Ðe ʋumenugbagbevi ɣiwo ƒe xexlẽme dzi ɖe kpɔtɔa? Mina míasrɔ̃ nu tso Autoimmune Neutropenia (AIN) ŋu!

Èbu nusita mía ŋutɔwo ƒe dɔlélenutsiŋutete, le esi teƒe be wòakpɔ mía ta la, ate ŋu adze mía ŋutɔwo ƒe lãmenugbagbeviwo dzi dzedze gɔme ɣeaɖewoɣia? Ema nye nɔnɔme aɖe si gɔme sese sesẽ vie, gake gɔmesese le eŋu si woyɔna be Autoimmune Neutropenia (AIN) . Nusi dzɔna enye be mía ŋutɔwo ƒe dɔlélenutsiŋutete dzea ʋumenugbagbevi ɣi ƒomevi vevi aɖe ŋutɔ dzi le míaƒe ŋutilã me, si woyɔna be `neutrophils.` Eyata mina míaƒo nu tso esia ŋu bɔbɔe, le mɔ si gɔme nàte ŋu ase nu.

Eyata nukae nye Autoimmune Neutropenia (AIN)?

Kpuie ko la, `Autoimmune Neutropenia` (AIN) nye dɔléle si do ƒome kple ʋu. Nusi dzɔna le afisia enye be míaƒe dɔlélenutsiŋutete si wobu be akpɔ mía ta la dzea mía ŋutɔwo ƒe ʋumenugbagbevi ɣi siwo woyɔna be `neutrophils` dzi vodadatɔe. Bu esia ŋu kpɔ, abe alesi asrafoha si le míaƒe dukɔa ta kpɔm dze mía ŋutɔwo míaƒe amewo dzi vodadatɔe ene.

Nukae nye `Neutrophils`?

Neutrophils nye míaƒe dɔlélenutsiŋutete ƒe akpa vevi aɖe ŋutɔ. Wole abe asrafo suewo ene le míaƒe ŋutilã me. Woƒe dɔ vevitɔe nye be woadi nu gbegblẽ siwo gena ɖe ŋutilãa me, abe dɔlékuiwo kple fungi siwo hea dɔlélewo vɛ ene, eye woatsrɔ̃ wo. Eyata, le `Autoimmune Neutropenia` gome la, mía ŋutɔwo ƒe dɔlélenutsiŋutete gblẽa `neutrophils` lãmenugbagbevi xɔasi siawo, eyata `neutrophils` ƒe xexlẽme le ʋu me dzi ɖena kpɔtɔna wu agbɔsɔsɔ si sɔ.

AIN ƒomevi vevi eve li:

1. Primary Autoimmune Neutropenia (AIN): Esia dzena zi geɖe le vidzĩwo kple ɖevi suewo ŋu . Nusi dzɔna le afisia enye be `neutrophils` ƒe xexlẽme dzi ɖena kpɔtɔna susu bubu aɖeke manɔmee. Gake nya nyuiae nye be zi geɖe la, nɔnɔme sia nu tsona le ƒe ʋɛ aɖewo megbe.

2. Secondary Autoimmune Neutropenia (AIN): Esia bɔ ɖe ɖevi tsitsiwo kple ame tsitsiwo me wu . Le afisia la, atikewɔwɔ me nɔnɔme bubu aɖe gbɔe neutrophil ƒe xexlẽme si bɔbɔ la tso. Le kpɔɖeŋu me, ate ŋu atso dɔlékui aɖe, ʋumenugbagbeviɣidɔ bubu, alo dɔléle bubu si dɔlékuiwutikewo tsona (nɔnɔme si me dɔlélenutsiŋutete dzea eya ŋutɔ ƒe ŋutilã dzi le) gbɔ. Zi geɖe la, AIN ƒe nɔnɔme evelia sia nɔa anyi didi .

Aleke gbegbee neutrophils siwo woyɔna be neutropenia ƒe xexlẽme le suee?

Autoimmune Neutropenia nye dɔléle si keke ta wu si woyɔna be Neutropenia ƒomevi ɖeka ko. Wobua neutropenia be enye esi nu mesẽ o, si le titina, alo esi nu sẽ, le ʋumenugbagbeviɣidɔ ƒe xexlẽme si le ʋu microlitre (microL) ɖeka me nu.

• Neutropenia Fafɛ: Neutrophil 1,000 – 1,500 le microL ɖeka me.
• Neutropenia si le titina: Neutrophils 500 – 1,000 le microL ɖeka me.
• Neutropenia Sesẽ: Neutrophils siwo mede 500 o le microL ɖeka me.

Nu vevitɔ kekeakee nye be ele be ɖɔkta naɖo kpe dzidzenu siawo dzi. Ne ɖikeke aɖe le mewò le esia ŋu la, ele vevie ŋutɔ be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo.

Aleke AIN kpɔa ŋusẽ ɖe nye ŋutilã dzii?

Alesi AIN kpɔa ŋusẽ ɖe dziwòe ate ŋu ato vovo tso ame ɖeka gbɔ yi bubu gbɔ. Enɔ te ɖe nu geɖe dzi, eyata anyo wu be nàƒo nu tso esia ŋu na wò ɖɔkta. Ne wò neutrophil ƒe xexlẽme ɖiɖi akpa la, anɔ eme be dɔlékuiwo axɔ wò . Ɣeaɖewoɣi la, dɔlékui siawo ate ŋu ade wò agbe afɔku me, vevietɔ ne mèyi atikewɔƒe kaba o.

Gake le go aɖewo me la, dɔlékui siwo mesẽ o koe autoimmune neutropenia ate ŋu ahe ame vɛ. Alo ate ŋu anye esi me dzesi aɖeke mele o. Esia tae wòle vevie be nàwɔ dɔ kple ɖɔkta be nànya nusi gbɔ wò ʋumenugbagbeviɣidɔ tso. Le nusi gbɔ wòtso nu la, wò ɖɔkta ate ŋu alé ŋku ɖe wò nɔnɔmea ŋu eye wòakpe ɖe ŋuwò nàɖu dɔlékuia dzi.

Amekae xɔa Autoimmune Neutropenia (AIN)?

• AIN Gbãtɔ: Vidzĩwo kple ɖevi suewo koŋue esia gblẽa nu le . Zi geɖe la, wokpɔnɛ le ɣleti 8 xɔxɔ lɔƒo.
• AIN evelia: Zi geɖe la, esia dzɔna le dɔléle bubu si dɔlélenutsiŋutete wɔna, abe lupus alo ƒunukpeƒetetedɔ ene, dzi. Zi geɖe la, wokpɔa ɖevi siwo ŋu AIN evelia le la le ƒe 10 lɔƒo. Zi geɖe la, wokpɔa ame tsitsi siwo ŋu AIN le la le ƒe 40 va ɖo ƒe 60 dome.

Aleke gbegbee autoimmune neutropenia bɔe?

AIN gbãtɔ nye nɔnɔme si mebɔ kura o . Ðevi siwo mexɔ ƒe 10 haɖe o siwo ade ɖeka le 100,000 ɖesiaɖe me koe wòdzena. Eyata àte ŋu akpɔ alesi gbegbe wòbɔe.

Nukae nye Autoimmune Neutropenia ƒe dzesiwo?

Menye ɣesiaɣie Autoimmune Neutropenia hea dzesi gãwo vɛ o. Ke hã, ɣeaɖewoɣi la, àte ŋu akpɔ dɔlékuiwo ƒe dzesiwo. Le kpɔɖeŋu me:

• Tomedɔléle: Esia nye dzesi siwo bɔ wu dometɔ ɖeka. Tsɔe be viwò suea yia edzi le tomevem, eye ne èyi ɖɔkta gbɔ la, wogblɔna na wò be to me dɔlékui bubue.
• Yagbɔgbɔdɔlékuiwo: Aɖuɖɔtoe, kɔdzidɔ, kple asrã enuenu.
• Nu me dɔlékuiwo: Nuwo abe nu me ƒoƒo kple aɖuɖɔtoedɔléle ene.
• Ŋutilã me dɔlékuiwo.
• Aklãdɔléle.
• Tagbɔdɔléle.
• Aɖuɖɔtoe me dɔlélewo (UTIs).
• Dɔlékuiwutike: Esia nye dɔlékui sesẽ aɖe ŋutɔ, si ate ŋu ade ame ƒe agbe afɔku me.

Zi geɖe la, dɔlékui siwo do ƒome kple AIN gbãtɔ mesẽna o, gake dɔlékui sesẽwo abe aklãdɔ, taɖuame, kple dɔlékuiwutikewo ene bɔ ɖe AIN evelia me wu.

Nukae hea autoimmune neutropenia vɛ?

Woda AIN ɖe hatsotso gbãtɔ alo evelia me le nusi gbɔ neutrophil ƒe agbɔsɔsɔ si bɔbɔ la tso nu.

Dɔlélenutsiŋutete ƒe Ʋumenugbagbeviɣidɔ Gbãtɔ (AIN Gbãtɔ) .

Le AIN gbãtɔ me la, dɔlékuiwutikewo tɔa ŋku ʋumenugbagbevi dzĩwo hetsrɔ̃a wo. Dɔlékuiwutikewo nye protein ƒomevi aɖe le míaƒe dɔlélenutsiŋutete me. Dɔ si wowɔna ɖaae nye be woatsrɔ̃ nusiwo gblẽa nu le ame ŋu, abe dɔlékuiwo kple dɔlékuiwo ene, siwo gena ɖe ŋutilãa me. Gake le ɣeyiɣi sia me la, numekulawo menya nusita tututu mía ŋutɔwo ƒe dɔlékuiwutikewo dzea ʋumenugbagbevi dzĩ siawo dzi haɖe o.

Dɔlélenutsiŋutete ƒe Ʋumenugbagbeviɣidɔ Evelia (AIN Evelia) .

Le AIN evelia me la, neutrophils ƒe xexlẽme dzi ɖena kpɔtɔna le nusi gbɔ wòtso alo nɔnɔme bubu aɖe ta. Esia nana dɔlélenutsiŋutete tsrɔ̃a neutrophils la.

Nusiwo ate ŋu ahe esia vɛ dometɔ aɖewoe nye:

• Dɔléle bubu siwo dɔlélenutsiŋutete hena vɛ: Kpɔɖeŋu aɖewoe nye ƒunukpeƒetetedɔ, lupus, kple ʋusɔgbɔdɔ si dɔlékuiwutikewo tsona.
• Kansa: Le kpɔɖeŋu me, `ʋumenugbagbevi gã granular lymphocyte leukemia`.
• Dɔlékuiwo: Dɔlékuiwo abe `HIV`, `Parvovirus`, `aklãdɔléle B`.
• Tumors: Abe `Wilms tumor`, `Hodgkin ƒe dɔléle` ene.
• Ahɔhɔ̃mekawo ƒe dɔlélewo: Le kpɔɖeŋu me, dɔléle si nye multiple sclerosis.
• Ayiku alo ƒumeŋuɖui dodo na ame.
• Atike aɖewo: Vevietɔ atike aɖewo siwo wozãna tsɔ daa kansa.

Aleke wowɔna dea dzesi Autoimmune Neutropenia? (Dɔléle ƒe dzesi) .

Ne asrã alo dɔlékui aɖe le ŋuwò la, wò ɖɔkta ate ŋu akpɔe be neutrophil ƒe agbɔsɔsɔ si le asiwò la mesɔ gbɔ le ʋu ƒe dɔwɔwɔ me be yeanya nusi gbɔ wòtso. AIN ƒe dɔléle didi ate ŋu asesẽ vie, elabena nu geɖe li siwo ate ŋu ahe esia vɛ. Wò ɖɔkta ate ŋu akpɔ AIN le esi wògbe nɔnɔme bubu siwo ate ŋu ana wò ʋumenugbagbevi dzĩwo ƒe xexlẽme naɖiɖi vɔ megbe.

Be nànya alo alé ŋku ɖe `Autoimmune Neutropenia` ŋu la, wò ɖɔkta ateŋu awɔ dodokpɔ siwo gbɔna:

• Ʋu ƒe xexlẽme blibo (CBC): CBC ate ŋu akpɔ neutrophils ƒe xexlẽme le wò ʋu me. Esi wònye be agbɔsɔsɔ siawo ate ŋu ato vovo ta la, zi geɖe la, wò ɖɔkta awɔ CBC siwo wu ɖeka atsɔ aɖo kpe ʋumenugbagbeviɣidɔ dzi eye wòalé ŋku ɖe wò ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ ŋu. CBC zazã edziedzi hã ate ŋu akpe ɖe ŋuwò nànya ne wò AIN la nɔa anyi didi.
• Ʋu si woɖena le lãme na ame: Wotsɔa nusuekpɔmɔ̃ doa ʋu aɖe kpɔna tsɔ léa ŋku ɖe ʋumenugbagbevi dzĩwo ƒe nɔnɔme kple woƒe nɔnɔme ŋu. Esia kpena ɖe ame ŋu le dɔlélewo didi hã me.
• Vitamin B12, folate, kple akɔbli dodokpɔwo: Dodokpɔ siawo ate ŋu akpɔe ɖa be nunyiame siawo mesɔ gbɔ o hã. Ŋutilãa hiã nusiawo be wòawɔ neutrophils.
• Aklã ƒe dɔwɔwɔ dodokpɔ: Esiawo ate ŋu alé ŋku ɖe aklã ƒe dɔwɔwɔ kple ne dɔlékui ƒe aklãdɔléle hã ŋu.
• HIV kple dɔlékui bubuwo ŋuti numekukuwo: Dɔlékuiwo ƒe dɔlékuiwo abe HIV ene hã ate ŋu ana ʋumenugbagbevi ɣiwo dzi naɖe akpɔtɔ.
• Flow cytometry: Esia nye dodokpɔ si wowɔna le nudokpɔƒe si léa ŋku ɖe lãmenugbagbeviwo ŋu be dɔléle ƒe dzesiwo le wo ŋu hã. Wozãnɛ tsɔ nyaa nenye be dɔlélenutsiŋutete ƒe dɔléle aɖe gbɔe neutropenia tso.
• Nɔnɔmetatawo ɖeɖe: Ne ɖikeke aɖe li be kansa abe ʋumenugbagbeviɣidɔ ene gbɔe AIN tso la, woate ŋu awɔ MRI alo CT scan.
• Ƒumeŋuɖui ƒe ʋuʋu kple lãmenugbagbeviwo ɖeɖe: Le afisia la, ɖɔktaa ɖea ƒumeŋuɖui sue aɖe hedoa eme kpɔ be dɔléle ƒe dzesiwo le eŋu hã. Esia ate ŋu akpe ɖe ame ŋu wòanya nenye be ʋumenugbagbeviɣidɔ abe ʋumenugbagbeviɣidɔ ene gbɔe ʋumenugbagbeviɣidɔ tsona.

Wò ɖɔkta ate ŋu aɖe gbe hã be woado ʋu kpɔ be dɔlékuiwutike siwo dzea ʋumenugbagbevi dzĩwo dzi le wò ʋu me hã. Dodokpɔ siwo bɔ wue nye I-GIFT (Indirect granulocyte immunofluorescence test) kple GAT (Granulocyte agglutination test).

Nublanuitɔe la, menye ɣesiaɣie kakaɖedzi le dodokpɔ siawo ŋu le AIN didi me o. Le nusi gbɔ wò neutropenia tso kple ɣeyiɣi si wodoe kpɔ nu la, dodokpɔ siawo mate ŋu ade dzesi dɔlékuiwutikewo o alo woate ŋu ana woakpɔ alakpa. Nusi do tso alakpatɔe nye ne dodokpɔa ɖee fia be dɔlékuiwutikewo le eme evɔ womele eme o.

Ne ɖɔktaa susui be nɔnɔme aɖe koŋ gbɔe ʋumenugbagbeviɣidɔ tsona la, ate ŋu abia be woawɔ dodokpɔ bubuwo.

Aleke wodaa Autoimmune Neutropenia ƒe dɔléleae?

Atikewɔwɔ nɔ te ɖe alesi wò nɔnɔmea nu sẽe dzi. Le kpɔɖeŋu me, ɖeko wòahiã be vidzĩ si ŋu neutropenia si me dzesi aɖeke mele o nawɔ CBC kple neutrophil ƒe xexlẽme edziedzi, gake ɖewohĩ mahiã be woawɔ atike nɛ enumake o. Ne dɔlékuiwo le viwòa ŋu enuenu la, wò ɖɔkta ate ŋu aŋlɔ dɔlékuiwutike siwo xea mɔ na dɔlékuiwo na wò be wòaxe mɔ ɖe dɔlékuiwo xɔxɔ nu. Zi geɖe la, wonaa dɔlékuiwutikewo tsɔ daa dɔlékuiwo, gake wonaa dɔlékuiwutike siawo siwo xea mɔ na dɔlékuiwo be woatsɔ axe mɔ ɖe dɔlékuiwo xɔxɔ nu.

Le amesi ŋu AIN evelia le gome la, ɖɔktaa ada nɔnɔme si gbɔ wòtso si na neutrophil ƒe agbɔsɔsɔ si le ɖiɖim la le. Woate ŋu aŋlɔ atike na wò hã be:

• Granulocyte colony-stimulating factor (G-CSF): Esiae nye atike vevitɔ na ʋumenugbagbeviɣidɔ sesẽwo. Ekpena ɖe ŋutilãa ŋu wòwɔa neutrophils geɖe wu. G-CSF ate ŋu axe mɔ ɖe dɔlékui siwo dona enuenu siwo do ƒome kple AIN gbãtɔ hã nu.
• Corticosteroids: Corticosteroids, abe prednisone ene, tea wò ŋutilã ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ ɖe to, si wɔnɛ be dɔlékuiwutike siwo dzea ʋumenugbagbevi dzĩwo dzi la dzi ɖena kpɔtɔna.
• Atike bubuwo: Wozã atike bubuwo abe IVIG, rituximab, kple alemtuzumab hã le dɔnɔ siwo ƒe lãme gblẽ vevie siwo ŋu autoimmune neutropenia sesẽ le ŋu.

Ðe woate ŋu axe mɔ ɖe Autoimmune Neutropenia nua?

Womate ŋu axe mɔ ɖe AIN Gbãtɔ alo AIN Evelia nu o . Ke hã, àte ŋu axe mɔ ɖe kuxi siwo do ƒome kple `Autoimmune Neutropenia`, si nye dɔlékuiwo ƒe dzɔdzɔ nu. Be nàte ŋu awɔ esia la, ele be nàwɔ afɔɖeɖe siwo hiã atsɔ akpɔ ɖokuiwò ta tso dɔlékuiwo me. Le kpɔɖeŋu me, ƒo asa na teƒe siwo amewo sɔ gbɔ ɖo, asikɔklɔ enuenu, kple tete ɖa tso dɔnɔwo gbɔ.

Etsɔme ka ƒomevie amesi ŋu Autoimmune Neutropenia le ate ŋu akpɔ mɔ na?

Zi geɖe la, AIN gbãtɔ kpɔa egbɔ le eɖokui si . Ðevi siwo ŋu AIN le ƒe 95% lɔƒo ƒe neutrophil ƒe agbɔsɔsɔ trɔna yia nɔnɔme si sɔ me ne woxɔ ƒe eve va ɖo etɔ̃. Ðevi siwo katã kloe ŋu AIN gbãtɔ le la hayana bliboe ne woxɔ ƒe 11. Esia naa kakaɖedzi ame ŋutɔŋutɔ, alo?

Le go bubuwo me, si woyɔna be AIN evelia la, wò hayahaya nɔ te ɖe nu geɖe dzi, vevietɔ nɔnɔme si gbɔ wòtso si na wò ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi ɖe kpɔtɔ. Nɔnɔme ma dada kple mɔxexe ɖe dɔlékuiwo nu ate ŋu akpe ɖe ŋuwò nàna wò ʋumenugbagbevi dzĩwo ƒe xexlẽme nagaɖo eƒe nɔnɔme nyuitɔ me.

Ɣekaɣie wòle be madi atikewɔlawo ƒe aɖaŋuɖoɖo?

Ne autoimmune neutropenia sesẽ aɖe le ŋuwò eye asrã dze ŋuwò la, yi ɖɔkta gbɔ enumake . Ɣeaɖewoɣi la, ɖewohĩ wò ɖɔkta ŋlɔ dɔlékuiwutikewo na wò do ŋgɔ be nàno ne asrã dze dziwò. Zi geɖe la, ahiã be woawɔ atike na wò le kɔdzi.

Ne autoimmune neutropenia sesẽ si nɔa anyi didi le ŋuwò la, wò ɖɔkta aɖe dzesi siwo wòle be nànya kple nusi nàte ŋu awɔ atsɔ axe mɔ ɖe kuxiwo nu me na wò.

Ðo ŋku edzi be: Ne wokpɔe be AIN le ŋuwò alo viwòa la, ƒo nu kple wò ɖɔkta tso alesi wògblẽa nu le ŋuwòe ŋu. Togbɔ be dzesiwo kple nusiwo gbɔ wòtsona le vovovo hã la, nya nyuiae nye be atikewɔwɔwo abe G-CSF ene wɔa dɔ ŋutɔ le neutrophil ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ me.

Ne AIN le viwòa ŋu la, do ʋu kpɔ edziedzi abe alesi wò ɖɔkta gblɔe ene. Nɔ ŋudzɔ ɖe dɔlékui ƒe dzesiwo ŋu, eye nàdi atike kaba ale si nàte ŋui ne ède dzesi ɖeke, be nàxe mɔ ɖe kuxi siwo ate ŋu ado mo ɖa nu.

Kpuie ko la (Gbedasi si Wotsɔ Yi Aƒeme) .

Enyo, eyata mele mɔ kpɔm be fifia èse `Autoimmune Neutropenia` (AIN) si ŋu míeƒo nu tsoe la gɔme nyuie wu.

• AIN nye nɔnɔme si me mía ŋutɔwo ƒe dɔlélenutsiŋutete gblẽa míaƒe ʋumenugbagbevi ɣi siwo woyɔna be `neutrophils`.
• Esia ate ŋu adzɔ le ɖevi suewo (Primary AIN) alo ame tsitsiwo (Secondary AIN) dzi. Zi geɖe la, AIN gbãtɔ si le ɖevi suewo me la kpɔa egbɔ le eɖokui si.
• Afɔku vevitɔe nye dɔlékuiwo xɔxɔ enuenu.
• Ʋudodokpɔ kple dodokpɔ bubuwo li woatsɔ anya dɔlélea.
• Atikewɔwɔa dometɔ aɖewoe nye ŋkuléle ɖe nu ŋu, atike siwo wua dɔlékuiwo, G-CSF, kple corticosteroids.
• Nu vevitɔe nye be mègatsi dzodzodzoe alo atsi dzodzodzoe o eye nàdi atikewɔlawo ƒe aɖaŋuɖoɖo ne dzesi siawo le ŋuwò alo viwòa ŋu. Ne wokpɔ dɔlélea dze sii kaba eye wokpɔ egbɔ nyuie la, àte ŋu anɔ agbe le lãmesẽ me kple AIN gɔ̃ hã.

Ne nya bubu aɖewo gale asiwò ku ɖe esia ŋu la, kpɔ egbɔ be yeƒo nu kple wò ɖɔkta. Woawoe nye amesiwo ate ŋu aɖo aɖaŋu nyuitɔ kekeake na wò.

` Neutropenia, Autoimmune Neutropenia, Ʋumenugbagbeviɣiwo, Dɔlélenutsiŋutete, Dɔlékuiwo, Ʋudɔlélewo, Ðeviwo ƒe Dɔlélewo