Koj niam, koj txiv, lossis ib tug neeg uas koj paub puas nco qab ntau zuj zus? Kev tsis nco qab tej yam me me xws li koj cov yuam sij nyob qhov twg lossis ib tug neeg lub npe tuaj yeem yog ib qho cim qhia ntxov ntawm tus kab mob Alzheimer. Txawm hais tias tseem tsis tau muaj kev kho rau tus kab mob loj no, ib yam tshuaj tshiab uas tuaj yeem ua rau qeeb qeeb ntawm tus kab mob tau txais kev pom zoo los ntawm US FDA (Food and Drug Administration). Qhov no yog ib qho kev cia siab zoo rau cov neeg mob thoob plaws ntiaj teb. Yog li cia peb tham ntxiv me ntsis txog cov tshuaj tshiab no, Leqembi.
Cov tshuaj tshiab no hu ua Leqembi yog dab tsi?
Thawj qhov uas yuav tsum nkag siab yog tias qhov no tsis yog kev kho mob rau tus kab mob Alzheimer. Tab sis nws pab tau. Nws tuaj yeem ua rau qeeb qeeb ntawm tus kab mob. Kev tshawb fawb tau qhia tias nws tuaj yeem ua rau qeeb qeeb ntawm tus kab mob li ntawm 27% dhau lub sijhawm 18 lub hlis.
Tam sim no koj yuav xav tias, 'Nws puas yuav ua qhov sib txawv tiag?' Yog lawm, nws yeej yuav ua li ntawd. Xav txog seb, ib tug neeg uas noj cov tshuaj no yuav muaj sia nyob tau 5 lub hlis ntev dua yam tsis muaj cov tsos mob hnyav dua li ib tug neeg uas tsis noj cov tshuaj, thiab yuav muaj peev xwm ua lawv txoj haujlwm, zoo siab nrog lawv tsev neeg, mus ntsib ib tug xeeb ntxwv kawm tiav ... Lub sijhawm ntxiv ntawd muaj nqis npaum li cas los ua tej yam zoo li no? Lub sijhawm ntawd yog qhov txiaj ntsig loj tshaj plaws ntawm cov tshuaj no.
Tiam sis nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov qhov no: Leqembi tsuas yog pom zoo rau cov neeg uas muaj tus kab mob Alzheimer's thaum ntxov xwb , uas txhais tau tias cov neeg uas muaj teeb meem kev xav me ntsis. Nws yuav tsis ua haujlwm rau ib tus neeg uas muaj tus kab mob hnyav dua.
Cov tshuaj no ua haujlwm li cas?
Yuav kom nkag siab qhov no, cia peb siv ib qho piv txwv me me. Hauv lub hlwb ntawm cov neeg mob Alzheimer's, ib qho protein tsis xav tau hu ua amyloid plaques tau tso rau hauv. Nws zoo li av nplaum uas daig hauv cov kav dej thiab maj mam daig hauv cov kav dej. Vim yog cov protein no tso rau hauv, kev sib txuas lus ntawm cov hlwb hlwb raug cuam tshuam, thiab cov hlwb maj mam pib tuag. Qhov no yog vim li cas kev nco ploj thiab tus cwj pwm hloov pauv.
Cov tshuaj no, hu ua Leqembi, tsom thiab tshem tawm cov amyloid plaques uas tau tsim hauv lub hlwb. Nws yog ib pawg tshuaj hu ua monoclonal antibodies. Cov tshuaj no feem ntau yog muab rau tus neeg mob ob zaug hauv ib hlis los ntawm kev txhaj tshuaj IV.
Cia peb saib qee qhov tseeb tseem ceeb txog cov tshuaj no hauv ib lub rooj.
| Cov ntsiab lus luv luv ntawm Leqembi (lecanemab) | |
|---|---|
| Hom tshuaj | Ib hom tshuaj monoclonal antibody. |
| Nws haum rau leej twg? | Tsuas yog rau cov neeg uas muaj tus kab mob Alzheimer's thaum ntxov, uas muaj kev puas tsuaj me ntsis ntawm kev paub. |
| Qhov zoo tshaj plaws | Kev kis tus kab mob qeeb qeeb li ntawm 27% hauv 18 lub hlis. |
| Yuav muab li cas | Nws muab los ntawm cov leeg ntshav (IV infusion) ob zaug hauv ib hlis. |
| Qhov txwv tseem ceeb tshaj plaws | Qhov no kho tsis tau tus kab mob. Nws tsis muaj txiaj ntsig rau cov neeg uas twb nyob rau theem mob hnyav lawm. |
Puas muaj kev pheej hmoo hauv kev siv qhov no?
Yog. Ib yam li txhua yam tshuaj, cov tshuaj no muaj qee qhov kev pheej hmoo thiab cov kev mob tshwm sim. Qhov tseeb, FDA tau tshaj tawm "lub thawv dub ceeb toom" rau cov tshuaj no, uas yog qib siab tshaj plaws ntawm kev ceeb toom kev nyab xeeb . Qhov laj thawj rau qhov ntawd yog ib qho mob hu ua ARIA.
ARIA yog dab tsi?
ARIA yog luv rau Amyloid-Related Imaging Abnormalities. Hais yooj yim xwb, cov tshuaj no ua rau qee tus neeg mob o lossis los ntshav me me (microbleeds) . Txawm hais tias cov no feem ntau tsis loj heev, qee zaum lawv tuaj yeem ua rau tuag taus.
- APOE4 gene: Cov neeg uas muaj ob daim qauv ntawm APOE4 gene mutation muaj feem yuav mob ARIA no ntau dua li lwm tus.
- Cov Tshuaj Ua Kom Ntshav Tsis Txhob Qhuav: Lwm yam tseem ceeb heev yog cov kws kho mob ceeb toom kom tsis txhob siv cov tshuaj no rau ib tus neeg uas noj cov tshuaj ua kom ntshav tsis txhob qhuav. Vim tias yog koj ua li ntawd, muaj feem ntau uas qhov ntshav me me yuav hloov mus ua qhov ntshav loj uas txaus ntshai rau lub neej (macro-bleed). Qee zaum qhov no tuaj yeem ua rau qaug dab peg, raug pw hauv tsev kho mob, lossis txawm tias tuag.
Yog li ntawd, ua ntej pib siv cov tshuaj no, nws yog ib qho tseem ceeb uas yuav tsum tham txog txhua yam kev pheej hmoo no nrog koj tus kws kho mob, ua qhov kev kuaj mob tsim nyog, thiab paub meej tias qhov no puas yog rau koj.
Yog li ntawd, kuv yuav tsum ua li cas?
Yog tias koj, tus nyeem ntawv ntawm tsab xov xwm no, muaj kev xav me ntsis tias koj lossis ib tus neeg ze koj muaj cov cim qhia ntxov ntawm tus kab mob Alzheimer, qhov zoo tshaj plaws ua yog mus ntsib kws kho mob yam tsis ncua sijhawm thiab tau txais kev kuaj mob kom raug.
Vim tias raws li peb tau tham ua ntej lawm, cov tshuaj zoo li Leqembi tsuas yog muaj txiaj ntsig rau theem pib ntawm tus kab mob xwb. Yog tias koj ncua sijhawm, koj yuav plam lub sijhawm rau kev kho mob. Tsis tas li ntawd, cov tshuaj tshiab zoo li no feem ntau yuav kim heev. Yog li nws yog ib lub tswv yim zoo los tham nrog koj tus kws kho mob txog qhov ntawd ua ntej pib kho mob.
Cov kws tshaj lij ntseeg tias yav tom ntej no, yuav muaj kev kho mob uas tuaj yeem nrhiav tau thiab tiv thaiv kab mob ua ntej tib neeg muaj cov tsos mob. Ib yam li peb tuaj yeem nrhiav tau thiab kho mob qog noj ntshav mis thiab qog noj ntshav prostate thaum ntxov, peb yuav muaj ib hnub tuaj yeem nrhiav tau thiab tiv thaiv kab mob Alzheimer's thaum ntxov. Txog thaum ntawd, cov tshuaj zoo li Leqembi muab kev cia siab zoo rau peb txhua tus.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Leqembi tsis yog tshuaj kho tau tus kab mob Alzheimer's. Nws tsuas yog ua kom tus kab mob qeeb zuj zus thaum nws tseem hluas xwb.
- Cov tshuaj no ua haujlwm los ntawm kev tshem tawm cov amyloid plaques uas tsim teeb meem hauv lub hlwb.
- Muaj kev pheej hmoo ntawm cov kev mob tshwm sim loj xws li lub hlwb o lossis cov ntshav me me (ARIA), yog li nws yog ib qho tseem ceeb uas yuav tsum tham txog txhua yam kev pheej hmoo nrog kws kho mob.
- Cov tshuaj no tsis haum rau cov neeg noj cov tshuaj thinner ntshav lossis cov neeg uas muaj mob hnyav.
- Yog koj lossis ib tug neeg ze koj muaj teeb meem nco qab, nrhiav kev kho mob sai li sai tau. Kev kuaj mob thaum ntxov yog qhov tseem ceeb rau kev kho mob.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus