Ke lohe kākou i ka huaʻōlelo "maʻi kanesa," hiki mai ka makaʻu a me ka hopohopo i ko kākou manaʻo. He mea maʻamau kēlā. Eia naʻe, me ka holomua o ka ʻepekema lapaʻau, ua hoʻomaikaʻi nui ʻia nā ʻano lapaʻau maʻi kanesa . I kēia lā, e kamaʻilio wau me ʻoukou e pili ana i kahi ʻano lapaʻau kupaianaha i hoʻololi i ka pāʻani i ke kaua ʻana i ke kanesa a lawe mai i ka manaʻolana hou i nā poʻe he nui. Ua kapa ʻia kēia ʻo Immunotherapy. I ka ʻōlelo maʻalahi, ma kahi o ka hāʻawi ʻana i nā lāʻau lapaʻau waho e hakakā ai i ke kanesa , hoʻohana mākou i kā mākou mau pale ponoʻī e hakakā ai. E nānā kākou pehea e hana ai kēia.
No laila, he aha ka Immunotherapy?
I mea e hoʻomaopopo ai i kēia, e lawe kākou i kahi laʻana liʻiliʻi. Inā loaʻa iā ʻoe kahi maʻi allergy , e like me nā ʻuku lepo, ua loaʻa paha iā ʻoe nā pana allergy. Loaʻa i nā pana kahi liʻiliʻi loa o ka allergen. Ke komo ia i loko o kou kino, hoʻomaka kāu ʻōnaehana pale e hana kūʻē iā ia, akā me ka ʻole o ka hoʻomaʻi ʻana iā ʻoe. Ke hoʻonui mālie ʻoe i ka nui, hoʻomaʻamaʻa kou kino i ka allergen. ʻO ia hoʻi, kūkulu kou kino i kahi palekana iā ia.
ʻO ke ʻano immunotherapy kekahi mea like. ʻO ke kanesa ka wā e hoʻomaka ai kekahi o kā mākou mau cell ponoʻī e hana "maikaʻi ʻole" ma waho o ke kaohi. ʻO ka manaʻolana o ka mālama ʻana i ka immunotherapy e kōkua i ka ʻōnaehana pale kūlohelohe o ko mākou kino e ʻike i kēia mau "cells maikaʻi ʻole" a hoʻomaʻamaʻa iā ia iho e luku iā lākou. E like me ke kaua ʻana i kahi virus a bacteria paha e komo i loko o ko mākou kino.
I ka ʻōlelo maʻalahi, ua like ka ʻōnaehana pale o ko mākou kino me nā mākaʻi o ka ʻāina. Ua like nā hunaola kanesa me nā lawehala i hoʻopunipuni ʻia e like me nā kānaka maʻamau. Kōkua ka Immunotherapy i nā mākaʻi e ʻike i kēia mau lawehala i hoʻopunipuni ʻia.
He aha nā ʻano nui o ka immunotherapy?
Ua ʻike nā kānaka noiʻi i kekahi mau ala e hiki ai i kā mākou ʻōnaehana pale ke ʻike a luku i nā hunaola kanesa. E nānā kākou i kekahi o nā ʻano nui.
| ʻAno o ka immunotherapy | Pehea e hana ai (ma nā huaʻōlelo maʻalahi) |
|---|---|
| ʻO ka Immunotherapy T-Cell Adoptive | Lawe ʻia nā pūnaewele T (nā koa pale) mai ke kino, hoʻoikaika ʻia i loko o ka lab, a laila hāʻawi ʻia i ke kino. |
| Nā mea pale i ka Checkpoint | Hoʻokuʻu ia i nā "breakpoints" a nā hunaola kanesa e hoʻohana ai e peʻe, e ʻae ana iā lākou e hoʻouka i ka ʻōnaehana pale. |
| Nā Antibodies Monoclonal | Ua like lākou me nā "lepili" kūikawā i hana ʻia ma ka hale hana. Hoʻopili kēia i nā hunaola kanesa, e hōʻailona ana iā lākou no ka ʻōnaehana pale e ʻike maʻalahi. |
| Nā lāʻau pale maʻi kanesa | Ua hoʻomaʻamaʻa ʻia ka ʻōnaehana pale maʻi e pale i ka ulu ʻana o kekahi mau maʻi kanesa (e like me ka lāʻau pale HPV) a i ʻole e hoʻouka i ke kanesa o ka maʻi kanesa e kū nei. |
1. Hoʻōla Lapaʻau Kelepona T Hoʻohānau (Hoʻōla Kelepona T i hoʻomaʻamaʻa kūikawā ʻia)
Ua like kēia me ke aʻo ʻana i nā pūʻali koa kūikawā. ʻO kekahi o nā koa nui i loko o kā mākou ʻōnaehana pale kino ua kapa ʻia ʻo nā T-cells .
Ma kēia lāʻau lapaʻau, lawe nā kauka i kekahi o kēia mau T-cell mai kou puʻupuʻu. A laila, ma ka lab, ʻimi lākou i ka mea o kēia mau T-cell ka mea e hakakā nui ana i ka maʻi kanesa. Koho lākou i nā "koa maikaʻi loa," hoʻololi i ka genetics iā lākou, hoʻoikaika iā lākou, a hoʻonui iā lākou i nā miliona.
ʻO ka mea hope loa, ua hoʻihoʻi ʻia kēia "pūʻali koa T-cell mana nui" i loko o kou kino ma o kahi IV. I kēia manawa, hele pololei kēia mau cell e ʻimi a luku i nā cell cancer.
ʻO kekahi o nā lāʻau lapaʻau kaulana loa ma lalo o kēia māhele ʻo ia ka CAR T-cell therapy . Hoʻohana ʻia ia no nā maʻi leukemia pediatric a me nā pākeke a me kekahi mau ʻano maʻi kanesa, e like me ka lymphoma, ʻaʻole i pane i nā lāʻau lapaʻau ʻē aʻe.
2. Nā mea pale i ka nānā ʻana
Loaʻa i ko kākou ʻōnaehana pale kino kahi ʻōnaehana o nā "brakes." Ua kapa ʻia kēia mau mea he mau checkpoints. Aia kēia mau brakes e pale aku i ko kākou ʻōnaehana pale kino mai ka hoʻouka kaua pono ʻole ʻana i ko kākou mau cell olakino ponoʻī.
Akā, hoʻohana pono nā hunaola maʻi kanesa ma kēia ʻōnaehana paleki. Hana lākou i nā protein ma ko lākou ʻili e hoʻāla ai i kēia mau wahi nānā, e hoʻouna ana i kahi hōʻailona i ka ʻōnaehana pale, me ka ʻōlelo ʻana, "ʻO wau kekahi o ʻoukou, mai hoʻouka mai iaʻu." Ua like ia me ka ʻaihue e ʻaʻahu ana i kahi ʻaʻahu mākaʻi.
Hana nā lāʻau lapaʻau hoʻopaʻa checkpoint ma ka hoʻokuʻu ʻana i kēia "pale pale" e hoʻopaʻa ana i nā hunaola kanesa. ʻAe kēia i kā mākou mau hunaola T e ʻike i ke kanesa ma ke ʻano he ʻenemi a hoʻouka iā ia.
Ua hoʻohana pono ʻia kēia ʻano lapaʻau no nā ʻano maʻi kanesa he nui, e like me ka māmā, ka umauma, nā puʻupaʻa, a me ke kanesa ʻili (melanoma).
3. Nā lāʻau pale monoclonal
He mau antibodies kēia, i hana kūikawā ʻia i loko o kahi keʻena hoʻokolohua. Ua like lākou me nā "missiles" hiki ke ʻimi a hopu i nā hunaola kanesa.
ʻAʻole hiki i kā mākou ʻōnaehana pale ke ʻike mau i nā hunaola kanesa he "ʻino." Kōkua nā antibodies monoclonal iā ia e hana pēlā. Hoʻopili kēia mau antibodies i ka ʻili o nā hunaola kanesa. A laila, me he mea lā e lele ana kahi hae ma luna o kēlā hunaola, e maʻalahi ai i ka ʻōnaehana pale ke ʻike. Me he mea lā e ʻōlelo ana, "Eia ka ʻenemi." A laila hiki i nā hunaola T ke luku maʻalahi i kēlā mau hunaola kanesa.
Loaʻa i kekahi mau antibodies monoclonal nā lāʻau anti-cancer ( chemotherapy ) a i ʻole nā mea radioactive i hoʻopili ʻia iā lākou. A laila lawe kēia antibody i ka lāʻau lapaʻau pololei i ka cell cancer a hāʻawi iā ia.
4. Nā lāʻau pale maʻi kanesa
Ua like kēia me nā lāʻau pale maʻamau. ʻElua ʻano nui:
- Nā lāʻau pale: ʻO kēia nā lāʻau pale e pale aku i nā maʻi e hiki ke hoʻoulu i ka maʻi kanesa. ʻO ka laʻana maikaʻi loa ʻo ia ka lāʻau pale HPV (Human Papillomavirus) . Hiki i kēia maʻi HPV ke hoʻoulu i ka maʻi kanesa cervical a me kekahi mau ʻano maʻi kanesa ʻē aʻe. ʻO ka loaʻa ʻana o ka lāʻau pale HPV hiki ke hōʻemi nui i kēlā pilikia. He mea nui loa e kamaʻilio me kāu kauka e pili ana i kēia a e ʻike hou aku.
- Nā lāʻau pale lāʻau: Ua hoʻolālā ʻia kēia mau mea e hoʻomaʻamaʻa i ka ʻōnaehana pale e hoʻouka i kahi maʻi kanesa i loko o ke kino.
He aha ka wā e hiki mai ana o ka immunotherapy?
He kahua e ulu wikiwiki ana ka Immunotherapy, ʻoiai ke hoʻāʻo mau nei nā kānaka ʻepekema e hoʻomaopopo maikaʻi i ke ʻano o ka hakakā ʻana o kā mākou ʻōnaehana pale maʻi kanesa.
Eia kekahi, ke hana ʻia nei ka noiʻi e ʻike inā hiki ke hāʻawi ʻia ka immunotherapy me ka hui pū ʻana me nā lāʻau ʻē aʻe, e like me ka chemotherapy, e hoʻomaikaʻi i nā hopena. I kekahi manawa, hāʻawi pū ʻia ʻelua ʻano immunotherapy.
Akā, aia nō kahi nīnau nui i pane ʻole ʻia. ʻO ia hoʻi, no ke aha e hana maikaʻi ai kēia lāʻau lapaʻau, e like me nā lāʻau lapaʻau ʻē aʻe, no kekahi mau maʻi ʻoiai ʻaʻole maikaʻi no kekahi. Ke hoʻomau nei ka noiʻi e ʻike i nā kumu no kēia.
Leka Lawe-Home
- He ʻano lapaʻau holomua loa ka Immunotherapy e hoʻohana ana i ka mana o ka ʻōnaehana pale o ko mākou kino e hakakā ai i ka maʻi kanesa.
- Ma mua o ka hoʻouka pololei ʻana i nā hunaola kanesa, hoʻomaʻamaʻa kēia i kā mākou ʻōnaehana hoʻomalu e ʻike a luku i kēlā mau hunaola.
- Aia nā ʻano lapaʻau immunotherapy like ʻole, e like me Checkpoint Inhibitors, CAR T-cell therapy, a me Monoclonal Antibodies.
- ʻAʻole kūpono kēia ʻano lapaʻau no kēlā me kēia ʻano maʻi kanesa a i ʻole kēlā me kēia maʻi. E hoʻoholo ʻia e ke kauka ma muli o kou kūlana olakino.
- Inā loaʻa iā ʻoe a i ʻole kekahi āu i ʻike ai i ka maʻi kanesa, e kamaʻilio me kāu kauka e pili ana i kēia mau lāʻau lapaʻau hou a nīnau i ka lāʻau lapaʻau kūpono loa iā ʻoe.
Immunotherapy, lāʻau lapaʻau maʻi kanesa, lāʻau lapaʻau maʻi kanesa sinhala , T-cells, checkpoint inhibitors, monoclonal antibodies, CAR T-cell therapy, maʻi kanesa, Sri Lanka
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