Wake waba nesikhathi esinzima ukulawula i-cholesterol yakho, noma ngabe uzame imithi ehlukahlukene, ukudla okunempilo, kanye nokuzivocavoca? Ngezinye izikhathi kuyenzeka. Lokhu kuyinselele ikakhulukazi uma unomlando womndeni we-cholesterol ephezulu. Namuhla, sikhuluma ngeklasi elisha lemithi elingasiza. Lezi zibizwa ngokuthi ama-PCSK9 inhibitors.
Ziyini lezi zithiyo ze-PCSK9?
Kalula nje, lezi yizidakamizwa ezinamandla zokwehlisa i-cholesterol ezinikezwa njengemijovo. Ngokuyinhloko zihlose i-LDL cholesterol (Low-Density Lipoprotein Cholesterol) , "i-cholesterol embi" sonke esiyazi njengembi emizimbeni yethu. Odokotela bavame ukunikeza le mithi kubantu abangazange bathole imiphumela efiselekayo yeminye imithi ye-cholesterol, njenge-statins, noma kubantu abanomlando womndeni we-cholesterol ephezulu.
Lo muthi usebenza kanjani emzimbeni?
Ukuze siqonde lokhu, ake sithathe isibonelo esincane. Cabanga ukuthi i-cholesterol embi (LDL) egazini lakho iwuhlobo lwenkunkuma. Ukuze sisuse lo mdaka futhi sihlanze igazi, isibindi sethu sinesitsha esikhethekile "somgqomo kadoti" ebusweni baso. Yilokhu esikubiza ngokuthi ama-receptor e-LDL ngokwezokwelapha. Lokho okwenziwa yila ma-receptor ukubamba i-cholesterol ye-LDL egazini bese siyiyisa esibindini ukuze ibhujiswe.
Manje nansi enye. Leyo yiprotheni ebizwa ngokuthi i-PCSK9 . Lokhu kukhiqizwa futhi yisibindi sethu. Kodwa umsebenzi wale phrotheni ye-PCSK9 ukubhubhisa ama-receptor e-LDL (amathini ethu kadoti) asusa i-cholesterol. Lapho izinga le-PCSK9 landa emzimbeni, ama-receptor amaningi e-LDL ayabhujiswa. Bese ukususwa kwe-cholesterol egazini kuyehla, futhi izinga le-cholesterol egazini liyakhuphuka.
Ngakho-ke, lokho okwenziwa umuthi wokugomela i-PCSK9 inhibitor ukuvimba leyo phrotheni ye-PCSK9 ebhubhisayo bese uyivimba ukuthi ingasebenzi. Ngemuva kwalokho ama-receptor ethu e-LDL awabhujiswa, futhi angasebenza ngokukhululeka. Umphumela uba ukuthi i-cholesterol eningi ye-LDL isuswa egazini, futhi amazinga e-cholesterol ancishiswa kakhulu. Kulula kakhulu, akunjalo?
Lo muthi unconyelwa bani?
Lona akuyona imithi efanela wonke umuntu. Udokotela wakho uzonquma ukuthi lo muthi ukulungele yini ngokusekelwe ezicini eziningana.
| Isimo | Incazelo |
|---|---|
| I-cholesterol ephezulu engalawulwa eminye imithi | Uma amazinga akho e-LDL esephezulu naphezu kokuthatha umthamo omkhulu we-statin kanye neminye imithi ye-cholesterol. |
| Izimo ze-cholesterol ephezulu ezizuzwe njengefa | Abantu ababenamazinga aphezulu kakhulu e-cholesterol kusukela ebuntwaneni ngenxa yezimo zofuzo ezifana ne-Familial Hypercholesterolemia. |
| Kulabo abasengozini enkulu kakhulu yesifo senhliziyo | Uma usuvele unesifo sohlangothi noma isifo sohlangothi, futhi ingozi yokuthi isimo esinjalo senzeke esikhathini esizayo iphezulu kakhulu. |
Ngingawuthola kanjani lo muthi?
Lezi zinikezwa njengomjovo, hhayi iphilisi. Kuye ngokuthi udokotela wakho uncoma ini, ngokuvamile uzothola lo mjovo esibhedlela noma emtholampilo njalo emavikini ambalwa noma ezinyangeni ezimbalwa. Izinhlobo ezimbili eziyinhloko ezisetshenziswa njengamanje eSri Lanka yi -Alirocumab (Praluent®) kanye ne -Evolocumab (Repatha®) .
Ngemva kokuqala lokhu kwelashwa, udokotela wakho uzokwenza ukuhlolwa kwegazi njalo futhi aqaphe amazinga akho e-cholesterol ukuze abone ukuthi asebenza kahle kangakanani.
Ziyini izinzuzo nemiphumela emibi?
Inzuzo enkulu yalo muthi ukuthi uyasebenza kakhulu ekunciphiseni amazinga e-cholesterol e-LDL. Ngokwezinye izifundo, zinganciphisa amazinga e-LDL phakathi kuka-50% no-70% . Lokhu kunciphisa kakhulu ingozi yokuhlaselwa yinhliziyo, isifo sohlangothi, nezinye izifo zenhliziyo.
Nakuba abantu abaningi bengenazo imiphumela emibi kakhulu, abanye bangase babe nemiphumela emincane.
- Ukuvuvukala, ukubomvu, noma ubuhlungu endaweni yokujova
- Ukuzizwa ukhathele (Ukukhathala)
- Ubuhlungu bemisipha
- Izimpawu ezifana nokubanda
Akuvamile kakhulu, abanye abantu bangase babe nemiphumela ethile ekusebenzeni kwesibindi noma kwezinso zabo. Yingakho kubaluleke kakhulu ukubona udokotela wakho njalo ukuze ahlolwe . Uma uhlangabezana nanoma yiziphi izimpawu ezingavamile, yazisa udokotela wakho ngokushesha.
Akwanele yini ukusebenzisa lo muthi kuphela?
Lona umbuzo obaluleke kakhulu. Impendulo ithi, "Cha, akwanele." Ama-inhibitor e-PCSK9 awawona umlingo. Ayingxenye eyodwa nje yohlelo lokwelapha oluphelele.
Khumbula, ukulawula i-cholesterol akukhona nje ukuphuza iphilisi, kodwa kumayelana nokushintsha yonke indlela yakho yokuphila.
Ngesikhathi uthola lo muthi wokugomela, kufanele nakanjani unakekele okulandelayo:
- Ukudla okunempilo: Yidla amafutha amancane, ushukela, nosawoti, kanye nezithelo, imifino kanye nokudla okune-fiber eningi.
- Ukuzivocavoca okuvamile: Zivocavoce njengokuhamba noma ukugijima okungenani imizuzu engama-30 ngosuku, okungenani izinsuku ezi-5 ngesonto.
- Ukulawula ukucindezeleka: Ukuphumula ingqondo ngezinto ezifana ne-yoga nokuzindla.
- Ubuthongo obanele: Thola amahora angu-7-8 obuthongo obuhle nsuku zonke.
- Ukuyeka ukubhema: Ukuyeka ngokuphelele ukubhema nemikhiqizo kagwayi.
Uzothola imiphumela emihle kakhulu ngokwelashwa nge-PCSK9 inhibitor uma uhlanganisa lezi zinguquko zendlela yokuphila. Ungalokothi uyeke ukuthatha imithi noma ushintshe umthamo ngaphandle kweseluleko sikadokotela wakho.
Umlayezo Wokuya Nawe Ekhaya
- Ama-inhibitor e-PCSK9 uhlobo olunamandla lomjovo olusetshenziselwa ukwehlisa amazinga aphezulu e-cholesterol ye-LDL angalawulwa ezinye izindlela zokwelapha.
- Lokhu kuvikela ama-receptor e-LDL esibindi futhi kwenza inqubo yokususa i-cholesterol egazini isebenze kahle kakhulu.
- Lokhu ukwelashwa okunconywa udokotela kuphela ezimweni ezithile (isib., i-cholesterol ephezulu ezuzwe njengefa, ingozi ephezulu yesifo senhliziyo).
- Kubaluleke kakhulu ukugcina indlela yokuphila enempilo ngenkathi uthola lokhu kwelashwa.
- Qhubeka nalokhu kwelashwa kuphela ngokweseluleko sikadokotela wakho, ulokhu uxhumana naye njalo.
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