Tej zaum koj yuav tau pom ib tug neeg hauv koj tsev neeg, tej zaum koj txiv lossis koj txiv ntxawm, noj tshuaj rau kab mob plawv, ntshav siab, lossis kev ua haujlwm tsis zoo ntawm lub cev. Ib yam li ntawd, cov kws kho mob tau sau ntau yam tshuaj rau cov kab mob ntawm daim tawv nqaij, cov kab mob ua pa xws li mob hawb pob, thiab lwm yam. Koj puas paub tias muaj ib pawg tshuaj tseem ceeb heev uas siv los kho ntau yam mob no? Pawg tshuaj ntawd, uas yog Phosphodiesterase Inhibitors, yog qhov peb yuav tham txog hauv tsab xov xwm no hnub no, yooj yim thiab ua siab zoo.
Hauv lus yooj yim, cov Phosphodiesterase Inhibitors no yog dab tsi?
Qhov no yuav zoo li lub npe nyuaj, tab sis qhov tseeb nws yooj yim heev. Cov no yog ib pawg tshuaj uas pab kom cov hlab ntsha hauv peb lub cev so thiab dav dua, ua rau lawv yooj yim dua rau kev ncig. Thaum cov ntshav ntws zoo dua, cov ntshav siab kuj raug tswj. Qhov no yog vim li cas cov tshuaj no thiaj siv los kho ntau yam mob, txij li ntawm daim tawv nqaij, pob qij txha, lub plawv, thiab lub ntsws mus rau kev ua haujlwm tsis zoo ntawm kev sib deev.
Cov tshuaj no ua haujlwm li cas hauv lub cev?
Peb lub cev muaj ib hom enzyme hu ua Phosphodiesterases (PDEs) . Hais yooj yim xwb, cov enzymes zoo li cov pab me me uas ua kom cov txheej txheem tshuaj lom neeg hauv peb lub cev sai dua. Muaj ntau hom PDE enzymes no. Lawv raug suav thiab sib cais. Qhov tshwj xeeb yog tias txhua hom PDE enzyme pom muaj nyob rau hauv cov chaw tshwj xeeb hauv lub cev.
| Hom enzyme PDE | Feem ntau nyob thiab ua haujlwm tau zoo |
|---|---|
| PDE-3 | Cov no pom muaj nyob rau hauv koj lub plawv thiab cov hlab ntsha . Lawv kuj koom nrog kev ua kom cov ntshav khov. |
| PDE-4 | Cov no pom muaj nyob rau hauv lub ntsws . Lawv ua rau cov leeg nqaij hauv txoj hlab pa nruj thiab qaug zog. |
| PDE-5 | Cov no pom muaj nyob rau hauv lub ntsws thiab hauv qhov chaw mos ntawm cov txiv neej. |
Cov Phosphodiesterase Inhibitors (PDE Inhibitors) ua haujlwm los ntawm kev thaiv cov haujlwm ntawm cov PDE enzymes uas tau hais los saum toj no. Nws zoo li kaw lub qhov rooj. Qee cov PDE Inhibitors tsuas yog tsom rau ib hom enzyme (xaiv), thaum lwm tus tuaj yeem cuam tshuam rau PDE enzymes feem ntau (tsis xaiv).
Cov tshuaj no kho cov mob tseem ceeb li cas?
Cov tshuaj no tau txais kev pom zoo los kho ntau tshaj kaum ob yam mob sib txawv. Cia peb saib qee pawg tseem ceeb.
Cov kab mob plawv thiab cov kab mob ntawm lub cev
- Lub plawv tsis ua haujlwm zoo: Thaum lub plawv qaug zog thiab tsis tuaj yeem tso ntshav mus rau lub cev raws li qhov xav tau.
- Mob ntshav siab hauv lub ntsws: Ntshav siab hauv cov hlab ntsha hauv lub ntsws.
- Cov ntshav ntws mus rau ceg tsis txaus (Peripheral artery disease - PAD): Cov ntshav tsis txaus, tshwj xeeb tshaj yog rau ceg.
- Tiv thaiv cov ntshav txhaws tom qab phais: Cov ntshav txhaws tom qab phais tuaj yeem ua rau muaj cov mob txaus ntshai xws li mob hlwb, mob plawv nres, thiab mob ntsws txhaws. Tiv thaiv lawv.
- Thrombocythemia: Kev tsim cov platelets ntau dhau, uas pab cov ntshav txhaws.
Cov kab mob inflammatory ntawm daim tawv nqaij thiab pob qij txha
- Kab mob eczema (Atopic dermatitis): o, khaus liab ntawm daim tawv nqaij.
- Psoriasis: Ib qho mob o ntawm daim tawv nqaij uas tshwm sim los ntawm lub cev tiv thaiv kab mob ua haujlwm ntau dhau.
- Mob pob qij txha psoriatic: Mob pob qij txha uas tshwm sim nrog mob psoriasis.
Cov kab mob ntsig txog lub cev xeeb tub ntawm cov txiv neej
- Benign prostatic hyperplasia: o ntawm cov qog prostate vim yog cov ua rau tsis yog mob qog noj ntshav.
- Kev ua haujlwm tsis zoo ntawm erection: Muaj teeb meem erection.
Cov kab mob ntawm lub cev ua pa
- Kab mob ntsws ua rau lub ntsws tsis ua haujlwm ntev (COPD): Ib pawg kab mob uas ua rau ua pa nyuaj.
- Cov menyuam mos uas yug tsis taus pa: Ua pa nyuaj uas tshwm sim rau cov menyuam mos uas yug tsis tau sijhawm , tshwj xeeb tshaj yog cov uas yug ua ntej 7 lub lis piam.
Cov tshuaj no muaj txiaj ntsig zoo li cas?
Muaj ntau qhov zoo rau kev siv cov tshuaj no.
- Cov qauv yooj yim: Cov no muaj nyob rau hauv daim ntawv ntawm cov tshuaj noj, cov tshuaj pleev rau sab nraud, thiab cov tshuaj txhaj IV. Qee cov tshuaj yuav tsum tau noj txhua hnub, thaum lwm cov tsuas yog noj tau thaum xav tau.
- Kev kho mob rau lub hom phiaj:Raws li peb tau tham ua ntej, vim tias kev kho mob tsuas yog tsom rau ib hom PDE enzyme tshwj xeeb, cov kev mob tshwm sim tsis xav tau tuaj yeem txo qis heev.
- Muaj ntau yam zoo ntawm ib yam tshuaj: Qee zaum ob yam kab mob uas tshwm sim ua ke tuaj yeem kho tau nrog ib yam tshuaj. Piv txwv li, ib tus neeg uas muaj ob qho tib si prostate loj thiab erectile dysfunction tuaj yeem muab PDE-5 inhibitor tadalafil . Ib yam li ntawd, Apremilast yog siv los kho ob qho tib si psoriasis thiab psoriatic mob caj dab.
Cia peb kuj paub txog cov kev mob tshwm sim thiab kev pheej hmoo.
Ib yam li lwm yam tshuaj, cov no tuaj yeem ua rau muaj kev phiv. Cov kev phiv no feem ntau nyob ntawm hom tshuaj PDE inhibitor uas koj noj.
Tseem ceeb heev: Yog tias koj noj tshuaj PDE-5 inhibitor (piv txwv li Sildenafil, Tadalafil) thiab mob hauv siab hauv 24 teev, thiab noj tshuaj nitroglycerin hauv qab nplaig, mus rau chav kho mob ceev hauv tsev kho mob (ETU) tam sim ntawd. Kev sib xyaw ua ke ntawm ob hom tshuaj no tuaj yeem ua rau muaj ntshav siab qis heev.
Hauv qab no yog qee qhov kev phiv uas cuam tshuam nrog cov tshuaj tseem ceeb.
| Pawg tshuaj | Cov kev mob tshwm sim me me thiab nruab nrab | Cov kev mob tshwm sim tseem ceeb / txaus ntshai |
|---|---|---|
| Cov Tshuaj PDE-3 inhibitors (Muab rau lub siab) | Mob taub hau, qaug zog, o, mob plab (xeev siab, ntuav), raws plab. | Lub plawv dhia tsis xwm yeem (arrhythmia), mob hauv siab, los ntshav tsis zoo, cov ntshav platelets tsawg. |
| Cov Tshuaj PDE-4 inhibitors (Muab rau cov kab mob ua pa/tawv nqaij) | Poob phaus, xeev siab, raws plab, mob taub hau, pw tsis tsaug zog, o qhov chaw uas tau siv cov tshuaj pleev. | Kev nyuaj siab ntxiv, xav tua tus kheej, ua xua ntau dhau (khaus heev, o). |
| Cov Tshuaj PDE-5 inhibitors (Muab rau qhov tsis muaj zog ntawm kev sib deev) | Mob taub hau, ntsej muag liab, mob plab, qhov ntswg txhaws, mob leeg, kiv taub hau. | Priapism: Mob erection uas kav ntev tshaj 4 teev yam tsis muaj kev txhawb nqa kev sib deev. Mus rau ETU tam sim ntawd. Kev hloov pauv ntawm kev pom kev, txo qis lossis tsis hnov lus. |
| Cov Tshuaj PDE Tsis Xaiv (piv txwv li Caffeine, Theophylline) | Tsis so, pw tsis tsaug zog, tshee hnyo, mob plab, mob taub hau. | Lub plawv dhia ceev ceev, lub plawv dhia tsis sib xws, qaug dab peg. |
Thaum twg koj yuav tsum tsis txhob noj cov tshuaj no?
Cov tshuaj no yuav ua rau muaj kev phom sij rau qee tus neeg. Yog tias koj muaj ib qho ntawm cov mob hauv qab no, koj yuav tsum nrog koj tus kws kho mob tham ua ntej noj cov tshuaj no.
- Rau txhua yam tshuaj PDE inhibitor: Yog tias koj tau muaj kev tsis haum tshuaj hnyav (ua xua rau tshuaj lossis tshuaj yeeb).
- Cilostazol (PDE-3): Qhov no tsis pom zoo yog tias koj muaj hom mob plawv tsis ua haujlwm.
- PDE-5 inhibitors: Koj yuav tsum tsis txhob noj cov no yog tias koj muaj kab mob plawv hnyav, nyuam qhuav muaj mob plawv nres lossis mob hlwb, lossis muaj mob angina tsis ruaj khov.
- Yog koj noj cov tshuaj nitrates , kev noj cov tshuaj PDE-5 inhibitors tuaj yeem ua rau koj cov ntshav siab poob qis dhau.
- Qee cov tshuaj PDE inhibitors (piv txwv li Cilostazol) tsis haum yog tias koj muaj teeb meem los ntshav.
Siv thaum cev xeeb tub
Yog tias koj cev xeeb tub lossis npaj yuav cev xeeb tub, tej zaum yuav zoo dua kom tsis txhob noj qee hom tshuaj PDE inhibitors. Nug koj tus kws kho mob txog qhov no.
Thaum twg koj yuav tsum mus ntsib kws kho mob tam sim ntawd?
Nws yog qhov zoo tshaj plaws los qhia rau koj tus kws kho mob yog tias koj muaj cov tsos mob txawv txawv thaum siv cov tshuaj no. Txawm li cas los xij, yog tias muaj ib qho ntawm cov hauv qab no tshwm sim, mus rau chav kho mob ceev (ETU) ntawm tsev kho mob yam tsis muaj kev ncua.
- Cov tsos mob ntawm kev mob plawv nres:Tej yam xws li mob hauv siab, nruj, ua pa nyuaj, tawm hws, kiv taub hau, xeev siab.
- Priapism: Mob erection uas kav ntev tshaj 4 teev yam tsis muaj kev txhawb nqa kev sib deev. Qhov no yog ib qho mob uas yuav tsum tau kho tam sim ntawd.
- Kev pom kev lossis kev hnov lus tsis zoo tam sim ntawd: Yuav tsum tau kho cov no ua ntej muaj kev puas tsuaj mus tas li.
Cov tshuaj no tseem ceeb heev, ob qho tib si cawm txoj sia thiab txhim kho lub neej zoo. Tab sis lawv yuav tsum tau noj raws li tus kws kho mob pom zoo thiab raws li qhov ntau npaum li tau teev tseg.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Cov tshuaj phosphodiesterase inhibitors yog ib hom tshuaj muaj zog uas kho ntau yam mob, suav nrog kab mob plawv, kev ua haujlwm tsis zoo ntawm kev sib deev, kab mob ntawm daim tawv nqaij, thiab kab mob ua pa.
- Tsuas yog noj cov tshuaj no raws li kws kho mob pom zoo xwb . Tsis txhob nug cov phooj ywg lossis nug lub tsev muag tshuaj kom yuav thiab siv lawv koj tus kheej.
- Qhia rau koj tus kws kho mob txog lwm yam tshuaj uas koj noj thiab lwm yam kab mob uas koj muaj.
- Yog tias koj muaj cov kev mob tshwm sim loj heev xws li mob hauv siab, priapism ntev tshaj 4 teev, lossis pom kev lossis hnov lus tsis zoo, mus rau chav kho mob ceev (ETU) tam sim ntawd.
- Tsis txhob muab koj cov tshuaj faib rau lwm tus. Cov tshuaj uas haum rau ib tus neeg yuav ua rau lwm tus muaj kev phom sij heev.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus