa okuqondiswe kuleso sifo.

Kodwa-ke, uma udokotela wakho engakwazi ukuthola imbangela yesimo sakho se-HES, ukwelashwa kuzogxila ekulawuleni izimpawu zakho. Isibonelo, uma i-HES ithinta amaphaphu akho futhi uthola izifo ezivame ukutheleleka, ukwelashwa kuzozama ukulawula lezo zifo.

Ngokuvamile, uma i-HES isheshe itholakale futhi yelashwe, kulapho amathuba okuba nezinkinga zesikhathi eside encipha khona.

Ngingayinakekela kanjani impilo yami?

Njengoba sishilo ngaphambili, odokotela bavame ukwelapha i-HES ngama-corticosteroids kanye ne-chemotherapy. Zombili lezi zindlela zokwelapha zingaba nemiphumela emibi . Ngakho-ke, khuluma nodokotela wakho ngale miphumela emibi nokuthi yini ongayenza ukuze unciphise imiphumela yayo.

• Thatha imithi yakho ngesikhathi.
• Landela imiyalelo kadokotela.
• Yidla ukudla okunempilo.
• Zama ukuphumula ngangokunokwenzeka.
• Hlala uqinile engqondweni.

Kufanele ngimbone nini udokotela wami?

Uma utholakale une-HES, futhi izimpawu zakho ziqhubeka noma ziba zimbi kakhulu, bona udokotela wakho ngokushesha. Futhi, qiniseka ukuthi uya khona emihlanganweni yakho ehleliwe yasemtholampilo.

Kufanele ngiye nini eGumbini Lezimo Eziphuthumayo?

Siyazi ukuthi isimo esibizwa ngokuthi i-hypereosinophilic syndrome (HES) singathinta izitho ezahlukene zomzimba, okuhlanganisa nenhliziyo. Ngakho-ke, uma inhliziyo yakho ithintwa yi-HES, futhi ubona izimpawu ezifana nobuhlungu besifuba obungazelelwe, ukuqina kwesifuba, isicanucanu, nokujuluka , kufanele uye ekamelweni eliphuthumayo ngokushesha. Lokhu kungaba izimpawu zokuhlaselwa yinhliziyo.

Yimiphi imibuzo okufanele ngiyibuze udokotela wami?

Ngenxa yokuthi i-HES iyisimo esingavamile, ungase ube nemibuzo eminingi ngaso. Nansi eminye imibuzo ongayibuza ukuze uqalise:

• Dokotela, iyini ngempela le Hypereosinophilic Syndrome?
• Kungani lokhu kwenzeke kimi?
• Ingabe lokhu kungelashwa?
• Yiziphi izindlela zokwelapha ezitholakalayo?
• Iyini imiphumela emibi yokwelashwa?
• Ingabe lesi simo se-HES singabuya?
• Ngingaphulukiswa ngokuphelele?

Okokugcina, izinto okufanele uzikhumbule (Umyalezo Wokuya Ekhaya)

I-Hypereosinophilic syndrome (HES) iyisifo esingavamile futhi ngezinye izikhathi esinzima ukusithola. Uma une-HES, kungenzeka ukuthi usugule izinyanga eziningi, uhlushwa izifo ezahlukahlukene, futhi ungazizwa kahle.

Kodwa izindaba ezinhle ukuthi uma usutholakale une-HES, kunezindlela zokwelapha ezisebenzayo ezitholakalayo. Kungathatha izinyanga eziningana ukuthi ukwelashwa kwakho kubonise imiphumela, ngakho zama ukubekezela. Futhi, uma unenkinga yokubhekana nezinselele zokugula kwesikhathi eside, khuluma nodokotela wakho. Bangakutshela ngezinhlelo nezinsiza ezingakusiza. Khumbula, awuwedwa!

I- Hypereosinophilic Syndrome, i-HES, ama-Eosinophilia, ama-Eosinophilia, amaseli amhlophe egazi, i-Eosinophilia, i-Eosinophilia, izimpawu, ukwelashwa