Ke hoʻoulu nei anei ka lāʻau lapaʻau maʻi kanesa i ka nāwaliwali? E aʻo kākou e pili ana iā G-CSF! (Granulocyte-Colony Stimulating Factor)

Ke mālama ʻia nei ʻoe a i ʻole kekahi āu i ʻike ai i ka maʻi kanesa , ʻo ia hoʻi, ka chemotherapy , e like me kā mākou e ʻike nei, ʻōlelo pinepine nā kauka, "Pono ʻoe e makaʻala, no ka mea, hiki ke emi iho nā pūnaewele e hakakā nei i ka maʻi." ʻO ke kumu o kēia, ʻoiai ke luku ʻia nā pūnaewele kanesa, hiki ke luku ʻia nā pūnaewele olakino e pono ai ko mākou kino i kekahi ʻano. No laila, aia kekahi ʻano lāʻau lapaʻau kūikawā e kōkua ana i nā pale o ke kino i kēia manawa. ʻO ia ka mea a mākou e kamaʻilio nei i kēia lā.

I ka ʻōlelo maʻalahi, he aha ka G-CSF?

He lāʻau lapaʻau ʻo G-CSF e kōkua ana i ko mākou kino e hana i nā neutrophils hou aʻe, kahi ʻano o nā hunaola koko keʻokeʻo e kōkua ana i ko mākou kino e hakakā i nā maʻi. Ua like kēia mau neutrophils me nā koa pale nui o ko mākou kino. Ke komo nā mea e like me nā germs , nā virus, a me nā bacteria i loko o ke kino, e hakakā kēia mau hunaola iā lākou a hoʻopakele iā mākou mai ka maʻi ʻana. Inā mākou e nānā i ke ʻano o ka inoa ʻo G-CSF, hiki iā mākou ke hoʻomaopopo maikaʻi i kēia:

• Granulocyte: ʻO kēia ka inoa i hāʻawi ʻia i kahi ʻano o ke koko keʻokeʻo . ʻO nā Neutrophils kekahi ʻano granulocyte. Hoʻoulu nui ʻo G-CSF i ka hana ʻana o kēia mau neutrophils.
• ʻO ke kumu hoʻoulu koloni: Ua like kēia me kahi protein e haʻi ana i nā cell "i ka mea e hana ai." Hiki iā G-CSF ke haʻi i kahi cell kumu i loko o ko mākou iwi iwi , "E lilo ʻoe i neutrophil i kēia manawa." Hiki iā ia ke haʻi aku i kahi neutrophil e kū nei e "māhele a hoʻonui."

I ka ʻōlelo maʻalahi, ʻo G-CSF kahi lāʻau lapaʻau e hele i ko kākou iwi iwi a hoʻouna i kahi leka e ʻōlelo ana, "Pōpilikia! Pono mākou i nā koa pale hou aku (neutrophils), hana koke iā lākou a hoʻokuʻu iā lākou i loko o ke koko."

He aha nā kūlana e hoʻohana ʻia ai ʻo G-CSF?

Hoʻohana nui ʻia ʻo G-CSF no ka mālama ʻana a me ka pale ʻana i ka neutropenia . ʻO ka neutropenia ka wā e emi ai ka nui o nā neutrophils i loko o ke koko ma mua o ka maʻamau. Ke hana ʻia kēia, ua emi nui ka hiki o ke kino ke hakakā i ka maʻi. Aia kekahi mau kumu nui e kuhikuhi ai kāu kauka i kēia lāʻau lapaʻau.

I ka wā o ka mālama ʻana i ka maʻi kanesa (Chemotherapy)

Ke pepehi nā lāʻau chemotherapy i nā hunaola kanesa, hiki iā lākou ke pepehi i nā neutrophils olakino. ʻO ia ke kumu he mea maʻamau ka neutropenia ma hope o ka chemotherapy. I kekahi manawa hiki i kēia ke hoʻoweliweli i ke ola. Hoʻemi ʻo G-CSF i kēia pilikia ma ka hoʻoulu ʻana i ka iwi iwi e hana koke i nā neutrophils hou.

I ka wā o kahi hoʻoili pūnaewele kumu

Pono paha nā kānaka me ke kanesa a i ʻole kekahi mau maʻi koko i nā hoʻoili cell kumu. Kōkua ʻo G-CSF i kēia kaʻina hana ma mua a ma hope.

• Ma mua o ke kāpili ʻana: Ke hāʻawi ʻia ʻo G-CSF, hoʻokuʻu ʻia kahi nui o nā hunaola kumu mai ka iwi iwi i loko o ke koko. A laila hōʻiliʻili nā kauka i kēlā mau hunaola kumu olakino.
• Ma hope o ke kāpili ʻana: Ma hope o ka luku ʻia ʻana o nā pūnaewele ʻano ʻē i loko o ke kino o ka mea maʻi, hoʻihoʻi ʻia nā pūnaewele kumu olakino i hōʻiliʻili mua ʻia i ke kino. Kōkua ʻo G-CSF i kēlā mau pūnaewele e ulu pono a lilo i mau pūnaewele koko maʻamau.

Nā kūlana neutropenia ʻē aʻe

Hānau ʻia kekahi poʻe me ka neutropenia koʻikoʻi. Hiki i kekahi ke loaʻa i ke kūlana me ke kumu ʻole. I kēia mau hihia, hoʻohana ʻia ʻo G-CSF e hoʻonui i nā pae neutrophil.

Nā ʻano o G-CSF a pehea e hāʻawi ʻia ai

Loaʻa ka lāʻau lapaʻau G-CSF ma ka mākeke ma lalo o nā inoa like ʻole. ʻOkoʻa iki kēia ma ke ʻano o ko lākou lōʻihi o ka hana a me ke kaʻina hana. ʻO ka maʻamau, hāʻawi ʻia ʻo G-CSF ma ke ʻano he inikini subcutaneous. I kekahi manawa hāʻawi ʻia ia ma ke ʻano he infusion IV. Inā hiki iā ʻoe ke hāʻawi iā ʻoe iho i ka inikini ma ka home, e wehewehe kāu kauka a kahu maʻi paha pehea e hana ai.

He aha nā hopena ʻaoʻao o G-CSF?

E like me nā lāʻau lapaʻau āpau, loaʻa iā G-CSF nā pono a me nā hopena ʻaoʻao. Akā e hoʻomanaʻo, ke kuhikuhi nei ke kauka i kēia lāʻau lapaʻau iā ʻoe no ka mea ʻoi aku ka nui o nā pono ma mua o nā pilikia. Nalo ka hapa nui o nā hopena ʻaoʻao ke hoʻōki ʻia ka lāʻau lapaʻau.

No ke aha e hoʻoulu ai ʻo G-CSF i ka ʻeha o ka iwi?

He hopena ʻaoʻao maʻamau kēia i ʻike ʻia e nā poʻe he nui. ʻOiai ʻaʻole ʻike ʻia ke kumu pololei, manaʻo nā kānaka ʻepekema no ka mea ʻo G-CSF ke kumu o ka hoʻomaka koke ʻana o ka iwi iwi e hana i nā hunaola hou i ka wikiwiki loa. ʻO ke kaomi i hoʻokumu ʻia e kēia ulu wikiwiki ʻana ka mea a mākou e manaʻo ai he ʻeha. Hiki ke hoʻomanawanui ʻia kēia ʻeha. Hiki iā ʻoe ke kamaʻilio me kāu kauka e pili ana i ia mea a loaʻa i kahi lāʻau hoʻopau ʻeha kūpono.

Āhea ʻoe e ʻike ai i ke kauka?

He mea nui loa ia e haʻi aku i kāu kauka e pili ana i nā hopena ʻaoʻao āu e ʻike ai i ka wā e lawe ana iā G-CSF. ʻOi aku hoʻi, inā ʻike ʻoe i kekahi o nā hōʻailona ma lalo nei, pono ʻoe e ʻimi koke i ke aʻo lapaʻau . I kekahi manawa pono paha ʻoe e hele i ka ʻOihana Pilikia o ka haukapila (ETU).

• Nā hōʻailona o ka maʻi: kuni, anuanu, ʻeha puʻu, ʻū.
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