Ðe ʋu mesɔ gbɔ ɖe mewòa? Mina míaƒo nu tso Megaloblastic Anemia ŋu!

Ðe ɖeɖi tea ŋuwò hã ɣesiaɣia? Ðe nèsena le ɖokuiwò me be yedɔ alɔ̃ ŋkeke bliboa, eye wò ŋutilã sena le eɖokui me be agbe mele ye ŋu be yeate ŋu awɔ naneke oa? Ɣeaɖewoɣi la, wò ŋutigbalẽ zua ɣie eye gbɔgbɔtsixe tsia ƒowò viea? Mègabu nusiawo be wonye nusiwo sɔ ko o. Esiawo ate ŋu anye wò ʋu ƒe kuxi aɖe ƒe dzesiwo. Egbea míele nu ƒom tso Megaloblastic Anemia , si nye dɔléle si hea dzesi siawo tɔgbe vɛ, vevietɔ ne vitamin B12 kple vitamin B9 (si woyɔna hã be folate) mesɔ gbɔ na wò o.

Nukae Nye Megaloblastic Anemia?

Kpuie ko la, ʋusɔgbɔdɔ si woyɔna be megaloblastic anemia nye ʋusɔgbɔdɔ ƒomevi aɖe si gblẽa nu le ʋumenugbagbevi dzĩ siwo le ʋua me ŋu. Nusi dzɔna le esia mee nye be ʋumenugbagbevi dzĩ siwo dona le míaƒe ƒumeŋuɖui me lolona wu alesi wòle . Esia tae wogayɔnɛ be ‘macrocytic anemia’, si fia be ʋumenugbagbevi gãwo ƒe anyimanɔmanɔ .

Ne míagblɔe bubui la, esia nye ʋusɔgbɔdɔ si me vitamin ƒe anyimanɔmanɔ le . Nɔnɔme sia dzɔna ne nunyiame eve siwo nye vitamin B12 kple vitamin B9 ( folate ) mesu ŋutilãa si o . Gake mègatsi dzi o, ɖɔktawo ate ŋu ada dɔléle sia to vitamin B12 kple B9 kpeɖeŋutɔ nana me.

Aleke ʋusɔgbɔdɔ si woyɔna be megaloblastic anemia kpɔa ŋusẽ ɖe míaƒe ŋutilã dzii?

Fifia kpɔ ɖa, míaƒe ŋutilã hiã ʋumenugbagbevi dzĩ siwo le lãmesẽ me ƒe agbɔsɔsɔ aɖe. Elabena lãmenugbagbevi dzĩ siawoe tsɔa ɔksidzin tso lãkusi me yia lãmeka siwo le ŋutilã bliboa me, eye wogbugbɔa ya si woyɔna be carbon dioxide. Abe ʋumenugbagbevi dzĩwo katã ene la, ʋumenugbagbevi dzĩwo dzea egɔme abe lãmenugbagbevi siwo le míaƒe ƒumeŋuɖui me ene.

Vitamin B12 kple vitamin B9 hiã vevie hafi ʋumenugbagbevi dzĩwo nate ŋu awɔ nyuie. Wo manɔmee la, míaƒe ŋutilã wɔa lãmenugbagbevi ƒomevi aɖe si mesɔ o si woyɔna be megaloblasts .

Bu eŋu kpɔ, megaloblast siawo, siwo nye lãmenugbagbevi siwo mãna hedzina ɖe edzi abe lãmenugbagbevi siwo le lãmesẽ me ene, mewɔa yeye o. Ema fia be ʋumenugbagbevi dzĩ siwo le ƒumeŋuɖui me dzi ɖena kpɔtɔna. Susu bubue nye be lãmenugbagbevi siawo siwo mesɔ o la lolo ŋutɔ. Le nyateƒe me la, wololo ale gbegbe be ɣeaɖewoɣi la, womate ŋu ado le ƒumeŋuɖui me gɔ̃ hã age ɖe ʋukawo me o. Ne wowɔe hã la, lãmenugbagbevi siawo siwo mesɔ o kuna kabakaba wu lãmenugbagbevi dzĩ siwo le lãmesẽ me. Ne esiawo katã ƒo ƒu la, ʋumenugbagbevi dzĩ siwo le ŋutilãa me ƒe xexlẽme dzi ɖena kpɔtɔna, si wɔnɛ be ʋusɔgbɔdɔ, si nye ʋu ƒe anyimanɔmanɔ.

Ðe esia nye dɔléle sesẽ aɖea?

Nusiwo gbɔ megaloblastic anemia tsona dometɔ ɖekae nye vitamin B12 ƒe anyimanɔmanɔ. Ne womewɔ atike na vitamin B12 ƒe anyimanɔmanɔ o la, ate ŋu ahe ahɔhɔ̃mekawo ƒe kuxiwo vɛ . Le kpɔɖeŋu me, ŋkuɖoɖonudzi ƒe dɔmawɔmawɔ nyuie, dadasɔ ƒe bu, kple abɔ kple afɔwo ƒe ʋuʋu alo ʋuʋudedi, si woyɔna be ‘paresthesia’. Eyata esia menye nusi woabu nu tsɛe o.

Aleke gbegbee dɔléle sia bɔe?

Megaloblastic anemia menye dɔléle si mebɔ o, gake nyatakaka si sɔ mele ɖɔktawo si be woagblɔ ame neni tututue wòxɔe o.

Nukae hea ʋusɔgbɔdɔ si woyɔna be megaloblastic anemia vɛ?

Abe alesi míegblɔe va yi ene la, nusi koŋ gbɔ esia tsoe nye be vitamin B12 alo vitamin B9 mesɔ gbɔ le míaƒe ƒumeŋuɖui me be wòawɔ ʋumenugbagbevi dzĩ siwo le lãmesẽ me siwo tsɔa oxygen yia ŋutilã bliboa me o.

Nukawoe hea vitamin B12 ƒe anyimanɔmanɔ vɛ?

Ame aɖewo va zua vitamin B12 ƒe veve elabena womeɖua nuɖuɖu siwo me vitamin B12 sɔ gbɔ ɖo o, abe lã, tɔmelã, azi, kple notsi ene. Ame bubuwo hã kpɔa kuxiwo le vitamin B12 xɔxɔ me, le atikewɔwɔ ƒe nɔnɔme aɖewo ta alo le atikewɔwɔ ta. Nɔnɔme mawo dometɔ aɖewoe nye:

• Ʋusɔgbɔdɔ si gblẽa nu le ame ŋu: Esia nye dɔléle si tsoa dɔlélenutsiŋutete gbɔ si xea mɔ na ŋutilãa be wòagaxɔ vitamin B12 o.
• Gastrectomy: Esia nye amekoko si me woɖea dɔgboa ƒe akpa aɖe ɖa. Esia ate ŋu akpɔ ŋusẽ ɖe vitamin B12 ƒe xɔxlɔ̃ dzi.
• Zollinger-Ellison ƒe dɔléle: Esia nye dɔléle si mebɔ o si hã xea mɔ na ŋutilãa be wòagaxɔ vitamin B12 o.
• Blind loop syndrome: Esia nye ne nuɖuɖu si míeɖuna metoa dɔgboa me nyuie o eye wòtsi teƒe ɖeka, afisi dɔlékuiwo tsina le eye wozãa vitamin B12 le.
• Tɔmelãwo ƒe tapeworm ƒe dɔléle: Woate ŋu axɔ tapeworm dɔlékui sia ne woɖu tɔmelã siwo womeɖa nyuie o, siwo ŋu dɔlélea le. Tapeworm siawo nɔa agbe to vitamin B12 xɔxɔ me.
• Dɔgbo ƒe dɔmawɔmawɔ nyuie: Le nɔnɔme sia me la, wò dɔgbo mete ŋu wɔa nuɖuɖumeŋusẽ si sɔ be wòaɖu nuɖuɖu o. Esia fia be ɖewohĩ nunyiame siwo katã nèhiã, abe vitamin B12 alo B9 ene, mele asiwò o.

Nukawoe hea vitamin B9 (folate) ƒe anyimanɔmanɔ vɛ?

Vitamin B9 (folate) ƒe anyimanɔmanɔ ate ŋu adzɔ ne míetsɔ amagbe damawo, atikutsetsewo, lã, kple mɔli siwo sɔ de míaƒe gbesiagbe nuɖuɖu me o, alo nuɖuɖu siwo me folic acid do ŋusẽe o. Susu bubuwo hã li:

• Nuɖuɖumeŋusẽ ƒe dɔlélewo: Ne dɔléle aɖe abe Crohn ƒe dɔléle alo celiac dɔléle ene le ŋuwò la, ɖewohĩ wò nuɖuɖumeŋusẽ maxɔ folic acid nyuie o.
• Ahanono fũu akpa : Ame siwo noa aha geɖe la tsɔa aha ɖɔlia nuɖuɖu ɣeaɖewoɣi. Esia wɔnɛ be womekpɔa folate si sɔ gbɔ o.
• Wò atikutsetsewo kple amagbewo ɖaɖa fũu akpa: Ne èɖa atikutsetsewo kple amagbewo wògbɔ eme la, dzoxɔxɔa ate ŋu agblẽ folate si le wo me le dzɔdzɔme nu.
• Hemolytic anemia: Esia nye ʋumenugbagbeviɣidɔ si me wò ʋumenugbagbevi dzĩwo tsrɔ̃na eye wò ƒumeŋuɖui megate ŋu gawɔa wo kaba o.
• Atike aɖewo: Atike aɖewo siwo naa alɔ̃madɔmadɔ kple dɔgbo me abiAtike siwo wonana na abi ƒe dɔdzẽ doa kplamatse folate ƒe xɔxlɔ̃ nyuie.
• Dialysis: Amesiwo le dialysis wɔm la ƒe nuɖuɖu megadzroa wo ɣeaɖewoɣi o le ayiku ƒe dɔmawɔmawɔ nyuie ta. Esia ate ŋu akpɔ ŋusẽ ɖe vitamin B12 agbɔsɔsɔme si wokpɔna tso nuɖuɖu me dzi. (Ele be nàxlẽ nu tso B9 hã ŋu le afisia, togbɔ be nyati gbãtɔa gblɔ be B12 hã la, ate ŋu anye B9 hã le nya siwo ƒo xlãe nu.)

Nukae nye ʋusɔgbɔdɔ si nye megaloblastic anemia ƒe dzesiwo?

Megaloblastic anemia ƒe dzesiwo sɔ kple ʋusɔgbɔdɔ ƒomevi bubuwo tɔ:

• Ðeɖiteameŋu: Ðeɖi te ŋuwò ale gbegbe be màte ŋu awɔ gbesiagbedɔwo o.
• Gbɔdzɔgbɔdzɔ: Ese le eɖokui me abe ɖe ame ƒe ŋutilã me agbe mele o, mete ŋu ʋãna alo wɔa naneke o ene.
• Pallor: Wò ŋutigbalẽ va nɔa ɣie wu alesi wòle dzɔdzɔmee.
• Gbɔgbɔtsixetsixe: Seselelãme si nye be gbɔgbɔtsixe tsia ame ƒo, gbɔgbɔtsixe ƒoƒo sesẽ.
• Taɖuame alo alɔ̃madɔmadɔ: Seselelãme be yele tsatsam alo yeƒe susu megale dɔ wɔm o.

Vitamin B12 ƒe anyimanɔmanɔ, vevietɔ, ate ŋu agblẽ nu le wò lãmekawo ŋu ɣeaɖewoɣi, si ana dzesiwo abe wò abɔwo kple afɔwo ƒe ʋuʋu, seselelãme ƒe bu, alo lãmekawo ƒe gbɔdzɔgbɔdzɔ ene.

Aleke ɖɔktawo wɔa nya sia tututue?

Ðɔktawo dea dzesi ʋusɔgbɔdɔ si me ʋu sina tona to megaloblastic anemia me to wò ŋutilã dodokpɔ kple nyawo biabia wò tso wò dzesiwo ŋu me. Woate ŋu adɔ hã be woado ʋu kpɔ, abe:

• Ʋu ƒe xexlẽme bliboa (FBC): Dodokpɔ sia léa ŋku ɖe wò ʋumenugbagbevi dzĩwo ƒe xexlẽme kple woƒe dɔwɔwɔ ŋu.
• Peripheral blood smear (PBS): Esia bia be nàlé ŋku ɖe wò ʋumenugbagbeviwo ŋu le nusuekpɔmɔ̃ me. Togbɔ be mɔ̃ aɖee léa ŋku ɖe ʋudodokpɔ aɖewo ŋu hã la, le go sia me la, ɖɔkta léa ŋku ɖe lãmenugbagbeviawo ŋu eye wòtsoa nya me.
• Reticulocyte count: Esia dzidzea ʋumenugbagbevi dzĩ siwo metsi o (reticulocytes) ƒe xexlẽme le wò ƒumeŋuɖui me. Esia kpena ɖe ɖɔktawo ŋu wokpɔnɛ nenye be wò ƒumeŋuɖui le ʋumenugbagbevi dzĩ siwo le lãmesẽ me wɔm wòsɔ gbɔ.

Aleke wowɔa nu ɖe ​​esia ŋui?

Ðɔktawo daa ʋusɔgbɔdɔ si me ʋu sina tona to vitaminwo nana me. Kpɔ esia ɖa:

• Vitamin B12 ƒe Dɔmawɔmawɔ nyuie ƒe Atikewɔwɔ: Wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàdo vitamin B12 na wò kwasiɖa ʋɛ aɖewo vaseɖe esime wò vitamin B12 ƒe agbɔsɔsɔ natrɔ ava nɔ abe alesi wòle ene. Ne kuxi aɖe si le wò ŋutilã ƒe ŋutete be wòaxɔ B12 ŋu gbɔe wò vitamin B12 ƒe anyimanɔmanɔ tso la, ahiã be nàdo B12 ɣleti ʋɛ aɖewo ɖesiaɖe le wò agbemeŋkekewo katã me. Azɔ hã, ate ŋu ahiã be amesiwo me B12 mesɔ gbɔ ɖo o le nɔnɔme aɖe si woyɔna be ʋusɔgbɔdɔ si gblẽa nu le ame ŋu ta la nano B12 ƒe kpeɖeŋutɔ le woƒe agbemeŋkekewo katã me.
• Vitamin B9 ƒe Dɔmawɔmawɔ nyuie ƒe Atikewɔwɔ: Wò ɖɔkta ate ŋu aŋlɔ folic acid ƒe atikekuiwo na wò be nàtsɔ aɖɔ vitamin B9 ƒe anyimanɔmanɔ ɖo. Woalé ŋku ɖe wò vitamin B12 ƒe agbɔsɔsɔ hã ŋu akpɔe ɖa be ele seɖoƒe si sɔ me hã. Esia le alea elabena ɣeaɖewoɣi la, vitamin B9 kpeɖeŋutɔ ate ŋu aɖe ʋusɔgbɔdɔ si nye megaloblastic anemia ƒe dzesiwo dzi akpɔtɔ eye wòatsyɔ vitamin B12 ƒe anyimanɔmanɔ si gbɔ wòtso (si ate ŋu agblẽ nu le lãmekawo ŋu) dzi.

Aleke míawɔ aɖe dɔléle sia xɔxɔ ƒe afɔkua dzi akpɔtɔ?

Mɔ vovovowo li siwo dzi woato aɖe afɔkua dzi akpɔtɔ:

• Dze agbagba nàɖu nuɖuɖu si da sɔ si tsɔa nuɖuɖu siwo me vitamin B12 kple vitamin B9 le ɖoa nɔƒe gbãtɔ .
• Ðe ahanono dzi kpɔtɔ. Ahanono edziedzi ate ŋu agblẽ nu le wò nuɖuɖumeŋusẽ ŋu eye wòana wò ŋutilã nagaxɔ vitamin B12 o.
• Ne dɔléle aɖe le ŋuwò si xea mɔ na wò be màte ŋu axɔ vitamin siawo o la, wɔ dɔ kple wò ɖɔkta be nàkpɔ nɔnɔme ma gbɔ.

Nuɖuɖu siwo me vitamin B12 le:

• Lãwo ƒe nuɖuɖu: Vitamin B12 sɔ gbɔ ɖe lã dzĩ, tɔmelã, koklolã, azi, notsi, kple nyinotsibabla bubuwo me.
• Nuɖuɖu siwo me ŋusẽ le: Esiawo nye nuɖuɖu siwo wotsɔ vitamin kple nunyiame aɖewo siwo mele dzɔdzɔme nu o do ŋusẽe. Kpɔɖeŋu aɖewoe nye ŋdi me nuku aɖewo, amɔwɔʋãnu si me nunyiame le, numiemiewo ƒe notsi aɖewo, kple abolo aɖewo. Ele vevie be nàlé ŋku ɖe nunyiame ŋuti nyateƒenya siwo woŋlɔ ɖe nuɖuɖua dzi ŋu be nàkpɔ egbɔ be vitamin B12 do ŋusẽ nuɖuɖua hã.

Nuɖuɖu siwo me vitamin B9 (folate) sɔ gbɔ ɖo:

• Amagbewo: Amagbe dama viviwo (abe aŋanyi, kale ene), peas, gbegãdzi, kple mɔli.
• Atikutsetse: Citrus-kutsetsewo (abe amititsetse kple tangerine ene).
• Lãwo ƒe nuɖuɖu: aklã, ƒumelãwo, lã kple koklolã.
• Azi kple nyinotsi nuɖuɖuwo.
• Nuɖuɖu siwo me ŋusẽ le: Folic acid le abolo, wɔ, pasta, bli, kple nuku aɖewo me. Azɔ hã, lé ŋku ɖe nusi woŋlɔ ɖe nuɖuɖua ƒe agba dzi ŋu be nàkpɔe ɖa be vitamin B9 (folic acid) do ŋusẽ nuɖuɖua hã.

Nukae mate ŋu akpɔ mɔ na ne megaloblastic anemia le ŋunye?

Ame geɖe hayana tso ʋusɔgbɔdɔ si woyɔna be megaloblastic anemia me le vitamin kpeɖeŋutɔ nono vɔ megbe. Wò ɖɔkta alé ŋku ɖe wò vitamin ƒe agbɔsɔsɔ ŋu ɣeaɖewoɣi be yeakpɔ egbɔ be vitamin B12 kple vitamin B9 sɔ gbɔ na wò. Le kpɔɖeŋu me, àte ŋu ado ʋu kpɔ le kwasiɖa ʋɛ aɖewo le atikewɔwɔ gɔmedzedze megbe be woakpɔe ɖa be atike siwo wotsɔ kpe ɖe eŋu na vitamin B12 kple/alo B9 ƒe agbɔsɔsɔ dzi ɖe edzi hã.

Aleke malé be na ɖokuinye?

Àte ŋu alé be na ɖokuiwò to mɔ sia dzi:

• No vitamin kpeɖeŋutɔ abe alesi wò ɖɔkta gblɔe ene pɛpɛpɛ.
• Tu nuɖuɖu nyuiwo ɖo be nàkpɔ egbɔ be vitamin B12 kple vitamin B9 sɔ gbɔ na ye.
• Lé be na wò lãmesẽ eye nàkpɔ ɖɔkta ne èse le ɖokuiwò me be ʋusɔgbɔdɔ ƒe dzesiwo gadze le ye ŋu ake.

Nenɔ susu me na wò be, ne megaloblastic anemia le ŋuwò la, efia be mèle vitamin B12 kple/alo vitamin B9 xɔm wòsɔ gbɔ o. Vitamin siawo kpena ɖe wò ŋutilã ŋu wòwɔa ʋumenugbagbevi dzĩ siwo le lãmesẽ me. Ʋumenugbagbevi dzĩ siwo le lãmesẽ me wɔa dɔ vevi si nye oxygen tsɔtsɔ yi wò ŋutilã katã me. Dzɔgbenyuietɔe la, ɖɔktawo ate ŋu aɖɔ gbɔdzɔgbɔdzɔ sia ɖo ne wona atike siwo akpe ɖe ŋuwò be vitamin B12 kple vitamin B9 nadzi ɖe edzi. Àte ŋu aɖu nuɖuɖu si me vitamin sɔ gbɔ ɖo hã eye nàbia wò ɖɔkta tso mɔ siwo dzi nàto akpɔ egbɔ be vitamin B12 kple vitamin B9 sɔ gbɔ na ye ŋu.

Kpuie ko la (Gbedasi si Wotsɔ Yi Aƒeme) .

Enyo, eyata mina míagbugbɔ aƒo nu tso nusi ŋu míeƒo nu tsoe egbea ŋu. Megaloblastic anemia nye nɔnɔme si me ʋumenugbagbevi dzĩ gã siwo mesɔ o dona le ƒumeŋuɖui me ne vitamin B12 alo vitamin B9 (folate) mele ŋutilãa si o.

• Dzesi vevitɔwoe nye ɖeɖiteameŋu si gbɔ eme, gbɔdzɔgbɔdzɔ, ŋutigbalẽ ƒe ɣie, kple gbɔgbɔ sesẽ. B12 ƒe anyimanɔmanɔ ate ŋu agblẽ nu le lãmekawo hã ŋu.
• Nusi gbɔ wòtsoe nye vitamin siawo ɖuɖu nyuie ƒe anyimanɔmanɔ tso nuɖuɖu me, alo atikewɔwɔ ƒe nɔnɔme aɖe si xea mɔ na ŋutilãa be wòate ŋu axɔ wo o.
• Wokpɔnɛ to ʋudodokpɔwo me, vevietɔ esiwo le abe CBC kple Peripheral Blood Smear ene.
• Atikewɔwɔa dometɔ aɖewoe nye vitamin B12 kple folic acid kpeɖeŋutɔ, siwo ate ŋu ahiã be ame aɖewo nano ɣeyiɣi didi.
• Mɔ nyuitɔ si dzi woato axe mɔ ɖe enu ahakpɔ egbɔe nye be woaɖu nuɖuɖu si da sɔ si me vitamin B12 kple B9 sɔ gbɔ ɖo, woaɖe aha sesẽ dzi akpɔtɔ, eye woada nɔnɔme siwo gbɔ wòtso nyuie.

Eyata ne dzesi siawo le ŋuwò la, nunya anɔ eme be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo kaba ale si nàte ŋui. Elabena ne wokpɔe kaba la, edada nɔa bɔbɔe eye wòhayana kabakaba.