He aha ka DHT? Pehea kona hopena i kou kino? (Dihydrotestosterone)

Ua lohe paha ʻoe i ka DHT a i ʻole Dihydrotestosterone ? Malia paha ʻae, ʻaʻole paha. Akā he mea nui loa kēia no ko mākou kino, ʻoi aku hoʻi no ke olakino o nā kāne. No laila, i kēia lā e kamaʻilio mākou e pili ana i kēia DHT ma ke ʻano maʻalahi e hiki ai iā ʻoe ke hoʻomaopopo.

He aha ka DHT (dihydrotestosterone)? I ka ʻōlelo maʻalahi...

I ka ʻōlelo maʻalahi, he hormone kūikawā ʻo DHT e kōkua i ka hoʻomohala ʻana i nā ʻano moekolohe kāne . ʻIke ʻoe, ua like nā hormones me nā ʻelele liʻiliʻi e kaohi ana i kēlā me kēia hana i loko o ko mākou kino. No DHT pū kekahi hui o nā hormones i kapa ʻia ʻo Androgen. ʻO Androgen ka inoa i hāʻawi ʻia i nā hormones e hoʻoulu ai i nā ʻano kāne.

E noʻonoʻo e pili ana i ia mea, hoʻomaka ka DHT e hana i loko o ke kino o ke kāne mai ka wā i loko o ka ʻōpū. A laila, loli ke kuleana o DHT i nā manawa like ʻole o kona ola. ʻOiai ʻaʻole maopopo loa i nā kānaka ʻepekema pehea e pili ai ka DHT i nā wahine, manaʻo lākou e pili paha ia i ka ulu ʻana o ka lauoho ma ke kino a ma nā wahi pilikino.

ʻO ka androgen nui i loko o ke kāne makua ʻo ia ka testosterone . Ma kahi o 10% o kēia testosterone e hoʻololi ʻia i DHT i kēlā me kēia lā . Hana ʻia kēia kaʻina hana ma ka ʻili a puni nā genitals a ma ka prostate gland i nā kāne. I nā wahine, hana ʻia kēia ma ka ʻili. Hana pū ia ma nā wahi e like me ko kākou akepaʻa. No ka mea, ʻoi aku ka nui o ka testosterone i loko o ke kino o nā kāne, ʻoi aku ke kiʻekiʻe o ko lākou mau pae DHT.

He aha ka hana a DHT i ko mākou kino?

Hana ʻo DHT i nā mea like ʻole ma nā pae like ʻole o ke ola o ke kāne. He mea nui loa ia i ka wā o ka ulu ʻana o ka fetal a me ka wā ʻōpio .

Eia naʻe, ʻaʻole e like me ka testosterone, ʻaʻole hana nui ka DHT i ka mālama ʻana i nā hana o ke kino i ke kāne makua. I ka wā makua, ʻike nui ʻia ka DHT i nā kūlana e like me ka hoʻonui ʻia ʻana o ka prostate a me ka nalowale o ka lauoho kāne.

Ke kuleana o DHT i ka wā o ka embryonic

ʻOiai i loko o ka ʻōpū, ulu nā ʻōpū moekolohe o kahi pēpē ma ke ʻano he kāne a wahine paha ma muli o kahi ʻano hormonal kikoʻī. I ke ʻano o ke keikikāne, hana pū ʻo DHT me nā hormones ʻē aʻe (me ka testosterone ) e kāohi i ka ulu ʻana o nā ʻano moekolohe wahine a paipai i ka ulu ʻana o nā ʻano moekolohe kāne .

He mea nui ka DHT no ka ulu ʻana o nā ʻōpū kāne waho, ka penis a me nā testicles, i loko o kahi fetus. Kōkua pū ka DHT i ka ulu ʻana o ka prostate gland.

DHT i ka wā ʻōpio

I ka hiki ʻana o ke keikikāne i ka wā ʻōpio, kōkua ʻo DHT i ka ulu ʻana o ka penis a me nā testicles. ʻAʻole wale ia, akā ʻo DHT ke kuleana nui no:

• Ma ka makaKe ulu nei i ka ʻumiʻumi.
• Ke ulu nei ka lauoho o ke kino.
• Ka ulu ʻana o ka lauoho ma nā wahi pilikino.
• Ka ulu ʻana o ka prostate .

He aha ka mea e hana ai inā piʻi aʻe nā pae DHT?

Pili kekahi mau kūlana olakino me nā pae DHT kiʻekiʻe. E nānā kākou i ko lākou ʻano:

• ʻO ka Benign Prostatic Hyperplasia (BPH)
• Ka maʻi ʻaʻai prostate
• ʻO ka alopecia Androgenetic (ka nalowale o ka lauoho kāne )
• ʻO ka Polycystic Ovarian Syndrome (i nā wahine) `(Polycystic Ovarian Syndrome - PCOS)`

ʻO ka Benign Prostatic Hyperplasia (BPH) a me DHT

ʻO ka Benign Prostatic Hyperplasia (BPH) kahi hoʻonui ʻia o kou kelepa prostate. He kūlana maʻamau loa ia i nā kāne ma luna o 50 mau makahiki .

Hiki i kou ʻōpū prostate ke hana i nā nui he nui o ka DHT. Hoʻoulu kēia DHT i ka hana maʻamau o ka ʻōpū prostate, a pinepine ke kumu o ka hoʻonui ʻana o ka ʻōpū prostate. Hiki i kēia BPH ke hana i nā pilikia e like me ka paʻakikī o ka mimi ʻana a me ka hana ʻino o ka moekolohe .

Ka maʻi ʻaʻai prostate a me DHT

ʻO ka poʻe me ka maʻi ʻaʻai prostate he kiʻekiʻe ko lākou pae o ka DHT. Hiki ke hoʻoulu ʻia ka maʻi ʻaʻai prostate e ka hoʻonui ʻia o ka hana DHT i loko o kou prostate, i hui pū ʻia me kekahi mau hoʻololi genetic e hoʻoulu ai i nā cell prostate e ulu me ke kāohi ʻole.

ʻO ka alopecia Androgenetic (poho lauoho) a me DHT

ʻO ka androgenic alopecia ka mea a mākou e kapa pinepine ai he male pattern baldness . I kēia kūlana, hāʻule ka lauoho mai luna a me ke alo o ke poʻo. Me ka hala ʻana o ka manawa, emi ka laina lauoho.

ʻO kekahi kumu o kēia hāʻule lauoho, ʻo ia ka hoʻonui ʻia o ka hana DHT i loko o kou mau follicle lauoho. Aia kekahi mau kumu ʻē aʻe, e like me nā mana genetic. Ke piʻi aʻe ka pae DHT, emi nā follicle lauoho, pōkole ke kaʻina ulu lauoho, a hāʻule ka lauoho i waho.

PCOS a me DHT

ʻO ka Polycystic Ovarian Syndrome (PCOS) kahi ʻano hormonal i kūlike ʻole e hoʻopilikia ai i nā wahine. Hana ʻia ia i ka wā e hana ai kā lākou ovaries i nā hormones androgen he nui, me ka testosterone. Ke alakaʻi nei kēia i nā pae kiʻekiʻe o DHT. Hiki i kēia ke hana i nā ʻano hōʻailona like ʻole, me nā wā kūpono ʻole, ka ulu nui ʻana o ka lauoho kino (hirsutism), a me ka acne .

He aha ka mea e hana ai inā e emi iho nā pae DHT?

Pili kekahi mau kūlana me nā pae DHT haʻahaʻa. E nānā kākou i ke ʻano o lākou:

• Ka hemahema o ka 5-alpha reductase `(ka hemahema o ka 5-alpha reductase)`
• ʻO ka testosterone haʻahaʻa / hypogonadism kāne

ʻO nā pae haʻahaʻa o ka DHT ma mua o ka maʻamau e pili nui i nā kāne. Manaʻo kekahi poʻe ʻepekema e hiki i nā pae haʻahaʻa o ka DHT i nā kaikamahine ke hoʻopaneʻe i ka wā ʻōpio.

Ka hemahema o 5-alpha reductase a me DHT

ʻO 5-alpha reductase kahi enzyme e kōkua i ka hoʻololi ʻana i ka testosterone i DHT. ʻO kahi mutation genetic e hoʻopilikia i ka hana ʻana o kēia enzyme hiki ke hoʻohaʻahaʻa a ʻaʻohe paha nā pae DHT. Ua kapa ʻia kēia he 5-alpha reductase deficiency. He kūlana kēia i hoʻoilina ʻia mai nā mākua a i nā keiki (he ʻano autosomal recessive) .

Hoʻopilikia ka hemahema o 5-alpha reductase i ka ulu ʻana o ka moekolohe o nā ʻōpū kāne genetically (ʻo ka poʻe me nā chromosomes XY). ʻO nā pēpē kāne i hānau ʻia me kēia hemahema e hōʻike pinepine i nā ʻano penei:

• ʻAʻole i hoʻomohala piha ʻia nā ʻāpana genitalia waho.
• ʻO ke alo o nā testicles hana i loko o ke kino (ʻaʻole i puka i waho).
• Ka ʻōpū prostate liʻiliʻi a ʻaʻohe paha.

He mea nui: I nā hihia koʻikoʻi o ka hemahema o ka 5-alpha reductase, hiki i nā pēpē kāne me nā chromosomes XY ke loaʻa i nā ʻāpana wahine waho. Eia nō naʻe, ʻaʻole pili ka emi ʻana o ka DHT i ka ulu ʻana o nā testicles (hiki iā lākou ke hana i ka sperm) a me nā ʻāpana kūloko. He ʻokoʻa kēia mai kahi maʻi i kapa ʻia ʻo Androgen Insensitivity Syndrome. Loaʻa i ka poʻe me kēia maʻi nā testicles maʻamau a me nā pae testosterone maʻamau a kiʻekiʻe paha, akā nele lākou i nā mea loaʻa androgen, no laila ʻaʻole lākou e hoʻomohala i nā ʻano moekolohe lua, a ʻaʻole lākou momona.

ʻAʻole ulu ka lauoho maka o nā keikikāne me ka maʻi genetic 5-alpha reductase deficiency i ka wā e hiki ai i ka wā ʻōpio. Eia nō naʻe, hana mau ko lākou kino i ka testosterone, kahi e alakaʻi ai i nā mea e like me ka leo hohonu, ka ulu ʻana o nā ʻiʻo, a me ka hoʻonui ʻia ʻana o ka penis.

Nā pae testosterone haʻahaʻa a me DHT

ʻO ka Testosterone i loko o kou kino ka mea e hoʻololi ai i DHT. No laila, inā haʻahaʻa kou pae testosterone, e haʻahaʻa hoʻi kāu mau pae DHT ma mua o ka maʻamau. ʻO kekahi inoa no nā pae testosterone haʻahaʻa ʻo ia ka hypogonadism kāne.

ʻElua ʻano nui o ka hypogonadism kāne: classical (i ka wā hānau a ma hope paha o ke ola) a me ka hoʻomaka hope. Ma muli o kou mau makahiki, hiki i ka hypogonadism kāne ke hana i nā ʻano pilikia like ʻole.

Pono anei au e ʻike i ke kauka e pili ana i koʻu mau pae DHT?

Inā manaʻo ʻoe he maʻi kou a i ʻole kāu keiki i hoʻokumu ʻia e ka DHT haʻahaʻa a kiʻekiʻe paha, e kamaʻilio me ke kauka.A laila hiki iā ia ke hana i nā hoʻokolohua e pono ai a kuhikuhi paha iā ʻoe i kahi mea loea i ka ʻōnaehana endocrine, e like me ka endocrinologist.

He mea nui ka Dihydrotestosterone, a i ʻole DHT, no ka ulu ʻana o ke kāne ma ke ʻano moekolohe. Akā inā kiʻekiʻe loa a haʻahaʻa paha kona mau pae, hiki iā ia ke hana i nā pilikia e like me ka ulu ʻole ʻana o nā ʻāpana genitalia waho, ka prostate i hoʻonui ʻia, a me ka nalowale o ka lauoho. Inā he mau hopohopo kāu e pili ana i kāu mau pae DHT, mai kānalua e kamaʻilio me kāu kauka. Hiki iā lākou ke holo i nā hoʻokolohua a ʻōlelo i nā lāʻau lapaʻau e hiki ke kōkua iā ʻoe.

Nā mea nui e hoʻomanaʻo mai kēia ʻatikala (Leka Lawe-Home)

• ʻO DHT kahi hormone androgen e kōkua nui i ka hoʻomohala ʻana i nā ʻano moekolohe kāne .
• He mea nui ka DHT no ka ulu ʻana o nā ʻāpana genitalia kāne i ka wā o ka ʻōpū a no ka ulu ʻana o ka lauoho maka a me ka lauoho kino i ka wā ʻōpio.
• Hiki i nā pae DHT kiʻekiʻe ke alakaʻi i nā kūlana e like me ka benign prostatic hyperplasia (BPH), ka maʻi prostate, ka nalowale o ka lauoho i nā kāne, a me ka PCOS i nā wahine.
• Inā haʻahaʻa nā pae DHT, hiki i nā kūlana e like me ka hemahema o 5-alpha reductase ke hoʻopilikia i ka ulu ʻana o ka moekolohe kāne.
• Inā he kānalua a hopohopo paha kāu e pili ana i kāu mau pae DHT, ʻoi aku ka maikaʻi o ka ʻimi ʻana i ke aʻo lapaʻau .

Ke lana nei koʻu manaʻo ua ʻoi aku kou maopopo i ka DHT. He mea nui loa ka ʻike ʻana i nā mea e like me kēia no kou olakino!

ʻO DHT, dihydrotestosterone, hormones, olakino kāne, testosterone, prostate, pohō lauoho, PCOS