Ènya nu tso dɔla sue sia si le wò ŋutilã me ŋua? (Adrenocorticotropic Lãmetsiŋusẽ - ACTH) .

Èbu nusi dzɔna le wò ŋutilã me ne nuteɖeamedzi le ŋuwò alo nèse le ɖokuiwò me be yele nyaƒoɖeamenu geɖe me la ŋu kpɔa? Xɔlɔ̃ sue aɖe le míaƒe ŋutilã si si míete ŋu kpɔna o si kpena ɖe mía ŋu le ɣeyiɣi siawo tɔgbe me. Woyɔe be ACTH. Egbea, míaƒo nu tso ACTH sia ŋu.

Nukae nye ACTH?

Kpuie ko la, ACTH nye lãmetsi aɖe si wò lãkusi si le lãkusi me wɔna. Ewɔa akpa gã aɖe le alesi wò ŋutilã wɔa nu ɖe ​​nuteɖeamedzi ŋui me . Ne ACTH do la, enaa dzesi wò adrenal glandwo be woawɔ cortisol, si mí katã míenya be “nuteɖeamedzi ƒe lãmetsi,” kple gbɔdɔdɔ ƒe lãmetsiwo ƒe ƒuƒoƒo aɖe si woyɔna be androgens.

Fifia ɖewohĩ èle eŋu bum be nukae nye lãmetsiŋusẽ siawo, alo? Lãmetsiŋusẽwo nye atike siwo wɔa dɔ vovovowo le wò ŋutilã me. Wole abe dɔlawo ene. Gbedasi siawo toa wò ʋu me yia wò ŋutinuwo, ŋutigbalẽ, lãmekawo, kple lãmeka bubuwo gbɔ. Dzesi siawo gblɔa nusi wòle be wò ŋutilã nawɔ kple ɣeyiɣi si wòle be wòawɔe.

Wò lãkusi nye lãkusi sue aɖe si lolo abe pea ene si le wò ahɔhɔ̃ ƒe gɔme, le hypothalamus te tututu. Enye wò lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe akpa aɖe. Akpa eve le pituitary gland la ŋu: ŋgɔgbe lãkusi kple megbeƒu. Wò ŋgɔgbe lãkusie nye nusi wɔa ACTH eye wòɖea asi le eŋu.

Nuka tututue dzɔna ɖe ACTH dzi?

Dɔ vevitɔ si ACTH wɔnae nye be wòaʋã wò adrenal glands be woaɖe lãmetsi si nye cortisol ɖa. Bu eŋu abe ACTH le abe aʋafiagã si le gbɔgblɔm na wò adrenal glands be woawɔ cortisol ene.

Cortisol nye lãmetsi vevi aɖe ŋutɔ si míaƒe ŋutilã hiã. Ekpɔa ŋusẽ ɖe ŋutilãa ƒe ŋutinu kple lãmenugbagbevi ɖesiaɖe kloe dzi. Woyɔa cortisol be “nuteɖeamedzi ƒe lãmetsi,” gake le nyateƒe me la, dɔ vevi bubu geɖewo le míaƒe ŋutilã me.

Nu vevi aɖewo siwo ku ɖe cortisol ŋue nye esi:

• Èkpɔa ŋusẽ ɖe alesi wò ŋutilã wɔa nui ne nuteɖeamedzi dzi .
• Ekpena ɖe ŋuwò nèɖua alesi wò ŋutilã zãa ami, protein, kple carbohydrates, si fia be wò lãmenugbagbeviwo ƒe dɔwɔwɔ dzi .
• Dɔdzẽ , si fia be ŋutilã ƒe akpa vovovowo vuvu eye wòbiãna la dzi ɖena kpɔtɔna.
• Eɖɔa ʋu ƒe sisi ɖo .
• Enaa sukli ƒe agbɔsɔsɔ le ʋu me ɖoa .
• Ekpena ɖe ŋuwò hã be nàɖɔ wò alɔ̃dɔdɔ kple nyɔnyrɔ̃ ƒe tsatsam ɖo .

Menye esia ɖeɖeko o, ACTH wɔa nu bubu aɖe hã. Eyae nye be eʋãa adrenal glands be woaɖe gbɔdɔdɔ ƒe lãmetsi siwo woyɔna be androgens la ɖa. Tsɔ kpe ɖe eŋu la, ACTH kpena ɖe ame ŋu wòwɔa atike siwo doa ŋusẽ lãmetsiŋusẽ geɖe wu, abe adrenaline kple noradrenaline ene.

Aleke wokpɔa ACTH ƒe agbɔsɔsɔ dzii?

Nuɖoanyi dodzidzɔname aɖe ŋutɔe kpɔa wò ŋutilã ƒe ACTH ƒe agbɔsɔsɔ dzi. Woyɔa esia be nyaŋuɖoɖo ƒe ɖoɖo. Elɔ wò hypothalamus, pituitary gland, adrenal glands, kple lãmetsi aɖewo ɖe eme. Míeyɔa ɖoɖo sia katã be Hypothalamic-Pituitary-Adrenal (HPA) axis . Eɖi nya sesẽ vie, alo? Gake ele bɔbɔe.

Tsɔe be ʋuka kple lãmeka sue aɖee do ƒome kple wò hypothalamus. Woyɔa esia be pituitary stalk. To atikutsetse sia dzie hypothalamus ƒoa nu kple pituitary gland eye wògblɔna nɛ be wòaɖe lãmetsi aɖewo ɖe go. Wò ahɔhɔ̃mekawo nye wò ahɔhɔ̃ ƒe akpa aɖe si kpɔa nuwo abe ʋu ƒe sisi, dzi ƒe tsotso, ŋutilã ƒe dzoxɔxɔ, kple nuɖuɖumeŋusẽ dzi.

Adrenal glands nye gland sue eve siwo le dzogoe etɔ̃ me siwo le wò ayikuwo tame.

Azɔ mina míakpɔ alesi nyaŋuɖoɖo ƒe ɖoɖo sia si kpɔa ACTH ƒe agbɔsɔsɔme dzi wɔa dɔe ɖa:

• Ne cortisol ƒe agbɔsɔsɔ si le wò ŋutilã me ɖiɖi la, wò hypothalamus ɖea lãmetsi aɖe si woyɔna be Corticotrophin-Releasing Hormone (CRH) .
• CRH sia ʋãa wò ŋgɔgbe lãkusi be wòaɖe ACTH ɖa.
• Emegbe ACTH ʋãa wò adrenal glands, vevietɔ adrenal cortex, be woaɖe cortisol kple androgens ɖa.
• Ne cortisol ƒe agbɔsɔsɔ dzi ɖe edzi alea la, eɖoa dzesi aɖe ɖe hypothalamus be wòaɖe CRH ƒe agbɔsɔsɔ dzi akpɔtɔ. Eye aleae wowua tsatsam la nu. Ele abe ‘on-off switch’ ene .

Menye esia ɖeɖeko o, ne èle nuteɖeamedzi me , si fia be èle nuteɖeamedzi me le susu me la, woʋãa ACTH wɔwɔ eye cortisol ƒe agbɔsɔsɔ dzina ɖe edzi.

Gake ne kuxi aɖe le wò hypothalamus, pituitary gland, alo adrenal glands ŋu la, lãmetsi siwo kpɔa gome le dɔ sia me, si nye ACTH, ƒe dadasɔ ate ŋu agblẽ.

Aleke woawɔ akpɔ ACTH ƒe agbɔsɔsɔ?

Wowɔa ʋudodokpɔ tsɔ léa ŋku ɖe wò ACTH ƒe agbɔsɔsɔ ŋu. Esia bia be nàɖe ʋu sue aɖe tso ʋuka aɖe si le wò alɔnu me.

Zi geɖe la, ɖɔktawo ɖea gbe be woawɔ cortisol dodokpɔ kpe ɖe ACTH dodokpɔ ŋu be woakpɔe ɖa be kuxiwo le pituitary gland alo adrenal glands ŋu hã.

Azɔ hã, ɖɔktawo ate ŋu awɔ nane si woyɔna be ACTH ƒe dodokpɔ si doa ŋusẽ ame ɣeaɖewoɣi . Esia doa alesi wò adrenal glands wɔa nu ɖe ​​ACTH ŋu nyuie la kpɔna. Esia ate ŋu akpe ɖe ame ŋu hã be woade dzesi kuxi siwo le pituitary kple/alo adrenal glands ŋu.

Nukae nye ACTH ƒe agbɔsɔsɔ si sɔ?

Abe cortisol ene la, zi geɖe la, ACTH ƒe agbɔsɔsɔ si le wò ʋu me sɔa gbɔ wu le ŋdi kanya. Vivivi la, edzi ɖena kpɔtɔna ne ŋkekea le yiyim, eye wòɖoa eƒe ɖoƒe si bɔbɔ wu le zãtitina lɔƒo. Gake ne èwɔa dɔ le zã me eye nèdɔa alɔ̃ le ŋkekea ƒe ɣeyiɣi vovovowo me la, nɔnɔme sia ate ŋu atrɔ.

Eyata zi geɖe la, ACTH dodokpɔwo bia be woaɖe ʋu le ŋdi me. Le goawo katã me la, ACTH ƒe agbɔsɔsɔ si sɔ le ŋdi ga 7:00 kple ŋdi ga 10:00 domee nye picogram 7.2 va ɖo 63.3 le mililita ɖeka me (7.2 va ɖo 63.3 pg/mL) .

Gake ɖo ŋku nu ɖeka dzi. Nusiwo sɔ ƒe didime siawo ate ŋu ato vovo tso dodokpɔxɔ ɖeka me yi bubu gbɔ, tso ɣeyiɣi yi ɣeyiɣi, kple tso ame gbɔ yi ame gbɔ. Ne wowɔ ACTH dodokpɔ na wò la, wò ɖɔktae axlẽ wò dodokpɔ me tsonu eye wòagblɔ na wò nenye be ehiã be woagawɔ dodokpɔ bubuwo alo mehiã o.

Nukae adzɔ ne ACTH ƒe agbɔsɔsɔ dzi ɖe edzi?

Ne wò ACTH ƒe agbɔsɔsɔ sɔ gbɔ la, anɔ eme be wò cortisol ƒe agbɔsɔsɔ hã sɔ gbɔ. Esi wònye be cortisol kpɔa ŋusẽ ɖe ŋutilãa dzi le mɔ geɖe nu ta la, àte ŋu akpɔ cortisol si sɔ gbɔ ƒe nugbegblẽ le ame ŋu tsɔ wu be nàkpɔ ACTH si sɔ gbɔ ƒe dzesiwo. Le go aɖewo me la, ne wò adrenal glands mele cortisol wɔm wòsɔ gbɔ o la, ACTH ƒe agbɔsɔsɔ ate ŋu adzi ɖe edzi. Le nɔnɔme mawo me la, àte ŋu akpɔ dzesi siwo nye cortisol si mebɔ o, ke menye ACTH si sɔ gbɔ o.

Susu geɖe li siwo tae ACTH ƒe agbɔsɔsɔ dzina ɖe edzi ɖo:

• Cushing ƒe dɔléle: Esiae nye nusi nana ACTH ƒe agbɔsɔsɔ dzina ɖe edzi wu. Esia tsoa dɔdzẽ si menye kansa o (adenoma) si le lãkusi me si naa ACTH sɔ gbɔ akpa gbɔ. Emegbe esia nana cortisol ƒe agbɔsɔsɔ dzina ɖe edzi. Ele vevie be míase vovototo si le Cushing ƒe dɔlélea kple Cushing ƒe dɔlélea dome gɔme . Cushing ƒe dɔlélea nye nu geɖe siwo hea Cushing ƒe dɔlélea vɛ la dometɔ ɖeka ko.
• Ectopic adrenocorticotropic hormone tumor: Ƒã ŋutɔ be dɔdzẽ si dona le wò lãkusi godo ate ŋu aɖe ACTH geɖe ɖa. Dɔdzẽ siwo ate ŋu awɔ ACTH le mɔ sia nu (togbɔ be ƒã ŋutɔ hã) dometɔ aɖewoe nye lãkusi me dɔdzẽ si menye kansa o, dɔdzẽ si le ƒukpo me lãmenugbagbeviwo , lãkusi me dɔdzẽ si le lãkusi me, lãkusi me lãmenugbagbevi suewo ƒe dɔdzẽ, kple lãkusi me dɔdzẽ .
• Adrenal insufficiency gbãtɔ: Nɔnɔme sia dzɔna ne nane gblẽ nu le wò adrenal glands ŋu eye womete ŋu wɔa cortisol nyuie o. Addison ƒe dɔléleaEsiae nye nusi gbɔ adrenal ƒe dɔmawɔmawɔ nyuie gbãtɔ tsona wu. Esia wɔnɛ be wò pituitary gland ɖea ACTH geɖe ɖe go elabena edi be yeaʋã adrenal glands.

Nukae dzɔna ne ACTH ƒe agbɔsɔsɔ dzi ɖe kpɔtɔ?

Ne ACTH ƒe agbɔsɔsɔ le sue le kuxi aɖe si le pituitary gland ŋu ta la, zi geɖe la, cortisol ƒe agbɔsɔsɔ hã aɖiɖi. Gake ne cortisol ƒe agbɔsɔsɔ sɔ gbɔ le kuxi aɖe si le adrenal gland ŋu ta la, ACTH ƒe agbɔsɔsɔ ate ŋu aɖiɖi.

Susu geɖe li siwo tae ACTH ƒe agbɔsɔsɔ ate ŋu aɖiɖi ɖo:

• Cushing ƒe dɔléle: Cushing ƒe dɔléle, si ate ŋu atso adrenal gland tumor alo corticosteroid atikewo zazã ɣeyiɣi didi na nɔnɔme bubuwo gbɔ la ate ŋu ana ACTH ƒe agbɔsɔsɔ naɖiɖi. Esia le alea elabena wò lãkusi mete ŋu ɖea ACTH ɖe go le mɔ nyuitɔ nu o le cortisol si sɔ gbɔ ta.
• Hypopituitarism: Esia nye dɔléle si mebɔ kura o. Esiae nye esime wò lãkusi me lãmetsiŋusẽ ɖeka, geɖe, alo wo katã mesɔ gbɔ akpa o. ACTH nye lãmetsi siwo ate ŋu agblẽ nu le ame ŋu la dometɔ ɖeka. Nu ɖesiaɖe si agblẽ le wò lãkusi ŋu, abe dɔdzẽ, amekoko, alo keklẽŋusẽdɔdamɔnu ene ate ŋu ana ʋumenugbagbeviɣidɔ natsi.

Ðewohĩ èse egɔme fifia be ACTH le vevie ŋutɔ be nàɖɔ wò cortisol ƒe agbɔsɔsɔ ɖo. Ne cortisol ƒe agbɔsɔsɔ si sɔ alo esi mebɔ o ƒe dzesiwo le fu ɖem na wò, abe lolo ƒe dzidziɖedzi alo eƒe ɖiɖi, ʋusɔgbɔdɔ alo ɖiɖi ene la, kpɔ egbɔ be yeyi ɖɔkta gbɔ. Ate ŋu awɔ cortisol kple ACTH ʋudodokpɔwo atsɔ anya ne wò adrenal gland alo pituitary gland gbɔe wò dzesiawo tso.

Eyata nu kawo dzie wòle be míaɖo ŋkui?

ACTH nye lãmetsi vevi aɖe ŋutɔ si pituitary gland wɔ si kpena ɖe mía ŋu míeɖua nuteɖeamedzi dzi le míaƒe ŋutilã me.

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- Esiae nye nusi ʋãa adrenal glands be woawɔ "stress hormone" cortisol .

- Cortisol kpɔa nu geɖe dzi, abe míaƒe lãmenugbagbeviwo ƒe dɔwɔwɔ, ʋu ƒe sisi, kple sukli ƒe agbɔsɔsɔ le ʋu me ene.

- Nuɖoanyi sesẽ aɖe si me hypothalamus, pituitary gland, kple adrenal glands le ye kpɔa ACTH ƒe agbɔsɔsɔ dzi .

- Ne ACTH ƒe agbɔsɔsɔ dzi ɖe edzi alo dzi ɖe kpɔtɔ la, ateŋu ahe Cushing ƒe dɔléle, Addison ƒe dɔléle vɛ.Lãmesẽkuxi vovovowo ate ŋu ado mo ɖa.

- Ne dzesi aɖewo le ŋuwò le go sia me la, anyo wu be nàyi ɖɔkta gbɔ vɔvɔ̃manɔmee eye nàdi aɖaŋuɖoɖo.

` ACTH, Adrenocorticotropic Lãmetsiŋusẽ, Cortisol, Pituitary gland, Adrenal lãkusiwo, Lãmetsiŋusẽwo, Nuteɖeamedzi