Ingabe une-gastrin eningi kakhulu esiswini sakho? Ake sixoxe nge-(Hypergastrinemia)!

Ingabe uvame ukuzizwa ungakhululekile esiswini, ugcwele, noma ezinye izinkinga zokugaya ukudla? Ngezinye izikhathi isizathu salokhu kungaba ukuthi izinga lehomoni ebizwa ngokuthi `(Gastrin)` elikhiqizwa emzimbeni wakho liphakeme kunejwayelekile. Namuhla, sizoxoxa ngalesi simo esibizwa ngokuthi `(Hypergastrinemia)` ngokuningiliziwe nangokulula kakhulu.

Kuyini `(i-Hypergastrinemia)`? Ake siqonde kahle!

Kalula nje, `(Hypergastrinemia)` kusho ukuthi izinga `(Gastrin)`, i-hormone esiza imizimba yethu ukugaya ukudla, liphakeme kakhulu kunalokho okudingekayo. Le hormone `(Gastrin)` ikhiqizwa uhlobo olukhethekile lweseli odongeni lwesisu engxenyeni engezansi yesisu sethu, okungukuthi, eduze kwamathumbu amancane. Lokhu sikubiza ngokuthi `(amaseli e-G)`.

Manje bheka, le hormone ethi `(Gastrin)` yiyona etshela isisu sethu ukuthi, "Kulungile, manje sikhipha i-asidi." Le asidi yesisu, okungukuthi `(i-asidi yesisu), ibaluleke kakhulu kithi. Ngoba, le asidi yesisu isisiza ukugaya ukudla esikudlayo futhi imunce izakhamzimba ezikulokho kudla, isibonelo `(ama-amino acid)` kanye namaprotheni.

Kodwa-ke, okungenzeka nge-`(Hypergastrinemia)` kuyinkimbinkimbi kakhulu. Ngezinye izikhathi kungabangela i-asidi eningi esiswini (`hyperchlorhydria`), kanti ngezinye izikhathi kungabangela i-asidi encane esiswini (`hypochlorhydria`). Ngakho-ke ukuthi i-`(Hypergastrinemia)` ikuthinta kanjani kuncike kwezinye izimo zezokwelapha oye wabhekana nazo, ukuhlinzwa oye wakwenza, kanye nemithi oyiphuzayo.

Ubani onamathuba amaningi okuthola lesi simo?

Eqinisweni, lesi simo esibizwa ngokuthi "i-Hypergastrinemia" singenzeka kunoma ubani, kungakhathaliseki ubudala noma ubulili. Ngakho-ke, kuhle ngathi sonke ukuqaphela lokhu.

Yiziphi izimbangela ze-`(Hypergastrinemia)`?

Kungaba nezimbangela eziningana zalesi simo, okuhlanganisa "i-Hypergastrinemia." Ezinye zibangela ukwehla kokukhiqizwa kwe-asidi esiswini, kanti ezinye zikhulisa ukukhiqizwa kwe-asidi esiswini. Ake sibheke lezi ezimbili ngokwehlukana.

Izimbangela zokuncipha kwe-asidi esiswini

Uma kwenzeka i-"Hypergastrinemia", ukukhiqizwa okuvamile kwe-asidi esiswini kungase kwehle ngenxa yalezi zizathu:

• Ama-antacid e-heartburn noma i-GERD (i-Gastroesophageal Reflux Disease): Uma usebenzisa njalo lolu hlobo lwemithi , lokho kungaba yimbangela.
• I-Chronic atrophic gastritis: Lokhu kwenzeka lapho udonga lwesisu luba buthaka kancane kancane futhi luvuvukale ngokuhamba kwesikhathi.
• Umdlavuza we-Colorectal: Lokhu kungathinteka futhi.
• Ukutheleleka kwe-`(H. pylori)`: `(Helicobacter pylori)` yibhaktheriya engaphila esiswini. Lokhu kutheleleka nakho kuyimbangela ye-`(Hypergastrinemia).`
• Ukwehluleka kwezinso: Lesi simo singase senzeke uma izinso zingasebenzi kahle.
• Ukusetshenziswa kwama-Proton Pump Inhibitors (PPIs):Ukusetshenziswa isikhathi eside kwemithi ye-PPI (njenge-omeprazole) kwe-gastritis, i-acid reflux, i-indigestion, noma isifo sesilonda se-peptic nakho kuyimbangela enkulu.
• Ukususwa kwezicubu zomthambo: Lokhu kuhilela ukususa ingxenye yomthambo womthambo womthambo. Lo mthambo ugijima usuka ebuchosheni uye esiswini futhi uthwala izimpawu eziya enhliziyweni nasesimisweni sokugaya ukudla. I-Hypergastrinemia ingenzeka ngemva kwalokhu kuhlinzwa.

Izimbangela zokwanda kwe-asidi esiswini

Manje ake sibheke ukuthi yini ebangela ukwanda kokukhiqizwa kwe-asidi esiswini (i-Hypergastrinemia):

• I-Antral G-cell hyperplasia (i-pseudo-Zollinger-Ellison syndrome / i-Ps-ZES): Lesi yisimo esingavamile. Sifana ne-Zollinger-Ellison syndrome, kodwa azikho izimila ezikhiqiza i-gastrin ku-pancreas noma engxenyeni yokuqala yamathumbu amancane (i-duodenum).
• Ukuvaleka kokuphuma kwesisu: Lesi simo singase senzeke lapho indlela esuka esiswini eya emathunjini amancane ivaliwe. Cabanga ngakho njengepayipi lamanzi elivalekile.
• I-neoplasia ye-endocrine ehlukahlukene yohlobo-1 (MEN-1): Lesi simo sibangela ukuba kukhule izimila ze-neuroendocrine ezindlaleni ze-adrenal, izindlala ze-thyroid, noma izindlala ze-parathyroid.
• I-Retained antrum syndrome: Lesi simo singase senzeke uma ingxenye encane yesisu (i-antrum) ishiywa ngemuva kokuhlinzwa ukuze kususwe izimila noma kwelashwe izilonda.
• I-Zollinger-Ellison syndrome (ZES): Lesi yisimo lapho izimila zikhiqiza khona i-hormone gastrin ngokweqile. Lesi simo (ZES) singabangela izilonda zesisu.

Yiziphi izimpawu zesimo `(i-Hypergastrinemia)`?

Uma une-`(Hypergastrinemia)`, ungase ube nezimpawu ezifana nalezi:

• Ubuhlungu besisu: Ungase ube nobuhlungu besisu obuvamile.
• Uhudo olungapheli: Uhudo oluhlala izinsuku eziningana.
• Izimila ze-pancreatic: Lezi zingaba izimila ezinomdlavuza noma ezingenabungozi.
• Izilonda zesisu: Izilonda ezenzeka ngokuvuvukala kwesisu.
• I-esophagitis enzima: Ukuvuvukala okukhulu kanye nobuhlungu emhubheni.

Odokotela bakuthola kanjani lesi simo?

Ukuze baxilonge ngokunembile i-hypergastrinemia, odokotela kudingeka banqume ukuthi isisu sakho sikhiqiza i-asidi engakanani. Baphinde balinganise izinga le-gastrin egazini lakho.

• Ngaphambi kwalokhu kuhlolwa, udokotela wakho uzokutshela ukuthi uzile ukudla (ungadli) isikhathi esithile .
• Futhi, uma ungumsebenzisi we-``(PPI)```,Kuzodingeka uyeke ukuthatha lowo muthi cishe isonto ngaphambi kokuhlolwa.
• Bese, bathatha isampula yegazi lakho bese behlola amazinga akho e-Gastrin. Ngezinye izikhathi, bangathatha lawa masampula egazi izikhathi eziningana ngosuku, phakathi nezinsuku eziningana, ukuze babone ukuthi amazinga akho e-Gastrin ayashintsha yini.

Uma udokotela wakho esola i-hypergastrinemia, angase acele ukuhlolwa okwengeziwe ukuze anqume ezinye izimo, okuhlanganisa:

• Ukuhlolwa kokukhuthazwa kwe-Secretin: Lokhu kuhilela ukukunikeza i-hormone ebizwa ngokuthi i-secretin, ekhiqizwa yingxenye yokuqala yamathumbu akho amancane (i-duodenum). Uma amazinga akho e-gastrin enyuka ngokuzumayo kakhulu, kungaba uphawu lwe-Zollinger-Ellison syndrome.
• Ukuhlolwa kwe-pH yesisu: Lokhu kuhlola amazinga e-asidi esiswini sakho. I-pH engaphansi kuka-2 nayo iyisibonakaliso sokuthi ungase ube ne-Zollinger-Ellison syndrome.

Iphathwa kanjani i-Hypergastrinemia?

Ukwelashwa kwe-hypergastrinemia kuncike embangela.

• Umdlavuza wamathumbu amakhulu, ukuvaleka komphimbo, isifo sezinso, kanye nezimo ezifana ne-`(MEN-1)` kanye ne-`(ZES)`: Uma lezi zimo zelashwa (ngokuvamile ngokuhlinzwa), izimpawu ze-`(Hypergastrinemia)` nazo ziyaphela.
• I-Atrophic gastritis (ACG) kanye nokutheleleka kwe-H. pylori: Lezi zimo zingelashwa ngama-antibiotic.
• Ama-Proton-pump inhibitors (PPIs): Uma uthatha i-PPI, i-hypergastrinemia ivame ukuxazululeka zingakapheli izinsuku ezinhlanu kuya kweziyisikhombisa ngemva kokuyeka imithi.
• I-Retained antrum syndrome: Ukususa izicubu ze-antral ezisele engxenyeni engezansi yesisu kunganciphisa inani le-asidi yesisu eyengeziwe ekhiqizwayo.

Into ebaluleke kakhulu ukukhuluma nodokotela wakho mayelana nokwelashwa okungcono kakhulu kwesimo sakho.

Ngingayinciphisa yini ingozi ye-`(Hypergastrinemia)`?

Uma usebenzisa isikhathi eside ama-antacid noma ama-PPI, kunengozi yokuthola i-hypergastrinemia. Ngakho-ke, kubalulekile ukukhuluma nodokotela wakho mayelana nendlela yokuphatha le ngozi.

Uma ngine-`(i-Hypergastrinemia)`, yini engingayilindela? Kwenzekani uma ingelashwa?

Uma i-hypergastrinemia ingelashwa kahle, amazinga e-gastrin emzimbeni ahlala ephezulu. Abacwaningi basola ukuthi lokhu kungabangela ukukhula kwamangqamuzana omdlavuza. Isibonelo:

• Umdlavuza wegazi: njenge-leukemia, i-lymphoma, kanye ne-multiple myeloma.
• Umdlavuza we-Esophageal
• Umdlavuza we-pancreatic

Futhi, i-`(Hypergastrinemia)` yesikhathi eside ingaholela ezimila zesisu `(gastric carcinoids)` noma `gastric adenocarcinoma`. Kunezinhlobo ezimbili ze-`(gastric carcinoids)`:

• Uhlobo I lwe-carcinoids yesisu: Lezi zihlotshaniswa nesifo se-gastritis esingamahlalakhona esingapheli.
• Ngokuvamile kwenzeka kwabesifazane.
• Kungabonakala ezindaweni eziningana esiswini.
• Amathuba okuba nomdlavuza aphansi.
• Uhlobo lwesibili lwe-carcinoids yesisu: Lokhu kuhlotshaniswa nezimo ze-ZES kanye ne-MEN-1.
• Kungenzeka kokubili kwabesilisa nabesifazane.
• Kungabonakala ezindaweni eziningana esiswini.
• Ngezinye izikhathi kungaphenduka umdlavuza (phakathi kuka-7% no-12%).

Uyini umbono womuntu one-`(Hypergastrinemia)`?

Isimo sempilo yesikhathi esizayo somuntu one-"Hypergastrinemia" sincike ezintweni eziningana:

• Imbangela yalesi sifo.
• Izakhi zofuzo.
• Umlando wezempilo.
• Indlela yokuphila.

Kodwa-ke, ngokwelashwa okufanele, abantu abane-"Hypergastrinemia" bangaphila impilo esebenzayo nejwayelekile.

Nginesifo se-`(Hypergastrinemia)`, ngingazinakekela kanjani?

Uma uthatha ama-antacid noma ama-PPI isikhathi eside, kubalulekile ukuthi uhlolwe njalo ngudokotela. Xhumana nodokotela wakho ukuze uthole iseluleko.

Kufanele ngimbone nini udokotela?

Uma uhlangabezana nanoma yiziphi zalezi zimpawu ezintsha, noma uma uzizwa sengathi izimpawu zakho ezikhona ziya ziba zimbi kakhulu, qiniseka ukuthi ubona udokotela bese uthola ukuhlolwa okuphelele.

Izinto okufanele uzikhumbule ngamafuphi

Kulungile-ke, ake sikhumbule nje lokho esikukhulume ngakho:

• I-Hypergastrinemia ukwanda kwe-gastrin ye-hormone emzimbeni.
• Le hormone (i-Gastrin) ithinta amazinga e-asidi esiswini (i-asidi inganda noma yehle).
• Kungaba nezizathu eziningi – izinto ezifana `(PPI)`/nokusetshenziswa okuqhubekayo kwama-antacid, ukutheleleka kwe-`(H. pylori)`, isifo sohudo, `(i-Zollinger-Ellison syndrome)`.
• Odokotela baxilonga lokhu ngokuhlola izinga le-"Gastrin".
• Ukwelashwa kusekelwe embangela eyinhloko.
• Ungazinaki izimpawu, ngoba zingakhula zibe yizimila nomdlavuza uma zingelashwa! Funa iseluleko sezokwelapha ngokushesha.

Ngithemba ukuthi lolu lwazi luwusizo. Hlala uphilile!

I- Hypergastrinemia, i-Gastrin, i-Stop Acid, ukugaya ukudla, i-Zollinger-Ellison syndrome, i-H. pylori, i-PPI, i-Gastritis, ukuvuvukala kwesisu