Ke kuhikuhi kāu kauka i kahi lāʻau i kapa ʻia ʻo Larotrectinib nou a i ʻole kekahi āu i ʻike ai, he mea maʻamau ka loaʻa ʻana o nā nīnau he nui e pili ana i ia mea. He aha ke ʻano o kēia lāʻau? He aha ka mea e hana ʻia me ia? Aia kekahi mau hopena ʻaoʻao? Ke noʻonoʻo nei paha ʻoe. Mai hopohopo. E kamaʻilio maʻalahi kākou e pili ana i kēia lāʻau, ma ke ʻano hiki iā ʻoe ke hoʻomaopopo.
He aha ka Larotrectinib?
I ka ʻōlelo maʻalahi, ʻo ka larotrectinib kahi ʻano lāʻau lapaʻau kūikawā e hoʻōki i ka ulu ʻana o nā hunaola kanesa. Ua kapa ʻia kēia ʻo 'targeted therapy'. ʻO ke ʻano kēia, hele pololei kēia lāʻau lapaʻau i kahi protein kikoʻī i loko o nā hunaola kanesa, e hoʻōki ana i kēlā mau hunaola mai ka ulu ʻana.
Akā, ʻaʻole kēia he lāʻau lapaʻau i hāʻawi ʻia i nā ʻano maʻi kanesa āpau. Hoʻāʻo ʻia kāu mau hunaola maʻi kanesa e ʻike inā he mutation kūikawā ko lākou i loko o kahi gene i kapa ʻia ʻo NTRK (neurotrophic receptor tyrosine kinase gene fusion) . ʻO ka poʻe wale nō me kēlā mutation genetic e pōmaikaʻi mai kēia lāʻau. No laila, inā ua kuhikuhi kāu kauka i kēia lāʻau lapaʻau nou, ʻo ia hoʻi, e pane maikaʻi ana paha kāu ʻano maʻi kanesa iā ia.
Nā mea e haʻi aku i kāu kauka ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau
Ma mua o ka hoʻomaka ʻana i kēia lāʻau lapaʻau, he mea nui loa ia e hāʻawi i kāu kauka i kahi wehewehe piha o kou kūlana olakino. E hōʻoia e haʻi iā lākou e pili ana i kēia mau mea:
| Kūlana | Nā mea e pono ai ʻoe e hōʻike |
|---|---|
| Maʻi akepaʻa | Inā he maʻi kou i ke akepaʻa. |
| Ka maʻi aʻalolo | Inā ʻūlū kou mau lālā a i ʻole he mau pilikia aʻalolo ʻē aʻe kāu. |
| Nā maʻi ʻaleka | Inā he maʻi allergy kou i kēia lāʻau lapaʻau, nā lāʻau lapaʻau ʻē aʻe, nā meaʻai, a i ʻole nā mea hoʻoluʻu. |
| Hāpai keiki | Inā hāpai ʻoe, e hoʻāʻo ana e hāpai, a i ʻole he kānalua paha no ia mea. |
| Ka hānai ʻana i ka waiū umauma | Inā ʻoe e hānai waiū ana i kāu pēpē. |
Pehea e pono ai iaʻu ke hoʻohana i kēia lāʻau lapaʻau?
ʻO ka mea nui loa, ʻo ia ka lawe ʻana i ka lāʻau lapaʻau e like me ka ʻōlelo a ke kauka.
- E ale i kēia capsule me kahi aniani wai .
- Mai uhaʻi, kuʻi, a nau paha i ke capsule.
- Hiki iā ʻoe ke lawe i kēia ma mua a ma hope paha o ka ʻai ʻana. Akā, e hoʻāʻo e lawe iā ia i ka manawa like i kēlā me kēia lā .
- He mea nui loa: Mai lawe pū i kēia lāʻau me ka wai pomelo.
- Mai ho'ōki i ka lawe ʻana i kāu lāʻau lapaʻau me ka ʻole o ke aʻo ʻana a kāu kauka.
Inā hāʻawi ʻia i nā keiki: Hiki ke kuhikuhi ʻia kēia lāʻau lapaʻau i kekahi manawa i nā keiki ʻōpio. Eia nō naʻe, pono ia i nā hana palekana kūikawā. E kamaʻilio me kāu kauka pediatric e pili ana i kēia.
He aha ka mea e hana ai inā piʻi ka nui o ka lāʻau (overdose)?
Inā manaʻo ʻoe ua lawe nui ʻoe i kēia lāʻau lapaʻau, mai hopohopo. E kāhea koke aku i ke Kikowaena ʻIke Poisons Lahui ma ka Halemai Lahui ʻo Colombo . A i ʻole e hele i ka Emergency Treatment Unit (ETU) o ka haukapila kokoke loa.
He aha inā poina iaʻu e lawe i kaʻu lāʻau lapaʻau?
Inā ʻoe e poina i kahi lāʻau lapaʻau, e lawe koke iā ia i kou hoʻomanaʻo ʻana. Eia nō naʻe, inā ʻoi aku ka liʻiliʻi ma mua o 6 mau hola a hiki i kāu lāʻau lapaʻau aʻe, e kāpae i ka lāʻau lapaʻau i poina a lawe i kāu lāʻau lapaʻau aʻe i ka manawa i hoʻonohonoho ʻia. Mai lawe i ʻelua lāʻau lapaʻau i ka manawa hoʻokahi.
Nā mea ʻē aʻe e launa pū me kēia lāʻau lapaʻau (Nā Hana like ʻana)
Hiki i kēia lāʻau lapaʻau ke launa pū me nā lāʻau lapaʻau a me nā meaʻai ʻē aʻe. No laila, e haʻi i kāu kauka e pili ana i nā mea āpau āu e lawe nei. Hoʻokomo pū kēia i nā lāʻau lapaʻau i kauoha ʻia, nā lāʻau lapaʻau ma luna o ke kauka kūʻai, nā huahana lāʻau, nā huaora, a me nā mea hoʻohui. Eia kekahi, e haʻi i kāu kauka inā ʻoe e puhipaka a inu waiʻona paha.
Aia ma lalo iho kekahi mau mea e hiki ke launa pū me kēia lāʻau lapaʻau.
- Nā lāʻau lapaʻau no ka maʻi HIV a i ʻole AIDS
- ʻO kekahi mau lāʻau antibiotic (e like me ka clarithromycin)
- Nā lāʻau lapaʻau no nā maʻi fungal (e like me ketoconazole)
- Nā lāʻau lapaʻau no ka maʻi epilepsy (e like me ka carbamazepine, phenytoin)
- ʻO kekahi mau lāʻau lapaʻau no ka maʻi puʻuwai
- Nā lāʻau lapaʻau immunosuppressant (e like me cyclosporine, tacrolimus)
- ʻO kekahi mau lāʻau anti-cancer (chemotherapy)
- ʻO ka lau nahele ʻo St. John's Wort
- Wai ʻāpala
ʻAʻole i piha kēia papa inoa, no laila he mea nui e hoʻomaopopo i kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe nei.
Nā mea e noʻonoʻo ai i ka wā e lawe ai i ka lāʻau lapaʻau
- Nā hoʻāʻo koko: ʻOiai e lawe ana i kēia lāʻau lapaʻau, e kauoha kāu kauka i nā hoʻāʻo koko i kēlā me kēia manawa e nānā i nā mea e like me ka hana o kou ake.
- Nā hana e pono ai ka nānā ʻana: Hiki i kēia lāʻau lapaʻau ke hoʻopūʻiwa iā ʻoe, hiamoe, a huikau paha. No laila, e pale i nā hana e pono ai ka nānā ʻana, e like me ka hoʻokele kaʻa a i ʻole ka hoʻohana ʻana i nā mīkini, a hiki i kou ʻike pono ʻana i ke ʻano o kēia hopena i kou kino.
- ʻO ka hāpai ʻana a me ka hānai ʻana i ka waiū (he mea nui loa):
- Nā Wahine: Mai hāpai i ka wā e lawe ana i kēia lāʻau lapaʻau a no hoʻokahi pule ma hope o ka hoʻōki ʻana i ka lāʻau lapaʻau. Inā ʻoe e hoʻolālā ana e hāpai a manaʻo paha ua hāpai ʻoe, e haʻi koke i kāu kauka.
- Nā Kāne: E pale i ka hānau ʻana i kahi keiki i ka wā e lawe ana i kēia lāʻau lapaʻau a no hoʻokahi pule ma hope o ka hoʻōki ʻana i ka lāʻau lapaʻau.
- Mai hānai waiū i kāu pēpē i ka wā e lawe ana i kēia lāʻau lapaʻau a no hoʻokahi pule ma hope o ka hoʻōki ʻana.
- Ka hānau keiki: Hiki i kēia lāʻau lapaʻau ke hoʻopilikia i kou hiki ke loaʻa nā keiki. Inā he mau nīnau kāu e pili ana i kēia, e kamaʻilio me kāu kauka.
Nā hopena ʻaoʻao o ka lāʻau lapaʻau
E like me nā lāʻau lapaʻau āpau, hiki i kēia ke loaʻa nā hopena ʻaoʻao. He mea liʻiliʻi kekahi, aʻo nā mea ʻē aʻe e pono ai ka nānā koke ʻana.
| Nā hopena ʻaoʻao e pono e hōʻike koke ʻia i kāu kauka | |
|---|---|
| Nā hopena alerika | ʻŌhūhū ʻili, maneʻo, pehu o ka maka, nā lehelehe a i ʻole ke alelo. |
| Nā hōʻailona o ka hōʻeha o ke akepaʻa | Mimi melemele/ʻeleʻele, melemele o nā maka a i ʻole ka ʻili, ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū, luaʻi, nalowale o ka makemake e ʻai, lepo melemele. |
| Nā pilikia o ka ʻōnaehana nerve | Pōniuniu, huikau, nalowale ke kaulike, ʻeha a mae paha nā lālā, paʻakikī ke ʻōlelo. |
| Nā hopena ʻaoʻao maʻamau e pono e hōʻike ʻia i ke kauka inā hoʻomau lākou | |
| Ka luaʻi ʻana | Ka maʻi pākī |
| Ka paʻa ʻana o ka ʻōpū | Kuke |
| Luhi | |
Inā loaʻa iā ʻoe kekahi mau hōʻailona ʻē aʻe i ʻōlelo ʻole ʻia ma kēia papa inoa, e kamaʻilio pū me kāu kauka e pili ana iā lākou.
Leka Lawe-Home
- He lāʻau lapaʻau i hoʻopili ʻia ʻo Larotrectinib no nā maʻi ʻaʻai me kahi hui ʻana o ka gene NTRK.
- He mea nui e haʻi aku i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, nā huahana lāʻau lapaʻau, a me nā mea hoʻopihapiha āu e lawe nei.
- E hōʻalo i ka inu ʻana i ka wai huaʻai a pau i ka wā e lawe ana i kēia lāʻau.
- E mālama pono i nā hana palekana e pili ana i ka hāpai ʻana, ka hānai ʻana, a me ka hānau keiki ʻana i ka wā e lawe ana i ka lāʻau lapaʻau a no hoʻokahi pule ma hope o ka hoʻōki ʻana.
- E ʻimi koke i ke kōkua lapaʻau inā loaʻa nā hōʻailona e like me ka hōʻino ʻia o ke akepaʻa a i ʻole nā pilikia neurological koʻikoʻi.
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