Ke hoʻomaka koke nei ʻoe i ka maneʻo, ʻulaʻula kou ʻili a puka mai nā ʻōhū? A i ʻole ke manaʻo koke nei ʻoe i ka maʻi i kou ʻōpū a makemake ʻoe e luaʻi? I kekahi manawa hana ʻia kēia mau mea ma hope o ka hoʻohana ʻana i kahi mea ʻala, a ma hope paha o ka ʻai ʻana i kahi meaʻai, a i kekahi manawa hiki ke hana ʻia me ke kumu ʻole. Inā ʻaʻole hiki iā ʻoe ke loaʻa ke kumu no kēia, a he ʻokoʻa kou mau hōʻailona i nā manawa like ʻole, hiki paha he mea ʻoi aku ia ma mua o ka maʻi allergy. I kēia lā ke kamaʻilio nei mākou e pili ana i kekahi ʻano maʻi, ʻo Mast Cell Activation Syndrome (MCAS).
He aha ka Mast Cell Activation Syndrome (MCAS)?
I ka ʻōlelo maʻalahi, ʻo MCAS kahi kūlana kahi e lilo ai kahi ʻano cell i loko o ko mākou kino i kapa ʻia ʻo 'mast cells' i mea hana nui ʻole a hoʻokuʻu i nā nui he nui o nā kemika i loko o lākou i loko o ke kino.
I kēia manawa, e nānā kākou i ke ʻano o kēia mau pūnaewele mast. E noʻonoʻo i kēia mau pūnaewele e like me nā kiaʻi palekana o ke kino. He ʻāpana lākou o kā mākou ʻōnaehana pale. ʻO kā lākou hana nui ke kaua aku i nā maʻi. Akā, hoʻokumu pū ʻia nā allergies e kēia mau pūnaewele. ʻO ka maʻamau, ke komo kahi mea ʻino iā mākou, no ka laʻana, kahi allergen i loko o ke kino, hoʻāla ʻia kēia mau pūnaewele mast a hoʻokuʻu i nā kemika i kapa ʻia ʻo 'mediators'. ʻO kēia mau kemika ke kumu o ka pane allergies i loko o ko mākou kino. I loko o ke kanaka olakino, ʻo kēia kaʻina hana ke pale iā mākou.
Akā, i loko o kekahi me MCAS, he ʻano koʻikoʻi loa kēia mau pūnaewele mast . Hoʻonāukiuki nui lākou i ka mea liʻiliʻi loa a hoʻokuʻu i ka nui o nā kemika i ka manawa hoʻokahi. Ua like ia me ka lawe ʻana mai i kahi pūʻali koa holoʻokoʻa e hopu i kahi ʻaihue liʻiliʻi. ʻO kēia mau kemika makemake ʻole ʻia ke kumu o nā hōʻailona ʻē a hoʻopilikia a mākou i kamaʻilio ai ma mua.
Aia kekahi mau mea e hiki ke hoʻoulu pinepine i kēia mau pūnaewele mast:
- Nā maʻi
- Kekahi mau lāʻau lapaʻau
- ʻAi make mai nā nahu pepeke
- Nā ʻala
- Ke kaumaha
- Hoʻoikaika kino
- Kekahi mau meaʻai
- Nā loli koke o ka mahana
He ʻelua mau mea like ʻole ʻo MCAS a me Mastocytosis?
ʻAe, mai huikau i nā mea ʻelua. ʻOiai pili nā maʻi ʻelua i nā cell mast, he ʻokoʻa lākou.
| Kūlana olakino | I ka ʻōlelo maʻalahi, he aha ka mea e hana ʻia? |
|---|---|
| ʻO ka mastocytosis | ʻO ka mea e hana ʻia ana ma kēia , ʻo ia ka hana ʻana o ke kino i kahi helu kiʻekiʻe loa o nā pūnaewele mast. Ua like ia me ka hoʻolimalima ʻana i nā kiaʻi palekana he nui loa. Hōʻiliʻili kēia mau pūnaewele keu i loko o nā ʻōpū e like me ka ʻili, ke akepaʻa, a me nā ʻōpū. He maʻi laha ʻole kēia. |
| MCAS (Mast Cell Activation Syndrome) | ʻO ka mea e hana ʻia ma kēia hihia, ʻo ia ka helu o nā pūnaewele mast i loko o ke kino he mea maʻamau, akā lilo nā pūnaewele ma laila i hyperactive. Hoʻonāukiuki nā kiaʻi ma laila i kahi mea liʻiliʻi loa a hoʻokuʻu i nā kemika. |
He aha nā kumu o MCAS?
Hiki ke hoʻokaʻawale ʻia ʻo MCAS i ʻekolu mau māhele nui e pili ana i ke kumu.
1. MCAS Mua: Hoʻokumu ʻia kēia e kahi pilikia me nā pūnaewele mast ponoʻī. ʻO ka pinepine, ʻo kahi mutation i loko o ka gene ``(KIT)`` ke kumu o kēia mau pūnaewele e hana ʻē. ʻO ka Mastocytosis ke kūlana nui i kēia ʻano.
2. MCAS Lua: Hana ʻia kēia ke hoʻoulu ʻia nā pūnaewele mast e kekahi kumu waho ʻē aʻe. No ka laʻana, hiki ke hana ʻia kēia e kahi hopena alerika koʻikoʻi, kahi maʻi maʻi mau, a i ʻole kekahi maʻi ʻē aʻe.
3. Idiopathic MCAS: ʻO ke ʻano o "Idiopathic" ʻo ia hoʻi "ʻaʻole hiki ke loaʻa ke kumu." Loaʻa i ka hapa nui o nā maʻi MCAS kēia ʻano. ʻO ke ʻano kēia, ʻaʻohe kumu kikoʻī e hana ai kēia mau cell mast i kahi ʻano ʻē. Hiki ke ʻike ʻia nā hōʻailona no nā mea hou i kēlā me kēia manawa.
He aha nā hōʻailona hiki ke loaʻa o ka MCAS?
ʻO kekahi o nā pilikia nui me MCAS, ʻo ia ka ʻokoʻa o nā hōʻailona a hiki ke hoʻopili i nā ʻōnaehana kino he nui i ka manawa hoʻokahi.
| Māhele hōʻailona | Nā hōʻailona i ʻike pinepine ʻia |
|---|---|
| ʻIli a me nā ʻano laulā | ʻUlu ka ʻili, maneʻo, ʻulaʻula/hives, pehu, hou nui, luhi mau, ʻeha kino. |
| ʻŌnaehana hoʻoheheʻe | ʻEha ʻōpū, nausea, luaʻi, diarrhea, constipation. |
| ʻŌnaehana aʻalolo (Neurological) | ʻEha poʻo, pilikia hoʻomanaʻo a me ka nānā ʻana (noe lolo), poniuniu, maule, hopohopo, kaumaha, hiamoe ʻole. |
| ʻŌnaehana puʻuwai a me ka hanu | Ka puʻuwai wikiwiki a kūpono ʻole paha (palpitations), paʻakikī ka hanu ʻana, paʻa ka umauma. |
Nānā kūikawā: Anaphylactic Shock
ʻO Anaphylaxis ke kūlana weliweli loa a hoʻoweliweli hoʻi i ke ola e hiki ke hana i nā poʻe me MCAS. He kūlana kēia e pono ai ka mālama olakino ulia pōpilikia.
Nā hōʻailona o ka anaphylaxis:
- Paʻakikī ka hanu ʻana, me ka manaʻo e like me ka ʻū ʻia o kou puʻu
- Ka pehu ʻana o nā lehelehe, ke alelo, a i ʻole ka maka
- Wikiwiki loa ka helu o ka puʻuwai.
- Ka hāʻule koke ʻana o ke koko
- ʻO ka pōʻino nui a me ka nawaliwali
- Ka luaʻi a me ka maʻi pākī
- ʻUlaʻula koke a me ka ʻulaʻula ma ke kino holoʻokoʻa
Inā ʻike ʻoe i hoʻokahi a ʻoi aku paha o kēia mau hōʻailona, mai hoʻokaʻulua. E kāhea koke aku i kahi ambulance a i ʻole e hele i ka Emergency Department (ETU) o ka haukapila kokoke loa.
Pehea e ʻike ai inā loaʻa iaʻu ka MCAS?
Hiki ke paʻakikī iki ka ʻike ʻana i ka MCAS no ka mea he ʻokoʻa loa nā hōʻailona. ʻO ka maʻamau, e ʻimi kāu kauka i ʻekolu mau mea kikoʻī.
1. Nā Hōʻailona: Ke kū ʻana o nā hōʻailona maʻi ʻaleka mau loa e like me ka maʻi ʻaleka i loko o ʻelua a ʻoi aku paha mau ʻōnaehana kino (e laʻa, ka ʻili a me nā ʻōpū).
2. Nā hoʻāʻo: ʻO nā hāpana koko a mimi paha i lawe ʻia i ka wā e ʻike ʻia ai nā hōʻailona e hōʻike ana i nā pae kiʻekiʻe o nā kemika e like me ka "tryptase" a me ka "histamine", i hoʻokuʻu ʻia e nā cell mast.
3. Pane i ka lāʻau lapaʻau: E emi ana nā hōʻailona ke hāʻawi ʻia i nā lāʻau lapaʻau e ālai ana i ka hana o nā cell mast, e like me nā antihistamines.
Inā hoʻokō ʻia kēia mau pae ʻekolu a pau, hiki i ke kauka ke kānalua i ka MCAS. I kekahi manawa hele pū ʻia ka MCAS me kahi kūlana i kapa ʻia ʻo "(POTS)" - Postural Orthostatic Tachycardia Syndrome. ʻO kēia ka manawa e piʻi ai ka puʻuwai i ka wā e kū ai.
Pehea e mālama ʻia ai?
ʻAʻohe lāʻau lapaʻau no MCAS i kēia manawa. Eia nō naʻe, hiki ke hoʻomalu maikaʻi ʻia nā hōʻailona a hiki ke hoʻokō ʻia ke ola maʻamau. ʻElua mau pahuhopu nui o ka lāʻau lapaʻau.
1. Ke pale ʻana i nā mea hoʻonāukiuki: ʻO ka mea nui loa, ʻo ia ka ʻike ʻana i nā mea e hoʻonāukiuki ai i kāu mau hōʻailona a pale aku iā lākou.
2. Ke kāohi ʻana i nā hōʻailona me ka lāʻau lapaʻau: E kuhikuhi ke kauka iā ʻoe i nā lāʻau lapaʻau like ʻole.
- Nā antihistamines H1 a me H2: Nā lāʻau lapaʻau e like me Cetirizine, Loratadine, Famotidine.
- Nā Mea Hoʻopaʻa Kelepona Mast: Nā lāʻau lapaʻau e pale ai i ka hoʻokuʻu ʻia ʻana o nā kemika mai nā kelepona mast.
- Nā mea pale Leukotriene: Nā lāʻau lapaʻau e like me Montelukast.
- No nā pilikia: Inā he pilikia o ka anaphylaxis, ʻōlelo aʻo nā kauka e mālama mau i kahi auto-injector (e like me EpiPen) i loaʻa ka '(epinephrine)' kokoke.
Nā mea e noʻonoʻo ai i ka wā e noho pū ana me MCAS
Hiki ke paʻakikī ka noho ʻana me MCAS, akā me ka mālama pono ʻana , hiki iā ʻoe ke ola me ka holomua me ke kūlana.
- ʻAi: Hiki i kekahi mau meaʻai ke hoʻoulu i ka MCAS. E makaʻala loa i nā meaʻai kiʻekiʻe i ka histamine (kīhi i hoʻomoʻa ʻia, iʻa i loko o ka pahu, nā tōmato, spinach, kokoleka). ʻOi aku ka maikaʻi o ke kūkākūkā ʻana me kāu kauka a ʻike i kahi meaʻai e hoʻomohala i kahi hoʻolālā meaʻai kūpono iā ʻoe.
- Hoʻokele koʻikoʻi: ʻO ke koʻikoʻi kekahi o nā mea hoʻoulu nui no ka MCAS. No laila, he mea nui loa ia e hoʻomaha i kou noʻonoʻo. Hiki i nā mea e like me ka noʻonoʻo ʻana, ka yoga, a me ke komo ʻana i kahi hana leʻaleʻa punahele ke kōkua.
- E kiʻi i ke kākoʻo: E kamaʻilio me ka ʻohana a me nā hoaaloha e pili ana i kou kūlana. Hiki nō hoʻi ke kōkua i ka hui pū ʻana me nā poʻe e hele nei i nā kūlana like.
- Kamaʻilio mau me kāu kauka: E kamaʻilio pinepine me kāu kauka a hoʻololi i kāu hoʻolālā lapaʻau e like me ka mea e pono ai.
Leka Lawe-Home
- ʻAʻole he moemoeā ka Mast Cell Activation Syndrome (MCAS), akā he kūlana maoli e pili ana i ka ʻōnaehana pale.
- Hiki ke ʻokoʻa loa nā hōʻailona mai kēlā kanaka a kēia kanaka. Inā loaʻa iā ʻoe nā ʻano hōʻailona like ʻole āu e ʻike ʻole ai i ke kumu, e ʻike i ke kauka.
- ʻO ka ʻike ʻana a me ka pale ʻana i nā mea hoʻoulu e hoʻoulu ai i kāu mau hōʻailona he ʻāpana nui ia o ka mālama ʻana.
- He pilikia hoʻoweliweli ola ka anaphylaxis e pono ai ka mālama koke ʻana. E makaʻala i kona mau hōʻailona.
- Me ka mālama kūpono a me nā hoʻololi ʻana i ke ʻano o ka nohona, hiki ke hoʻomalu maikaʻi ʻia ʻo MCAS a hiki iā ʻoe ke alakaʻi i kahi ola maʻamau a hana. E hana pū me kāu kauka e hana i kēia.
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