Ke paʻa maʻalahi nei kou koko? E aʻo kākou e pili ana i ka hemahema o ka Antithrombin!

ʻOiai inā he ʻeha liʻiliʻi ma ko kākou kino, e pau ke kahe ʻana o ke koko ma hope o kekahi manawa a paʻa ke koko, ʻeā? He ʻano hana kupaianaha maoli nō ia no ko kākou kino e pale aku iā ia iho. Eia naʻe, inā e hoʻonui ʻia kēia paʻa koko ma mua o ka mea e pono ai, a inā paha e hana ʻia nā paʻa koko i loko o ke kino me ke kumu ʻole? A laila hiki ke lilo i pilikia. I kēia lā e kamaʻilio mākou e pili ana i kahi kumu kūikawā e hoʻoulu ai i ke koko e paʻa pono ʻole. ʻO ia ka Antithrombin Deficiency , kapa pū kekahi iā ia ʻo Antithrombin III Deficiency.

He aha maoli ka Antithrombin Deficiency?

I ka ʻōlelo maʻalahi, ʻo ka hemahema o ka antithrombin kahi kūlana e pili ana i kā mākou kaʻina hana koko. Ma kēia, aia kahi emi ʻana o ka protein i kapa ʻia ʻo antithrombin, kahi mea nui i loko o ko mākou kino e pale ai i ka nui o ke koko koko, a i ʻole ʻaʻole ia e hana pono.

E noʻonoʻo i kēia ʻano. Ke hoʻopiha nei ʻoe i kahi ʻauʻau me ka wai. Pono kekahi e pani i ka faucet ma mua o ka piha ʻana, a i ʻole e ninini ʻia ka wai a pau. Pēlā, i ka wā e hoʻomaka ai ko kākou koko e paʻa, ʻo ia ka mea i kapa ʻia ʻo antithrombin e "hoʻōki" iā ia i ka manawa kūpono, e pale ana iā ia mai ka hana nui ʻana. No laila, inā ʻaʻole lawa kou antithrombin i loko o kou kino, a inā ʻaʻole ia e hana pono ana, hiki iā ʻoe ke loaʻa nā ʻōpū koko e hana mau nei, e like me ka piha ʻana o ka ʻauʻau. ʻO ia ke kumu e piʻi ai kou pilikia o ka hoʻomohala ʻana i nā ʻōpū koko kūpono ʻole .

ʻO ka poʻe me kēia maʻi, ʻoi aku ka pilikia o ka loaʻa ʻana o nā ʻūpā koko i loko o nā aʻa koko hohonu o nā wāwae (ʻDeep Vein Thrombosisʻ a i ʻole DVTʻ) a me ka pilikia o ka haki ʻana o kahi ʻūpā koko a paʻa i loko o kahi aʻa koko i loko o nā māmā (Pulmonary Embolismʻ a i ʻole PEʻ) . Hiki i kēia ke lilo i mau kūlana weliweli loa.

Pehea ka maʻamau o kēia ʻano?

He ʻano laha ʻole ka hemahema o ka Antithrombin. Ua manaʻo ʻia hoʻokahi wale nō i loko o 2,000 a 3,000 mau kānaka i loaʻa iā ia. ʻAʻole ia manaʻo ʻaʻole ia e hiki i nā kānaka āpau.

He aha nā hōʻailona o ka nele o ka antithrombin?

ʻAʻole nā ​​kānaka a pau me kēia maʻi e loaʻa nā hōʻailona like. ʻAʻole paha e loaʻa i kekahi poʻe kekahi mau hōʻailona. Eia nō naʻe, ʻo ka hapa nui o ka manawa e hana ʻia ai ke koko mua ma mua o 40 mau makahiki .

ʻO nā hōʻailona i ʻike pinepine ʻia:

• ʻO ka Deep Vein Thrombosis (DVT): Hiki i kēia ke hoʻoulu i ka wāwae e pehu, ʻulaʻula, ʻeha, a mehana ke pā.
• ʻO ka Pulmonary Embolism (PE): Hiki i kēia ke hana i ka pōkole koke o ka hanu, ka ʻeha o ka umauma (ʻoi aku hoʻi i ka wā e hanu ana), ka hanu wikiwiki, ka ʻū ʻana (i kekahi manawa me ke koko), a me ka pōkole o ka hanu. He kūlana kēia e pono ai ka mālama ʻana i ka pilikia.

Ma waho aʻe o kēia mau mea, ʻoiai he kakaikahi, i loko o nā aa koko o ka lolo , a i ʻole i loko o nā aa koko o ka ʻōpūAia kahi hiki ke hoʻokumu ʻia nā ʻūpā koko.

No ke aha i loaʻa ai kēia hemahema antithrombin?

ʻO ka hapa nui o ka manawa, ʻo ke kumu o kēia maʻi he genetic , ʻo ia hoʻi he mea ia a mākou e hoʻoilina ai mai ko mākou mau mākua mai.

• Hoʻololi ʻana o ka Gene: Loaʻa ka hemahema o ka Antithrombin i nā poʻe i loaʻa kahi loli (mutation) i loko o ka gene i kapa ʻia ʻo `SERPINC1`. Ke kuhikuhi nei kēia gene i ke kino e hana i ka antithrombin.
• Hoʻoilina: Hiki iā ʻoe ke hoʻoilina i kēia hoʻololi ʻana o ka gene mai kekahi o nā mākua. Inā pēlā, he 50% kou manawa e loaʻa ai ke ʻano. ʻAʻole ia he mea nui inā he kaikamahine a he keikikāne paha. Eia nō naʻe, ʻo nā pēpē i hoʻoilina i kēia hoʻololi ʻana o ka gene mai nā mākua ʻelua, ʻaʻole lākou e ola. He mea kākaʻikahi loa kēia.

ʻO ka mea nui, ʻaʻole nā ​​​​kānaka a pau me kēia hoʻololi ʻana o ka gene e ulu i nā ʻūpā koko. Hiki i kekahi poʻe ke ola i ko lākou ola holoʻokoʻa me ka ʻole o nā pilikia.

Pehea e ʻike ai nā kauka i kēia?

Inā loaʻa iā ʻoe kēia mau hōʻailona, ​​a i ʻole ʻike ʻoe i kekahi o kou ʻohana i loaʻa i kēia maʻi, he manaʻo maikaʻi e ʻike i ke kauka a nānā ʻia. ʻO ka maʻamau, e hana ke kauka i kēia mau mea:

• Hoʻokolokolo kino: E hoʻokolokolo ʻia kou kino.
• Mōʻaukala lapaʻau: E nīnau ʻia ʻoe e pili ana i kāu mau hōʻailona a inā paha ua loaʻa i kekahi o kou ʻohana nā pilikia like.
• Hoʻāʻo koko: ʻO ka mea nui loa, ʻo ia ka loaʻa ʻana o kahi hoʻāʻo koko kūikawā e nānā ai i ka pae o ka antithrombin i loko o kou koko.

ʻO kēia mau hoʻokolohua wale nō ke ala e hōʻoia ai inā aia kēia kūlana a ʻaʻole paha.

He aha kāu e hana nei ma ke ʻano he lāʻau lapaʻau?

ʻO ke ʻano o ka lāʻau lapaʻau e pili ana inā he ʻūpā koko kou a ʻaʻole paha.

• Inā he ʻūpā koko kou: E hoʻoholo paha kāu kauka e hoʻomaka iā ʻoe ma kahi lāʻau hoʻomāmā koko . ʻO kēia ka warfarin pinepine (ua lohe paha ʻoe iā ia ma ke ʻano he Coumadin). Hiki i kēia ke hala i kekahi mau mahina, a i ʻole he ola holoʻokoʻa paha.
• Inā ʻaʻole ʻoe i loaʻa i kahi ʻūpā koko: ʻOiai inā he hemahema antithrombin kou, inā ʻaʻole ʻoe i loaʻa i kahi ʻūpā koko, ʻaʻole pono ʻoe e hoʻomau i ka lawe ʻana i nā lāʻau hoʻokahe koko. Eia nō naʻe, i kekahi mau hihia (no ka laʻana, ma mua o ke ʻoki kino nui) hiki ke hāʻawi ʻia no kahi manawa pōkole.
• I ka wā hāpai: ʻOiai ma waena o 3% a me 50% o nā wahine hāpai me kēia ʻano hiki ke loaʻa nā ʻūpā koko i ka wā hāpai, hiki i ke kauka ke hoʻoholo e hāʻawi i kahi inikini o kahi lāʻau i kapa ʻia ʻo 'Heparin' e pale aku i ka hoʻokumu ʻana o nā ʻūpā koko i kēlā manawa.

Pehea e mālama ai iaʻu iho? (ʻOiai e loaʻa ana ka lāʻau lapaʻau)

Inā ʻoe e lawe ana i nā lāʻau hoʻokahe koko e like me Warfarin a i ʻole Heparin, he mea nui loa e lawe i ka lāʻau e like me ka ʻōlelo a kāu kauka.Eia kekahi, e hōʻoia e hele i kēlā me kēia manawa āu i hālāwai ai me ke kauka.

Ma muli o ka loaʻa ʻana o ka pilikia o ke kahe ʻana o ke koko i kēia lāʻau lapaʻau, pono e nānā mau kāu kauka e loaʻa ana iā ʻoe ka mahele kūpono. Hoʻohana ʻia nā hoʻāʻo koko e like me ka hoʻāʻo 'Prothrombin Time' (PT) e nānā inā pololei ka mahele o Warfarin.

Ma ka kaohi pono ʻana i ka nui o ka lāʻau lapaʻau ma kēia ʻano, hiki ke pale ʻia nā ʻūpā koko weliweli a hiki ke pale ʻia ke kahe koko pono ʻole.

He aha kaʻu e hana ai e hōʻemi i ka pilikia o nā ʻūpā koko?

Inā loaʻa iā ʻoe ka hemahema o ka antithrombin, aia kekahi mau mea hiki iā ʻoe ke hana e hōʻemi i kou pilikia o ke koko:

• E pale i ka lawe ʻana i nā lāʻau hoʻomalu hānau: ʻoiai nā mea i loaʻa ka estrogen. E kamaʻilio me kāu kauka e pili ana i kēia.
• E hōʻalo i ka lāʻau lapaʻau hormone: ʻO kekahi mau lāʻau lapaʻau hormone i lawe ʻia ma hope o ka menopause hiki ke hoʻonui i ka pilikia.
• Mai noho ma ke kūlana hoʻokahi no ka lōʻihi loa: ʻOiai inā e hele ana i kahi mamao loa a i ʻole e hana ana ma kahi hoʻokahi no ka lōʻihi loa, e ala aʻe ma ka liʻiliʻi i kēlā me kēia ʻelua hola a hele wāwae iki a hoʻoluliluli i kou mau wāwae.
• Mai puhipaka a hoʻohana i nā huahana paka: He mea ʻino loa ka puhipaka i nā kīʻaha koko a hoʻonui nui i ka pilikia o nā ʻūpā koko.
• E mālama i ke kaumaha olakino: ʻO ka momona kekahi kumu o ke koko.

Eia kekahi, ʻo nā mea e like me ka trauma nui, ke ʻoki kino, ka hāpai ʻana, ka hānau keiki ʻana, a me ka ʻelemakule e hoʻonui pū i kou pilikia o ke koko. Inā pono ʻoe e hana i ke ʻoki kino a i ʻole e kali ana i kahi pēpē, e haʻi i kāu kauka e pili ana i kou kūlana. Hiki iā ia ke hāʻawi iā ʻoe i kahi antithrombin concentrate kūikawā ma ke ʻano he injection intravenous (IV), inā pono.

Aia kekahi ala e pale aku ai i kēia kūlana mai ka hanana ʻana?

ʻO ka mea pōʻino, ʻoiai he maʻi hoʻoilina ia, ʻaʻohe ala e pale aku ai i ka hemahema antithrombin hoʻoilina . ʻAʻole hiki iā mākou ke hoʻololi i nā genes a mākou e hoʻoilina ai mai ko mākou mau mākua. Eia nō naʻe, aia nā mea hiki iā mākou ke hana e hōʻemi i ko mākou pilikia o nā ʻūpā koko.

He aha kāu e manaʻo ai inā loaʻa iā ʻoe ka nele o ka antithrombin?

Ma kahi o hoʻokahi i loko o ʻekolu mau kānaka me kēia maʻi e loaʻa i nā ʻūpā koko i ka wā makua.

• ʻO ke ʻoki kino a me ka neʻe ʻole: Inā ʻoe e hana ʻia ana i ke ʻoki kino a noho paʻa ʻole no ka manawa lōʻihi (e.g., inā pono ʻoe e noho ma kahi moe), ʻoi aku ka nui o kou pilikia o ka loaʻa ʻana o nā ʻūpā koko.
• Ka ʻelemakule: Hoʻonui iki ʻia kēia pilikia me ka ʻelemakule.
• Hāpai keiki: Hiki i nā poʻe me ka hemahema antithrombin ke hoʻomohala i nā ʻōpū koko maʻamau i ka wā hāpai a ma hope paha o ka hānau ʻana, no laila e pono e uku ʻia ka nānā kūikawā i kēia.

Pehea ka lōʻihi o kēia kūlana?

No ka mea, he maʻi hoʻoilina ia, ua hānau ʻia ʻoe me ia. He mea ia e mau ana no ke ola a pau. ʻO ia hoʻi, ʻaʻole hiki ke ho'ōla loa ʻia. Akā, inā mālama pono ʻia, hiki iā ʻoe ke ola me nā pilikia liʻiliʻi.

He aha ka manaʻo no kēia kūlana?

ʻO kou manaʻo no ke ʻano o ka maʻi, aia nō ia inā ua loaʻa iā ʻoe kahi ʻūpā koko a i ʻole. Hiki i ka lawe ʻana i ka lāʻau hoʻokahe koko ke kōkua i ka pale ʻana i kahi ʻūpā koko ʻē aʻe mai ke kūkulu ʻia ʻana. Eia nō naʻe, he mea nui e lawe i ka lāʻau e like me ka mea a kāu kauka e ʻōlelo ai iā ʻoe, ma ka nui kūpono, a no ka manawa kūpono.

He aha kaʻu e makaʻala nui ai?

Inā loaʻa iā ʻoe ka hemahema o ka antithrombin, he mea nui e makaʻala i nā hōʻailona hōʻailona o ka 'DVT' (kahi ʻaʻa koko i ka wāwae) a me ka 'PE' (kahi ʻaʻa koko i loko o ka māmā) i hiki iā ʻoe ke loaʻa koke ke kōkua.

• Nā hōʻailona DVT: ka pehu ʻana, ka ʻeha, ka ʻulaʻula, a me ka mehana i ka pā ʻana ma kekahi wāwae (hoʻokahi wale nō wāwae).
• Nā Hōʻailona o ka PE: Pōkole koke o ka hanu, ʻeha ka umauma (e ʻoi aku ka ʻino i ka wā e hanu ana), hanu wikiwiki, pōkole o ka hanu, ʻū (i kekahi manawa me ke koko).

Inā ʻoe e lawe ana i nā lāʻau hoʻokahe koko (e like me Warfarin), e makaʻala i kēia mau mea no ka mea aia ka pilikia o ke kahe ʻana o ke koko:

• E akahele loa i ka hoʻohana ʻana i nā mea ʻoi (pahi, ʻūmiʻi, a pēlā aku)
• E hōʻalo i nā haʻuki e hiki ai ke hōʻeha (e like me ka rugby, ka mokomoko) i ka hiki. A i ʻole, e ʻaʻahu i nā lole pale kūpono.
• Inā ʻaʻole e pau ke kahe ʻana o ke koko mai kahi ʻeha maʻalahi, a inā paha e loaʻa iā ʻoe nā palapū me ke kumu ʻole, e haʻi i kāu kauka.

Āhea wau e ʻike ai i ke kauka?

Inā kānalua ʻoe he DVT kou, e ʻike koke i ke kauka. He mea nui e mālama koke i ka DVT, no ka mea, hiki i kahi ʻūpā koko ma ka wāwae ke hemo a hele i nā māmā, e hana ana i ka PE.

Inā ʻoe e lawe ana i ka lāʻau lapaʻau e like me Warfarin, e haʻi koke aku i kāu kauka inā hāʻule ʻoe a inā he kahe koko ʻē kou (e laʻa, mai kou ihu, ʻāʻī, a i ʻole ka ʻōpala).

I ka manawa hea ʻoe e pono ai e hele i ka Emergency Treatment Unit (ETU) ?

I loko o ia kūlana , pono ʻoe e hele koke i ka Emergency Treatment Unit (ETU) o ka haukapila:

• Inā loaʻa iā ʻoe nā hōʻailona o ka `Pulmonary Embolism (PE)` (e like me ka pōkole koke o ka hanu, ka ʻeha o ka umauma).
• He aha inā manaʻo ʻoe he mau hōʻailona kou o DVT , akā ʻaʻole hiki iā ʻoe ke hoʻokaʻaʻike aku i kāu kauka?
• Inā ʻoe e lawe ana i nā lāʻau hoʻokahe koko, inā e kuʻi ʻoe i kou poʻo, inā e luaʻi ana ʻoe i ke koko, a inā ʻaʻole hiki iā ʻoe ke hoʻōki i ke kahe ʻana mai kahi ʻeha.

He mau pilikia hoʻoweliweli kēia i ke ola, no laila mai hoʻokaʻulua.

He aha nā nīnau koʻikoʻi e pono iaʻu e nīnau aku i kaʻu kauka?

Ke ʻike ʻoe he maʻi kou, hiki iā ʻoe ke nīnau i kāu kauka e like me kēia:

• Pono anei au e lawe iā Warfarin a i ʻole kekahi lāʻau hoʻokahe koko ʻē aʻe? Pehea ka lōʻihi e pono ai iaʻu e lawe?
• He manaʻo maikaʻi anei ka hoʻāʻo ʻia ʻana o nā lālā ʻē aʻe o koʻu ʻohana (nā mākua, nā kaikaina, nā keiki) no ka Antithrombin Deficiency?
• He aha nā hoʻomaʻamaʻa e hiki iaʻu ke hana me ka palekana me kēia maʻi?
• Aia kekahi mau mea kūikawā e pono iaʻu e ʻike ma mua o ka hāpai ʻana?

E nīnau i nā nīnau e like me kēia i mea e maopopo ai kou kūlana.

ʻO ka mea hope loa, nā mea e pono ai ʻoe e hoʻomanaʻo (Leka Lawe-Home)

ʻOiai he maʻi hoʻoilina ka Antithrombin Deficiency, ʻaʻole hiki iā mākou ke kāohi iā ia. Eia nō naʻe, ma ka ʻike ʻana i kēia maʻi a me ka lawe ʻana i nā hana e pono ai, hiki iā ʻoe ke ola i kahi ola olakino.

ʻO ka mea nui loa no ʻoe a me kou ʻohana e ʻike i nā hōʻailona hōʻike o DVT a me PE i hiki iā ʻoe ke ʻike mua a ʻimi koke i ka lāʻau lapaʻau inā hewa kekahi mea.

ʻO ke kāohi ʻana i kou kaumaha, ka noho ʻana i ka hana (hoʻoikaika kino mau), a me ka pale ʻana i ka puhi paka e hiki ke kōkua iā ʻoe e hōʻemi i kou pilikia o ka loaʻa ʻana o nā ʻōpū koko i makemake ʻole ʻia. Ma kēia ʻano, hiki iā ʻoe ke kāohi i ka hopena o kēia maʻi i kou ola i kekahi ʻano. E kamaʻilio pinepine me kāu kauka a e hahai pono i kāna ʻōlelo aʻo. Mai hopohopo, ʻaʻole ʻoe hoʻokahi!

hemahema antithrombin , ke koko ʻana, DVT, embolism pulmonary, nā maʻi genetic, nā lāʻau hoʻokahe koko, warfarin, heparin