Ingabe nawe unenkinga nge -cholesterol ? Mhlawumbe uthatha umuthi owunikezwe udokotela wakho, ulawula ukudla kwakho , futhi uzivocavoca. Kodwa kusenzima ukwehlisa amazinga akho e-cholesterol, akunjalo? Ngezinye izikhathi, kungakhathaliseki ukuthi uzama kangakanani, amazinga e-cholesterol embi emzimbeni wakho angahlala ephezulu. Kulesi sihloko, sizokhuluma ngeqembu elisha lemithi elingasiza abantu abanjalo.
Kalula nje, ziyini lezi zithiyo ze-PCSK9?
Lokhu kungase kuzwakale njengegama eliyinkimbinkimbi, kodwa kusebenza kalula kakhulu. Ama-PCSK9 inhibitors ayiqembu lemithi ehlisa i-cholesterol. Ngokukhethekile, ahlose i-LDL (Low-Density Lipoprotein) cholesterol , okuyi-"cholesterol embi" eyingozi emizimbeni yethu. Abanye abantu banamazinga aphezulu e-cholesterol kukho konke ukuphila kwabo. Kulabo bantu, lolu hlobo lomuthi lungaba usizo kakhulu.
Kulungile, manje ake sibone ukuthi igama elithi `PCSK9` lisho ukuthini. `I-PCSK9` uhlobo olukhethekile lweprotheyini ekhiqizwa yisibindi sethu. Igama lale protheyini yi-`proprotein convertase subtilisin/kexin type 9`. Ekwenzayo ukulawula izinto ezibizwa ngokuthi `ama-LDL receptors` emzimbeni wethu. Izifundo zezokwelapha zithole ukuthi uma umzimba womuntu ukhiqiza ngokwemvelo iphrotheyini ye-`PCSK9` eningi, lowo muntu unamathuba amaningi okuba ne -cholesterol ephezulu .
Ubani odinga lo muthi?
Lona umbuzo obaluleke kakhulu. Ngoba lo muthi awunikezwa wonke umuntu one-cholesterol ephezulu. Ngokuvamile kunezimo ezimbili eziyinhloko lapho udokotela wakho angakunikeza khona lo muthi 'we-PCSK9 inhibitor':
1. Uma i-cholesterol ingalawulwa ngeminye imithi: Uma usuvele usebenzisa eminye imithi yokwehlisa i-cholesterol, njenge-`(statins)` kodwa amazinga akho e-cholesterol esephezulu, ungase ucabangele lo muthi njengesinyathelo esilandelayo.
2. Ezimweni ezithile zofuzo: Abanye abantu banesimo sofuzo, sokuzalwa esine-cholesterol ephezulu. Lokhu kubizwa ngokuthi "i-familial hypercholesterolemia" kwisayensi yezokwelapha.Lomuthi uwusizo kakhulu nakubantu abanalesi simo.
Khumbula, umgomo oyinhloko walo muthi ukwehlisa amazinga akho e-cholesterol, ngaleyo ndlela kuncishiswe ingozi yezinkinga ezinkulu zenhliziyo nemithambo yegazi njengokuhlaselwa yinhliziyo kanye nesifo sohlangothi .
Lo muthi usebenza kanjani emzimbeni?
Ukuze siqonde lokhu, ake sithathe isibonelo esincane.
Cabanga ukuthi umzimba wakho “unezandla ezibamba i-cholesterol.” Sibiza lezi ngokuthi “ama-receptor e-LDL.” Lawa “ma-receptor” atholakala kakhulu ebusweni bamaseli ethu esibindi. Lawa “zandla” abamba i-cholesterol embi entanta egazini (i-LDL cholesterol) bese eyiyisa esibindini. Isibindi sibe sesiyiphula leyo cholesterol bese siyisusa emzimbeni. Lena inqubo evamile.
Kodwa kukhona into embi lapha. Leyo yiprotheni ethi `(PCSK9)` esikhulume ngayo ngaphambilini. Le phrotheni ethi `PCSK9` isebenza njengesikelo. Ekwenzayo ukubhubhisa lezo zandla ezibamba i-cholesterol, okungukuthi, `ama-receptor e-LDL`, futhi inciphise umsebenzi wazo. Lapho iphrotheni ethi `PCSK9` yanda emzimbeni, inani `lezandla` ezibamba i-cholesterol liyancipha. Khona-ke i-cholesterol embi egazini ayikwazi ukususwa yisibindi futhi iqoqeke egazini.
Manje cishe usuyaqonda ukuthi umuthi we-`PCSK9 inhibitor` wenzani. Ukuze kube sobala, lo muthi uvimbela iphrotheni ye-`PCSK9` esebenza njengesikelo. Lokho kusho ukuthi, uma lo muthi uthathwa, iphrotheni ye-`PCSK9` ayikwazi ukubhubhisa lezo zandla ezibamba i-cholesterol (ama-receptor e-LDL).
Kwenzekani-ke?
- Kunezitho zokwamukela i-LDL ezisebenzayo kakhulu.
- Lezi 'zandla' ezisebenzayo zibamba i-cholesterol embi eningi egazini bese ziyiyisa esibindini.
- Isibindi sisusa leyo cholesterol emzimbeni.
Umphumela wokugcina ukwehla okukhulu kwezinga le-cholesterol embi egazini lakho.
Lo muthi usebenza kahle kangakanani? Futhi yiziphi izinhlobo zawo?
Ama-PCSK9 inhibitors ayizinhlobo zemithi eziye zabonakala zisebenza kahle kakhulu kwabanye abantu. Ezinye izifundo zithole ukuthi le mithi inganciphisa amazinga e-cholesterol embi (i-LDL cholesterol) ngamaphesenti afinyelela ku-70 futhi inganciphisa nengozi yokuhlaselwa yinhliziyo cishe ngengxenye yesithathu.
Kunezinhlobo ezimbili ze-'PCSK9 inhibitors' ezisetshenziswa kakhulu eSri Lanka nasemhlabeni jikelele njengamanje:
- `Alirocumab` (igama lomkhiqizo: Praluent®)
- `Evolocumab` (igama lomkhiqizo: Repatha®)
Uwuthatha kanjani umuthi?
Leli akulona iphilisi okufanele uliphuze nsuku zonke. `Izithibi ze-PCSK9` zinikezwa njengomjovo.Ngokuvamile kuzodingeka uthole lo muthi wokugoma njalo emavikini ambalwa noma njalo ezinyangeni ezimbalwa, njengoba kunqunywe udokotela wakho.
Ngesikhathi ethatha lo muthi, udokotela wakho uzokwenza ukuhlolwa kwegazi njalo ukuze ahlole ukuthi umuthi usebenza kahle kangakanani. Ngezinye izikhathi lo muthi unganikezwa wodwa, kanti ngezinye izikhathi unganikezwa uhlanganiswe nomuthi osuvele uwuthatha, njenge-statin.
Yiziphi izinzuzo kanye nemiphumela engemihle engaba khona?
Njenganoma yimuphi umuthi, lo muthi ungaba nezinzuzo kanye nemiphumela emibi emincane. Kodwa-ke, abantu abaningi ababi nemiphumela emibi kakhulu.
| Incazelo | Izibonelo |
|---|---|
| Izinzuzo eziyinhloko |
|
| Imiphumela emibi evamile | |
| Imiphumela emibi engavamile |
Ingabe umuthi wodwa wanele? Cha, lokhu kuyingxenye yohlelo olukhulu.
Lokhu kubaluleke kakhulu. Kungakhathaliseki ukuthi uthatha i-PCSK9 inhibitor noma omunye umuthi wokwehlisa i-cholesterol, kuyingxenye eyodwa kuphela yohlelo lwakho lokwelashwa oluphelele. Kunezinye izinto eziningi ongazenza ukuze uvikele impilo yenhliziyo yakho, ngaphandle kokuthembela kuphela emithini.
- Ukudla okuhle: Yidla amafutha amancane, ushukela, nosawoti, bese udla imifino eminingi, izithelo, imifino kanye nokudla okune-fiber eningi.
- Ukuzivocavoca: Zivocavoce ngendlela enempilo yenhliziyo, njengokuhamba ngokushesha, ukugijima, noma ukugibela ibhayisikili, okungenani izinsuku ezimbalwa ngesonto.
- Ukulawula ukucindezeleka: Ukuphumula ingqondo yakho ngezinto ezifana nokuzindla kanye ne-yoga.
- Ubuthongo obuhle: Lala okungenani amahora angu-7-8 njalo ebusuku.
- Gwema ukubhema: Uma ubhema, yeka ngokuphelele.
Uzothola imiphumela emihle kakhulu uma uhlanganisa lezi zinguquko zendlela yokuphila nemithi.
Udokotela wakho kuphela ongenza isinqumo sokugcina sokuthi kufanele uthathe lo muthi isikhathi esingakanani, nokuthi uwuyeke noma uqhubeke nawo. Ngakho-ke, kubalulekile ukulandela imiyalelo kadokotela wakho ngqo.
Umlayezo Wokuya Nawe Ekhaya
- Ama-"PCSK9 inhibitors" awuhlobo lomuthi olusebenza kahle kakhulu, olunikezwa njengomjovo, ezimweni ze-cholesterol ephezulu okunzima ukuzilawula ngemithi evamile.
- Lokhu kusiza isibindi ukususa "i-cholesterol embi" (i-LDL) egazini.
- Lokhu akuvamile ukunikezwa njengokwelashwa kokuqala. Udokotela wakho uzokucabangela kuphela uma ezinye izindlela zokwelapha zehlulekile.
- Ngesikhathi uthatha lo muthi, kubaluleke kakhulu ukugcina indlela yokuphila enhle ehlanganisa ukudla okunempilo kanye nokuzivocavoca umzimba.
- Khuluma ngokukhululekile nodokotela wakho mayelana nokuthi lo muthi ukulungele yini noma cha kanye nalo lonke ulwazi oluhlobene nawo.
Izithibi ze-PCSK9, i-cholesterol, i-cholesterol, i-LDL cholesterol, ukuhlaselwa yinhliziyo, isifo sohlangothi, i-hypercholesterolemia yomndeni, i-statin, i-Alirocumab, i-Evolocumab
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