Koj lub cev puas xav tias koj tsis tswj tau koj tus kheej? Cia peb kawm txog qhov no (Autoimmune Autonomic Ganglionopathy - AAG)!

Puas muaj tej lub sij hawm koj cia li kiv taub hau? Los yog koj puas xav tias muaj ib yam dab tsi txawv txawv hauv koj lub plab, koj lub qhov ncauj qhuav, los yog koj tswj tsis tau koj txoj kev ua pa? Txawm hais tias tej no zoo li yog tej yam ib txwm muaj, tej lub sij hawm tej zaum yuav muaj ib zaj dab neeg nyuaj dua tom qab lawv. Qhov ntawd yog ib qho ntawm cov mob uas tsis tshua muaj, tab sis tsim nyog paub, uas peb yuav tham txog hnub no.

Kab mob "Autoimmune Autonomic Ganglionopathy - AAG" no yog dab tsi? Cia peb nkag siab yooj yim, puas yog?

Hais yooj yim xwb, "Autoimmune Autonomic Ganglionopathy" lossis "(AAG)" yog ib qho mob uas peb lub cev tiv thaiv kab mob, uas yog, lub cev tiv thaiv kab mob, ua yuam kev tawm tsam peb lub paj hlwb autonomic. Xav txog, qhov no zoo li yuav tshwm sim yog tias cov tub rog uas yuav tsum tiv thaiv peb lub teb chaws ua yuam kev tawm tsam peb cov chaw tseem ceeb.

Peb lub cev lub paj hlwb autonomic zoo li peb lub "automatic system". Uas yog, nws tswj ntau yam uas tshwm sim tau yam tsis tas siv neeg, yam tsis tau peb paub. Piv txwv li:

• Koj txoj kev ua pa
• Lub plawv dhia ceev (lub plawv dhia ceev)
• Ntshav siab
• Tawm hws
• Kev zom zaub mov

Ntau yam no tsis yog ib yam dab tsi uas peb xav txog. Lawv tshwm sim yam tsis tas siv tes. Lub paj hlwb autonomic yog qhov uas pab kom cov haujlwm autonomic no khiav tau zoo. Hauv AAG, lub cev tseem ceeb no puas lawm. Qhov no yog ib qho mob hu ua autonomic neuropathy, lossis dysautonomia.

Vim li cas peb lub cev thiaj ua li no? Yog vim li cas?

Qhov tseeb, txawm tias cov kws kho mob tseem tsis tuaj yeem hais meej tias qhov ua rau muaj qhov "(AAG)" no yog dab tsi. Tab sis qee qhov tseeb tau raug tshawb pom.

• Feem ntau, uas yog , kwv yees li peb ntawm tsib tus neeg uas muaj "AAG", qhov mob no tshwm sim tom qab rov zoo los ntawm lwm yam kab mob, lossis tom qab kis kab mob. Nws zoo li ib qho kev phiv ntawm tus kab mob ntawd.
• Muaj ib txhia neeg yuav muaj tus mob hu ua paraneoplastic AAG. Qhov no yog thaum qee cov tshuaj tiv thaiv kab mob uas peb lub cev tiv thaiv kab mob tsim los teb rau tus mob xws li mob qog noj ntshav mus tawm tsam lub paj hlwb autonomic.

Qhov no ua li cas rau peb lub cev? Cia peb saib ze dua.

Peb lub paj hlwb autonomic muaj cov hlwb hu ua autonomic ganglia . Cov no zoo li cov kev sib tshuam ntawm tsheb ciav hlau. Muaj ntau cov lus xa thiab tau txais los ntawm cov no. Qhov kev sib pauv lus no yog qhov tseem ceeb rau kev ua haujlwm ntawm peb lub cev, uas yog, cov kev ua uas peb tsis tswj (reflexes), kom raug tswj.

Hauv AAG, peb lub cev tiv thaiv kab mob tawm tsam cov receptors tshwj xeeb hauv cov ganglia no. Cov receptors yog qhov chaw uas cov lus tau txais. Yog li thaum cov receptors no raug puas tsuaj, cov lus ntawm cov hlab ntsha ntawd tsis mus lossis tsis dhau mus zoo. Yog li ntawd, tej yam uas tshwm sim yam tsis siv neeg, xws li kev tswj ntshav siab thiab kev tawm hws, pib mus tsis zoo.

Xav txog seb, yog tias qhov 'kev sib txuas' hauv koj lub tsev 'lub rooj hloov hluav taws xob loj' xoob, lub teeb yuav tsis tig, lub kiv cua yuav tsis tig, thiab lwm yam. Yog li ntawd nws yog li cas nrog qhov no.

Tus mob no hu ua '(AAG)' ntau npaum li cas?

Qhov no yeej yog ib qho mob tsis tshua muaj. Piv txwv li, hauv Tebchaws Meskas, tsuas muaj li ntawm 100 tus neeg raug kuaj pom tias muaj tus kab mob no txhua xyoo. Yog li nws tsis tshua muaj nyob hauv Sri Lanka. Yog li ntawd, tsis txhob ntshai thaum koj hnov ​​txog qhov no, qhov no tsis yog ib yam dab tsi uas tshwm sim rau ntau tus neeg.

Cov tsos mob ntawm `(AAG)` yog dab tsi? Peb yuav paub lawv li cas?

Cov tsos mob ntawm tus mob no yuav txawv ntawm ib tus neeg mus rau ib tus neeg. Tsis yog txhua tus yuav muaj cov tsos mob zoo ib yam. Cov tsos mob feem ntau yog:

• Cem quav: Qhov no txhais tau tias cem quav thiab nyuaj rau mus rau chav dej.
• Cov menyuam kawm ntawv qhib (Adie cov menyuam kawm ntawv): Qee zaum tsuas yog ib lub qhov muag cov menyuam kawm ntawv thiaj li qhib thiab tej zaum yuav rhiab rau lub teeb.
• Qhov ncauj qhuav lossis qhov muag qhuav: Ib qho kev xav zoo li tsis muaj qaub ncaug lossis kua muag hauv qhov muag.
• Tsaus muag / Ua tsis taus pa: Tej zaum koj yuav tsaus muag tam sim ntawd yam tsis muaj laj thawj pom tseeb.
• Neurogenic orthostatic hypotension: Muaj kev xav tias kiv taub hau thiab qaug zog thaum sawv ntawm qhov chaw zaum lossis sawv ntawm txaj. Qhov no yog tshwm sim los ntawm kev poob qis sai sai ntawm cov ntshav siab.
• Nyuaj tso zis / tso zis tsis tau: Xav tias tso zis tsis tau txawm tias koj xav tso zis los xij.

Kwv yees li ob ntawm peb tus neeg uas muaj AAG tau pom tias muaj cov tshuaj tiv thaiv kab mob hu ua ganglionic acetylcholine receptor antibodies (g-AChR antibodies) ntau hauv lawv cov ntshav. Cov kws tshawb fawb ntseeg tias muaj kev sib txuas ntawm cov tshuaj tiv thaiv g-AChR no thiab qhov hnyav ntawm cov tsos mob.

Tus kws kho mob kuaj mob li cas txog tus kab mob "(AAG)" no?

Yog koj muaj cov tsos mob zoo li no, thawj qhov uas kws kho mob yuav ua yog nug koj txog koj cov tsos mob thiab kuaj koj. Tom qab ntawd, lawv yuav ua qee qhov kev kuaj tshwj xeeb los xyuas seb koj lub paj hlwb ua haujlwm li cas.

Nov yog qee yam ntawm lawv:

• Kev kuaj mob plab: Piv txwv li, kev kuaj "Plab zom mov tag." Qhov no kuaj seb cov khoom noj tawm hauv koj lub plab sai npaum li cas.
• `Kev kuaj mob axon reflex ntau npaum li cas (QSART)`: Qhov no ntsuas seb koj cov qog hws ua haujlwm zoo npaum li cas.
• `Kev kuaj hws Thermoregulatory`: Qhov kev kuaj no yog ua los nrhiav seb lub cev hws puas tau txo qis lossis nce ntxiv, thiab yog vim li cas.
• 'Kev sim lub rooj qaij': Hauv qhov kev sim no, koj yuav tsum pw rau ntawm ib lub txaj tshwj xeeb thiab lub txaj maj mam tig ntsug, saib seb koj lub plawv dhia thiab ntshav siab hloov li cas.
• Kev kuaj zis: Qhov no tuaj yeem muab lub tswv yim rau koj txog seb koj lub zais zis ua haujlwm zoo npaum li cas.

Ntxiv mus, yuav muaj kev kuaj ntshav los xyuas seb cov tshuaj "(g-AChR antibodies)" puas muaj nyob rau hauv cov lus hais saum toj no . Yog tias cov tshuaj antibody no muaj ntau, ces qhov no yog ib qho pov thawj ntxiv tias nws yuav yog "(AAG)". Txawm li cas los xij, qhov kev kuaj ntshav no txawv ntawm "AChR antibody test", uas yog siv los kuaj lwm yam kab mob hauv lub paj hlwb hu ua "(Myasthenia Gravis)."

Puas muaj kev kho rau qhov no? Yuav ua li cas tau?

Vim tias AAG yog ib qho mob tsis tshua muaj, tseem tsis tau muaj tus qauv, "qhov no yog kev kho mob". Feem ntau , qhov kev tsom mus rau kev tswj cov tsos mob yog.

Cov kws kho mob tsim ib txoj kev npaj kho mob los ntawm kev sib xyaw ntau txoj kev kho mob. Qee qhov ntawm lawv suav nrog:

• Kev pauv ntshav hauv cov ntshav / plasmapheresis: Qhov no suav nrog kev noj qee cov ntshav ntawm koj, tshem tawm cov tshuaj lom xws li cov tshuaj tua kab mob ntawm cov ntshav hauv cov ntshav, thiab tom qab ntawd muab cov ntshav huv rov qab rau koj lub cev.
• Kev kho mob immunoglobulin hauv cov hlab ntsha (IVIG): Qhov no suav nrog kev muab koj lub cev immunoglobulin (ib feem ntawm cov ntshav uas tawm tsam kab mob) uas tau los ntawm cov neeg noj qab nyob zoo. Qhov no pab ua rau lub cev tiv thaiv kab mob tsis txhob ntxhov siab.
• Cov tshuaj corticosteroids txhaj rau hauv cov hlab ntsha: Cov tshuaj steroids tiv thaiv kev o ntau, xws li methylprednisolone (Solu-Medrol®) lossis hydrocortisone (Solu-Cortef®), raug muab los ntawm kev txhaj tshuaj.
• Cov tshuaj tiv thaiv kab mob: Cov no ua haujlwm los ntawm kev txo qhov ua haujlwm ntau dhau ntawm lub cev tiv thaiv kab mob. Piv txwv li, cov tshuaj xws li rituximab (Rituxan®).

Puas muaj ib txoj kev los tiv thaiv qhov teeb meem '(AAG)' no?

Yeej tsis muaj ib txoj kev lav tias yuav tiv thaiv qhov no tau, vim nws tsis tshua muaj. Txawm li cas los xij, qee yam mob, xws li mob qog noj ntshav, tuaj yeem ua rau koj muaj feem yuav mob qog noj ntshav ntau dua me ntsis. Yog tias koj tau muaj mob qog noj ntshav, ntawm no yog qee yam uas koj tuaj yeem ua tau los saib xyuas koj txoj kev noj qab haus huv tag nrho:

• Kev tawm dag zog tsis tu ncua: tshwj xeeb yog kev tawm dag zog aerobic.
• Yog koj muaj "(Dysautonomia), kev noj zaub mov uas muaj ntsev thiab dej ntau tuaj yeem pab tswj koj cov ntshav siab. (Qhov no yog ib yam dab tsi uas koj yuav tsum tham nrog koj tus kws kho mob.)
• Kev tswj kev ntxhov siab: Siv cov txheej txheem noj qab haus huv xws li kev tawm dag zog, tham nrog ib tug phooj ywg, thiab sau ntawv rau hauv phau ntawv xov xwm.
• Pw tsaug zog zoo: Pw tsaug zog tsawg kawg 7-8 teev hauv ib hnub.
• Hnav cov khaub ncaws nruj: Cov no pab txhim kho kev ncig ntshav thiab txo qhov o (tshwj xeeb tshaj yog nyob rau hauv ob txhais ceg).

Qhov teeb meem '(AAG)' no puas kho tau tag nrho? Yuav muaj dab tsi tshwm sim rau yav tom ntej?

Kuv yuav tsum hais tias, txawm hais tias kuv tu siab,AAG kho tsis tau. Txawm li cas los xij, ntau tus neeg tuaj yeem tswj lawv cov tsos mob tau zoo rau lub sijhawm ntev. Qhov xav tsis thoob yog, kwv yees li ib ntawm peb tus neeg uas muaj AAG yuav maj mam zoo dua yam tsis muaj kev kho mob. Txawm li cas los xij, feem ntau cov neeg yuav tsum tau daws qee cov tsos mob thoob plaws lawv lub neej.

Koj xav nug tus kws kho mob li cas ntxiv?

Yog tias koj xav tias koj muaj tus mob zoo li no, nws yog ib qho tseem ceeb heev uas yuav tsum mus ntsib kws kho mob zoo thiab nug txog cov hauv qab no:

• Dab tsi yog qhov ua rau kuv cov tsos mob feem ntau?
• Kuv yuav tsum ua dab tsi los xyuas kom meej tias kuv muaj '(AAG)'?
• Cov kev kho mob rau `(AAG)` yog dab tsi?
• Txawm tias tsis kho mob los, cov tsos mob ntawm tus kab mob "(AAG)" yuav ploj mus li cas?
• Kuv yuav tsum hloov pauv dab tsi hauv kuv lub neej kom txhim kho kuv txoj kev noj qab haus huv tag nrho?

Lwm yam mob tiv thaiv kab mob dab tsi cuam tshuam nrog autonomic neuropathy?

"(AAG)" tshwj xeeb vim tias nws, ntawm ib sab, yog kab mob ntsig txog lub cev tiv thaiv kab mob, thiab ntawm qhov tod tes, yog kab mob autoimmune ntawm lub paj hlwb.

Tsis tas li ntawd xwb, muaj qee yam kab mob uas cuam tshuam nrog lub cev tiv thaiv kab mob uas ua rau muaj kev pheej hmoo ntawm kev mob "dysautonomia" (kev mob ntawm lub paj hlwb autonomic). Piv txwv li:

• Kab mob celiac
• "(Guillain-Barré Syndrome)" (Guillain-Barré Syndrome)
• `(Lupus / mob lupus erythematosus)` (Kab mob Lupus)
• (Kab mob caj dab Rheumatoid) (Kab mob caj dab Rheumatoid)
• Sjögren's Syndrome (Sjögren's Syndrome)

Yog li koj tuaj yeem pom, cov no yog cov xwm txheej uas tuaj yeem sib txuas ua ke.

Thaum kawg, tej yam yuav tsum nco ntsoov (Cov Lus Coj Mus Tsev)

Zoo, yog li tam sim no koj paub lawm tias '(Autoimmune Autonomic Ganglionopathy - AAG)' yog ib yam kab mob tsis tshua muaj uas peb lub cev tiv thaiv kab mob tawm tsam peb lub paj hlwb autonomic. Cov tsos mob tuaj yeem suav nrog kev poob siab tam sim ntawd, kev poob qis ntawm 'siab' thaum sawv ntsug, thiab teeb meem plab.

Tsis txhob ntshai thaum koj hnov ​​qhov no. Qhov no tsis tshua muaj. Tsis tas li ntawd, cov tshuaj immunosuppressant thiab 'plasmapheresis' siv los kho qhov no. Txawm hais tias nws tsis tuaj yeem kho tau tag nrho, feem ntau cov neeg tuaj yeem tswj cov tsos mob zoo thiab ua neej nyob li qub.

Qhov tseem ceeb tshaj plaws yog mus ntsib kws kho mob uas tsim nyog sai li sai tau yog tias koj muaj cov tsos mob no. Yog tias koj paub lawv thaum ntxov, koj tuaj yeem pib kho thiab txo qhov cuam tshuam rau koj lub neej. Koj tsis nyob ib leeg, thiab muaj cov kws kho mob uas tuaj yeem pab tau.

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