Ingabe une-immune protein eningi kakhulu emzimbeni wakho? Ake sifunde nge-Polyclonal Gammopathy ngamagama alula!

Wake watshelwa udokotela ukuthi unezinga eliphezulu kakhulu lamaprotheni athile omzimba (ama-immunoglobulins) egazini lakho? Kujwayelekile ukuzizwa wesaba kancane uma uzwa into efana naleyo. Kodwa ungakhathazeki. Namuhla sizokhuluma ngesimo esibizwa ngokuthi "i-Polyclonal Gammopathy." Sizochaza ukuthi siyini, kungani senzeka, nokuthi yini ongayenza ngakho ngendlela elula neqondakala kalula.

Iyini le Polyclonal Gammopathy?

Kalula nje, i-polyclonal gammopathy yisimo lapho amangqamuzana athile omzimba egazini lakho ekhiqiza khona ama-antibodies amaningi kakhulu, noma ama-immunoglobulins, uhlobo lweprotheni esiza imizimba yethu ukulwa nezifo. Cabanga ngala ma-antibodies njengamasosha omzimba okuzivikela. Yiwo alwa nezifo namagciwane uma engena.

Ngakho-ke, igama elithi "polyclonal" lisho ukuthi izinhlobo ezahlukene zamaseli omzimba ziyahlangana futhi zenze izinhlobo eziningi ezahlukene zama-antibodies. Kufana namaqembu ahlukene asebenza ndawonye, ​​hhayi nje uhlobo olufanayo lwamasosha.

Kungani lokhu kwenzeka? Lokhu kungithinta kanjani?

Uma une-polyclonal gammopathy, kusho ukuthi isimiso sakho somzimba sokuzivikela sisebenza ngokweqile . Kunjengokungathi sihlala siqaphile. Isizathu esiyinhloko salokhu ukuthi isimiso sakho somzimba sokuzivikela sihlala sithola izimpawu ezivela ekuthelelekeni noma isifo sokuzivikela komzimba, sisitshela ukuthi "senze ama-antibodies, senze ama-antibodies."

Okusho ukuthi, i-polyclonal gammopathy ingaba uphawu lwesinye isifo esiyisisekelo . Isibonelo, uma unomdlavuza, noma uma unesifo sesibindi, noma uma unesifo sokuzivikela komzimba njenge-rheumatoid arthritis, ungase ube nale polyclonal gammopathy. Ngakho-ke, lapho odokotela bebona lokhu, bafuna, "Kungani amasosha omzimba evuselelwa kangaka?"

Uyini umehluko phakathi kwe-polyclonal kanye ne-monoclonal gammopathy?

Lokhu kungase kubonakale kujule kancane, kodwa masikwenze kube lula. Kunezinhlobo ezimbili zamaseli amhlophe egazini lethu ezibizwa ngokuthi ama-'B cells' kanye nama-'plasma cells'. Lawa yiwo enza ama-antibodies ('Immunoglobulins') esikhulume ngawo ngaphambili.

• I-Polyclonal Gammopathy: Lapha, womabili amaseli e-B kanye namaseli e-plasma ayahlangana ukuze akhiqize izinhlobo eziningi ezahlukene zama-antibodies. Njengoba nje amafektri ahlukene ekhiqiza izinhlobo eziningi ezahlukene zezimpahla.
• I-Monoclonal Gammopathy:Okwenzekayo lapha ukuthi `amaseli e-plasma' kuphela aqoqana futhi enze uhlobo olulodwa lwe-antibody oluningi kakhulu, olubizwa ngokuthi `i-M protein`. Lesi yisimo esihlukile kancane. Lokhu kungahlotshaniswa nezimo zomdlavuza njenge `Multiple Myeloma`. Kodwa-ke, abanye abantu bangaba nesimo esibizwa ngokuthi `i-Monoclonal Gammopathy of Undetermined Significance` (MGUS). Uma lokho kwenzeka, udokotela wakho uzokuhlola njalo ukuze abone ukuthi umdlavuza uyaqala yini. Ngakho-ke kuhle ukuqaphela lokho futhi.

Okubalulekile: I-Polyclonal gammopathy ngokuvamile ayiyona umdlavuza. Iyindlela yokusabela kwamasosha omzimba.

Ingabe kukhona amanye amagama alokhu?

Yebo, odokotela basebenzisa amanye amagama amaningana ngesimo se-polyclonal gammopathy. Ayinhloko yilawa:

• I-Hypergammaglobulinemia: Lokhu kubhekisela ekwandeni kwenani le-gamma globulin (uhlobo lwe-antibody) egazini.
• Isifo se-Polyclonal: Leli futhi elinye igama.

Yiziphi izimbangela ze-Polyclonal Gammopathy?

Ochwepheshe basacwaninga imbangela eqondile yalesi simo. Kodwa-ke, sivame kakhulu kubantu abanezifo ezithile, izifo ezihlasela amasosha omzimba, noma umdlavuza wegazi. Ngezinye izikhathi, imithi ethile ethathwa kwezinye izimo nayo ingandisa ingozi.

Ziyini izimpawu zalesi simo?

Esikhathini esiningi, i-polyclonal gammopathy ayibangeli zimpawu ezithile. Ungase ube nezimpawu ngenxa yesifo esiyisisekelo esibangele i-gammopathy.

Ake sithi une-pneumonia enomkhuhlane omkhulu kanye nokukhwehlela. Ngemuva kwalokho uzobonisa izimpawu ezihlobene naleyo pneumonia. Lapho udokotela eyelapha, angenza ukuhlolwa kwegazi futhi athole lesi simo se-polyclonal gammopathy ngengozi. Okusho ukuthi, sivame ukutholakala uma ufuna okunye.

Ingabe lokhu kuyinto edluliselwa yigciwane noma amagciwane?

Cha. I-polyclonal gammopathy ayibangelwa ngqo yigciwane noma amabhaktheriya. Kuyindlela yokusabela kwesistimu yokuzivikela yomzimba . Kodwa-ke, i-polyclonal gammopathy ingabangelwa ukutheleleka kwegciwane noma amabhaktheriya okungaphansi. Okusho ukuthi, igciwane noma amabhaktheriya avuselela isistimu yokuzivikela yomzimba.

Odokotela bakuthola kanjani lokhu? (Ukuxilongwa)

Odokotela basebenzisa kakhulu ukuhlolwa kwegazi okukhethekile ukuxilonga i-polyclonal gammopathy. Lokhu kubizwa ngokuthi i-Serum Protein Electrophoresis (SPEP) .

Uma udokotela wakho esekutholile kakade ukuthi unesifo sokuzivikela komzimba, ukutheleleka, isifo sesibindi, noma umdlavuza, noma esola ukuthi unesifo esinjalo, angenza lolu vivinyo lwe-'SPEP' ukuze athole ukuthi isimiso sakho somzimba sokuzivikela sisabela kanjani.

Ukuhlolwa kwe-`SPEP` kungasiza kanjani ekutholeni lokhu?

Kulula kakhulu. Udokotela uthatha isampula yegazi kuwe. Bese, elabhorethri, basebenzisa le ndlela ebizwa ngokuthi i-'SPEP' ukuhlukanisa izinhlobo ezahlukene zamaprotheni egazini lakho nokuhlola amazinga awo.

Lawa mazinga amaprotheni angatshela udokotela wakho okuningi ngempilo yesimiso sakho somzimba sokuzivikela . Isibonelo, angakunikeza izinkomba mayelana nokuthi unesifo sesibindi (esingadala i-polyclonal gammopathy), noma ukuthi unesifo noma umdlavuza.

Ingabe kukhona okunye ukuhlolwa kokuthola lokhu?

Yebo. Ngezinye izikhathi, uma udokotela wakho esola ukuthi unegciwane lesimiso sakho sezinzwa esiyinhloko, njenge-meningitis, angase ahlole noketshezi lwakho lwe-cerebrospinal (CSF) , njengoba ukutheleleka okunjalo kungabangela ne-polyclonal gammopathy.

Yiziphi izindlela zokwelapha lokhu?

Into ebalulekile okufanele uyiqonde lapha ukuthi i-polyclonal gammopathy iyimpendulo yesistimu yomzimba, hhayi isifo ngokwaso. Ngakho-ke, akukho ukwelashwa okuqondile kwalesi simo.

Udokotela wakho uzokwelapha isimo esiyisisekelo esibangele ukuba amasosha omzimba asebenze ngokweqile. Isibonelo, uma sibangelwa ukutheleleka, ukutheleleka kuzokwelashwa. Uma sibangelwa isifo sokuzivikela komzimba, kuzonikezwa ukwelashwa okufanele.

Ngesikhathi elapha lesi simo esiyisisekelo, udokotela wakho uzohlola kabusha amazinga akho e-immunoglobulin ukuze abone ukuthi i-polyclonal gammopathy yehlile noma iphelile yini.

Ingabe ukuthuthukiswa kwe-Polyclonal Gammopathy kungavinjelwa?

Ngeshwa, abacwaningi abakayitholi indlela yokuvimbela lesi simo. Ngenxa yokuthi sivame ukwenzeka njengomphumela wesinye isifo, into engcono kakhulu ongayenza ukuvimbela lesi sifo esiyisisekelo.

Ngingazi kanjani ukuthi ngisengozini yokuthola lesi simo?

Uma unezimo ezithile zezokwelapha, usengozini enkulu yokuthola i-polyclonal gammopathy. Ezinye zalezi zimo zifaka:

• Izimo zokuzivikela komzimba: Izibonelo zifaka phakathi i-lupus, i-rheumatoid arthritis, kanye ne-Sjogren's syndrome.
• Izinkinga zegazi: Isibonelo, i-Sickle Cell Anemia.
• Umdlavuza wegazi: njenge-leukemia kanye ne-lymphoma.
• Eminye imidlavuza: Umdlavuza wezinso, umdlavuza wesibindi, umdlavuza wamaphaphu, umdlavuza wesibeletho.
• Izifo: Ukutheleleka nge-HIV, Umalaleveva, i-Mononucleosis, i-Pneumonia, i-Tuberculosis.
• Isifo sesibindi: I-Autoimmune Hepatitis, i-Cirrhosis, i-Viral Hepatitis.
• Uma uke wavezwa yi- asbestos .

Uma unezinye zalezi zimo, noma uma uzizwa sengathi izimpawu zakho ziya ziba zimbi kakhulu, qiniseka ukuthi ukhuluma nodokotela wakho. Angakuhlola ukuthi awunayo yini i-polyclonal gammopathy, uma kudingeka.

Yini engingayilindela uma ngine-Polyclonal Gammopathy?

Uma une-polyclonal gammopathy, ungase ube sengozini encane yokutheleleka kanye ne-anemia. Kodwa izindaba ezinhle ukuthi ngokwelashwa okufanele kwesifo esiyisisekelo esibangele i-gammopathy, i-gammopathy kanye nezingozi ezihambisana nayo zinganyamalala.

Ingabe lesi simo singase senzeke izikhathi ezingaphezu kwesisodwa?

Yebo, i-polyclonal gammopathy ingenzeka izikhathi ezingaphezu kwesisodwa, ngoba uma imbangela eyisisekelo iphinda ivele, le mpendulo yomzimba ingaphinde ivele.

Uma nginalesi simo, kufanele ngizinakekele kanjani?

Into ebaluleke kakhulu ukulandela imiyalelo kadokotela wakho ngqo. Ikakhulukazi leyo ephathelene nokuzivikela ezifweni. Isibonelo, izinto ezilula njengokugqoka imaski lapho uya ezindaweni ezinabantu abaningi nokugeza izandla zakho njalo kungenza umehluko omkhulu.

Umlayezo Wokuya Nawe Ekhaya

Kulungile, ngakho-ke ngokwalokho esikuxoxile, ngithemba ukuthi unombono omuhle nge-Polyclonal Gammopathy noma i-Hypergammaglobulinemia.

• Kalula nje, lokhu kusho ukuthi amasosha omzimba wakho akhiqiza ama-immunoglobulins amaningi kakhulu (ama-antibodies) .
• Lokhu kukhomba ukuthi amasosha omzimba wakho asebenza kanzima kakhulu . Kufanele kube nesizathu salokho.
• Udokotela wakho uzokwelapha isimo esiyisisekelo esibangele lokhu, futhi le gammopathy ivame ukuba ngcono.

Ngakho-ke, ungesabi ngoba nje into efana nale isembhalweni. Khuluma nodokotela wakho futhi uqonde kahle ukuthi kwenzekani nokuthi yini okudingeka yenziwe. Ngikufisela impilo enhle!

'i-polyclonal gammopathy, i-hypergammaglobulinemia, i-immunoglobulin, i-antibody, isimiso somzimba sokuzivikela, i-SPEP, iseli B, iseli le-plasma