Koj cov ntshav puas txhaws tsis muaj laj thawj? Cia peb kawm ntxiv txog Factor V Leiden Thrombophilia!

Tsis yog peb lub cev txhua tus zoo ib yam, puas yog? Tej zaum peb yuav muaj qhov sib txawv me me hauv peb lub cev uas peb tsis paub txog. Hnub no peb yuav tham txog ib qho mob uas tau txais los ntawm noob caj ces, uas ua rau peb cov ntshav txhaws ntau dhau, uas txhais tau tias nws yuav txhaws tsis tsim nyog. Qhov no hu ua Factor V Leiden Thrombophilia .

Yog li ntawd, Factor V Leiden yog dab tsi?

Hais yooj yim xwb, qhov no yog ib qho teeb meem ntshav txhaws uas tau txais los ntawm noob caj noob ces. Yog li ntawd, koj yug los nrog kev hloov pauv hauv koj cov noob caj noob ces. Qhov kev hloov pauv no ua rau koj cov ntshav yuav txhaws ntau dua li qub. Qhov no ua rau koj muaj feem yuav mob ntau dua li qub:

• Kab Mob Ntshav Sib Nraus (DVT): Qhov no yog thaum cov ntshav txhaws tsim nyob rau hauv cov leeg ntshav tob ntawm koj lub cev, tshwj xeeb tshaj yog nyob rau hauv koj ob txhais ceg lossis caj npab. Txawm li cas los xij, lawv qee zaum tuaj yeem tsim nyob rau hauv cov leeg ntshav hauv qhov chaw xws li lub siab, lub raum, lub hlwb, thiab qhov muag.
• Kab mob ntsws (PE) : Qhov no txaus ntshai me ntsis. Qhov tshwm sim ntawm no yog tias ib qho ntawm cov ntshav txhaws uas tau hais los saum toj no, lossis cov ntshav txhaws uas tau tsim nyob rau lwm qhov, tawg tawm, mus ncig los ntawm cov ntshav, thiab daig hauv ib qho ntawm koj lub ntsws.

Tiam sis ntawm no yog qhov teeb meem, tsuas yog vim koj muaj tus mob no tsis tau txhais hais tias koj yuav tau txais DVT lossis PE . Qhov tseeb, kwv yees li cuaj ntawm kaum tus neeg uas muaj tus mob no yuav tsis muaj ntshav txhaws tsis zoo hauv lawv lub neej. Txawm li cas los xij, nws yog ib qho tseem ceeb kom nkag siab tias koj muaj kev pheej hmoo siab dua li lwm tus.

Qhov tshwm sim ntawm tus mob 'Factor V Leiden' no txawv ntawm ntau haiv neeg sib txawv. Feem ntau pom ntau dua ntawm cov neeg dawb hauv Tebchaws Meskas thiab Tebchaws Europe.

• Kwv yees li ntawm 5 ntawm 100 tus neeg uas yog neeg European.
• Kwv yees li 2 ntawm 100 tus neeg yog neeg Hispanic keeb kwm.
• Muaj li ntawm 1 ntawm 100 tus neeg uas yog neeg dub lossis neeg Amelikas Ib Txwm.
• Ntawm cov neeg Esxias, nws tsawg dua 1 ntawm 100.

Txawm li cas los xij, kwv yees li ib ntawm tsib tus neeg uas muaj cov ntshav txhaws hauv lawv cov leeg tau pom tias muaj qhov sib txawv ntawm 'Factor V Leiden' gene. Qhov no hu ua "Factor V Leiden." Tsab ntawv V sawv cev rau tus lej Roman rau tsib.

Cov tsos mob ntawm tus mob no yog dab tsi?

Nov yog qee yam uas yuav tsum nco ntsoov: Qhov kev hloov pauv caj ces no ib leeg tsis ua rau muaj tsos mob . Koj tuaj yeem muaj nws mus tas koj lub neej yam tsis paub txog nws. Txawm li cas los xij, raws li tau hais ua ntej, cov tsos mob tsuas yog tshwm sim yog tias cov ntshav txhaws tsim.

Tseem Ceeb: Yog tias koj xav tias koj muaj cov tsos mob ntawm 'DVT' lossis 'PE', hu rau 911 lossis koj tus xov tooj xwm txheej ceev hauv zos tam sim ntawd . Txwv tsis pub, mus rau chav kho mob xwm txheej ceev hauv tsev kho mob ze tshaj plaws sai li sai tau nrog ib tus neeg. Qhov no tsis yog ib yam dab tsi uas yuav tsum ncua.

Cov tsos mob ntawm cov hlab ntsha tob tob (DVT) yuav muaj xws li:

• O ntawm ib ceg lossis caj npab, xav tias kub thaum kov, thiab hloov xim tawv nqaij (tej zaum yuav tig liab lossis xiav).
• Hnov mob thaum kov ceg lossis caj npab ntawd, mob thaum nias .
• Cov leeg ntshav hauv qab daim tawv nqaij uas loj dua li qub thiab pom tau rau ntawm qhov chaw .
• Yog tias cov ntshav txhaws tsim nyob rau hauv cov leeg ntshav hauv lub plab, koj yuav mob plab lossis mob hauv qab plab .
• Yog tias cov ntshav txhaws hauv lub hlwb, lawv tuaj yeem ua rau mob taub hau tam sim ntawd, hnyav thiab/lossis qaug dab peg .

Cov tsos mob ntawm pulmonary embolism (PE) yuav muaj xws li:

• Ua pa nyuaj tam sim ntawd .
• Mob hauv siab thaum ua pa tob tob, hnoos, lossis txham.
• Hnoos, qee zaum nrog me ntsis ntshav tawm nrog rau cov hnoos qeev .
• Suab nrov thaum ua pa.
• Lub plawv dhia ceev heev (tachycardia) .
• Xav tias ntxhov siab thiab tsis nyob twj ywm .
• Hnov kiv taub hau, zoo li koj yuav tsis nco qab (tsis tshua muaj, koj yuav tsis nco qab) .

Dab tsi ua rau muaj Factor V Leiden?

Qhov laj thawj tseem ceeb rau qhov no yog qhov sib txawv ntawm cov noob caj noob ces . Muaj ib qho protein hauv peb lub cev uas pab cov ntshav txhaws, nws hu ua 'Coagulation factor V' . Yog hais kom meej, nws pab tiv thaiv kev los ntshav thaum muaj kev raug mob. Yog li, peb lub cev raug qhia kom ua cov protein no los ntawm ib qho noob caj noob ces hu ua 'F5' .

Feem ntau, peb txhua tus tau txais ob daim qauv ib txwm ntawm cov noob caj noob ces 'F5' no. Txawm li cas los xij, yog tias koj tau txais ib lossis ntau daim qauv tsis zoo ntawm cov noob caj noob ces no, lawv hais tias koj muaj qhov sib txawv 'Factor V Leiden' (qee zaum hu ua 'mutation'). Lub npe 'Leiden' los ntawm lub nroog Leiden hauv Netherlands qhov chaw uas cov kws tshawb fawb tau tshawb pom qhov sib txawv ntawm cov noob caj noob ces no.

Qhov kev hloov pauv ntawm cov noob caj noob ces 'Factor V Leiden' no ua rau muaj kev hloov pauv me me hauv cov protein 'factor V' uas tsim tawm hauv peb lub cev. Vim yog qhov kev hloov pauv no, cov protein 'factor V' uas tau hloov pauv no tiv taus kev ua haujlwm ntawm ob qho protein tseem ceeb uas tswj cov ntshav txhaws , Protein C ('Protein C') thiab Protein S ('Protein S') . Hais yooj yim, cov protein tswj hwm no tsis tuaj yeem nres nws. Tom qab ntawd, cov protein 'factor V' ua haujlwm ntau dua li nws yuav tsum tau ua, thiab cov ntshav pib txhaws tsis tsim nyog, txawm tias nws tsis xav tau los xij.

Qhov no puas yog ib yam dab tsi uas dhau los ntawm tsev neeg mus rau tsev neeg?

Yog, yeej muaj tseeb. Koj tuaj yeem tau txais tus mob no los ntawm koj niam lossis koj txiv, lossis ob leeg. Factor V Leiden yog tau txais los ntawm tus qauv autosomal dominant.Qhov ntawd txhais tau tias, txawm tias koj tsuas yog tau txais cov noob caj noob ces txawv txav no los ntawm ib tug ntawm koj niam koj txiv xwb, koj tseem tuaj yeem tau txais cov mob no.

Feem ntau cov neeg (uas muaj Factor V Leiden) tsuas tau txais ib daim qauv tsis zoo ntawm cov noob caj noob ces xwb. Qhov no hu ua heterozygous . Tsis tshua muaj, koj tuaj yeem tau txais ob daim qauv tsis zoo ntawm cov noob caj noob ces los ntawm koj niam thiab txiv. Qhov no hu ua homozygous .

Muaj lwm yam dab tsi ntxiv uas ua rau muaj kev pheej hmoo ntawm cov ntshav txhaws?

Ib tug neeg uas muaj Factor V Leiden yuav muaj feem ntau dua los tsim cov ntshav txhaws yog tias:

• Yog tias koj tau txais ob daim qauv ntawm cov noob caj noob ces 'F5' uas tsis zoo li tau hais ua ntej (yog tias koj yog 'homozygous') .
• Yog tias koj cov txheeb ze ntshav (xws li niam, txiv, cov kwv tij neej tsa) muaj keeb kwm ntawm DVT lossis PE .
• Yog tias koj muaj lwm yam mob ntshav txhaws .
• Yog koj tab tom phais (tshwj xeeb tshaj yog tom qab phais loj, vim koj yuav nyob ib qho chaw ntev heev).
• Yog koj cev xeeb tub (thaum lub sijhawm no, kev hloov pauv ntawm cov tshuaj hormones thiab tus menyuam tuaj yeem ua rau muaj kev nyuaj siab rau cov leeg ntshav).
• Yog tias koj noj qee hom tshuaj tiv thaiv kev yug me nyuam (uas muaj estrogen) lossis kev kho mob hloov tshuaj hormones .

Yog tias koj muaj ib qho ntawm cov yam ntxwv no, nws yog ib qho tseem ceeb heev uas yuav tsum nrog koj tus kws kho mob tham thiab kawm txog kev pheej hmoo ntawm cov ntshav txhaws thiab cov kev ceev faj uas koj tuaj yeem ua.

Vim muaj tus mob no, yuav muaj teeb meem dab tsi tshwm sim?

Yog tias koj muaj Factor V Leiden Thrombophilia, koj yuav muaj cov hauv qab no:

• Tsim muaj 'DVT' lossis 'PE' ua ntej hnub nyoog 50 xyoo .
• Ntau tshaj ib zaug, txhais tau tias muaj ntau zaus uas muaj "DVT" lossis "PE" tshwm sim.
• Cov ntshav txhaws tsim nyob rau hauv cov leeg ntshav uas feem ntau tsim cov ntshav txhaws tsawg dua , piv txwv li, nyob rau hauv cov leeg ntshav ntawm lub siab, lub hlwb, thiab lub raum.
• DVT lossis PE thaum cev xeeb tub lossis tom qab yug menyuam .
• DVT lossis PE yuav tshwm sim hauv lub sijhawm luv luv tom qab pib noj tshuaj tiv thaiv kev yug menyuam .

Cov kws kho mob kuaj mob li cas?

Cov kws kho mob tuaj yeem nrhiav tau seb koj puas muaj tus mob no los ntawm kev kuaj ntshav . Qhov no kuj tseem yuav suav nrog kev kuaj noob caj noob ces . Koj tus kws kho mob yuav hais kom kuaj rau tus mob no, tshwj xeeb yog:

• Yog tias koj tau muaj DVT lossis PE ua ntej , tshwj xeeb tshaj yog tias nws tshwm sim thaum muaj hnub nyoog hluas dua li qhov xav tau.
• Yog tias ib lossis ntau tus ntawm koj cov txheeb ze muaj keeb kwm ntawm cov ntshav txhaws .

Yuav kho tus mob Factor V Leiden li cas?

Factor V Leiden yog ib qho mob uas kav ntev mus ib txhisQhov ntawd txhais tau tias tam sim no tsis muaj kev kho mob tshwj xeeb lossis kev kho rau qhov kev hloov pauv ntawm cov noob caj noob ces no. Hloov chaw, kev kho mob ua haujlwm los yaj cov ntshav txhaws uas twb muaj lawm thiab txo qhov kev pheej hmoo ntawm cov ntshav txhaws yav tom ntej . Koj tus kws kho mob yuav pom zoo cov kev kho mob xws li:

• Cov tshuaj Anticoagulant (tseem hu ua cov tshuaj ua kom cov ntshav nyias) : Cov no pab yaj cov ntshav txhaws uas twb muaj lawm thiab tiv thaiv cov ntshav txhaws tshiab kom tsis txhob tsim.
• Cov thom khwm nruj : Cov no yog cov thom khwm nruj tshwj xeeb uas hnav rau ntawm ob txhais ceg kom txhim kho kev ncig ntshav thiab txo qhov kev pheej hmoo ntawm cov ntshav txhaws.
• Kev Muab Lub Tshuab Lim Vena Cava Tso Rau Hauv : Qhov no yog ib lub cuab yeej me me uas muab tso rau hauv cov leeg ntshav loj kom tiv thaiv cov ntshav txhaws kom tsis txhob mus rau hauv lub ntsws. Tsis yog txhua tus neeg xav tau nws.
• Kev phais tshem cov ntshav txhaws : Qee zaum, yuav tsum tau phais kom tshem cov ntshav txhaws loj.

Koj yuav tsum noj tshuaj uas ua rau cov ntshav nyias ntev npaum li cas nyob ntawm seb koj puas muaj feem yuav muaj ntshav txhaws ntxiv. Ib txhia neeg tsuas yog yuav tsum noj tshuaj no ob peb lub hlis xwb. Lwm tus neeg yuav tsum noj ntev heev, txawm tias tas lawv lub neej. Koj tus kws kho mob yuav piav qhia txog txoj kev kho mob uas zoo tshaj plaws rau koj.

Thaum twg koj yuav tsum mus ntsib kws kho mob?

Yog koj paub tias koj muaj tus mob no, nws yog ib qho tseem ceeb uas yuav tsum tau nrog kws kho mob sib tham tsis tu ncua.

• Mus kuaj mob dav dav tsawg kawg ib xyoos ib zaug .
• Yog tias koj muaj DVT lossis PE thiab tab tom tau txais kev kho mob, koj yuav tsum mus ntsib koj tus kws kho mob rau kev teem sijhawm rov qab mus ntsib kws kho mob tas li kom pom tias kev kho mob mus li cas.
• Yog koj noj tshuaj ua kom cov ntshav nyias xws li Warfarin , koj yuav tsum kuaj ntshav (Prothrombin time test - PT/INR test) tsis tu ncua kom paub tseeb tias cov tshuaj ua haujlwm zoo thiab noj raws li qhov ntau npaum li cas.

Tsis tas li ntawd, nws yog ib qho tseem ceeb uas yuav tsum tau tham nrog kws kho mob hauv cov xwm txheej zoo li no:

• Ua ntej siv cov tshuaj tiv thaiv kev yug menyuam (tshwj xeeb tshaj yog cov uas muaj estrogen).
• Ua ntej pib siv tshuaj hormones hloov kho .
• Yog tias koj npaj yuav cev xeeb tub, ua ntej ntawd .

Qhov no hais li cas txog lub neej ntev?

Rau feem ntau ntawm cov neeg, kev muaj Factor V Leiden tsis cuam tshuam rau lawv lub neej ib txwm . Txawm tias koj muaj cov ntshav txhaws, yog tias koj tau txais kev kho mob sai thiab raug, koj tuaj yeem tiv thaiv cov teeb meem loj . Yog tias koj muaj kev txhawj xeeb txog koj lub neej ntev lossis cov teeb meem yav tom ntej, nrog koj tus kws kho mob tham txog lawv.

Yog tias peb muaj Factor V Leiden, peb yuav tsum zam dab tsi?

Koj tus kws kho mob yuav muab lus qhia rau koj raws li koj tus kheej qhov xwm txheej, tab sis feem ntau, nws yog qhov zoo tshaj plaws kom tsis txhob ua tej yam no:

• Haus luam yeeb, vaping, thiab siv lwm yam khoom haus luam yeeb .
• Zaum tib qho chaw ntev heev (piv txwv li, ua haujlwm hauv chaw ua haujlwm, caij tsheb npav lossis tsheb ciav hlau ntev, lossis caij dav hlau ntau teev). Yog tias ua tau, sawv thiab taug kev tsawg kawg ib teev ib zaug.
• Tsis txhob haus cawv ntau dhau , tshwj xeeb tshaj yog thaum caij dav hlau ntev.
• Cov tshuaj tiv thaiv kev yug me nyuam thiab kev kho mob hloov tshuaj hormones uas muaj estrogen (koj yuav tsum nrog koj tus kws kho mob tham ua ntej siv cov no).

Puas yog Factor V deficiency thiab Factor V Leiden tib yam?

Yog, tsis txhob xav tsis thoob ob qho no. Cov no yog ob qho mob caj ces sib txawv kiag li . Txawm li cas los xij, ob qho mob no cuam tshuam nrog kev hloov pauv hauv cov noob caj ces 'F5'.

Hauv Factor V Leiden Thrombophilia, kev hloov pauv caj ces ua rau koj cov ntshav txhaws yooj yim dua.

Txawm li cas los xij, nyob rau hauv ib qho mob hu ua 'Factor V deficiency' , kev hloov pauv caj ces tiv thaiv koj cov ntshav kom tsis txhob khov zoo thaum xav tau. Qhov no txhais tau tias koj muaj feem yuav los ntshav. 'Factor V deficiency' yog ib qho mob ntshav tsawg heev (kwv yees li ib ntawm ib lab). Nws tuaj yeem ua rau muaj tej yam xws li ntshav ntswg ntau zaus, ntshav hnyav thaum lub sijhawm muaj hli, thiab ntshav tas li tom qab phais.

Thaum kawg, tej yam uas yuav tsum nco ntsoov

Yog li ntawd, yog tias koj pom tias koj lossis ib tus neeg koj paub muaj Factor V Leiden Thrombophilia, tsis txhob ntshai tam sim ntawd. Nco ntsoov tias, feem ntau ntawm cov neeg uas muaj tus mob no tuaj yeem ua neej noj qab nyob zoo yam tsis muaj kev txhaws ntshav .

Txawm li cas los xij, yog tias koj muaj cov ntshav txhaws, muaj cov kev kho mob zoo . Qhov tseem ceeb tshaj plaws yog ua raws li koj tus kws kho mob cov lus qhia kom zoo, mus kuaj thiab kho koj xav tau, thiab ua neej nyob zoo siab nrog tus mob no, tswj nws kom zoo ua ntej nws dhau los ua teeb meem.

` Factor V Leiden, Thrombophilia, ntshav txhaws, DVT, PE, kab mob caj ces, ntshav txhaws, teeb meem caj ces