Ðe ame tsitsi aɖe le miaƒe ƒomea me, ɖewohĩ dawò, fofowò, alo tɔgbuiwò, si ŋlɔa nuwo be zi ɖeka, trɔa eƒe nuwɔna ne etsi tre, ƒoa nu tso nu siwo mele afima o ŋu ɣeaɖewoɣi, abe “Amekae le afima?” Ðe azɔlizɔzɔ sesẽna nɛ vie gɔ̃ hãa? Ne dzesi siawo tɔgbe le ŋuwò la, ɖewohĩ manye tsitsi si sɔ abe alesi míesusui ene o. Egbea míele nu ƒom tso dɔléle tɔxɛ aɖe si ate ŋu ahe dzesi mawo tɔgbe vɛ ŋu, si woyɔna be ‘ Dementia ’ alo Lewy Body Dementia , si le ‘Memory Loss Diseases’ ƒe hatsotso me.
Nukae nye Lewy Ŋutilã ƒe Tagbɔdɔléle (LBD) ko?
Kpuie ko la, LBD ye nye tagbɔdɔléle ƒomevi evelia si bɔ wu le Alzheimer ’s dɔlélea megbe. Zi geɖe la, edzea amesiwo xɔ wu ƒe 50 dzi.
Esia le alea elabena protein ƒe ƒuƒoƒo siwo woyɔna be “Lewy ŋutilãwo” dzɔna le míaƒe ahɔhɔ̃menugbagbeviwo me. Woyɔa protein sia ƒomevi be alpha-synuclein. Ne ƒuƒoƒo siawo ƒo ƒu ɖe ahɔhɔ̃a me la, wodoa kplamatse ahɔhɔ̃a ƒe dɔwɔwɔ nyuie, vevietɔ míaƒe ŋkuɖoɖonudzi, ʋuʋu, tamebubu ŋutete, seselelãme, kple nuwɔna .
Lewy ƒe ŋutilã siawo gblẽa atike vevi eve siwo le ahɔhɔ̃a me ƒe wɔwɔ me.
1. Acetylcholine: Esia le vevie ŋutɔ na míaƒe ŋkuɖoɖonudzi kple nusɔsrɔ̃.
2. Dopamine : Esia kpɔa míaƒe ŋutilã ƒe ʋuʋu, seselelãme , kple alɔ̃dɔdɔ dzi.
LBD ƒomevi vevi evee li. Ðeka nye ' Dementia with Lewy bodies' eye evelia nye ' Parkinson 's disease dementia'. Vovototo sue aɖewo le ɖoɖo si nu dzesiawo dzena le la me.
Aleke esia to vovo tso Alzheimer kple Parkinson ƒe dɔlélewo gbɔe?
Ame geɖe tɔtɔa nɔnɔme etɔ̃ siawo elabena woƒe dzesiwo ɖi wo nɔewo ŋutɔ. Ke hã, vovototo siwo dze ƒã le wo dome. Esia nyanya le vevie na dɔlélea didi kple atike nyuitɔ xɔxɔ.
| Atikewɔwɔ ƒe nɔnɔme | Ðoɖo si nu ŋkuɖoɖonudzi ƒe kuxiwo kple ʋuʋu ƒe kuxiwo dzɔna ɖo | Nu tɔxɛ bubuwo |
|---|---|---|
| Lewy Ŋutilã ƒe Tagbɔdɔléle (LBD) . | Zi geɖe la, ʋuʋu ƒe kuxiwo (azɔlizɔzɔ sesẽ, ʋuʋudedi) kple ŋkuɖoɖonudzi ƒe kuxiwo (nuŋlɔɖi be) dzɔna le ɣeyiɣi ɖeka me alo le ƒe ɖeka me. | Susukpɔkpɔ ate ŋu adzɔ le dɔlélea ƒe gɔmedzedze. REM alɔ̃dɔdɔ ƒe nuwɔna ƒe kuxi bɔ. Lɔlɔ̃ ɖe nu dzi kple tamebubu ƒe ŋutetewo nɔa tɔtrɔm le ŋkekea me katã (ɣeaɖewoɣi la, enyo ŋutɔ, ɣebubuɣiwo la, etɔtɔna ŋutɔ). |
| Alzheimer ƒe Dɔléle | Edzea egɔme tso ŋkuɖoɖonudzi ƒe kuxiwo dzi (vevietɔ ŋkuɖoɖonudzi ɣeyiɣi kpui aɖe). Ʋuʋu ƒe kuxiwo dzɔna le dɔlélea ƒe akpa mamlɛawo me. | Zi geɖe la, wokpɔa susumenuwo ne dɔlélea de ŋgɔ ŋutɔ, si fia be le eƒe nuwuwu. |
| Parkinson ƒe Dɔléle | Edzea egɔme tso ʋuʋu ƒe kuxiwo (ʋuʋudedi, lãmekawo ƒe sesẽ). Ŋkuɖodzikuxiwo (tagbɔdɔ) dona emegbe ŋutɔ le dɔlélea me, alo ɖewohĩ madze gbeɖe o. | Ekpɔa ŋusẽ ɖe ʋuʋu dzi koŋ. Ne tagbɔdɔ dzɔ la, woyɔnɛ be ‘Parkinson ƒe dɔléle tagbɔdɔléle’. |
Vevietɔ wu la, atike siwo wonana na nɔnɔme siawo hã to vovo, eyata dɔlélea didi nyuie le vevie ŋutɔ.
Nukawoe nye afɔku siwo ate ŋu ana woaxɔ LBD?
Dzɔdzɔmeŋutinunyalawo menya nusita tututu ame aɖewo ƒe ahɔhɔ̃ me Lewy ƒe ŋutilã va ɖo haɖe o, gake wode dzesi afɔku geɖe siwo ate ŋu ahe esia vɛ.
- Ƒe: Ƒe 50 kple edzivɔ xɔxɔ nye afɔku gã aɖe.
- Atikewɔwɔ ƒe nɔnɔme bubuwo:Nɔnɔmewo abe Parkinson ƒe dɔléle alo REM alɔ̃dɔdɔ ƒe nuwɔna ƒe kuxi ene ƒe amesinɔnɔ.
- Ƒome ŋutinya: Togbɔ be womebua esia be enye domenyiŋusẽfianu o hã la, ne LBD nɔ wò ƒomea me kpɔ la, afɔku si le eme be nàxɔe la dzina ɖe edzi vie.
- Ŋutsu alo nyɔnu nyenye: Ŋutsuwo ate ŋu axɔ dɔléle sia wu nyɔnuwo.
Nukawoe nye LBD ƒe dzesi veviwo?
Menye dɔnɔwo katãe dzea dzesi ɖeka o. Dzesi aɖewo ate ŋu anɔ bɔbɔe, evɔ bubuwo ya nu sẽ. Woate ŋu ama dzesiawo ɖe hatsotso ene me.
| Nɔnɔmewo ƒe hatsotso | Kpɔɖeŋuwo |
|---|---|
| Ŋusẽkpɔɖeamedzi ɖe Tamebubu Ŋutetewo Dzi | Nyametsotsowo wɔwɔ sesẽ, didiƒe didi sesẽ, susu tsɔtsɔ ɖo nu ŋu sesẽ, ŋkuɖoɖo nu dzi, ŋkuléle ɖe teƒe ɖeka ŋu, nusiwo mele afima o kpɔkpɔ (susumenuwo), tɔtɔ le ɣeyiɣi kple teƒe ŋu. |
| Zɔzɔ̃ | Afɔwo ƒe ʋuʋu ne wole zɔzɔm, ŋutilã ƒe sesẽ, dadasɔ kple anyidzedze, ʋuʋudedi, ŋgɔgbe bɔbɔ, nu mimi sesẽ, mo ƒe dzedzeme dzi ɖeɖe kpɔtɔ, kple gbe si gbɔdzɔ. |
| Ŋusẽ si wòkpɔna ɖe alɔ̃dɔdɔ dzi | Drɔ̃ewo ƒe fefewɔwɔ le alɔ̃ me (e.g., ɣlidodo, abɔ kple afɔwo ƒe ʋuʋu, tso aba dzi), alɔ̃dɔdɔ fũ le ŋkeke me, alɔ̃madɔmadɔ, kple alesi wòhiã be woaʋuʋu afɔwo (Restless legs syndrome). |
| Ŋusẽkpɔɖeamedzi ɖe Seselelãme Kple Nuwɔna Dzi | Blanuiléle, dzimaɖitsitsi, dzimaɖitsitsi, paranoia, dziku ƒe dodo kpata, nukoko alo avifafa si dzi womate ŋu aɖu o (pseudobulbar affect). |
Nukae nye LBD ƒe dzesi gbãtɔwo?
Zi geɖe la, nusiwo mele afima o kpɔkpɔ (Hallucinations) .Susukpɔkpɔ nye dzesi gbãtɔ si dzena le LBD dɔnɔ siwo ade 80% me. Esia fia be wokpɔa nuwo, abe lãwo, amewo, kple nɔnɔmewo ene, siwo mele afima o. Tsɔ kpe ɖe eŋu la, woate ŋu akpɔ tɔtrɔ siwo va le tamebubu ŋutete, ŋkuɖoɖonudzi, kple alɔ̃dɔdɔ ƒe kuxiwo hã me le gɔmedzedzea me.
Aleke ɖɔkta wɔa anya LBD?
Womate ŋu atsɔ dodokpɔ ɖeka akpɔ LBD o. Esi wònye be eƒe dzesiwo sɔ kple tagbɔdɔ ƒomevi bubuwo ta la, ate ŋu asesẽ be woakpɔe, vevietɔ le eƒe gɔmedzedze. Eyata ɖɔkta aɖe agbe nɔnɔme bubu siwo hea dzesi mawo tɔgbe vɛ.
Wò ɖɔkta ate ŋu awɔ dodokpɔ geɖe, abe:
- Lãmedodokpɔ kple numedzodzro tsitotsito tso wò dzesiwo ŋu.
- Ahɔhɔ̃mekadodokpɔ: Wò ŋku ƒe dɔwɔwɔ, ŋusẽ, dadasɔ, azɔlizɔzɔ, kple ŋku ƒe ʋuʋu me dzodzro.
- Ʋudodokpɔ: Kpɔe ɖa be lãmetsiŋusẽ alo vitamin ƒe agbɔsɔsɔ mesɔ o hã.
- Ahɔhɔ̃ ƒe fotoɖeɖe: CT alo MRI scan ate ŋu adi tɔtrɔ siwo do ƒome kple tagbɔdɔléle ƒomevi bubuwo. Woate ŋu awɔ scan tɔxɛwo abe PET alo SPECT ene hã.
- Alɔ̃dɔdɔ ƒe dodokpɔwo: Kpɔ alɔ̃dɔdɔ ƒe kuxiwo abe REM alɔ̃dɔdɔ ƒe nuwɔna ƒe kuxi ene ɖa.
Nukae nye atike siwo wozãna na LBD?
Fifia la, atike alo atike aɖeke meli na LBD o. Gake atikewɔmɔnu aɖewo li siwo ate ŋu akpe ɖe ame ŋu wòaɖu dzesiawo dzi eye wòana agbea nanɔ bɔbɔe wu .
- Atikewo:
- Atikewo abe `donepezil (Aricept)` kple `rivastigmine (Exelon)`, siwo wonaa Alzheimer dɔnɔwo ɖe tamebubu kple ŋkuɖoɖonudzi ƒe kuxiwo ta.
- Atikewo abe levodopa ene na ʋuʋu ƒe kuxiwo (ʋuʋudedi, sesẽme).
- Atikewo abe melatonin alo clonazepam (Klonopin) ene na alɔ̃dɔdɔ ƒe kuxiwo.
- Atikewɔmɔnu Bubuwo:
- Lãmesẽfefe: Kamedede siwo ana ame ƒe ʋuʋu kple dadasɔ nanyo ɖe edzi.
- Dɔwɔwɔ ƒe atikewɔwɔ: Be nàsrɔ̃ alesi woawɔ gbesiagbedɔwo bɔbɔe wu.
- Aɖaŋuɖoɖo: Be woakpɔ susu me kuxiwo abe blanuiléle kple dzimaɖitsitsi ene gbɔ.
Vevietɔ ŋutɔ: Tagbɔdɔlélawo dometɔ aɖewo siwo wozãna tsɔ daa tagbɔdɔlélewo ate ŋu akpɔ ŋusẽ gbegblẽ ɖe amesiwo ŋu LBD le dzi. Esiawo ate ŋu ana dzesiawo (vevietɔ nusiwo mele afima o kpɔkpɔ kple ʋuʋu ƒe kuxiwo) nagblẽ ɖe edzi. Eyata mègazã atike aɖeke wò ɖɔkta ƒe aɖaŋuɖoɖo manɔmee o.
Aɖaŋuɖoɖo na amesi le agbe kple LBD kple wo dzikpɔlawo
LBD ƒe agbenɔnɔ nye kuxi na dɔnɔa kple wo dzikpɔlawo siaa, gake ne wowɔ ɖoɖo nyuie hekpe ɖe eŋu la, mɔzɔzɔa ate ŋu ana wòanɔ bɔbɔe wu.
- Bu dedienɔnɔ ŋu kpɔ: Ðe mɔxenu siwo ate ŋu ana nàge ɖe aƒea me la ɖa. De grab bars tsileƒea.
- Na kpekpeɖeŋu nasu asiwò: Ƒo nu tso esia ŋu na wò ƒometɔwo kple xɔlɔ̃wo. Xɔ woƒe kpekpeɖeŋu. Dɔnɔdzikpɔla hã hiã gbɔɖeme.
- Wɔ ɖoɖo do ŋgɔ: Wɔ ɖoɖo ɖe senyawo kple ganyawo ŋuti ɖoɖowo ŋu do ŋgɔ le dɔnɔa ƒe didi nu.
- Dzi nedzɔ wò: Na dɔnɔa nakpɔ gome le nusiwo ana woakpɔ dzidzɔ ahakpɔ dzidzɔ (abe haƒoƒo sese, nutata, kple bubuawo ene) me.
LBD ƒe agbenɔƒe le mama dedie nu nye ƒe 7-8 le dzesiawo ƒe gɔmedzedze megbe, gake esia ateŋu ato vovo tso ame ɖeka gbɔ yi bubu gbɔ. Ne wokpɔ dɔnɔ aɖewo dzi nyuie hewɔ atike na wo la, woate ŋu anɔ agbe ƒe 20 sɔŋ.
Gbedasi si Wotsɔ Yi Aƒeme
- Lewy body dementia (LBD) nye dɔléle si protein ƒe agbɔsɔsɔ si le ahɔhɔ̃a me si gblẽa nu le ŋkuɖoɖonudzi, ʋuʋu, kple nuwɔna dzi hena vɛ.
- Esia to vovo tso Alzheimer ƒe dɔléle kple Parkinson ƒe dɔléle gbɔ le ɖoɖo si nu dzesiawo le kple woƒe nɔnɔme nu. Nukpɔkpɔ ƒe tɔtɔ kple alɔ̃dɔdɔ ƒe kuxiwo bɔ ɖe LBD me.
- Togbɔ be atike blibo aɖeke meli na esia o hã la, atikewo kple atikewɔmɔnu vovovowo ate ŋu aɖu dzesiawo dzi eye wòana agbea nanɔ bɔbɔe.
- Ne ame aɖe si te ɖe ŋuwò le dzesi siawo kpɔm la, mègatsi dzodzodzoe eye nàyi ɖɔkta kaba ale si nàte ŋui . Dɔlélea didi nyuie le vevie ŋutɔ.
- Dɔnɔdzikpɔla ƒe susu kple ŋutilã me lãmesẽ hã le vevie ŋutɔ. Mègahe ɖe megbe le kpekpeɖeŋu didi ne ehiã o.
Lewy Ŋutilã ƒe Tagbɔdɔléle, LBD, Tagbɔdɔléle, Ŋkuɖodzinyawo ƒe Bubu, Alzheimer, Parkinson, Ame Tsitsiwo ƒe Lãmesẽ
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