ʻO ka hoʻāʻo koko huna e hoʻoulu ai i ka maʻi puʻuwai, pono e ʻike nā mea a pau (Lipoprotein(a) - Lp(a))

Hāʻawi ʻoe i ke koko e nānā i kāu cholesterol a loaʻa ka hōʻike. LDL, HDL, triglycerides... He mea hōʻoluʻolu nui ka ʻike ʻana ua maʻamau nā mea āpau, ʻeā? "ʻAuē... ʻAʻohe oʻu cholesterol, ʻaʻole e loaʻa iaʻu nā pilikia puʻuwai," e noʻonoʻo paha ʻoe. Akā, ua ʻike anei ʻoe e pili ana i kahi ʻenemi huna ʻaʻole i ʻike ʻia ma kēia hōʻike cholesterol maʻamau, akā he hopena nui i ka maʻi puʻuwai? I kēia lā e kamaʻilio mākou e pili ana i kēlā.

He aha ka Lipoprotein(a) a i ʻole Lp(a)?

I ka pōkole, ʻo Lipoprotein(a) , a i ʻole Lp(a) no ka pōkole, he ʻāpana momona i loko o ko kākou koko, e like me ka cholesterol. Akā he mea kūikawā iki kēia. Hiki i kēia ʻāpana Lp(a) ke pipili i nā paia o ko kākou mau kīʻaha koko (nā aʻa) me ka ʻoi aku ka ʻino ma mua o ka cholesterol LDL a kākou e ʻike nei he "cholesterol maikaʻi ʻole", a paʻa mālie iā lākou. E noʻonoʻo i kahi kaʻa ma ke alanui, i ka wā e piʻi ai kēia Lp(a), ua ālai ʻia ke kahe koko i loko o ko kākou mau kīʻaha koko. I ka lāʻau lapaʻau, kapa mākou i kēia he maʻi cardiovascular atherosclerotic (ASCVD) . ʻO kēia kūlana ka mea e alakaʻi ai i nā maʻi koʻikoʻi e like me ka hōʻeha puʻuwai a me ka hahau ʻana i ka hala ʻana o ka manawa.

ʻO ka pilikia nui me kēia, ʻo ia ka piʻi ʻana o ka pae o ka Lp(a) ma mua o ka mea a mākou e ʻai ai a hoʻoikaika kino paha, akā, ma muli o ko mākou mau genes . ʻO ia hoʻi, he mea ia a mākou e hoʻoilina ai mai ko mākou mau mākua mai. ʻAʻole pili i ke olakino o kou ola ʻana, hiki i kou pae Lp(a) ke kiʻekiʻe ma ke ʻano genetic. ʻO ia ke kumu, ʻoiai inā maikaʻi kāu hōʻike cholesterol maʻamau, he mea nui e makaʻala i kēia pilikia huna.

No ke aha he mea nui kēia hoʻāʻo? ʻO wai ka mea i ʻoi aku ka pilikia?

A hiki i kēia manawa, ua kūkākūkā nui ʻia ka hoʻāʻo Lp(a) i waena o nā kauka puʻuwai. Akā ke loli nei kēlā. Ke paipai nei nā hui lapaʻau koʻikoʻi o ka honua i kēia manawa e pono i kēlā me kēia pākeke ke hana i ka hoʻāʻo Lp(a) ma ka liʻiliʻi hoʻokahi i ko lākou ola .

E noʻonoʻo, aia kekahi mau maʻi i loaʻa i ʻelua a ʻekolu paha mau hōʻeha puʻuwai, nā stent, ke ʻoki bypass, akā ʻaʻohe kumu i loaʻa no ke kumu o kēia hana. I ia mau hihia, ke nānā ʻia ka pae Lp(a), ua ʻike ʻia he kiʻekiʻe loa. ʻO ia hoʻi, ʻo ia paha ke kumu nui i hūnā ʻia no ka manawa lōʻihi.

E nānā kākou i ka papa ma lalo nei e ʻike i ka ʻokoʻa ma waena o kahi hoʻāʻo cholesterol maʻamau a me kahi hoʻāʻo Lp(a).

ʻO wai ka mea i ʻoi aku ka pilikia?

ʻOiai hiki i kekahi ke loaʻa i nā pae Lp (a) kiʻekiʻe, hiki i kekahi mau hui ke piʻi iki aʻe ka pilikia:

• ʻO ka poʻe me ka mōʻaukala ʻohana o ka maʻi puʻuwai: Inā ua loaʻa i kahi hoahānau pili, e like me kou makuahine, makuakāne, a i ʻole nā ​​​​kaikuaʻana, ka hōʻeha puʻuwai a i ʻole ka hahau ʻana i ka wā ʻōpiopio (ma lalo o 55 no nā kāne, ma lalo o 65 no nā wahine), ʻoi aku ka nui o kou loaʻa ʻana o nā pae Lp (a) kiʻekiʻe.
• Kekahi mau hui lāhui: Ua hōʻike ʻia nā noiʻi he kiʻekiʻe aʻe paha nā pae Lp(a) o ka poʻe mamo ʻApelika ma mua o nā hui lāhui ʻē aʻe.
• Nā wahine postmenopausal: Hiki ke piʻi iki aʻe nā pae Lp(a) i nā wahine ma hope o ka menopause.
• Nā maʻi me ka maʻi diabetes: ʻO ka hui pū ʻana o ka maʻi diabetes a me nā pae Lp(a) kiʻekiʻe e hoʻonui nui i ka pilikia o ka maʻi puʻuwai.

He aha kā mākou e hana ai inā kiʻekiʻe ka pae Lp(a)?

ʻAe, ke noʻonoʻo nei paha ʻoe, "Pehea inā kiʻekiʻe koʻu pae Lp(a)? Aia kekahi lāʻau lapaʻau no kēia?" He nīnau koʻikoʻi loa kēia.

I kēia manawa, ʻo nā lāʻau lapaʻau e kuhikuhi pololei ana a hoʻohaʻahaʻa i nā pae Lp(a) aia nō i nā pae hope loa o ka noiʻi. Nui ka manaʻolana no nā lāʻau lapaʻau e like me Pelacarsen , nona nā hopena e manaʻo ʻia e loaʻa i ka makahiki 2025.

Akā, ʻaʻole hiki iā ʻoe ke kali wale no ia mea e hana ʻia. ʻO ka mea nui wale nō ka ʻike ʻana ua kiʻekiʻe kou pae Lp(a). Ma kēlā ala, hiki iā ʻoe a me kāu kauka ke hana i nā hana ʻē aʻe e hōʻemi ai i kou pilikia maʻi puʻuwai holoʻokoʻa.

Inā kiʻekiʻe kou pae Lp(a), e ʻōlelo paha kāu kauka i kēia mau mea:

1. E kāohi pono i ka cholesterol LDL: Inā kiʻekiʻe kou Lp(a), he mea nui loa ia e mālama i nā pae LDL ("cholesterol maikaʻi ʻole") i ka haʻahaʻa loa. Hiki ke hana ʻia kēia ma ke kau ʻana i nā lāʻau lapaʻau e like me nā statins .

2. Ke kāohi ʻana i nā kumu pilikia ʻē aʻe: Pono e kāohi pono ʻia nā kumu pilikia ʻē aʻe e like me ke koko kiʻekiʻe, ka maʻi diabetes, ka puhipaka, a me ka momona.

3. Ke hoʻomaopopo ʻana i ka ʻohana: ʻOiai he ʻano hoʻoilina nā pae Lp(a), inā kiʻekiʻe kou mau pae Lp(a), he mea nui loa ia e hoʻomaopopo i kāu mau keiki, nā kaikaina, a me nā mākua e hana pū i kēia hoʻokolohua.

He memo kūikawā e pili ana i nā lāʻau statin

Aia kekahi manaʻo kuhihewa i waena o kekahi poʻe e hiki i nā lāʻau lapaʻau statin cholesterol ke hoʻonui iki i nā pae Lp(a). He ʻoiaʻiʻo paha kēia. Eia nō naʻe, ʻoi aku ka nui o nā pono o nā statins i ka hoʻohaʻahaʻa ʻana i ka LDL cholesterol a me ka hōʻemi ʻana i ka pilikia o ka maʻi puʻuwai ma mua o nā hopena ʻaoʻao o ka piʻi iki ʻana o nā pae Lp(a). No laila, mai hoʻōki i ka lawe ʻana i kāu statin me ka ʻole o ke aʻo lapaʻau.

E kamaʻilio me kāu kauka e pili ana i ka hoʻāʻo ʻana i kāu Lp(a). ʻOiai ʻaʻole kēia he hoʻāʻo maʻamau, e kuhikuhi paha lākou iā ʻoe no kēia hoʻāʻo ma hope o ke kūkākūkā ʻana i kou mōʻaukala ʻohana a me nā kumu pilikia. He hana waiwai nui kēia hiki iā ʻoe ke hana no kou olakino i ka wā e hiki mai ana.