He maʻi hoʻoilina anei ka maʻi Alzheimer? E ʻike pono kākou i ke ʻano o ia mea.

Aia kekahi o kou ʻohana, malia paha kou makuahine, kou makuakāne, a kupuna wahine paha, kupuna kāne paha, i ka maʻi ʻo Alzheimer? Ke hana ʻia kēlā, he mea maʻamau loa ka manaʻo nui i ka makaʻu a me ka hopohopo, me ka noʻonoʻo ʻana, "Auē, e loaʻa anei iaʻu kēia maʻi pū kekahi?", "He mea kēia e holo nei i loko o ka ʻohana?" Ke hoʻāʻo nei nā kānaka ʻepekema e ʻike i ke kumu pololei o ka maʻi ʻo Alzheimer. Akā hoʻokahi mea i maopopo, ʻo ia hoʻi, he pilina kēia maʻi me ko kākou mau genes. No laila i kēia lā, e kamaʻilio kākou e pili ana i ka pilina ma waena o ka maʻi ʻo Alzheimer a me ko kākou mau genes.

E nānā mua kākou, he aha kēia mau genes?

I ka ʻōlelo maʻalahi, ʻo nā genes nā kiʻi e kūkulu a kāohi i ko mākou kino. E like me nā kiʻi āu e kahakiʻi ai ma mua o ke kūkulu ʻana i hale. ʻAʻole wale ke kala o kou mau maka a me ke ʻano o kou lauoho e hoʻoholo ai i kou hiki ke loaʻa i kekahi mau maʻi, akā hoʻoholo pū lākou i kou hiki ke loaʻa i kekahi mau maʻi.

Loaʻa iā kākou kēia mau genes mai ko kākou mau mākua mai. Mālama ʻia lākou i loko o nā mea i kapa ʻia he chromosomes i loko o nā cell o ko kākou kino. He 23 mau pālua o kēia mau chromosomes ko ke kanaka olakino, a i ʻole 46 i ka huina. ʻO ka maʻamau, loaʻa iā kākou hoʻokahi mai kēlā me kēia pālua, hoʻokahi mai ko kākou makuahine a hoʻokahi mai ko kākou makuakāne. No laila, pēlā kākou e loaʻa ai nā ʻano o ko kākou mau mākua.

ʻO ka maʻi Alzheimer a me nā genes i ka wā lohi

I ka wā e pili ana i ka maʻi Alzheimer, ʻelua ʻano nui. ʻO kekahi ke ʻano maʻamau, kahi e kū pinepine ai ma hope o 65 mau makahiki. Ua kapa ʻia kēia ʻo Late-Onset Alzheimer's.

Ua ʻike nā kānaka noiʻi i kahi gene e hoʻonui ai i ka pilikia o ka loaʻa ʻana o kēia ʻano maʻi Alzheimer. Aia ia ma kā mākou chromosome 19. Ua kapa ʻia kēia gene ʻo ka gene APOE . Aia nā ʻano like ʻole o kēia gene APOE. I waena o lākou, ʻo ke kanaka me ka ʻano i kapa ʻia ʻo APOE4 he kiʻekiʻe iki ka pilikia o ka loaʻa ʻana o ka maʻi Alzheimer ma mua o nā mea ʻē aʻe. Ua hōʻoia ʻia kēia e nā haʻawina he nui i hana ʻia a puni ka honua.

E kamaʻilio kākou e pili ana i ka Alzheimer's i ka wā mua

ʻO kēia kekahi ʻano o ka maʻi Alzheimer. He mea kākaʻikahi loa ia. I kēia hihia, ʻike ʻia nā hōʻailona i ka wā ʻōpiopio, e like me nā makahiki 30, 40, a i ʻole 50. No ka mea, hoʻopilikia pinepine ia i kekahi mau lālā o ka ʻohana, ua kapa ʻia hoʻi ʻo ia ka maʻi Alzheimer ʻohana mua.

Ua ʻike nā kānaka noiʻi i nānā i ka DNA o ia mau ʻohana he mau loli ko lākou i nā genes ma nā chromosomes 1, 14, a me 21. ʻO kēia mau loli i nā genes ke kumu o ko lākou ulu ʻana i ka maʻi i ka wā ʻōpiopio.

ʻO Down syndrome a me Alzheimer's

Maanei pono mākou e kamaʻilio kikoʻī e pili ana i ka chromosome 21. Ua lohe paha ʻoe i kahi maʻi i kapa ʻia ʻo Down syndrome. Loaʻa iā lākou kahi kope keu o ka chromosome 21 ma mua o ke kanaka maʻamau. ʻO ka mea kupanaha, i ka wā e ʻelemakule ai ka poʻe me Down syndrome, nui o lākou e loaʻa i ka maʻi Alzheimer. Hōʻike pū ko lākou mau hunaola lolo i ka pōʻino like i ʻike ʻia i nā maʻi Alzheimer. Ke noiʻi nei nā kānaka ʻepekema i ka pilina ma waena o kēia mau kūlana ʻelua.

Hiki i ka papa ma lalo nei ke wehewehe hou aku i kēia mau ʻano ʻelua o Alzheimer iā ʻoe.

Ke hana ʻia nei nā hoʻāʻo genetic no ka maʻi Alzheimer?

He nīnau kēia a ka poʻe he nui. ʻAe, hiki i kahi hāpana koko ke haʻi iā ʻoe i ke ʻano o ka gene APOE āu. Akā, ʻaʻole pono nā hopena o kēlā hoʻāʻo e haʻi iā ʻoe inā e loaʻa iā ʻoe ka maʻi Alzheimer a i ʻole. ʻO ia ke kumu e hoʻohana nui ʻia ai kēia mau hoʻāʻo no nā kumu noiʻi.

ʻAʻole ʻōlelo pinepine nā kauka i ka hoʻāʻo genetic no ka maʻi Alzheimer i ka wā lohi.No ka mea, ʻo nā hopena e hoʻoulu ai i ka hopohopo pono ʻole a me ke kaumaha. E noʻonoʻo, inā ʻike ʻoe he gene APOE4 kou, e noho mau ʻoe me ka makaʻu, ʻoiai ʻaʻole paha ʻoe e loaʻa i ka maʻi. ʻAʻole ia he mea maikaʻi.

Eia nō naʻe, inā ua loaʻa i kekahi mau lālā o kou ʻohana ka maʻi i ka wā ʻōpiopio a ke ʻike nei ʻoe i nā hōʻailona like, hiki i kāu kauka ke paipai i kēia ʻano hoʻāʻo e hōʻoia i ka hoʻomaka mua ʻana o Alzheimer's. Eia nō naʻe, e hoʻomanaʻo i nā hihia he nui, hiki i ke kauka ke ʻike i ka Alzheimer's me ka ʻole o ka hoʻāʻo genetic.

He aha nā pono e loaʻa iā mākou mai ka noiʻi ʻana i kēia mau genes?

Manaʻo nā kānaka ʻepekema he nui aku paha nā genes e pili ana i ka maʻi Alzheimer. ʻO ka loaʻa ʻana o kēia mau genes e hāʻawi mai iā mākou i kekahi mau pono nui i ka wā e hiki mai ana.

• Ka hoʻomaopopo maikaʻi ʻana i ka maʻi: Kōkua kēia noiʻi iā mākou e hoʻomaopopo i ke kumu e ulu ai kēia maʻi i kekahi poʻe a me ke kumu e hoʻopilikia ai i nā poʻe like ʻole ma nā ʻano like ʻole.
• Ke ʻike ʻana i ka poʻe i pilikia nui: Inā ʻike mua ʻia ka poʻe i pilikia nui i ka loaʻa ʻana o ka maʻi, hiki ke hāʻawi ʻia iā lākou ka ʻōlelo aʻo a me ka lāʻau e pono ai e pale aku i ka maʻi.
• Hiki ke hoʻomohala ʻia nā lāʻau lapaʻau hou: ʻO ka ʻike pono i nā genes e hoʻoulu ai i ka maʻi e maʻalahi ai i nā mea noiʻi ke loaʻa nā lāʻau lapaʻau hou a maikaʻi hoʻi e kuhikuhi ana iā lākou.

No laila, ʻo nā genes hoʻokahi wale nō ʻāpana o ka puzzle paʻakikī ʻo ia hoʻi ʻo Alzheimer's. Nui nā mea e hoʻopilikia iā ia, e like me ko mākou nohona, nā mea a mākou e ʻai ai, a me nā mana o ke kaiapuni.