Za mu yi magana game da maganin Amvuttra na cututtukan zuciya da ake kira ATTR-CM? (ATTR-CM & Amvuttra)

Wataƙila ba ka taɓa jin labarin cututtuka da ke faruwa ba idan wani nau'in furotin a jikinmu ya taru ba daidai ba kuma ya shiga cikin muhimman gabobin jiki kamar zuciya da jijiyoyi. Waɗannan galibi cututtuka ne da ba kasafai ake samun su ba. A magani, ana kiran wannan nau'in sinadarin furotin amyloidosis . A yau, za mu yi magana game da wata cuta mai wuya da ake kira ATTR-CM, wadda ke shafar zuciya musamman, wato, inda ake sanya waɗannan furotin a cikin tsokar zuciya, kuma ana amfani da maganin zamani mai suna Amvuttra don magance ta.

Menene ainihin ATTR-CM?

A taƙaice dai, ATTR-CM yanayi ne da, saboda lahani na kwayoyin halitta ko kuma yana faruwa ta halitta yayin tsufa, furotin TTR, wanda ake samarwa a jikinmu, yana canza siffa kuma yana taruwa tare kuma yana sanya kansa a cikin bangon tsokar zuciya. Cikakken sunan wannan shine Transthyretin Amyloid Cardiomyopathy.

Ka yi tunani a kai, bangon zuciyarmu yana buƙatar sassauƙa don yin famfo yadda ya kamata. Amma idan waɗannan sunadaran suka taru, bangon zuciya yana yin kauri da tauri . Muna kiran wannan da ciwon zuciya. Wannan yana sa zuciya ba ta iya yin famfo da jini yadda ya kamata. Bayan lokaci, wannan ma yana iya kaiwa ga gazawar zuciya.

Wasu mutanen da ke fama da ATTR-CM ba sa fuskantar wata alama, amma wasu suna fuskantar alamun kamar na bugun zuciya na yau da kullun.

• Ƙarancin numfashi (dyspnea)
• Kumburi, musamman a ƙafafu da idon sawu
• Ruɗani ko rashin bege
• Ƙara bugun zuciya ko bugun zuciya mara tsari
• Ciwon ƙirji

Wannan zai iya sa ka ji gajiya da sauri lokacin da kake yin abubuwa kamar hawa matakala, yin ayyukan gida, ko tafiya ta ɗan lokaci.

Bugu da ƙari, wasu alamomin da ba su da alaƙa da zuciya na iya faruwa. Misali, rauni, jin kasala ko ciwo a hannaye da ƙafafu, gumi mai yawa, jiri ko suma, da matsalolin narkewar abinci.

Ta yaya maganin Amvuttra yake aiki?

Domin fahimtar wannan, da farko muna buƙatar sanin kaɗan game da wani furotin da ake kira TTR. TTR (Transthyretin) furotin ne da ake samarwa galibi a cikin hanta. Babban aikinsa shine jigilar hormones na thyroid da bitamin A a cikin jiki.

A cikin mutanen da ke fama da ATTR-CM, lahani na kwayoyin halitta yana sa a samar da furotin na TTR a cikin siffar da ba ta dace ba. Wannan siffar da ba daidai ba ta furotin tana taruwa ta kuma yi ta zuba a cikin zuciya.

Maganin Amvuttra yana aiki a matsayin maganin hana ƙwayoyin cuta. Wato, wannan maganin yana tafiya kai tsaye zuwa hanta kuma yana toshe furotin ɗin TTR da ke da lahani.Yana rage aikin kwayar halittar da ake ƙirƙira. Kamar rage girman sauti ne a rediyo.

Allurar Amvuttra allura ce ta ƙarƙashin fata. Yawanci ƙwararren ma'aikacin lafiya ne ke ba da wannan allurar bayan wata uku .

Ta yaya aka gwada nasarar wannan maganin?

Kamar kowace sabuwar magani, an tabbatar da ingancin AMVUTTRA ta hanyar wani babban bincike. A cikin wannan binciken, an bai wa marasa lafiya 655 na ATTR-CM allurar rigakafin Amvuttra, yayin da aka bai wa ɗayan rukunin allurar rigakafin placebo wacce ba ta da magani a kowane watanni 12 na tsawon shekaru uku.

Masu bincike sun duba abubuwa da dama domin auna ko wannan maganin yana da tasiri.

• Gwajin tafiya na mintuna shida: Wannan yana auna nisan da za ka iya tafiya a daidai lokacin da kake tafiya cikin mintuna 6. Wannan nisan yana raguwa yayin da yanayin zuciyarka ke ta'azzara.
• Rarraba Ƙungiyar Zuciya ta New York (NYHA): Wannan yana auna tsananin alamun gazawar zuciya. Akwai azuzuwa huɗu (I, II, III, IV). Mafi girman adadin azuzuwan, haka cutar ke ƙara tsananta.

• Tambayoyin Ingancin Rayuwa (KCCQ-OS): Wannan yana auna tasirin cutar ga ingancin rayuwar majiyyaci.

Me binciken ya gano?

A ƙarshen lokacin jiyya na shekaru uku, masu binciken sun yi nazarin sakamakon.

Babban abin da aka gano shi ne cewa marasa lafiyar da suka karɓi Amvuttra sun sami ƙarancin haɗarin mutuwa ko kuma zuwa asibiti ba zato ba tsammani ko kuma zuwa ɗakin gaggawa (ETU) da kashi 28% saboda gazawar zuciya , idan aka kwatanta da waɗanda suka karɓi placebo (allurar rigakafi).

Wani muhimmin abu kuma shi ne cewa a ƙarshen watanni 42, haɗarin mutuwa daga kowace irin matsala ya ragu da kashi 35% a cikin rukunin da suka karɓi Amvuttra.

Bugu da ƙari, marasa lafiyar da aka yi wa Amvuttra magani sun sami raguwar iya tafiya da ingancin rayuwa.

Amma ku tuna, waɗannan sakamakon bincike ba za su kasance iri ɗaya ga kowa ba. Kai da likitanka za ku buƙaci ku yanke shawara tare ko Amvuttra ya dace da ku da kuma ko fa'idodin sun fi illa.

Bari mu koyi game da sakamakon da illa.

Har yaushe ake ɗauka don ganin sakamako?

Amvuttra magani ne da ke aiki akan lokaci. Saboda haka, ba a ganin sakamakon nan take. Yana iya ɗaukar watanni da yawa ko fiye kafin a ga wani ci gaba a alamun.

Yadda ake sarrafa illolin da ke tattare da hakan?

Ɗaya daga cikin manyan illolin Amvuttra shine raguwar matakan bitamin A a cikin jini. Wannan saboda furotin na TTR shine abin da ke jigilar bitamin A a cikin jiki. Idan maganin ya rage samar da TTR, jigilar bitamin A kuma yana raguwa.

• Likitanka zai riƙa yin odar gwaje-gwajen jini akai-akai domin duba matakan bitamin A ɗinka. Yana da matuƙar muhimmanci a yi waɗannan gwaje-gwajen akan lokaci.
• Ƙara abinci mai wadataccen bitamin A (misali karas, dankali mai zaki, alayyafo, ƙwai, madara, barkono ja ) a cikin abincinku.
• Idan ka lura da wani canji a ganinka (musamman raguwar gani da dare), ka sanar da likitanka nan da nan.
• Dangane da matakin bitamin A ɗinka, likitanka zai iya ba da shawarar shan ƙarin bitamin A.

Ba waɗannan kaɗai ba ne illar Amvuttra. Idan kana da wasu alamomin da ke damunka, ka tabbata ka yi magana da likitanka .