Menya be esesẽna be nàgblɔ nusi nèsena le ɖokuiwò me ne wò ɖɔkta gblɔ na wò be no me dɔdzẽ le ŋuwò. Enye nusi sɔ be nyabiase kple vɔvɔ̃ geɖe nava susu me na wò. Gake nu vevitɔ kekeake siwo ate ŋu akpe ɖe ŋuwò le mɔzɔzɔ sesẽ sia me dometɔ ɖekae nye be nàse wò kansa ƒe nɔnɔme tututu gɔme. Nyanya afisi kansa la le, eƒe ƒomevi, eƒe lolome, kple protein aɖewo siwo le wò kansa lãmenugbagbeviwo me le vevie ŋutɔ le nyametsotso wɔwɔ le atikewɔwɔ ŋu me.
Kpuie ko la, nukae nye HER2-Negative?
Mina míase esia gɔme ale. Lãmenugbagbevi siwo le míaƒe ŋutilã me le abe aƒe suewo ene. ‘Antena’ tɔxɛwo le aƒe siawo me siwo xɔa gbedasiwo tso gota. Le atikewɔwɔ me la, míeyɔa nusiawo be xɔla. Antenna siawo mee lãmenugbagbevi xɔa gbedasiwo abe ‘be yeatsi’ kple ‘be yeama’ ene.
HER2 (Human Epidermal Growth Factor Receptor 2) nye antenna tɔxɛ mawo dometɔ ɖeka. HER2 kpena ɖe lãmenugbagbevi siwo le lãmesẽ me ƒe tsitsi dzi. Gake kansa lãmenugbagbeviwo wɔa HER2 antenna sia wògbɔa eme ɣeaɖewoɣi, si sɔ gbɔ sã wu alesi wòle dzɔdzɔmee. Emegbe kansa la xɔa gbedasi ɣesiaɣi si gblɔna nɛ be ‘wòatsi’, eye kansa la dzea kaka gɔme kabakaba ŋutɔ. Míeyɔa nɔnɔme sia be HER2-Positive .
Eyata, ne wò ɖɔkta gblɔ be wò no me dɔdzẽ nye HER2-negative , ekema efia be HER2 antenna sia si sɔ gbɔ wu mele wò kansa lãmenugbagbeviwo si o. Kpuie ko la, nu vevi aɖeke mele wò kansa si na wòtsina kabakaba o.
Le nyateƒe me la, esia nye nya nyui vaseɖe afi aɖe, elabena kansa siwo me HER2 mele o la mewɔa nuvevi ame boo o wu kansa siwo me HER2 mele o. Wobu no me dɔdzẽ akpa gãtɔ le xexeame be HER2-negative.
Aleke nàwɔ anya wò kansa ƒe HER2 ƒe nɔnɔme tututu?
Kansa siwo me HER2 mele o kple esiwo me HER2 mele o siaa ƒe dzesiwo sɔ. Wò ɖɔkta mate ŋu agblɔ ƒomevi si le ŋuwò na wò to wò dodokpɔ ko me o. Ahiã be wòaɖe wò dɔdzẽ ƒe kpɔɖeŋu sue aɖe (biopsy) eye wòana woadoe kpɔ. Dodokpɔ sia aɖe HER2 protein ƒe agbɔsɔsɔme si tututu le kansa lãmenugbagbeviwo me afia.
Ele be míalé ŋku ɖe nu geɖe ŋu wu HER2 ɖeɖeko!
Menye HER2 koe kpɔa ŋusẽ ɖe kansa ƒe tsitsi dzi o. Mɔ̃memi ƒomevi eve bubuwo ( hormone receptors - HR) le míaƒe ŋutilã me siwo sea veve ɖe lãmetsiŋusẽwo nu.
- Estrogen Xɔla (ER) .
- Progesterone Xɔxɔnu (PR) .
Ne lãmetsi siawo le kansa lãmenugbagbeviwo dzi la, lãmetsi siwo nye estrogen kple progesterone ate ŋu akpe ɖe kansa la ŋu wòatsi. Ðɔktawo ƒoa nu tso dɔlékui siawo katã ŋu ɖekae. Esia fia be woate ŋu ama wò kansa si me HER2 mele o la ɖe ƒomevi eve me:
1. HR-Positive / HER2-Negative: Esia fia be kansa la mesea veve ɖe HER2 nu o, ke boŋ esea veve ɖe lãmetsiŋusẽwo nu. Esiae nye no me dɔdzẽ ƒomevi si bɔ wu .
2. HR-Negative / HER2-Negative: Esia fia be kansa la mesea veve ɖe HER2 alo lãmetsiŋusẽ aɖeke nu o. Esi wònye be lãmenugbagbevi etɔ̃ siawo katã (HER2, ER, PR) bu ta la, wogayɔa ƒomevi sia be Triple Negative .
Nu siawo katã nyanya akpe ɖe ŋuwò kple wò ɖɔkta miakpɔ wò kansa ƒe nugbagbeviwo ƒe nuwɔna nyuie wu, si akpe ɖe ŋuwò nàtia atikewɔmɔnu si sɔ na wò wu eye wòwɔa dɔ nyuie wu.
Nukae nye kansa si me HER2 mele o ƒe atikewo?
Esi wònye be wò kansa nye HER2-negative ta la, womatsɔ atike si woɖo taɖodzinu na wò, si ku ɖe HER2 protein ŋu o. Esia le alea elabena ele be HER2 antenna nanɔ atikeawo ŋu le kansa lãmenugbagbeviwo dzi hafi woate ŋu awɔ dɔ. Ke boŋ woanɔ te ɖe afisi wò kansa le kple nenye be lãmetsiŋusẽwo ƒe dɔléle le eŋu nu atia atike bubuwo.
- Amekoko kple keklẽŋusẽ: Ne wokpɔ kansa la kaba la, amekoko ate ŋu aɖee ɖa keŋkeŋ. Woate ŋu akafu keklẽŋusẽdɔdamɔnu hã do ŋgɔ na amekoko alo le amekoko vɔ megbe.
- Endocrine/ Hormone therapy: Atikewɔwɔ sia le vevie ŋutɔ ne wò kansa nye HR-Positive/HER2-Negative. Ewɔa dɔ to lãmetsiŋusẽwo abe estrogen ene ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ le ŋutilãa me me. Ne lãmetsiŋusẽawo nu yi la, gbedasi si kansa lãmenugbagbeviwo buna be woatsi, eye kansa ate ŋu aɖiɖi alo adzudzɔ tsitsi.
- Atikewɔwɔ: Woate ŋu ana atikewɔmɔnu ɣeaɖewoɣi kpe ɖe lãmetsiŋusẽtikewɔwɔ ŋu na kansa siwo me HR-positive / HER2-negative. Esia nɔ te ɖe nusiwo nye afisi kansa la le kple alesi wòxɔe, ƒe si nèxɔ, kple wò lãmesẽ bliboa dzi. Ɣeaɖewoɣi la, atikewɔmɔnu ƒe nugbegblẽ ate ŋu asɔ gbɔ wu viɖe siwo dona tso eme, eyata ele vevie be nàƒo nu kple wò ɖɔkta tso nusi nyo na wò ŋu.
- Dɔlélenutsiŋutete ƒe dɔdamɔnu: Ne wò kansa ƒe dɔmawɔmawɔ nyuie zi gbɔ zi etɔ̃ eye wòde ŋgɔ, eye protein bubu si woyɔna be PD-L1 le eme la, atikewɔwɔ sia ate ŋu anye tiatia. Ewɔa dɔ to wò ŋutɔ wò dɔlélenutsiŋutete ƒe dɔwɔwɔ be wòawɔ avu kple kansa la me.
Nukpɔsusu Kple Nyagblɔɖi
Nu vevitɔ kekeake le no me dɔdzẽ ŋue nye be nàke ɖe eŋu hafi wòakaka ɖe ŋutilã ƒe akpa bubuwo. Ne wò kansa si me HER2 mele o la le no me la, ƒe 5 ƒe agbetsitsi ƒe agbɔsɔsɔme sɔ gbɔ ŋutɔ. Esia nye nyateƒe vevietɔ ne wò kansa nye HR-positive.
Kansa siwo me dɔléle etɔ̃ le la dada sesẽ vie elabena womewɔa nu ɖe lãmetsiŋusẽ ƒe atikewɔwɔ alo HER2-dɔdamɔnu siwo woɖo taɖodzinu na ŋu o. Woate ŋu awɔ adã wu hã.
Ƒe 5 ƒe agbetsitsi ƒe agbɔsɔsɔme si wotu ɖe kansa ƒe afɔɖeɖe dzi la le ete. Esiawo nye mamã dediewo ko, nenɔ susu me na wò be wò ame ɖekaɖekawo ƒe nɔnɔme ate ŋu ato vovo.
| Kansa ƒomevi | Alesi wòkakae | Ƒe 5 ƒe agbetsitsi le ƒomedodo me |
|---|---|---|
| HR-Nu Nyui / HER2-Nu gbegblẽ (Ame ƒomevi si bɔ wu) . | No me koe seɖoƒe li na (Localized) . | 100% . |
| Ekaka ɖe ʋuka siwo te ɖe eŋu me (nutome) . | 90% . | |
| Adzɔge ʋĩi | 31% . | |
| Etɔ̃-Negative (HR-Negative / HER2-Nyagbegblẽ) . | No me koe seɖoƒe li na (Localized) . | 91% . |
| Ekaka ɖe ʋuka siwo te ɖe eŋu me (nutome) . | 65% . | |
| Adzɔge ʋĩi | 12% . |
Xexlẽdzesi siawo megavɔ̃ o. Ame akpe geɖe ƒe mamã dediewo koe esiawo nye. Wò ame ɖekaɖekawo ƒe nukpɔsusu anɔ te ɖe nu geɖe dzi, siwo dometɔ aɖewoe nye alesi wò ŋutilã wɔa nui ɖe atikewɔwɔ ŋu kple wò lãmesẽ bliboa. Eyata, gblɔ wò nɔnɔmea kple dodokpɔ bubu ɖesiaɖe si ahiã wò na wò ɖɔkta faa.
Gbedasi si Wotsɔ Yi Aƒeme
- HER2-Negative fia be protein vevi aɖeke mele wò kansa lãmenugbagbeviwo si si nana wotsina kabakaba o. Zi geɖe la, esia wɔnɛ be kansa siawo megawɔa nuvevi ame boo o.
- Ne wò kansa nye HER2-negative gɔ̃ hã la, enyanya nenye be esea veve ɖe lãmetsiŋusẽwo nu (HR-positive) alo mesea veve o (HR-negative) le vevie ŋutɔ be nànya atikewɔwɔ.
- Atikewɔwɔ ƒe tiatia nɔ te ɖe kansa ƒe ƒomevi kple afisi wòdzɔ ɖo, kple wò ŋutɔ wò lãmesẽ dzi. Amekoko, keklẽŋusẽdɔdamɔnu, lãmetsiŋusẽdɔdamɔnu, kple atikewɔmɔnuwoe nye atikewɔmɔnu vevitɔwo.
- Aʋa sia wɔwɔ kple kansa menye nusi wòle be wò ɖeka nawɔ o. Ƒo nu tso wò nyabiasewo kple vɔvɔ̃wo katã ŋu na wò ɖɔkta. Nyatakaka siwo sɔ ƒe amesinɔnɔe nye wò ŋusẽ gãtɔ kekeake le mɔzɔzɔ sia me.
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