Felty Syndrome yog dab tsi? Qhov no tseem ceeb rau cov neeg uas muaj mob pob qij txha!

Tej zaum koj kuj yuav mob pob qij txha, o, thiab me ntsis tawv nqaij ntawm koj ob txhais ceg thaum sawv ntxov, puas yog? Feem ntau, cov no tuaj yeem tshwm sim los ntawm mob pob qij txha rheumatoid. Tab sis koj puas paub tias muaj lwm yam teeb meem uas tuaj yeem tshwm sim nrog tus mob pob qij txha no, tab sis nws tsis paub zoo, tab sis nws tseem ceeb heev uas yuav tsum paub txog? Ntawd yog Felty Syndrome. Cia peb tham txog qhov no kom meej me ntsis hnub no.

Felty Syndrome yog dab tsi tiag?

Hais yooj yim xwb, Felty Syndrome yog kev sib xyaw ua ke ntawm peb yam mob uas tshwm sim ua ke. Lawv yog:

• Mob pob qij txha caj qaum (Rheumatoid Arthritis) - ib qho mob uas feem ntau ntawm koj paub txog.
• Neutropenia - Qhov no yog qhov txo qis ntawm cov neutrophils, ib hom qe ntshav dawb hauv cov ntshav.
• Splenomegaly - Qhov no txhais tau hais tias lub pores, ib lub cev hauv lub cev, loj dua li qub.

Feem ntau nws pib nrog mob pob qij txha rheumatoid (RA). Ob qho mob ntxiv tshwm sim ua teeb meem ntawm RA. Cov kws kho mob hu cov no 'extra-articular manifestations'. Ntawd yog, mob pob qij txha tsis yog tsuas yog rau cov pob qij txha xwb, tab sis cuam tshuam rau cov pob qij txha sab nraud ntawm lawv. Qhov no yog vim muaj cov txheej txheem o uas ua rau mob pob qij txha. Txawm hais tias nws yog ib qho uas cov teeb meem no tshwm sim sab nraud ntawm cov pob qij txha nrog RA, Felty Syndrome yog ib qho mob tsis tshua muaj.

Qhov no cuam tshuam li cas rau koj?

Felty's syndrome pib nrog Rheumatoid Arthritis. Tom qab ntawd koj muaj mob hnyav thiab o ntawm koj cov pob qij txha. Tom qab ntawd, thaum muaj mob xws li Neutropenia thiab Splenomegaly, nws cuam tshuam rau koj lub cev tiv thaiv kab mob. Neutropenia yog qhov txo qis ntawm ib hom qe ntshav dawb hu ua neutrophils. Cov neutrophils no yog ib hom qe ntshav tseem ceeb heev uas tiv thaiv peb lub cev ntawm cov kab mob. Yog li thaum lawv txo qis, qhov muaj feem yuav muaj kab mob nce ntxiv. Lub qhov ntswg loj tuaj yeem yog lwm qhov laj thawj rau qhov txo qis ntawm neutrophils.

Tus mob no feem ntau tshwm sim li cas?

Felty's syndrome tshwm sim rau li ntawm 2% ntawm cov neeg uas muaj mob rheumatoid arthritis. Ib yam li RA, Felty's syndrome muaj li peb npaug ntau dua rau cov poj niam dua li cov txiv neej. Qhov nthuav yog, yuav luag txhua tus neeg uas muaj RA uas muaj Felty's syndrome yog 'seropositive'. Qhov no txhais tau tias cov kev kuaj mob lees paub tias lawv muaj ib yam dab tsi hu ua rheumatoid factor antibodies hauv lawv cov ntshav. 'seronegative' cov neeg, txhais tau tias cov neeg uas tsis muaj cov antibodies ntawd, tsis tshua muaj Felty's syndrome.

Cov tsos mob ntawm qhov no yog dab tsi?

Feem ntau, cov tsos mob thawj zaug uas tshwm sim yog cov mob rheumatoid arthritis. Cov no suav nrog:

• Mob pob qij txha
• Pob qij txha o
• Kev sib koom ua ke, tshwj xeeb tshaj yog thaum sawv ntxov

Ib txhia neeg yuav muaj lwm yam tsos mob ntxiv rau RA hauv lawv cov pob qij txha. Piv txwv li:

• Cov pob uas tsim nyob rau hauv qab daim tawv nqaij ze ntawm cov pob qij txha (cov no hu ua rheumatoid nodules)
• Cov qog ntshav o hauv cov chaw xws li caj dab thiab caj dab
• Lub siab yuav o thiab mob thaum kov.
• Qhov muag thiab qhov ncauj qhuav (qhov no hu ua Sjogren's syndrome)
• Qhov muag liab, o (qhov no hu ua episcleritis)
• Cov kab mob ntawm daim tawv nqaij, tshwj xeeb tshaj yog ntawm ob txhais ceg
• Cov cim qhia txog kev los ntshav hauv qab daim tawv nqaij
• Ua pa nyuaj vim yog lub ntsws o
• Mob hauv siab vim yog o ntawm lub plawv
• Ua npaws
• Qaug zog thiab tsis muaj zog
• Tsis qab los noj mov los yog poob phaus yam tsis paub meej

Ntxiv rau cov no, Felty Syndrome kuj muaj lwm cov tsos mob. Qee zaum cov tsos mob no yuav tshwm sim ua ntej pib muaj cov tsos mob RA.

• Kev kis kab mob ntau zaus thiab kav ntev. Piv txwv li suav nrog mob khaub thuas, mob plab, thiab mob tawv nqaij.
• Mob qog ntshav hauv lub qhov ncauj. Tej zaum yuav hnov ​​​​​​hauv tes thiab tej zaum yuav mob.
• Cov tawv nqaij tsis zoo li qub (zoo li cov pob).

Tiam sis qhov xav tsis thoob yog, qee zaum koj tuaj yeem kuaj pom tias muaj Felty Syndrome yam tsis muaj tsos mob. Kev kuaj ntshav thiab kev ntsuas tuaj yeem qhia tau tias koj muaj tag nrho peb yam mob ua ntej koj txawm hnov ​​​​​​cov tsos mob.

Feem ntau qhov no pib thaum muaj hnub nyoog li cas?

Feem ntau Felty Syndrome tshwm sim rau cov neeg laus, ntawm hnub nyoog 50 thiab 70 xyoo. Rau cov neeg feem coob, Felty Syndrome tshwm sim tom qab lawv muaj cov tsos mob ntawm mob pob qij txha rheumatoid li ntawm 10 txog 15 xyoos.

Vim li cas Felty Syndrome thiaj tshwm sim?

Mob pob qij txha caj qaum yog ib yam kab mob uas hu ua "autoimmune disease". Qhov no txhais tau hais tias peb lub cev tiv thaiv kab mob tawm tsam qee qhov ntawm peb lub cev zoo li lawv yog yeeb ncuab. Ntau tus kws tshawb fawb ntseeg tias Felty Syndrome yog ib qho teeb meem loj ntawm RA. Hauv cov kab mob autoimmune no, peb lub cev tsim cov "antibodies" tawm tsam qee cov protein. Cov antibodies no mus ntes cov protein ntawd thiab qhia tias lawv raug rhuav tshem. Qhov no yog li cas kev o tuaj ntxiv.

Cov tshuaj tiv thaiv kab mob no tej zaum yuav tsis muaj nyob rau hauv RA tas li. Txawm li cas los xij, rau cov neeg uas muaj Felty Syndrome, cov tshuaj tiv thaiv kab mob no yeej muaj nyob. Qhov muaj cov tshuaj tiv thaiv kab mob no yog ib qho laj thawj uas ua rau RA hnyav dua thiab lwm yam teebmeem sab nraud ntawm cov pob qij txha (kev tshwm sim sab nraud ntawm cov pob qij txha) nce ntxiv. RA nrog cov tshuaj tiv thaiv kab mob hu ua 'seropositive RA'. Kev tshawb fawb qhia tau hais tias ob qho tib si seropositive RA thiab Felty Syndrome muaj feem cuam tshuam nrog qee yam 'genetic factors'. Qhov no txhais tau tias lawv tuaj yeem kis mus rau ntau tiam neeg mus rau qee qhov.

Mob caj dab rheumatoid (RA) ua rau neutropenia thiab splenomegaly li cas?

Yuav ua li cas Neutropenia tshwm sim

Neutropenia yog qhov txo qis ntawm cov qe ntshav dawb hu ua neutrophils. Muaj ob qho laj thawj tseem ceeb rau qhov no. Ib qho yog tias koj cov pob txha tsis tsim cov neutrophils txaus. Los yog, cov neutrophils hauv koj lub cev raug rhuav tshem. Hauv Felty Syndrome, ob qho no tuaj yeem tshwm sim. Cov txheej txheem autoimmune uas tau hais ua ntej tuaj yeem cuam tshuam rau kev tsim cov neutrophils hauv cov pob txha, thiab cov neutrophils uas twb tau tsim tawm tuaj yeem raug rhuav tshem. Tsis tas li ntawd, lub pores loj hlob yog lwm qhov laj thawj rau kev txo qis ntawm neutrophils.

Yuav ua li cas Splenomegaly tshwm sim

Koj lub qhov ntswg txoj haujlwm yog lim cov qe ntshav qub, tsis muaj txiaj ntsig tawm ntawm koj cov ntshav. Tab sis thaum koj lub qhov ntswg loj dhau (splenomegaly), nws ua haujlwm ntau dhau thiab pib tshem tawm ntau cov qe ntshav zoo. Mob pob qij txha caj qaum qee zaum tuaj yeem ua rau lub qhov ntswg loj. Qhov ua rau tseeb tseem tsis tau meej. Lub qhov ntswg kuj tseem tuaj yeem loj tuaj yam tsis muaj neutropenia. Tsis tas li ntawd, tsis tshua muaj, Felty Syndrome tuaj yeem tshwm sim yam tsis muaj lub qhov ntswg loj.

Cov teeb meem txaus ntshai ntawm Felty Syndrome yog dab tsi?

Vim tias Felty Syndrome ua rau koj lub cev tiv thaiv kab mob tsis muaj zog, koj muaj feem yuav kis tau kab mob ntau zaus thiab loj heev . Txawm tias koj feem ntau muaj mob me me uas yooj yim kho, qhov mob no tuaj yeem hnyav txaus kom ntev thiab qee zaum ua rau tuag taus. Kev kis kab mob tsis tswj tau tuaj yeem ua rau muaj mob txaus ntshai hu ua sepsis. Cov neeg uas muaj Felty Syndrome kuj muaj feem yuav kis tau qee hom mob qog noj ntshav, xws li lymphoma.

Tiamsis tsis txhob ntshai thaum koj hnov ​​​​​​cov no. Cov kev pheej hmoo no muaj tseeb, tab sis lawv tuaj yeem tswj tau nrog kev kho mob thiab kev saib xyuas zoo.

Yuav ua li cas thiaj paub qhov no?

Cov kws kho mob kuaj pom tias muaj Felty Syndrome thaum lawv pom tias muaj mob rheumatoid arthritis, neutropenia, thiab splenomegaly. (Tsis tshua muaj, kev kuaj mob tuaj yeem ua tau yam tsis muaj tus po loj.)

Cov kev ntsuam xyuas feem ntau yog:

• Kev kuaj ntshav: Kev suav cov ntshav tag nrho, tshwj xeeb yog los xyuas seb muaj pes tsawg tus neutrophils.
• Cov duab X-ray ntawm cov pob qij txha: Tshawb xyuas seb puas muaj mob pob qij txha.
• Kev ntsuas lub qog ntawm lub qog: Piv txwv li, kev ntsuas ultrasound lossis CT scan.
• Kev kuaj mob pob txha:Qhov no pab kom ntseeg tau tias tsis muaj lwm yam mob.

Yuav kho qhov no li cas?

Muaj peb lub hom phiaj tseem ceeb thaum kho Felty Syndrome:

• Tswj cov mob hauv qab ntawm Rheumatoid Arthritis.
• Yog tias cov qe ntshav dawb tsis muaj zog (neutropenia) hnyav heev, ces kho nws ncaj qha.
• Tiv thaiv kev kis kab mob thiab kho lawv yog tias lawv tshwm sim.

Felty Syndrome yog tshwm sim los ntawm kev kho mob lossis tsis tau tswj hwm tus mob rheumatoid arthritis (RA). Rau ntau tus neeg, neutropenia kuj zoo dua thaum lawv tus mob RA zoo dua. Yog li ntawd, cov kws kho mob xub nrhiav kev xaiv cov tshuaj kho mob rheumatic uas hloov kho kab mob (DMARDs) rau RA. Lawv kuj sim zam cov tshuaj tiv thaiv kab mob kom ntau li ntau tau.

Muaj ntau hom DMARDs uas siv tau rau Felty Syndrome:

• Methotrexate thiab folic acid (txo cov kev mob tshwm sim ntawm methotrexate)
• Abatacept
• Rituximab
• Leflunomide

Tab sis yog tias koj cov neutropenia tsis zoo dua nrog cov DMARDs no, lossis yog tias koj cov neutropenia hnyav heev, lossis yog tias koj twb muaj kev kis kab mob lawm, koj tus kws kho mob yuav sim lwm yam kev kho mob kom nce koj cov neutrophil suav. Cov no yuav suav nrog:

• Ib hom tshuaj tiv thaiv kab mob hu ua G-CSF (granulocyte colony-stimulating factor).
• Cov tshuaj corticosteroid luv luv.
• 'Splenectomy' - Qhov no txhais tau tias phais tshem tawm lub pole uas ua haujlwm ntau dhau.

Tsis tas li ntawd xwb, cov kws kho mob yuav ua cov kauj ruam tshwj xeeb los tiv thaiv koj ntawm kev kis kab mob, tshwj xeeb yog tias koj txoj kev kho mob cuam tshuam rau koj lub cev tiv thaiv kab mob. Lawv yuav pom zoo cov yam xws li:

• Noj cov tshuaj tua kab mob dav dav.
• Tau txais cov tshuaj tiv thaiv kab mob tsim nyog.
• Ua tib zoo saib xyuas koj lub qhov ncauj thiab cov hniav kom noj qab haus huv.

Yog tias ib tug neeg uas muaj tus kab mob Felty Syndrome tau txais kev kis kab mob, cov kws kho mob yuav saib qhov no ua qhov tseem ceeb heev. Yog tias qhov no tshwm sim rau koj , koj yuav tsum tau txais kev kho mob tam sim ntawd . Koj tus kws kho mob yuav sau ntawv kom noj tshuaj muaj zog.

Lub neej cia siab ntev npaum li cas nrog Felty Syndrome?

Tsis muaj cov ntaub ntawv tam sim no txog lub neej ntev ntawm cov neeg uas muaj Felty Syndrome. Txawm li cas los xij, feem ntau, cov kev kho mob tau zoo dua qub nyob rau xyoo tas los no. Yog li muaj lub sijhawm zoo uas txhua txoj kev kho mob yuav ua tiav rau koj. Qhov kev pheej hmoo tseem ceeb ntawm kev tuag hauv Felty Syndrome tseem yog los ntawm kev kis kab mob hnyav . Yog li ntawd, kev ua cov kauj ruam los tiv thaiv koj tus kheej ntawm kev kis kab mob tuaj yeem ua qhov sib txawv loj rau koj txoj kev noj qab haus huv mus sij hawm ntev.

Felty Syndrome yog ib qho teeb meem uas tsis tshua muaj thiab feem ntau tsis quav ntsej txog ntawm tus mob rheumatoid arthritis (RA). Yog tias koj muaj tus mob RA uas tsis tau tswj hwm ntev, lossis yog tias koj cov tshuaj tsis ua haujlwm zoo li yav dhau los, koj yuav muaj tus mob Felty Syndrome. Ib txhia neeg muaj tus mob no yam tsis muaj tsos mob dab tsi. Nws yuav ua rau kuv ntxhov siab me ntsis thaum paub tias tus kab mob uas cuam tshuam rau koj cov pob qij txha kuj tuaj yeem cuam tshuam rau koj cov qe ntshav.

Thaum koj twb muaj mob RA lawm, thiab tej zaum lwm yam tsos mob, nws yuav nyuaj rau koj nrhiav kev kuaj mob tshiab. Tab sis Felty Syndrome tsis ua rau muaj ntau yam tsos mob tshiab, thiab nws yuav tsis tas yuav kho ntxiv. Qhov tseem ceeb yog kom paub txog cov kev pheej hmoo. Los ntawm kev ua haujlwm nrog koj tus kws kho mob los kho koj tus mob RA thiab tiv thaiv kev kis kab mob, koj tuaj yeem tswj hwm Felty Syndrome.

Thaum kawg, tej yam uas yuav tsum nco ntsoov

Felty Syndrome yog ib yam mob uas tshwm sim tau rau qee tus neeg uas muaj mob rheumatoid arthritis (RA). Nws yog tus yam ntxwv los ntawm kev txo qis ntawm cov qe ntshav dawb hu ua neutrophils hauv koj cov ntshav (neutropenia) thiab lub po loj (splenomegaly).

• Qhov kev pheej hmoo tseem ceeb yog kev kis kab mob ntau zaus, yog li nws tseem ceeb heev uas yuav tsum tiv thaiv koj tus kheej ntawm kev kis kab mob.
• Txawm hais tias qhov no yuav zoo li txaus ntshai me ntsis los xij, tus mob no tuaj yeem tswj tau zoo nrog kev kho mob thiab kev qhia kom zoo .
• Yog koj muaj mob RA, nrhiav kev pab kom paub txog cov tsos mob ntxiv no. Yog koj muaj kev txhawj xeeb dab tsi , nrog koj tus kws kho mob tham. Lawv yuav pab tau koj.

Felty Syndrome, Mob Pob Qij Txha Rheumatoid, Neutropenia, Splenomegaly, Mob Pob Qij Txha, Mob Pob Qij Txha O, Neutrophils, Spleen, Kev Tiv Thaiv Kab Mob