So wo maame, wo papa, anaa obi a wunim no werɛ fi kɛse? Nneɛma nketenkete te sɛ baabi a wo safe wɔ anaa obi din a wo werɛ fi no betumi ayɛ Alzheimer yare no ho sɛnkyerɛnne a edi kan. Ɛwom sɛ wɔda so ara nni aduru biara a wɔde bɛsa yare a emu yɛ den yi de, nanso U.S. FDA (Food and Drug Administration) apene aduru foforo bi a ebetumi ama yare no akɔ so brɛoo no so koraa. Eyi yɛ anidaso kɛse ankasa ma ayarefo a wɔwɔ wiase nyinaa. Enti momma yɛnka aduru foforo yi ho asɛm kakra, Leqembi.
Dɛn ne aduru foforo a wɔfrɛ no Leqembi yi?
Ade a edi kan a ɛsɛ sɛ yɛte ase ne sɛ eyi nyɛ aduru a wɔde sa Alzheimer yare no. Nanso ɛboa. Ebetumi ama yare no akɔ so brɛoo. Nhwehwɛmu ada no adi sɛ ebetumi ama yare no akɔ so brɛoo bɛyɛ 27% wɔ asram 18 mu.
Afei ebia woresusuw ho sɛ, ‘So ɛbɛma nsakrae aba ankasa?’ Yiw, akyinnye biara nni ho sɛ ɛbɛyɛ saa. Susuw ho hwɛ, obi a ɔnom saa aduru yi betumi atra ase asram 5 a ne sɛnkyerɛnne ahorow no nsɛe nsen obi a ɔnom aduru no, na obetumi ayɛ n’ankasa adwuma, n’ani agye n’abusua ho, akɔhwɛ banana bi a wawie sukuu... Saa bere a ɛboro so no som bo dɛn de yɛ nneɛma te sɛ eyi? Saa bere no ne mfaso kɛse a ɛwɔ aduru yi so.
Nanso ɛho hia sɛ wokae eyi: Wɔkamfo Leqembi kyerɛ nnipa a wɔwɔ Alzheimer yare no mfiase nkutoo , a ɛkyerɛ wɔn a wɔreda adwene mu yare a emu nyɛ den adi. Ɛrenyɛ adwuma mma obi a ɔwɔ yare a emu yɛ den kɛse.
Ɔkwan bɛn so na saa aduru yi yɛ adwuma?
Sɛ yɛbɛte eyi ase a, momma yɛmfa nhwɛso ketewaa bi. Wɔ Alzheimer ayarefo amemene mu no, wɔde protein bi a wɔmpɛ a wɔfrɛ no amyloid plaques gu hɔ. Ɛte sɛ efĩ akɔhyɛ nsu afiri mu na nkakrankakra akɔhyɛ paipu no mu. Esiane sɛ protein ahorow yi gu hɔ nti, nkitahodi a ɛda amemene mu nkwammoaa ntam no sɛe, na nkakrankakra nkwammoaa no fi ase wuwu. Eyi nti na nkae yera na suban sesa no.
Saa aduru yi a wɔfrɛ no Leqembi no de n’ani si amyloid ntini a ayɛ kɛse wɔ amemene no mu no so na eyi fi hɔ. Ɛka nnuru bi a wɔfrɛ no monoclonal antibodies ho. Wɔtaa de saa aduru yi ma ɔyarefo no mprenu ɔsram biara denam IV a wɔde ma no so.
Momma yɛnhwɛ aduru yi ho nokwasɛm ahorow bi a ɛho hia wɔ pon bi so.
| Leqembi (lecanemab) ho nsɛm tiawa . | |
|---|---|
| Aduru ko a wɔde yɛ | Aduru a ɛyɛ monoclonal antibody type aduru bi. |
| Henanom na ɛfata? | Nnipa a wɔwɔ Alzheimer yare no mfiase, a wɔn adwene mu yɛ wɔn naa kakraa bi nkutoo. |
| Mfaso titiriw | Yare no trɛw brɛ ase bɛyɛ 27% wɔ asram 18 ntam. |
| Sɛnea wɔde ma | Wɔnam ntini mu (IV infusion) so ma mprenu ɔsram biara. |
| Anohyeto a ɛho hia sen biara | Eyi nsa yare no. Mfaso biara nni so mma wɔn a yare no mu yɛ den dedaw no. |
So asiane bi wɔ eyi a wɔde bedi dwuma no mu?
Aane. Te sɛ nnuru nyinaa no, eyi wɔ asiane ne nsunsuanso bɔne bi. Nokwarem no, FDA de “adaka tuntum kɔkɔbɔ” ama saa aduru yi, a ɛyɛ ahobammɔ ho kɔkɔbɔ a ɛkorɔn sen biara . Nea enti a ɛte saa ne tebea bi a wɔfrɛ no ARIA.
Dɛn ne ARIA?
ARIA yɛ Amyloid-Related Imaging Abnormalities tiawa. Sɛ yɛbɛka no tiawa a, saa aduru yi betumi ama nnipa binom amemene mu ahonhon anaasɛ mogya nketenkete (microbleeds) . Bere a mpɛn pii no eyinom nyɛ aniberesɛm de, nanso ɛtɔ mmere bi a ebetumi de nkwa ato asiane mu.
- APOE4 awosu mu abɔde mu nkwaadɔm: Nnipa a wɔwɔ APOE4 awosu mu nkwaadɔm mu nsakrae no abien no wɔ asiane kɛse mu sɛ wobenya ARIA tebea yi sen afoforo.
- Nnuru a Ɛma Mogya Tew: Ade foforo a ɛho hia paa ne sɛ nnuruyɛfo bɔ kɔkɔ denneennen sɛ ɛnsɛ sɛ wɔde aduru yi di dwuma mma obi a ɔnom nnuru a ɛma mogya tu. Efisɛ sɛ woyɛ saa a, hokwan kɛse wɔ hɔ sɛ mogya ketewaa bi bɛdan mogya kɛse a ɛde nkwa to asiane mu (macro-bleed). Ɛtɔ mmere bi a, eyi betumi ama akisikuru, wɔde no akɔ ayaresabea, anaa owu mpo.
Enti, ansa na wubefi saa aduru yi ase no, ɛho hia sɛ wo ne wo duruyɛfo susuw asiane ahorow yi nyinaa ho pefee, yɛ nhwehwɛmu a ɛho hia, na wosi so dua sɛ ebia eyi fata wo anaa.
Enti dɛn na ɛsɛ sɛ meyɛ?
Sɛ wo, asɛm yi akenkanfo no, adwenem yɛ wo naa kakra mpo sɛ wo anaa obi a ɔbɛn wo wɔ Alzheimer yare no ho sɛnkyerɛnne a edi kan a, ade a eye sen biara a ɛsɛ sɛ woyɛ ne sɛ wobɛkɔ oduruyɛfo nkyɛn a worenkyɛ na woahu sɛnea obi anya yare no pɛpɛɛpɛ.
Efisɛ sɛnea yɛadi kan aka ho asɛm no, nnuru te sɛ Leqembi ho wɔ mfaso wɔ yare no mfiase nkutoo. Sɛ wokyɛ a, ebia wobɛpa hokwan a ɛbɛma woanya ayaresa no. Afei nso, mpɛn pii no, nnuru foforo te sɛ eyinom bo betumi ayɛ nea ne bo yɛ den. Enti ɛyɛ papa sɛ wo ne wo duruyɛfo bɛkasa afa saa asɛm no ho ansa na woafi ayaresa ase.
Abenfo gye di sɛ daakye a enni akyiri no, wobenya ayaresa ahorow a ebetumi ahu yare na asiw ano ansa na nkurɔfo ada sɛnkyerɛnne biara adi. Sɛnea yebetumi ahu nufu mu kokoram ne prostate kokoram na yɛasa no ntɛm no, saa ara na da bi yebetumi ahu Alzheimer yare no na yɛasiw ano ntɛm. Enkosi saa bere no, nnubɔne te sɛ Leqembi ma yɛn nyinaa nya anidaso kɛse.
Nkrasɛm a Wɔde Kɔ Fie
- Leqembi nyɛ aduru a wɔde sa Alzheimer yare no. Ɛma yare no kɔ so brɛoo wɔ ne mfiase nkutoo.
- Saa aduru yi yɛ adwuma denam amyloid ntini a epira a ɛboaboa ano wɔ amemene no mu a eyi fi hɔ no so.
- Asiane wɔ hɔ sɛ obi benya nsunsuanso bɔne a emu yɛ den te sɛ amemene mu ahonhon anaa mogya a ɛtɔ nketenkete (ARIA), enti ɛho hia sɛ wo ne oduruyɛfo susuw asiane ahorow no nyinaa ho.
- Saa aduru yi mfata wɔn a wɔnom nnuru a ɛma mogya tu anaa wɔn a wɔwɔ yare a emu yɛ den.
- Sɛ wo anaa obi a ɔbɛn wo rehyia ɔhaw wɔ nkaeɛ mu a, hwehwɛ aduruyɛfoɔ afotuo a ɛnntwentwɛn wo nan ase. Ɛho hia sɛ wohu yare no ntɛm ansa na wɔasa.
💬 Comments (0)
Wɔnnya nyɛɛ nsɛm biara. Fa wo nsɛm no ka ho wɔ ha nea edi kan.
Fa wo nsɛm no ka ho