Ne èyi ɖɔkta gbɔ la, ɣeaɖewoɣi la, woŋlɔa atike siwo mènya ŋkɔ gɔ̃ hã na wò o, alo? Vevietɔ ne míele nu ƒom tso atike siwo do ƒome kple susu ƒe lãmesẽ ŋu la, míate ŋu adi be míanya nu vie, eye ɖewohĩ míavɔ̃ vie gɔ̃ hã. Egbea míele nu ƒom tso atikewo ƒe hatsotso aɖe si sesẽ vie, gake wòle vevie ŋutɔ la dometɔ ɖeka ŋu. Emae nye atike siwo woyɔna be Dopamine Antagonists ƒe hatsotso. Mègavɔ̃ ne èse ŋkɔa o, mina míase esia gɔme bɔbɔe ŋutɔ.
Nuka tututue nye dopamine ƒe dɔlékuiwutikewo?
Hafi míase esia gɔme la, ele be míanya nusi "Dopamine" nye. Kpuie ko la, dopamine nye atikewo ƒe dɔla le míaƒe ahɔhɔ̃ me. Le atikewɔwɔ me la, míeyɔa esia be ahɔhɔ̃mekawo ƒe dɔwɔwɔ. Tsɔe be wotoa dɔla siawo dzi ɖɔlia nyatakakawo le lãmenugbagbevi siwo le míaƒe ahɔhɔ̃ me dome.
Akpa aɖewo le lãmenugbagbevi siwo le míaƒe ahɔhɔ̃ me si woyɔna be "nuxɔlawo." Esiawo le abe safui siwo gena ɖe safui me ene. Dɔla si woyɔna be dopamine ye nye safui si sɔ na safui ƒe do sia. Ne safui sia (dopamine) yi eye wòdo ka kple safui ƒe do (nuxɔla) la, lãmenugbagbevi si ŋu nya ku ɖo la "ʋuna."
Azɔ kpɔ ɖa, atike aɖe si woyɔna be dopamine antagonist wɔa nu wɔnuku aɖe ŋutɔ. Atike sia hã yia safui (xɔla) ma gbɔ eye wòɖonɛ. Gake menaa lãmenugbagbevi la wɔa dɔ o. Ele abe safui gbagbã aɖe si tsi safuia me ene. Eyae nye be atike sia xea mɔ na safui ŋutɔŋutɔ, si nye dopamine, be wòagava eye wòado ka kple safuia o.
Kpuie ko la, atike siawo wɔa dɔ to dopamine ƒe dɔwɔwɔ dzi ɖuɖu le ahɔhɔ̃a me vaseɖe afisi wòhiã. Dɔléle sia dzi ɖuɖu le vevie ŋutɔ elabena dopamine ƒe agbɔsɔsɔ dzina ɖe edzi madzemadzee le tagbɔdɔléle aɖewo me.
Nɔnɔme kawo mee wozãa atike sia na?
Woate ŋu ama atike siwo tsia dopamine nu ɖe hatsotso vevi eve me:
1. Tagbɔdɔlékuiwutikewo: Esiawoe wozãna wu.
2. Atike siwo tsia ʋumenugbagbeviɣidɔ nu: Atike aɖewo dzena le hatsotso siawo evea siaa me.
Le tagbɔdɔléle ta (Antipsychotics) .
Atike siawo le vevie ŋutɔ le nɔnɔme siwo gbɔna dzi kpɔkpɔ me:
- Tagbɔdɔléle kple tagbɔdɔ bubu siwo do ƒome kplii
- Nu eve ƒe susu ƒe dɔmawɔmawɔ nyuie
- Delusional disorder ƒe dɔléle
- Mania ƒe nuwɔna
- Blanuiléledɔ sesẽ si ŋu tagbɔdɔléle ƒe dzesiwo le alo esi mele eŋu o
- Tɔtɔ sesẽ
- Tagbɔdɔléle siwo atike vɔ̃ɖiwo zazã hena vɛ
Le ʋuʋudedi kple ʋuʋudedi gome (Antiemetics) .
Togbɔ be ʋuʋudedi kple ʋuʋudedi nye nya sue aɖe na ame aɖewo hã la, le go aɖewo me la, woate ŋu anye afɔku. Le kpɔɖeŋu me, atike siawo kpena ɖe ame ŋu be woaɖu aɖuɖɔtoe si gbɔ eme dzi le atikewɔɣi le kansadɔnɔwo ŋu. Wozãa wo hã tsɔ dzudzɔa aɖuɖɔtoe kple aɖuɖɔtoe si atike si naa alɔ̃dɔdɔ ame hena vɛ le amekoko vɔ megbe.
| Atikewo ƒe hatsotso | Kpɔɖeŋu aɖewo siwo wozãna zi geɖe |
|---|---|
| Dzidzime Gbãtɔ (Typical) Antipsychotics | Haloperidol, Chlorpromazine, Fluphenazine ƒe atike |
| Dzidzime evelia (Atypical) Antipsychotics | Olanzapine, Risperidone, Quetiapine, Aripiprazole, Clozapine ƒe atike |
| Atike siwo wua ʋusɔgbɔdɔ | Metoclopramide, Prochlorperazine, Domperidone (si wozãna le Sri Lanka) . |
Vevietɔ: Esiawo nye kpɔɖeŋu ʋɛ aɖewo ko. Wò ɖɔkta koe ate ŋu anya atike nyuitɔ kekeake na wò.
Viɖe kawoe le atike siawo ŋu?
Atike siawo ate ŋu akpe ɖe ame geɖe siwo ŋu tagbɔdɔ le ŋu ŋutɔ be woanɔ agbe si sɔ. Woawo manɔmee la, woate ŋu axɔ dɔnɔ aɖewo ɖe kɔdzi le woƒe agbemeŋkekewo katã me. Atike siawo ate ŋu akpɔ dɔnɔwo ta tso nuveviwɔame me eye woana woanɔ agbe nyuie le hadome.
Azɔ hã, ʋuʋudedi sesẽ le kansa dada me ate ŋu ade ame ƒe agbe afɔku me. Le nɔnɔme mawo me la, atike siawo wɔa dɔ abe agbeɖela ene.
Mina míanya nu tso eƒe nugbegblẽ le ame ŋu kple afɔku siwo le eme hã ŋu.
Abe atike ɖesiaɖe ene la, atike siwo tsia dopamine nu ate ŋu ahe nugbegblẽ le ame ŋu vɛ. Esiawo ate ŋu ato vovo le atike si ƒomevi nèno, agbɔsɔsɔme si nàno, kple wò ŋutilã ƒe nɔnɔme nu. Ne èkpɔ nugbegblẽ aɖewo la, mègadzudzɔ atikeawo nono o eye nàgblɔe na wò ɖɔkta enumake.
| Nusiwo ate ŋu ado tso eme | Numeɖeɖe bɔbɔe |
|---|---|
| Atike si naa ame ƒe dzi dzea eme | Enye nusi me ame geɖe tona. Ate ŋu ana ɖeɖi nate ame ŋu eye wòadɔ alɔ̃. |
| Kuxi siwo do ƒome kple ʋuʋu | Nuwo abe dzimaɖitsitsi (akathisia), lãmekawo ƒe ʋuʋu alo ʋuʋu le lɔlɔ̃nu faa me (dystonia), kple lãmekawo ƒe ʋuʋu ɣeyiɣi didi le mo alo ŋutilã me le lɔlɔ̃nu faa me (tardive dyskinesia). |
| Ʋu ƒe sisi ƒe ɖiɖi | Ne ètsi tre kpata la, wò ŋkuwo ate ŋu azu blɔ eye àse le ɖokuiwò me be yegbɔdzɔ (Orthostatic hypotension). |
| Lãmetsiŋusẽ ƒe tɔtrɔ | Lãmetsiŋusẽ si nye prolactin ƒe dzidziɖedzi ate ŋu ana nyɔnuwo nadzudzɔ dzinukpɔkpɔ eye tsi si le abe notsi ene nado tso woƒe no me. |
| Ahɔhɔ̃mekawo ƒe Dɔléle Vɔ̃ɖi | Esia nye nɔnɔme si mebɔ kura o gake wòsesẽ ŋutɔ, eye wòdea ame ƒe agbe afɔku me. Ne èkpɔ dzesiwo abe dzoxɔxɔ sesẽ, lãmekawo ƒe ʋuʋu, kple tɔtɔ ene la, ele be nàyi kɔdzi ƒe Atikewɔwɔ Kpata (ETU) enumake. |
Ðe mate ŋu aku ʋu esime mele atike sia noma?
Dopamine ƒe dɔlékuiwutike geɖe ate ŋu ana ame nadɔ alɔ̃ eye ame ƒe ŋudzɔnɔnɔ dzi naɖe akpɔtɔ. Eyata nunya le eme be nàƒo asa na ʋukuku alo mɔ̃ siwo hiã be woanɔ ŋudzɔ ne èle atike sia zãm zi gbãtɔ alo ne èle atike ƒe agbɔsɔsɔme trɔm. Anyo wu be nàbia wò ɖɔkta tso esia ŋu eye nàwɔ ɖe eƒe aɖaŋuɖoɖo dzi.
Gbedasi si Wotsɔ Yi Aƒeme
- Dopamine mɔxenu nye atike vevi aɖe ŋutɔ si xea mɔ na atike aɖe si woyɔna be dopamine ƒe dɔwɔwɔ le ahɔhɔ̃a me eye wozãnɛ tsɔ daa tagbɔdɔlélewo kple ʋuʋudedi.
- Atike sia nana ame geɖe nɔa agbe si sɔ, si me lãmesẽ le.
- Abe atikewo katã ene la, esiawo ate ŋu agblẽ nu le ame ŋu, vevietɔ ʋuʋu ƒe kuxiwo kple alɔ̃dɔdɔ.
- Mègadzudzɔ atike sia nono alo atrɔ eƒe agbɔsɔsɔme gbeɖe atikewɔlawo ƒe aɖaŋuɖoɖo manɔmee o. Esia wɔwɔ ate ŋu anye afɔku.
- Ne èkpɔ nugbegblẽ aɖewo la, ƒo nu tso eŋu na wò ɖɔkta gaglãa. Woate ŋu akpɔ eƒe nugbegblẽ le ame ŋu ƒe akpa gãtɔ gbɔ.
- Ele vevie ŋutɔ be nàna wò ɖɔkta nanya nu tso atike bubu ɖesiaɖe si nèzãna ŋu.
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