Ingabe unesifo sesibindi esibizwa ngokuthi i-PBC, noma i-Primary Biliary Cholangitis? Uma kunjalo, umuthi wokuqala udokotela wakho awunike wona kungenzeka ukuthi awusebenzanga kahle njengoba ubulindele. Ungakhathazeki ngakho. Abantu abaningi baye baba nokuhlangenwe nakho okufanayo. Into ebalulekile ukuhlala unethemba futhi uqaphele ukuthi yini ongayenza ngokulandelayo. Namuhla, ake sixoxe ngalokho ongakwenza ngesikhathi esinjengalesi nokuthi yiziphi izindlela zokwelapha ezintsha ezitholakalayo.
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Okokuqala, iyini i-PBC ngamagama alula?
I-PBC iyisimo esiyinkimbinkimbi, sesikhathi eside lapho amasosha omzimba wethu ehlasela khona imigudu ye-bile encane esibindini sethu. Cabanga ngale migudu ye-bile njengemibhobho emincane esibindini sethu. Umsebenzi wayo oyinhloko ukuthwala i-bile, uketshezi olusiza ekugayeni ukudla, luphume esibindini.
Manje, uma kwenzeka i-PBC, amangqamuzana ethu omzimba alimaza la mapayipi. Bese la mapayipi evalwa, bese i-bile ingahambi kahle bese inamathela ngaphakathi kwesibindi. Njengoba nje izimoto zibhajwa emotweni. Lapho i-bile iqoqana ngale ndlela, iqala ukulimaza amangqamuzana esibindi. Ngokuhamba kwesikhathi, lo monakalo ungabangela izibazi esibindini. Lokhu sikubiza ngokuthi i -fibrosis . Uma lesi simo siba sibi kakhulu, singaholela engcupheni ye-cirrhosis, isimo esibizwa ngokuthi ukwehluleka kwesibindi.
Lokhu kuhlukile kancane kwezinye izifo ezibangelwa ukuzivikela komzimba. Ngoba i-PBC ayiphenduli kahle emithini ecindezela amasosha omzimba esetshenziselwa ezinye izifo ezibangelwa ukuzivikela komzimba. Esinye isizathu kungaba ukuthi isibindi sesivele sonakele ngezinga elithile ngesikhathi lesi sifo sitholakala. Kodwa ungakhathazeki, ngokuthuthuka kwesayensi, manje sekukhona izindlela ezinhle zokwelapha lokhu.
Isinyathelo sokuqala sokwelashwa: imithi ye-UDCA
Kunemigomo eminingana eyinhloko yokwelapha i-PBC: ukunciphisa ukuqhubeka kwesifo, ukulawula izimpawu, nokuvimbela izinkinga ezibangelwa ukulimala kwesibindi.
Uma usuthole ukuthi une-PBC, umuthi wokuqala udokotela wakho angase akuqale ngawo yi- Ursodeoxycholic acid , noma i-UDCA ngamafuphi. Ungase ukwazi ngegama lomkhiqizo i-Ursodiol. Lo muthi usebenza ngokusiza isibindi ukuthi sikhiphe inyongo ebhajwe esibindini futhi unciphise ukwakheka kwezibazi (fibrosis) esibindini. Lokhu kubalulekile, ngoba izibazi yizona ezingagcina ziholele ekuqineni kwesibindi kanye nokwehluleka kwesibindi.
Kodwa iqiniso liwukuthi, i-UDCA ayisebenzi kuwo wonke umuntu. Leli yiphuzu eliyinhloko esikhuluma ngalo namuhla.
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Check Availability →Kungani i-UDCA yodwa inganele?
Ucwaningo luthole ukuthi phakathi kuka-25% no-50% weziguli ezithatha i-UDCA azitholi imiphumela elindelekile kulo muthi. Lokhu kusho ukuthi ukuhlolwa kokusebenza kwesibindi kwazo akubonisi intuthuko enkulu.
Ngale ndlela, umuntu ongasabeli kahle ku-UDCA unengozi ephindwe kahlanu yokuba ne-cirrhosis. Futhi ingozi yokufa ngenxa yalesi sifo iphindwe kathathu . Ngakho-ke uma i-UDCA ingasebenzi, kubalulekile ukukhuluma nodokotela wakho ngezinyathelo ezilandelayo, kunokuqhubeka nje nokuyisebenzisa.
Uyazibuza ukuthi kungani i-UDCA ingasebenzi kahle? Kungaba nezizathu eziningana zalokho.
| Izizathu zokwehluleka kokwelashwa kwe-UDCA | Incazelo elula |
|---|---|
| Usuvele unezibazi zesibindi (i-cirrhosis) | Uma isibindi sesivele sonakele ngezinga elithile lapho kutholakala lesi sifo, kungaba nzima ukusilawula nge-UDCA yodwa. |
| Amazinga aphezulu e-GGT | Uma ukuhlolwa kwegazi lakho kubonisa amazinga aphezulu kakhulu e-enzyme yesibindi ebizwa ngokuthi i-gamma-glutamyl transferase (GGT) lapho utholakala ukuthi unesifo okokuqala, lokho kungaba yimbangela yokusabela kabi ekwelashweni. |
| Umzimba awukwazi ukubekezelela umuthi. | Imizimba yabanye abantu ayikwazi ukubekezelela i-UDCA, okusho ukuthi ayikwazi ukuthatha umuthi ngesilinganiso esinqunyiwe ngenxa yemiphumela emibi. |
Uma unesinye noma ngaphezulu salezi zizathu, sekuyisikhathi sokucabangela ukwelashwa komugqa wesibili . Umgomo lapha akukhona nje ukuthuthukisa imiphumela yokuhlolwa kwegazi lakho. Kubalulekile futhi ukulawula izimpawu ezithinta ikhwalithi yokuphila kwakho, njengokulunywa okungabekezeleleki , ukukhathala ngokweqile, nokungalali . Ngoba i-UDCA ayinikezi impumuzo enkulu kulezi zimpawu.
Ukwelashwa komugqa wesibili: Yiziphi lezi zinketho ezintsha?
Izindlela zokwelapha ze-PBC ziyashintsha ngokushesha. Imithi emisha eminingana isesigabeni sokugcina sokuvunyelwa. Ake sibheke izindlela zokwelapha zamanje nezizayo.
I-Obeticholic acid (OCA)
Uma i-UDCA ingasebenzi kahle, noma uma ungakwazi ukubekezelela i-UDCA, umuthi olandelayo oyinhloko udokotela wakho azowusebenzisa yi- obeticholic acid , noma i-OCA . Ngokuvamile itholakala ngaphansi kwegama lomkhiqizo i-Ocaliva.
Ngezinye izikhathi i-OCA inganikezwa kanye ne-UDCA. Okusho ukuthi, zombili izidakamizwa zisetshenziswa ndawonye. I-OCA ingeqembu lemithi ebizwa ngokuthi i-farnesoid X receptor agonists . Kalula nje, umsebenzi wayo uku:
1. Kunciphisa inani lenyongo ekhiqizwa yisibindi.
2. Kusiza ekukhipheni inyongo esibindini.
Ngale ndlela, uma i-OCA isetshenziswa yodwa noma ne-UDCA, ukusebenza kwesibindi kuyathuthuka futhi izinga lokuqhekeka kwesibindi liyancipha.
Kodwa omunye wemiphumela emibi eyinhloko ye-OCA ukuthi ingandisa ukulunywa kweziguli ezine-PBC. Ngakho-ke, uma ukulunywa kuyanda ngemva kokuqala lo muthi, kufanele nakanjani utshele udokotela wakho ngakho. Ngemuva kwalokho angashintsha umthamo noma akunike ukwelashwa okuhlukile.
Umkhakha wokwelashwa kwe-PBC ushintsha njalo, ngakho-ke kubalulekile ukuthi impilo yakho ihlale ixhumana nodokotela wakho futhi ixoxe ngemithi emisha.
Umlayezo Wokuya Nawe Ekhaya
- I-PBC yisifo sesibindi sesikhathi eside esidinga ukwelashwa. Ungasinaki.
- I-UDCA iyisidakamizwa sokuqala esibaluleke kakhulu kulokhu, kodwa kungenzeka inganikezi imiphumela efanayo kuwo wonke umuntu.
- Uma ungatholi imiphumela emihle evela ku-UDCA noma ungakwazi ukubekezelela imiphumela emibi, akusikho ukuphela kokwelashwa. Manje sekukhona ukwelashwa kwesibili okusebenzayo, njenge-OCA.
- Ungenzi izinqumo zokwelashwa wedwa. Khuluma nodokotela wakho ngokukhululekile njalo mayelana nokwelashwa kwakho, ukuhlolwa kwegazi kanye nezimpawu.
- Ukuhlolwa kwezokwelapha kanye nokuhlolwa kwegazi (ikakhulukazi ukuhlolwa kokusebenza kwesibindi) ngesikhathi kubalulekile ekulawuleni lesi sifo.
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