Ðe wò hã nèsena le ɖokuiwò me be yedze dɔa? Nukae nye dɔléle sia si vaa ame dzi le susu aɖeke manɔmee? (Mast Cell Dɔwɔwɔ ƒe Dɔléle) .

Ðe nèsena le ɖokuiwò me ɣeaɖewoɣi be yedze dɔ vevie zi ɖekaa? Ele abe nulɔdɔ sesẽ aɖe le ŋuwò ene. Ðewohĩ wò ŋutilã bliboa abiã, avuvu, avuvu, wò dɔgbo natsi, àɖe aɖuɖɔ, alo gbɔgbɔ sesẽ na wò. Gake nusiawo medzɔna le esi nèɖu nane alo ka asi nane ŋu ta o. Ne nusiawo dzɔ le susu aɖeke ta la, ate ŋu anye nɔnɔme aɖe si woyɔna be `Mast Cell Activation Syndrome (MCAS).` Mina míaƒo nu tso esia ŋu tsitotsito egbea.

Nukae nye ``Mast Cell Activation Syndrome (MCAS)''?

Kpuie ko la, MCAS nye nɔnɔme si me lãmenugbagbevi ƒomevi aɖe si le míaƒe ŋutilã me si woyɔna be ``mast cells'' va wɔa dɔ fũu akpa le susu aɖeke manɔmee, si hea dzesi sesẽwo vɛ. Fifia ɖewohĩ ànɔ eŋu bum be, "Nenemae nulɔdɔ nye." Ẽ, nulɔdɔ hã lɔ ``mast cells'' ƒe dɔwɔwɔ ɖe eme.Gake zi geɖe la, nusi gbɔ wòtsona kɔte nɔa nulɔdɔ ŋu . Le kpɔɖeŋu me, ame aɖewo ƒe nu léa dzi na shrimp, atikutsetse, alo ke ʋetsuviwo. Gake le MCAS me la, esesẽna be woake ɖe nusi koŋ gbɔ wòtso ŋu. Dzesi siawo dzena zi ɖeka.

Le go aɖewo me la, lãmenugbagbevi siawo ƒe dɔwɔwɔ ate ŋu ahe nulɔdɔ sesẽ aɖe si ate ŋu ade ame ƒe agbe afɔku me si woyɔna be anaphylaxis vɛ. Esia ate ŋu ana gbɔgbɔ nasesẽ eye ʋu ƒe sisi naɖiɖi afɔkutɔe. Ne èkpɔ anaphylaxis ƒe dɔléle sesẽ aɖe la, ele be nàƒo ka na 911 alo ayi xɔ si te ɖe ŋuwò kpata me enumake.

Mast cells le abe asrafowo ene le míaƒe dɔlélenutsiŋutete me. Wokpena ɖe ame ŋu be woawɔ avu kple dɔlékuiwo. Eyata, esɔ be vɔvɔ̃ naɖo ŋuwò ne dzesi siawo siwo womekpɔ dze sii o le ŋuwò. Gake esɔ be mast cells nawɔ dɔ. Le kpɔɖeŋu me, mast cells wɔa dɔ le nɔnɔmewo abe aɖuɖɔtoedɔ, asrã, atikewo alo nuɖuɖuwo ƒe anaphylaxis, kple mastocytosis ene me. Esiae nana míekpɔa dzesi siawo siwo doa dziku, siwo me afɔku le ɣeaɖewoɣi.

Ke hã, ``Mast Cell Activation Syndrome (MCAS)`` nye nɔnɔme si mebɔ kura o . Ðɔktawo dea dzesi MCAS ne nusiwo gbɔna le eme:

• Ne dzesi siwo gbugbɔna vaa dziwò siwo nèsusu be ate ŋu anye anaphylaxis le susu aɖeke manɔmee.
• Ne dzesi siawo gblẽ nu le wò ŋutilã ƒe dɔwɔwɔ siwo wu ɖeka ŋu le ɣeyiɣi ɖeka me (le kpɔɖeŋu me, ŋutigbalẽ kple dɔgbo siaa).
• Ne dodokpɔwo ɖe kpeɖodzi fia be mast cells le dɔ wɔm.
• Ne atike siwo tɔa ŋku mast cells dzi ɖe wò dzesiwo dzi kpɔtɔ.

Mast cells kple akpa si wowɔna

Mast cells nye míaƒe dɔlélenutsiŋutete ƒe lãmenugbagbeviwo .Akpa. Woƒe dɔ si sɔ enye be woakpɔ míaƒe ŋutilã ta tso dɔlékuiwo (e.g. dɔlékuiwo, dɔlékuiwo) alo nu gbegblẽ bubu siwo gena ɖe míaƒe ŋutilã me la si me. Lãmenugbagbevi siawo nɔa míaƒe lãkusiwo me, eye ne wokpɔ nane si wosusu be egblẽa nu le ame ŋu la, woɖea atikewo abe histamine ene, si naa dɔlélenutsiŋutete wɔa dɔ eye wòdzea agbagba be yeawɔ avu kple amedzidzela la.

Ɣeaɖewoɣi la, wowɔa nu ɖe ​​nusiwo mele be woawɔ nu ɖe ​​wo ŋu o ŋu. Ɣemaɣie míexɔa nulɔdɔwo . Gake zi geɖe la, nulɔdɔwo hea dzesi suesuesuewo abe ŋku ƒe ʋuʋu kple ŋɔti me tsi ene vɛ. Nusi dzɔna le MCAS mee nye be dzesi siwo nu sẽ wu la dzena le susu aɖeke si medze o ta.

Aleke gbegbee ``Mast Cell Activation Syndrome (MCAS)'' nye nu sesẽe?

MCAS ƒe sesẽme nɔ te ɖe dzesi siwo nèkpɔna dzi. Ame aɖewo ƒe dzesiwo ate ŋu anɔ bɔbɔe vie, eye ŋutigbalẽ ƒe dzesiwo koe anɔ wo ŋu. Ame bubuwo ate ŋu akpɔ nɔnɔme siwo nu sẽ wu, abe anaphylaxis ene. Anaphylaxis ate ŋu awu ame ne womedae nyuie o. Gake nuwɔna siwo ade ame ƒe agbe afɔku me ɖe MCAS ŋu mebɔ kura o .

Nukae nye `Mast Cell Activation Syndrome (MCAS)` ƒe dzesiwo?

MCAS ate ŋu ana dzesi sesẽwo nadze le wò ŋutilã ƒe akpa vovovowo. Dzesi siawo ate ŋu anye:

• Ʋu ƒe sisi ƒe ɖiɖi.
• Ŋutilã ƒe dzodzro, pink, kple dzoxɔxɔ (`Flushing`).
• Ŋutilã si le ʋuʋum.
• No me ʋuʋu.
• Vuvu - vevietɔ mo, nuyi, ŋku, aɖe alo ŋɔti (`Angioedema`).
• Dɔmeɖui alo aɖuɖɔtoe (ɖewohĩ woɖɔlia wo nɔewo le wo ame evea dome).
• Dɔgbo ƒe vevesese.
• Yagbɔgbɔ sesẽ.
• Gbɔdzɔgbɔdzɔ alo alɔ̃madɔmadɔ.
• Ŋkuɖodzinu ƒe bu alo tamebubu sesẽ (ahɔhɔ̃ me fuɖename).
• Gbɔdzɔgbɔdzɔ.
• Ƒunukpeƒewo ƒe vevesese.
• Anaphylaxis (nulɔdɔ sesẽ si me dzesi siwo le etame dometɔ ɖeka alo esi wu nenema le).

Be nàke ɖi MCAS la, ele be dzesi siawo nakpɔ ŋusẽ ɖe wò ŋutilã ƒe dɔwɔwɔ eve ya teti dzi. Ema nye:

• Lãmetsiŋusẽ ƒe dɔwɔwɔ (ahɔhɔ̃ kple lãmekawo).
• Yagbɔgbɔ ƒe ɖoɖo (aɖuɖɔtoewo kple yaƒoƒomɔ̃wo).
• Dzi kple ʋukawo ƒe dɔwɔwɔ (dzi kple ʋukawo).
• Nuɖuɖumeŋusẽ (dɔgbo kple dɔgbo).

Aleke wòsena le eɖokui me ne mast cells wɔ dɔ kpata?

Ne nulɔdɔ aɖe dzɔ ɖe dziwò kpɔ la, ɖewohĩ ènya alesi wòsena le eɖokui me ne wowɔ dɔ na mast cells. Gake le amesiwo ŋu MCAS le gome la, nɔnɔmea nu sẽna wu nulɔdɔ si bɔ, eye wògblẽa nu le ŋutilã ƒe akpa vovovowo ŋu. Wò ŋutigbalẽ ate ŋu avuvu, abiã, adze ƒoƒo gɔme, alo ʋu nado gɔ̃ hã. Ðewohĩ aɖuɖɔtoe kple ʋuɖɔɖɔ ate ŋu anɔ ŋuwò. Le nɔnɔme sesẽwo me la, wò mo kple ŋɔti ate ŋu avuvu, eye wò ʋu ƒe sisi ate ŋu aɖiɖi. Ðo ŋku edzi be ne èkpɔ dzesi sesẽ siawo la, ele be nàƒo ka na 911 alo ayi kɔdzi si te ɖe ŋuwò enumake.

Nukae nye nusiwo gbɔ `Mast Cell Activation Syndrome (MCAS)` tsona?

MCAS tsoa wò mast cells ƒe dɔwɔwɔ le esime mele be woawɔe o gbɔ. Lãmenugbagbevi siwo woyɔna be mast cells susuna be nane si gblẽa nu le ame ŋu ge ɖe ŋutilãa me eye ehiã be woakpɔ eta. Ɣemaɣie woɖea protein siwo hea dzesiawo vɛ la ɖe go. Le nulɔdɔwo me la, míate ŋu anya nusi na ŋutilãa le nu wɔm wògbɔ eme. Gake le MCAS me la, esesẽna be woake ɖe susu si me kɔ si tae mast cells la ɖea protein siawo ɖe go ɖo.

Le nyateƒe me la, ame aɖeke menya nusita tututu mast cells sea veve ɖe nusiwo womedi o nu alea gbegbe haɖe o.

Nukawoe ate ŋu ahe mast cell ƒe dɔwɔwɔ vɛ?

Togbɔ be nu geɖe, abe nuɖuɖuwo kple aŋɔ ene, ate ŋu ana mast cells nawɔ dɔ eye histamine nado hã la, womate ŋu agblɔ be MCAS ƒe dzesi sesẽwo tsoa nulɔdɔ aɖe koŋ gbɔ o. Gake àte ŋu akpɔe be dzesi siawo nu sẽna wu ne tɔtrɔwo va le wò agbenɔnɔ alo nuto si me nèle me, le kpɔɖeŋu me, le ɣeyiɣi siwo me nuteɖeamedzi le vevie alo ne yame ƒe nɔnɔme trɔ. Ne nu aɖe koŋ zazã vɔ megbe koe wò dzesiawo dzena la, ke gblɔe na wò ɖɔkta. Le nɔnɔme ma me la, ɖewohĩ MCAS mele ŋuwò o, ke boŋ nulɔdɔ aɖe le ŋuwò.

Aleke wokpɔa Mast Cell Activation Syndrome (MCAS) ƒe dɔlélea?

Ðɔkta ate ŋu asusui be MCAS le ŋuwò le wò dodokpɔ, nuƒoƒo tso wò dzesiwo, kple atikewɔwɔ ŋutinya ŋu vɔ megbe. Ðɔktawo akpɔe be MCAS le ŋuwò ne wowɔ ɖe nɔnɔme siwo gbɔna dzi:

• Ne mast cell ƒe dɔwɔwɔ ƒe dzesiwo le ŋuwò.
• Ne èwɔ nu nyuie ɖe atike siwo wowɔna tsɔ naa mast cell ƒe dɔwɔwɔ ŋu.
• Ne dodokpɔwo ɖe dzesi siwo fia be mast cell ƒe dɔwɔwɔ.
• Ne mast cells ƒe xexlẽme si sɔ le wò ŋutilã me (mast cells ƒe agbɔsɔsɔ fũ fia be mast cell dɔléle bubu abe mastocytosis ene ate ŋu anɔ ŋuwò).

MCAS dodokpɔ

Be nàlé ŋku ɖe MCAS ŋu la, wò ɖɔkta ateŋu awɔ ʋudodokpɔ atsɔ akpɔe ɖa be atike aɖe si woyɔna be ``tryptase'' le wò ʋu me hã. ``tryptase'' nye nusi dzina ɖe edzi ne wowɔ ``mast cells'' dɔ. Ahiã be woawɔ dodokpɔ sia zi geɖe – ne èle lãmesẽ me kple ne dzesi sesẽwo le ŋuwò siaa. Gake ɖo ŋku edzi be, woateŋu ado ``tryptase'' ɖe dzi le atikewɔwɔ ƒe nɔnɔme bubuwo hã me. Eyata ``tryptase'' ƒe agbɔsɔsɔme ɖeɖe mateŋu anya ne MCAS le ŋuwò o. Ame aɖewo ƒe ``tryptase'' ƒe agbɔsɔsɔ ateŋu asɔ gbɔ wu alesi wokpɔ mɔe ne dzesi aɖeke mele wo ŋu o gɔ̃ hã.

Wò ɖɔkta ate ŋu awɔ ŋutigbalẽ si me nulɔdɔ le ƒe dodokpɔwo alo ʋu si me nulɔdɔ le hã atsɔ akpɔe ɖa be nu bubu siwo gbɔ wòtso hã.

Vevietɔ: Ne histamine ƒe ʋudodokpɔ ɖee fia be histamine sɔ gbɔ hã la, ɖɔktawo meƒo nya ta be MCAS le ŋuwò o.

Aleke wodaa Mast Cell Activation Syndrome (MCAS) ƒe dɔléleae?

Ðɔktawo zãa atikewo tsɔ dea dzesi MCAS eye woɖea wò dzesiwo dzi kpɔtɔna. Ne atike siwo tɔa ŋku mast cells dzi meva nyo na wò o la, ke ɖewohĩ MCAS mele ŋuwò o.

Le wò dzesiwo nu la, wò ɖɔkta ate ŋu aŋlɔ atikewo abe esiawo ene na wò:

• Histamine type 1 receptor blockers (Antihistamines) : Esiawo nye atike siwo wozãna tsɔ daa nulɔdɔ ƒe dzesiwo. Kpɔɖeŋuwo: Loratadine, Cetirizine, Fexofenadine.
• Histamine type 2 receptor blockers (atihistamine siwo ɖea dɔgbo me acid dzi kpɔtɔna) : Wona esiawo na ʋuʋudedi kple dɔgbo ƒe vevesese. Kpɔɖeŋuwo: Ranitidine alo Famotidine.
• Aspirin : Woate ŋu ana aspirin be wòaɖe tsi ƒe sisi dzi akpɔtɔ.
• Leukotriene modifiers : Esiawo kpena ɖe ame ŋu be gbɔgbɔ nɔa bɔbɔe. Kpɔɖeŋuwo: Montelukast, Zafirlukast.
• Omalizumab (XOLAIR®) : Esia ate ŋu aɖe afɔku si le anaphylaxis me dzi akpɔtɔ.
• Epinephrine : Ðɔktawo zãa epinephrine tsɔ dzudzɔa anaphylaxis. Àte ŋu alé epinephrine-tike (EpiPen®, Auvi-Q®) ɖe asi nenye be anaphylaxis dze ŋuwò.
• Mast cell stabilizers : Atikewo abe cromolyn sodium ene xea mɔ na atikewo ƒe dodo tso mast cells me (degranulation).
• Corticosteroids : Esiawo ɖea abi dzi kpɔtɔna, ʋua yaƒoƒomɔ̃wo, eye woɖea tsi si le lãmenugbagbeviwo me dzi kpɔtɔna. Gake le afɔku si le eƒe nugbegblẽ le ame ŋu ta la, ɖɔktawo meŋlɔa steroid na MCAS zi geɖe o.

Ðe woada Mast Cell Activation Syndrome (MCAS) keŋkeŋ gbeɖekaa?

Ao, atike aɖeke meli na MCAS o. Ne MCAS le ŋuwò la, ahiã be nàtsɔ atikewo akpɔ egbɔ.

Nukae nye ame si ŋu MCAS le ƒe agbenɔƒe?

Ðɔktawo le mɔ kpɔm be ame akpa gãtɔ siwo ŋu MCAS le anɔ agbe didi abe amesi si MCAS mele o ene. Gake esi wònye be esia nye dɔléle si ŋu wokpɔ yeyee ta la, míate ŋu agblɔ alesi wòakpɔ ŋusẽ ɖe agbenɔƒe dzii kple kakaɖedzi o.

Aleke malé be na ɖokuinye?

Mɔ siwo dzi nàto akpɔ ɖokuiwò dzi kple MCAS dometɔ aɖewoe nye esi:

• Wɔ wò dzesiwo ŋuti nuŋlɔɖigbalẽ. Ŋlɔ nusiwo nye wò dzesiwo, nusiwo nèɖu kple nunono ɣemaɣi, kple nusiwo nèdo goe la ɖi. Bu nusiwo to vovo le ɣeyiɣi siawo me ne wotsɔe sɔ kple esime dzesi aɖeke menɔ ŋuwò o ŋu kpɔ. Ne ède dzesi nɔnɔme aɖewo la, gblɔe na wò ɖɔkta.
• Gblɔ alesi nàwɔ nui le nɔnɔme sia me, kple afisi wò epinephrine-tike alo atike bubu si nèzãna kpata le na xɔ̃wò veviwo, ƒometɔwo, alo amesiwo nèdoa goe zi geɖe.

Ɣekaɣie wòle be mayi Dɔwɔƒe si Kpɔa Nudzɔdzɔ Kpatawo Gbɔ (ETU) ?

Togbɔ be MCAS ƒe dɔléle sesẽwo mebɔ o hã la, ne èkpɔ nulɔdɔ sesẽ alo anaphylaxis ƒe dzesiwo la, zã epinephrine-tike ne ɖe le ŋuwò. Emegbe ƒo ka na 911 alo yi xɔ si me wowɔa dɔ kpata le si te ɖe ŋuwò enumake. Dzesi siwo dzena le anaphylaxis ŋu dometɔ aɖewoe nye:

• Mo, nuyi, aɖe, alo ŋɔti ƒe vuvu.
• Gbɔgbɔ alo nu mimi sesẽ.
• Dzi ƒe tsotso.
• Ʋu ƒe sisi ƒe ɖiɖi.

Nya kawoe wòle be mabia nye ɖɔkta?

Ate ŋu aɖe vi be nàbia wò ɖɔkta nya siawo abe esiawo ene:

• Nukae wòle be mawɔ ne nɔnɔme sia gavloe ɖe edzi/edzi ɖe edzi nam zi ɖeka?
• Aleke wòle be mano nye atike?
• Aleke wòle be mazã nye epinephrine-tike kple ɣekaɣie?
• Ɣekaɣie wòle be mayi xɔ si me wowɔa dɔ kpata le?
• Ɣekaɣie magava kpɔ wò ake?

Ðe ``Mast cell activation'' nye dɔléle si tsoa dɔlélenutsiŋutete gbɔa?

Ao, menye dɔléle si tsoa dɔlélenutsiŋutete gbɔe MCAS nye o.

Kpɔe ɖa le susu me be siren aɖe le edzi yim. Dedienɔnɔdzikpɔlawo gbɔna. Miaƒe ``mast cells`` de dzesi afɔku aɖe eye wole yɔyɔm be woana kpekpeɖeŋu. Gake... le nyateƒe me la, afɔku aɖeke meli o. Abe aɖaʋawɔla si doa dziku ene la, ɖeko wò ``mast cells`` le ɣlidodo ƒe gaƒoƒoawo ƒom kpata aɖeke manɔmee. Le esi teƒe be woakpɔ tawò tso dɔléle me la, woawoe le dɔ lém na wò boŋ.

Togbɔ be míenya nusita tututu ame aɖewo ƒe mast cells wɔa nu wògbɔa eme o hã la, mɔ aɖewo li siwo dzi míato akpɔ MCAS gbɔ. De dzesi nuxlɔ̃amedzesi siwo fia kaba be woawɔ nu ɖe ​​ame ŋu. Ne èse le ɖokuiwò me be yeƒe dzesiwo le dodom la, ƒo nu kple wò ɖɔkta. Nu vevitɔe nye be nàtsɔ epinephrine-tike ɖe asi ɣesiaɣi eye nànya alesi nàzãe kple ɣeyiɣi si nàzãe. Ðewohĩ màhiãe gbeɖe o, gake dzadzraɖo ɖe nuwɔna si mèle mɔ kpɔm na o ŋu ate ŋu ana wò susu nadze akɔ anyi.

Nusiwo wòle be nànya (Take-Home Message) .

• Mast cell activation syndrome (MCAS) nye dɔléle si mebɔ o si hea nulɔdɔ ƒe dzesi sesẽwo vɛ evɔ womekpɔ nusi gbɔ wòtso si dze ƒã o.
• Esia ate ŋu akpɔ ŋusẽ ɖe ŋutilã ƒe ɖoɖo geɖe dzi zi ɖeka.
• Nɔnɔme siwo ate ŋu ade ame ƒe agbe afɔku me abe `Anaphylaxis` ene ate ŋu ado mo ɖa, eyata di atikewɔlawo ƒe aɖaŋuɖoɖo enumake ne dzesi sesẽwo do mo ɖa.
• Togbɔ be womate ŋu ada MCAS keŋkeŋ o hã la, woate ŋu atsɔ atikewo aɖu dzesiawo dzi.
• Nya nu tso wò dzesiwo ŋu, na epinephrine-tike nanɔ asiwò be nàzãe kpata, eye nàna wò ƒomea nanya nu tso eŋu.
• Ne nya aɖe le asiwò ku ɖe MCAS ŋu la, mègavɔ̃ be yeabia wò ɖɔkta o.

` Mast cells, MCAS, nulɔdɔ, anaphylaxis, histamine, tryptase, dɔlélenutsiŋutete