Ingabe nawe unephunga elifana nelenhlanzi? Ake sifunde nge-Trimethylaminuria (TMAU)!

Ngezinye izikhathi ekuphileni kwethu, kuyenzeka izinto ezingajwayelekile, akunjalo? Wake wezwa ngesimo lapho umzimba womuntu, umjuluko, umoya, noma umchamo kunuka njengenhlanzi ebolile? Kuzwakala kungavamile, akunjalo? Kodwa, kukhona ngempela isimo esinjalo. Lesi yisimo esizokhuluma ngaso namuhla, i-Trimethylaminuria, noma `(TMAU)` ngamafuphi. Abanye abantu basibiza nangokuthi ``Fish Odor Syndrome``.

Kuyini i-trimethylaminuria (TMAU)?

Kalula nje, i-trimethylaminuria (TMAU) iyisifo se-metabolic . Manje ungase uzibuze ukuthi iyini i-metabolic disorder. Ngaphakathi emizimbeni yethu, izinqubo zamakhemikhali, noma izinqubo ze-metabolic , zenzeka ukuze kuguqulwe ukudla esikudlayo kube amandla futhi kwenziwe izinto ezidingwa yimizimba yethu. Ama-enzyme emizimbeni yethu asiza lezi zinqubo ukuthi zenzeke kahle. Ngakho-ke, kulesi simo esibizwa ngokuthi i-trimethylaminuria, ngenxa yoshintsho emsebenzini we-enzyme ethile, amanye amakhemikhali akhiqizwa emzimbeni awakwazi ukuhlukaniswa kahle. Yingakho lelo phunga elibi njengenhlanzi livela ekujulukeni, ekuphefumuleni, ematheni, kanye nomchamo.

Kungenzeka ukuthi uke wezwa odokotela bebiza lesi simo ngokuthi `(TMAU)` noma `(Fish Odor Syndrome)`. Akukho ukwelashwa okuphelele kwalokhu okwamanje . Kodwa, ungakhathazeki. Ungazinciphisa kakhulu lezi zimpawu ngokushintsha lokho okudlayo nokuphuzayo, usebenzisa insipho ethile nama-lotion, kanye nokulawula ukucindezeleka kwakho.

Yiziphi izinhlobo eziyinhloko ze-`(TMAU)`?

Kunezinhlobo ezimbili eziyinhloko ze-trimethylaminuria:

1. I-Trimethylaminuria Eyinhloko : Lolu uhlobo lokuzalwa . Lokhu kusho ukuthi lesi simo sibangelwa izinguquko ezithile (`(ukuguqulwa kwezakhi zofuzo)`) ezakhiweni zofuzo (`(ukuguqulwa kwezakhi zofuzo)`) ezizuzwe kumama nakubaba.

2. I-Trimethylaminuria yesibili : Lokhu kwenzeka kamuva ekuphileni . Leli phunga elifana nelenhlanzi lingabangelwa yizimo ezithile zezokwelapha noma izithasiselo zokudla.

Sivame kangakanani lesi simo?

Eqinisweni, i-TMAU iyisimo esingavamile kakhulu . Ucwaningo olulodwa lubonisa ukuthi sithinta umuntu oyedwa kuphela kubantu abangu-200,000 kuya kwesigidi emhlabeni jikelele. Kodwa-ke, kuthiwa futhi abesifazane banamathuba amancane okuba naso kunabesilisa.

Kodwa-ke, abanye abacwaningi bakholelwa ukuthi kungenzeka kube nabantu abaningi abane-`(TMAU)` emphakathini kunalokho okuboniswa yilezi zibalo. Ngoba abantu abaningi bacabanga ukuthi lokhu kuyinkinga yokuhlanzeka kwabo . Ngakho-ke, abatsheli muntu ngakho noma baye kudokotela ngenxa yamahloni. Ngakho-ke, abatholi ukuxilongwa (`(Ukuxilongwa)`).

Ziyini izimpawu ze-trimethylaminuria?

Uphawu oluyinhloko nolusobala kakhulu iphunga elifana nelenhlanzi elivela emzimbeni, emoyeni, nasekujulukeni . Leli phunga ngezinye izikhathi lingaba libi kangangokuthi lingaba nesicanucanu. Kwabanye abantu, lingahambisana nomlomo omubi (`(Halitosis)`) kanye nephunga elinamandla elivela emchameni.

Ngezinye izikhathi, umuntu one-`(TMAU)` uzwa leli phunga kakhulu uma ejuluka noma lapho ecindezelekile. Kodwa-ke, kwabanye abantu, leli phunga linamandla kangangokuthi noma ngabe baya ekamelweni abahlala kulo, bemi ngaphesheya kwekhawunta esitolo, noma behleli ohlangothini olufanayo lwebhasi noma isitimela, abanye bangalizwa. Cabanga ukuthi kunzima kangakanani lokho.

Yiziphi izimbangela ze-`(TMAU)`?

I-Trimethylaminuria yenzeka lapho umsebenzi we-enzyme ebizwa ngokuthi `(FMO3)` emzimbeni wethu uphazamiseka. `(FMO3)` imele i-flavin- containing monooxygenase 3. Umsebenzi oyinhloko wale enzyme ukulawula ikhemikhali ebizwa ngokuthi `( Trimethylamine )` ekhiqizwa emzimbeni wethu. Le trimethylamine iyimbangela yalelo phunga lenhlanzi. Le trimethylamine ikhiqizwa lapho ukudla okuthile esikudlayo, isibonelo, inhlanzi, ubhontshisi namaqanda, kugaywa.

Okuvame ukwenzeka yilokhu: Lapho i-trimethylamine inqwabelana emizimbeni yethu, i-enzyme `(FMO3)` iyafika iyibhidlize, iyiguqule ibe yikhemikhali engenaphunga. Bese kuthi, noma idlula isuka ohlelweni lwethu lokugaya ukudla iye egazini lethu, ayinuki.

Kodwa, kwenzekani uma leyo enzyme `(FMO3)` ingasebenzi kahle? Leyo trimethylamine enukayo iyanda emizimbeni yethu. Uma iyanda, igcina iphuma ngokujuluka, ukuphefumula, amathe, kanye nomchamo, bese kuphuma lelo phunga elifana nelenhlanzi. Uyaqonda?

Abantu abane -primary trimethylaminuria (`(Primary TMAU)`) baba nalesi simo ngoba bazuza amakhophi angajwayelekile ezakhi zofuzo ezenza i-`(FMO3)` enzyme (`(Abnormal FMO3 genes)`) kubo bobabili umama nobaba.

Ku -trimethylaminuria yesibili (`(Secondary TMAU)`), i-enzyme yakho ye-`(FMO3)` ayikwazi ukuphula i-trimethylamine ngesinye isizathu. Lokhu kungabangelwa yi:

• Uma unesifo esithile, njengokwehluleka kwesibindi noma i-hepatitis ebangelwa yigciwane , singaphazamisa ukusebenza kwe-enzyme futhi siyivimbele ekuqhekekeni kwe-trimethylamine.
• Uma i-microbiome yamathumbu akho ingalingani, okusho ukuthi kukhona ukungalingani phakathi kwamagciwane amahle namabi esiswini sakho, i-trimethylamine eningi kakhulu inganqwabelana. Khona-ke i-enzyme (i-FMO3) ayikwazi ukususa lonke lelo phunga.
• Uma uthatha izithasiselo eziqukethe i-choline noma i-carnitine , lezi zakhi zinegalelo ekwakhekeni kwe-trimethylamine.

Yiziphi izinkinga zalesi simo?

Indlela isimo esibizwa ngokuthi i-trimethylaminuria esithinta ngayo ikhwalithi yempilo yakho(`(Ikhwalithi yokuphila)`) ingaba yingozi kakhulu. Ucwaningo lubonisa ukuthi abantu abanalesi simo bavame ukugwema ubudlelwano, imisebenzi, kanye nemisebenzi yomphakathi ngoba besaba ukuthi abanye bazobona iphunga elibi. Ngenxa yalokhu, abantu abanalesi simo bangaba nezinkinga ezahlukene zempilo yengqondo. Isibonelo:

• Ukukhathazeka (`(Ukukhathazeka)`)
• Ukucindezeleka
• Ukukhathazeka nokwesaba okungenangqondo (`(I-Paranoia)`)

Nakuba kungavamile kakhulu, abanye abantu abane-TMAU kubikwe ukuthi banemicabango yokuzibulala (`(ukuziphatha kokuzibulala)`). Lokhu kukhombisa ukuthi umthelela wengqondo walesi simo ungaba yingozi kangakanani.

Itholakala kanjani i-trimethylaminuria?

Odokotela baxilonga i-TMAU ngokulinganisa inani le-trimethylamine emchameni wakho. Lokhu kuvame ukwenziwa ngokuhlolwa komchamo . Ngaphezu kwalokho, udokotela wakho angancoma ukuhlolwa kwezakhi zofuzo ukuze anqume ukuthi unefomu eliyinhloko (okungukuthi, lokuzalwa) noma lesibili (okungukuthi, elitholwe).

Yiziphi izindlela zokwelapha i-trimethylaminuria?

Udokotela wakho angase ancome izinto ezahlukene ukusiza ekunciphiseni izimpawu ze-TMAU.

• Ukudla: Kunconywa ukuthi kuqedwe ukudla okuthile okwandisa ukukhiqizwa komzimba kwamakhemikhali abangela lesi simo (TMAU).
• Insipho ekhethekile nama-lotion: Kunconywa ukusebenzisa insipho ekhethekile nama-lotion asiza ekunciphiseni iphunga lenhlanzi esikhumbeni.
• Imithi: Ngezinye izikhathi imithi inganikezwa futhi.
• Ukusekelwa kwempilo yengqondo: Ungase futhi welulekwe ukuthi ufune ukwelulekwa kwengqondo ukuze kukusize ubhekane nokucindezeleka okubangelwa yilesi simo.

Yiziphi izinhlobo zokudla okufanele zisuswe?

Uma une-trimethylaminuria, odokotela bavame ukukutshela ukuthi unciphise noma ugweme ngokuphelele ukudla okulandelayo:

• Inhlanzi nezinye izilwane zasolwandle (ikakhulukazi izinhlanzi zasemanzini anosawoti)
• Amaqanda (ikakhulukazi izikhupha zamaqanda)
• Isibindi nezinye izitho zangaphakathi zesilwane
• Imifino efana nobhontshisi, ubhontshisi kanye ne-lentile
• Imifino ye-Cruciferous efana neklabishi, i-broccoli, i-cauliflower, kanye namahlumela aseBrussels
• I-Peanut
• Ubisi nemikhiqizo yobisi (kwabanye)
• Ukudla kanye nezithako zokudla okunempilo ezicebile ku-choline kanye ne-L-carnitine

Okubalulekile: Akuwona wonke umuntu okudingeka ayeke konke lokhu kudla. Kungcono ukukhuluma nodokotela noma isazi sokudla ukuze uthole ukuthi yikuphi ukudla okufanele.

Yimiphi imithi enikezwayo ye-`(TMAU)`?

Udokotela wakho angase akunike imithi efana nalena ukuze anciphise izimpawu ze-TMAU:

• Ama-antibiotic nama-probiotic : Le mithi isiza ukunciphisa inani lamagciwane emathunjini akho, ngaleyo ndlela inciphise ukukhiqizwa kwe-trimethylamine.
• Amalahle asebenzayo : Lokhu kufana nesiponji. Kumunca i-trimethylamine emzimbeni futhi kuyasiza ukuthi ikhishwe esitulweni.
• Imithi yokucindezeleka kanye nemithi yokwelapha ukukhathazeka : Le mithi inikezwa ukwelapha izinkinga zempilo yengqondo abanye abantu abane-TMAU ababhekana nazo.

Udokotela wakho angakudlulisela nosizo lwezempilo yengqondo . Ukukhuluma nodokotela wengqondo noma umeluleki kubaluleke kakhulu uma unenkinga yokuzethemba nezinkinga zomfanekiso womzimba. Ukwelashwa kwengqondo kungakusiza ufunde ukuthi ungabhekana kanjani nesimo sakho nokulawula ukucindezeleka.

Yini umuntu one-trimethylaminuria angayilindela?

I-Trimethylaminuria yisifo esingamahlalakhona . Lokhu kusho ukuthi ayinakwelapheka ngokuphelele noma ibe ngcono ngokwayo. Kodwa-ke, njengoba kushiwo ngaphambili, kunezindlela zokwelapha nezinto ongazenza ukunciphisa izimpawu ze-TMAU nokunciphisa umthelela lesi simo esinawo empilweni yakho.

Ngizinakekela kanjani ?

Ukuzinakekela kubaluleke kakhulu uma uhlala ne-TMAU. Nazi ezinye izinto okufanele uzicabangele:

• Ukuhlanzeka komuntu siqu : Ukusebenzisa insipho nama-lotion anenani eliphansi le-`(pH)` kungasiza ekunciphiseni iphunga lomzimba wakho. Buza udokotela wakho ukuthi yiliphi inani le-`(pH)` elikufanele nokuthi yimiphi imikhiqizo engcono kakhulu.
• Qaphela ukuthi udlani : Ukudla okuningi kungenza i-trimethylaminuria ibe yimbi kakhulu. Khuluma nochwepheshe wezokudla ukuze uhlele ukudla kwakho kanye nokukhetha ukudla ukuze uthole izakhamzimba ozidingayo.
• Lawula ukucindezeleka : Ukucindezeleka okwandisiwe kungandisa izimpawu ze-TMAU. Ngakho-ke, buza udokotela wakho ngezindlela zokusiza ukunciphisa amazinga akho okucindezeleka. (isib. ukuzindla, i-yoga, ukuvivinya umzimba ngokuphefumula)
• Thola ukwesekwa : I-Trimethylaminuria iyisimo esingavamile, ngakho-ke ungase uzizwe unesizungu futhi unesizungu. Ngakho-ke, kungaba usizo olukhulu ukuxhumana namaqembu okusekela lapho kungatholakala khona abanye abanesimo esifanayo .

Kufanele ngimbone nini udokotela wami?

Uma izimpawu zakho zingathuthuki ngisho nangemva kokwenza izinguquko ekudleni kwakho kanye nokulawula ukucindezeleka, qiniseka ukuthi ubona udokotela wakho. Angaxoxa ngezinye izindlela zokwelapha ongazicabangela.

Yimiphi imibuzo okufanele ngiyibuze udokotela wami?

Ngenxa yokuthi i-trimethylaminuria iyisimo esingavamile, ungase ungazi okuningi ngayo. Nansi eminye imibuzo ongayibuza udokotela wakho:

• Kungani ngingene kulesi simo?
• Yiziphi izindlela zokwelapha ezingcono kakhulu ongincomayo?
• Ungangincoma iqembu lokusekela noma uhlelo lapho ngingathola khona usizo?

Ingabe abantu abane-trimethylaminuria bangazinuka bona ngokwabo?

Lokhu kuyinkinga nakubantu abaningi. Yebo, sivame ukuhogela izithukuthuku zethu kanye nephunga lomzimba, futhi abantu abane-`(TMAU)` bangalihogela iphunga labo. Kodwa-ke, ngezinye izikhathi, uma sebejwayele iphunga labo, bangase bangaliboni kakhulu njengabanye. Futhi, akubona bonke abantu abangasho ukuthi abalihogeli; abanye abantu bangase bangaboni nokuthi imizimba yabo inephunga elingavamile.

Ekugcineni, umyalezo obaluleke kakhulu

I-Trimethylaminuria yisimo esingenza umuntu angabi namandla okuzenzela lutho, hhayi ngokomzimba kuphela, kodwa nangokwengqondo . Ngisho noma ingabangeli ubuhlungu obungokomzimba, ingabangela ubuhlungu obukhulu kanye nezibazi engqondweni. Abanye abantu abanalesi simo bazihlukanisa nomphakathi futhi bazame ukuhlala bodwa, besaba ukuthi bazoba yinkathazo kwabanye. Ngisho nangemva kokushintsha ukudla kwabo nokulandela ezinye izeluleko, abanye abantu abane-`(TMAU)` banomuzwa wokuthi kusadingeka bagcine izimpilo zabo kude nabanye. Lolu hlobo lokuzihlukanisa nomphakathi lungabangela ukuthi ube nezinto ezifana nokucindezeleka nokukhathazeka.

Khumbula, awuwedwa . Uma ubhekene nalesi simo, sicela ungabi namahloni noma wesabe ukucela usizo kudokotela wakho. Bangakuqonda lokho obhekene nakho futhi bangakutshela ngezinhlelo nezinsizakalo ezingakusiza. Impilo yakho yengqondo ibaluleke njengempilo yakho yomzimba. Ngakho-ke qiniseka ukuthi uyayicabanga nayo.

i- trimethylaminuria, i-fish odor syndrome, i-fish odor syndrome, iphunga lomzimba, izifo ze-metabolic, i-FMO3 enzyme, i-trimethylamine