So wo nufu mu kokoram yɛ HER2-Negative? Momma yɛnka eyi ho asɛm tiawa! (HER2-Nufu mu Kokoram a Ɛnyɛ Den) .

Minim sɛ ɛyɛ den sɛ wobɛka nea wote nka bere a wo duruyɛfo ka kyerɛ wo sɛ wowɔ nufu mu kokoram no ho asɛm. Ɛyɛ ade a ɛfata sɛ wubenya nsɛmmisa ne ehu pii aba w’adwene mu. Nanso nneɛma a ɛho hia sen biara a ebetumi aboa wo wɔ akwantu a emu yɛ den yi mu biako ne sɛ wobɛte sɛnea wo kokoram no te ankasa ase. Sɛ wuhu baabi a kokoram no wɔ, ne su, ne kɛse, ne protein ahorow bi a ɛwɔ wo kokoram nkwammoaa mu a, ɛho hia yiye wɔ ayaresa ho gyinaesi mu.

Sɛ yɛbɛka no tiawa a, dɛn ne HER2-Negative?

Momma yɛnte eyi ase saa kwan yi so. Nkwammoaa a ɛwɔ yɛn nipadua mu no te sɛ afie nketewa. Saa afie yi wɔ ‘antenna’ soronko a wogye nkrasɛm fi abɔnten. Wɔ nnuruyɛ mu no, yɛfrɛ saa ntini a ɛma wogye nneɛma yi. Ɛyɛ saa antenna ahorow yi mu na nkwammoaa bi nya nkrasɛm te sɛ ‘sɛ enyin’ ne ‘sɛ ɛbɛkyekyɛ’.

HER2 (Human Epidermal Growth Factor Receptor 2) yɛ antena titiriw a ɛte saa no mu biako. HER2 boa ma nkwammoaa a ɛte apɔw nyin so. Nanso, ɛtɔ mmere bi a kokoram nkwammoaa yɛ HER2 antena yi pii dodo, na ɛboro sɛnea ɛte daa no so. Afei kokoram no nya nkrasɛm bere nyinaa a ɛka kyerɛ no sɛ ‘ennyin’, na kokoram no fi ase trɛw ntɛmntɛm yiye. Yɛfrɛ tebea yi HER2-Positive .

Enti, sɛ wo duruyɛfo ka sɛ wo nufu mu kokoram no yɛ HER2-negative , ɛno kyerɛ sɛ wo kokoram nkwammoaa no nni HER2 antenna foforo yi. Sɛ yɛbɛka no tiawa a, wo kokoram no nni ade titiriw biara a ɛma enyin ntɛmntɛm.

Wobɛyɛ dɛn ahu wo kokoram no HER2 tebea ankasa?

Kokoram a HER2-negative ne HER2-positive nyinaa ho sɛnkyerɛnne yɛ pɛ. Wo duruyɛfo ntumi nkyerɛ wo type ko a wowɔ denam wo nhwehwɛmu a ɔbɛyɛ ara kwa so. Ɛho behia sɛ ɔfa wo akisikuru no ketewaa bi (biopsy) na ɔma wɔyɛ ho nhwehwɛmu. Saa sɔhwɛ yi bɛma wɔahu HER2 protein no dodow pɔtee a ɛwɔ kokoram nkwammoaa no mu.

Ɛsɛ sɛ yɛhwɛ pii sen HER2 kɛkɛ!

Ɛnyɛ HER2 nkutoo ne ade a ɛka kokoram nyin. Nneɛma a ɛma nipadua no nya nkwaadɔm ( hormone receptors - HR) ahorow abien foforo wɔ yɛn nipadua mu a ɛyɛ mmerɛw wɔ hormone ahorow ho.

• Nneɛma a Ɛma Estrogen (ER) .
• Nneɛma a Ɛma Progesterone (PR) .

Sɛ saa ntini ahorow yi wɔ kokoram nkwammoaa so a, nkwaadɔm a wɔfrɛ no estrogen ne progesterone betumi aboa ma kokoram no anyin. Nnuruyɛfo bom ka saa nneɛma a ɛma nipadua no nya ahoɔden yi nyinaa ho asɛm. Eyi kyerɛ sɛ wobetumi akyekyɛ wo kokoram a ɛnyɛ HER2 no mu bio ayɛ no ahorow abien:

1. HR-Positive / HER2-Negative: Eyi kyerɛ sɛ kokoram no nyɛ nea ɛyɛ mmerɛw wɔ HER2 ho, na mmom ɛyɛ mmerɛw wɔ hormone ahorow ho. Eyi ne nufu mu kokoram a abu so sen biara .

2. HR-Negative / HER2-Negative: Eyi kyerɛ sɛ kokoram no nyɛ nea ɛyɛ mmerɛw wɔ HER2 anaa hormone ahorow ho. Esiane sɛ saa ntini abiɛsa yi nyinaa nni hɔ (HER2, ER, PR) nti, wɔsan frɛ saa ɔkwan yi Triple Negative .

Saa nneɛma yi nyinaa a wubehu no bɛboa wo ne wo duruyɛfo no ma woahu sɛnea wo kokoram no wɔ abɔde mu no yiye, na ɛno bɛboa wo ma woapaw ayaresa a ɛfata na etu mpɔn sen biara ama wo.

Dɛn ne ayaresa ahorow a wɔde sa kokoram a HER2 nnim?

Esiane sɛ wo kokoram no nni HER2 nti, wɔremma wo ayaresa a wɔde wɔn ani asi so, a ɛde wɔn ani si HER2 protein no so. Ɛte saa efisɛ ɛsɛ sɛ nnuru no nya HER2 antenna a ɛwɔ kokoram nkwammoaa no so na ama ayɛ adwuma. Mmom no, wobegyina baabi a wo kokoram no wɔ ne sɛ ebia ɛyɛ mmerɛw wɔ hormone ahorow ho so apaw ayaresa afoforo.

• Oprehyɛn ne mframa a wɔde ma: Sɛ wohu kokoram no ntɛm a, oprehyɛn betumi ayi afi hɔ koraa. Wobetumi akamfo mframa a wɔde sa yare nso akyerɛ ansa na wɔayɛ oprehyɛn anaa bere a wɔayɛ no oprehyɛn akyi.

• Endocrine/ Hormone therapy: Saa ayaresa yi ho hia yiye sɛ wo kokoram no yɛ HR-Positive/HER2-Negative a. Ɛyɛ adwuma denam nkwaadɔm te sɛ estrogen dodow a ɛtew nipadua no mu so. Sɛ hormone ahorow no fi hɔ a, kokoram nkwammoaa no hwere nkrasɛm a ɛne sɛ wobenyin no, na ebia kokoram no bɛtew anaasɛ ebegyae nyin.

• Nnuru a wɔde sa yare: Ɛtɔ mmere bi a wobetumi de nnuru a wɔde sa yare aka hormone ayaresa a wɔde sa kokoram a HR-positive / HER2-negative ho. Eyi gyina nneɛma te sɛ kokoram no fã ne ne fã, mfe a woadi, ne w’akwahosan nyinaa so. Ɛtɔ mmere bi a, nnuru a wɔde sa yare no mu nsunsuanso bɔne betumi asen mfaso a ɛwɔ so, enti ɛho hia sɛ wo ne wo duruyɛfo kasa fa nea eye ma wo ho.

• Nkwammoaa a ɛko tia nyarewa no ayaresa: Sɛ wo kokoram no yɛ nea enye mprɛnsa na ɛkɔ anim, na ɛwɔ protein foforo a wɔfrɛ no PD-L1 a, saa ayaresa yi betumi ayɛ ɔkwan a wobɛfa so. Ɛyɛ adwuma denam w’ankasa nipadua mu tumi a ɛko tia nyarewa a ɛkanyan no ma ɛko tia kokoram no so.

Nsusuwii ne Nkɔmhyɛ

Ade a ɛho hia sen biara wɔ nufu mu kokoram ho ne sɛ wubehu ansa na atrɛw akɔ nipadua no afã afoforo. Sɛ wo kokoram a HER2 nnim no wɔ nufu no mu a, mfe 5 a wode bɛtra ase no dɔɔso yiye. Eyi te saa titiriw sɛ wo kokoram no yɛ HR-positive a.

Kokoram abiɛsa a ɛnyɛ papa no yɛ den kakra sɛ wɔbɛsa efisɛ ɛnyɛ hormone ayaresa anaa ayaresa a wɔde HER2 asi wɔn ani so no ho dwuma. Wobetumi nso ayɛ basabasa kɛse.

Ase hɔ no yɛ mfe 5 a wɔde tra ase a egyina kokoram no gyinabea so. Eyinom yɛ sɛ wɔkyekyem pɛpɛɛpɛ a, ma ɛntra w’adwenem sɛ ebia w’ankorankoro tebea bɛyɛ soronko.

Mma akontaabu ahorow yi nnyɛ wo hu. Eyinom yɛ nnipa mpempem pii a wɔkyekyem pɛpɛɛpɛ. W’ankorankoro adwene begyina nneɛma pii so, a sɛnea wo nipadua yɛ n’ade wɔ ayaresa ho ne w’akwahosan nyinaa ka ho. Enti, ka wo tebea no ne nhwehwɛmu foforo biara a ebia wubehia ho asɛm nkyerɛ wo duruyɛfo.