Somatostatin yog dab tsi? Cia peb kawm txog cov tshuaj hormones zoo kawg no hauv peb lub cev!

Niaj hnub no peb yuav tham txog ib tug neeg xa xov tshuaj lom neeg uas txawv txawv thiab tseem ceeb heev hauv peb lub cev. Nws lub npe yog somatostatin. Tej zaum koj yuav tsis tau hnov ​​​​​​txog lub npe no ua ntej. Tab sis koj puas paub, nws pab tswj ntau yam hauv peb lub cev, zoo li ib tug neeg zais cia. Cia peb saib seb somatostatin yog dab tsi, nws ua haujlwm li cas, thiab nws tseem ceeb npaum li cas rau peb txoj kev noj qab haus huv.

Somatostatin yog dab tsi tiag?

Hais yooj yim xwb, somatostatin yog ib yam tshuaj hormones uas tsim tawm hauv peb lub cev. Tam sim no tej zaum koj yuav xav paub tias 'hormones' yog dab tsi. Nws yooj yim heev. Cov tshuaj hormones yog cov tshuaj uas nqa cov lus ntawm ntau qhov ntawm peb lub cev. Lawv zoo li 'postmen' hauv peb lub cev. Cov lus no qhia peb cov kabmob, daim tawv nqaij, thiab cov leeg kom ua ib yam dab tsi lossis tsum tsis txhob ua ib yam dab tsi.

Yog li ntawd, cov tshuaj hormone tshwj xeeb no hu ua somatostatin feem ntau nres kev tsim cov tshuaj hormones, tswj qee yam haujlwm hauv peb lub cev zom zaub mov (gastrointestinal (GI) tract), thiab tseem tswj kev faib cov cell sai (tshwj xeeb tshaj yog cov cell mob qog noj ntshav). Nws zoo li tus tub ceev xwm tsheb khiav, thaum muaj qee yam ntau dhau, nws muab lub cim, "Okay, okay, nres tam sim no."

Cov somatostatin no tsim tawm qhov twg?

Tam sim no cia peb saib seb qhov twg cov tshuaj somatostatin hormone zoo kawg no tsim tawm hauv peb lub cev. Nws tau tsim tawm ntau qhov chaw:

• Txoj hnyuv (GI): Qhov no yog lub cev ntev zoo li lub raj uas khiav ntawm lub qhov ncauj mus rau lub qhov quav uas pab peb zom cov khoom noj uas peb noj. Qhov no yog qhov chaw uas koj cov hnyuv koom nrog.
• Pancreas: Qhov no yog ib lub qog nyob hauv peb lub plab. Ib lub qog yog ib lub cev uas tsim cov tshuaj lom neeg. Lub pancreas tsim cov enzymes uas pab zom zaub mov, nrog rau cov tshuaj hormones tseem ceeb xws li insulin thiab glucagon .
• Hypothalamus: Qhov no nyob hauv peb lub hlwb. Nws zoo li lub 'chaw tswj' ntawm peb lub cev. Nws pab tswj lub cev kom zoo (piv txwv li, tswj kom muaj ib puag ncig sab hauv ruaj khov). Nws kuj muab cov lus txib rau lub qog pituitary, uas nyob hauv qab hypothalamus, kom tso tawm qee cov tshuaj hormones.
• Lub Cev Nervous System (CNS): Qhov no suav nrog peb lub hlwb thiab tus txha caj qaum. Yog los ntawm lub cev no cov lus xa los ntawm lub hlwb mus rau lwm qhov ntawm lub cev.

Lwm lub npe rau somatostatin

Somatostatin kuj muaj ntau lub npe hu ua lwm yam. Yog tias koj tus kws kho mob hais ib lub npe no, tej zaum lawv hais txog tib yam:

• SS, SST los yog SOM
• Cov tshuaj hormones inhibitory hormone (GHIH)
• Somatotropin tso tawm -inhibiting factor (SRIF)
• Somatotropin tso tawm -inhibiting hormone (SRIH)

Puas yog somatostatin kuj siv ua tshuaj?

Muaj tseeb tiag, qee zaum, cov kws kho mob siv cov tshuaj somatostatin ua tshuaj los kho qee yam kab mob. Piv txwv li:

• Qee yam kab mob plab hnyuv
• Acromegaly yog ib qho mob tsis tshua muaj uas lub cev tsim cov tshuaj hormones loj hlob ntau dhau.
• Qee hom mob qog noj ntshav hu ua neuroendocrine tumors (NETs) .
• Qee lwm yam kab mob endocrine (piv txwv li, lub qog uas tsim cov tshuaj hormones).

Cov haujlwm tseem ceeb ntawm cov tshuaj hormones somatostatin yog dab tsi?

Zoo, tam sim no cia peb saib seb lub luag haujlwm tseem ceeb ntawm cov tshuaj somatostatin no yog dab tsi.

Hais yooj yim xwb, nws txoj haujlwm tseem ceeb yog kom tsis txhob muaj lwm cov tshuaj hormones uas peb lub cev endocrine tsim tawm thiab tswj kev tso tawm qee yam secretions los ntawm lub cev exocrine.

Lub 'endocrine system' yog hais txog lub cev uas tso cov tshuaj hormones los ntawm cov qog hauv peb lub cev ncaj qha mus rau hauv cov ntshav. Piv txwv li, cov qog thyroid, cov qog pituitary, thiab cov qog adrenal . Lub 'exocrine system' yog hais txog lub cev uas tso cov khoom tsim los ntawm cov qog los ntawm ib txoj hlab ntsha. Piv txwv li, cov qog salivary thiab cov qog hws .

Yog li ntawd, ib yam li kaw lub qhov dej, somatostatin ib ntus nres qee cov tshuaj hormones thiab cov kua qaub uas peb lub cev tsis xav tau. Xav txog seb, yog tias koj tsuas yog tso lub qhov dej qhib, dej yuav raug pov tseg, puas yog? Ib yam li ntawd, yog tias lub cev tsim cov tshuaj hormones ntau dua li nws xav tau, teeb meem tuaj yeem tshwm sim. Somatostatin tswj qhov ntawd.

Ib qho ntxiv yog tias somatostatin kuj pab tiv thaiv cov hlwb kom tsis txhob faib sai sai, xws li cov hlwb qog noj ntshav.

Nws kuj ua haujlwm ua ib qho neurotransmitter hauv peb lub paj hlwb hauv nruab nrab (CNS). Ib qho neurotransmitter yog ib qho tshuaj xa xov uas ib lub hlwb paj hlwb (neuron) tso tawm los cuam tshuam rau lwm lub hlwb.

Yuav ua li cas somatostatin cuam tshuam rau ntau qhov ntawm peb lub cev

Tam sim no cia peb saib seb somatostatin cuam tshuam li cas rau txhua qhov ntawm peb lub cev:

• Hauv hypothalamus: Somatostatin nres kev tso tawm cov tshuaj hormones uas peb lub qog pituitary tsim tawm, xws li cov tshuaj hormones loj hlob , cov tshuaj hormones thyroid-stimulating (TSH) , thiab prolactin .
• Hauv lub pancreas: Nov yog insulin ,Nws inhibits qhov kev tso tawm ntawm cov tshuaj hormones pancreatic xws li glucagon thiab gastrin , thiab tseem tswj kev tso tawm ntawm cov enzymes pancreatic uas pab zom zaub mov.
• Hauv lub cev zom zaub mov (GI tract): Nws txo cov kua qaub hauv plab, uas raug txhawb thaum peb noj mov. Nws kuj txwv tsis pub tso cov tshuaj hormones zom zaub mov xws li secretin thiab gastrin .
• Hauv lub paj hlwb nruab nrab (CNS): Ntawm no, nws pab hloov txoj kev xa cov lus los ntawm cov hlab ntsha (neurotransmission) thiab txoj kev uas kev nco tau tsim.

Dab tsi ua rau somatostatin tso tawm?

Zoo, yog li tam sim no koj yuav xav paub tias, 'Somatostatin no tso tawm li cas? Dab tsi ua rau nws?' Yog hais qhov tseeb, cov kws tshawb fawb tseem tsis tau nkag siab tag nrho tias peb lub cev tswj kev tso tawm ntawm somatostatin no li cas, thiab cov nqaij twg ua rau nws tso tawm. Txog tam sim no, nws tau pom tias muaj ntau hom cell thiab cov protein sib txawv koom nrog.

Muaj ib txoj kev tshawb fawb qhia tau hais tias cov piam thaj (glucose) , uas yog peb lub cev lub zog tseem ceeb, tsis yog tsuas yog tswj kev tso tawm ntawm somatostatin xwb, tab sis kuj pab txhawb rau nws cov khoom tsim tawm. Hauv txoj kev tshawb fawb ntawd, cov kws tshawb fawb tau pom tias thaum cov piam thaj hauv cov ntshav qis, insulin ua rau muaj kev tso tawm ntawm somatostatin (piv txwv li, nres kev tsim cov insulin), thiab thaum cov piam thaj hauv cov ntshav siab , glucagon ua rau muaj kev tso tawm ntawm somatostatin (piv txwv li, nres kev tsim cov glucagon).

Txhais tau hais tias, vim tias insulin ua rau cov ntshav qab zib qis, thaum koj cov ntshav qab zib qis, somatostatin raug tso tawm los tiv thaiv nws kom tsis txhob poob qis dua, kom tiv thaiv kev tso tawm insulin. Nws yog qhov xav tsis thoob li cas tej yam raug tswj hwm hauv peb lub cev, puas yog?

Cov teeb meem thiab cov mob ntsig txog Somatostatin

Feem ntau, cov teeb meem loj nrog somatostatin tsis tshua muaj. Tab sis qhov mob tseem ceeb uas tshwm sim yog ib hom mob qog noj ntshav tsawg heev hu ua somatostatinoma . Qhov no yog ib qho qog uas loj hlob hauv lub cev endocrine. Qhov qog no loj hlob hauv lub txiav lossis lub plab zom mov (GI tract). Qhov no ua rau muaj somatostatin ntau dhau.

Tus mob no, hu ua somatostatinoma, tuaj yeem tshwm sim yam tsis tau npaj tseg, lossis nws tuaj yeem cuam tshuam nrog qee yam kev mob caj ces . Qee qhov ntawm cov mob no yog:

• Mob qog nqaij hlav ntau yam hauv cov qog endocrine (MEN hom 1):Qhov no kuj yog ib qho mob tsis tshua muaj, uas yog los ntawm noob caj ces uas muaj ntau yam qog nqaij hlav hauv ntau qhov chaw ntawm lub cev endocrine.
• Neurofibromatosis hom 1 (NF1): Qhov no kuj yog ib yam mob uas tau los ntawm noob caj noob ces. Nws ua rau muaj cov pob café-au-lait thiab cov qog nqaij hlav zoo rau ntawm daim tawv nqaij.
• Kab mob Von Hippel-Lindau: Qhov no kuj yog ib qho mob uas tsis tshua muaj los ntawm noob caj noob ces. Nws tuaj yeem ua rau muaj qog nqaij hlav tsis muaj teeb meem lossis mob qog nqaij hlav hauv lub hlwb, tus txha caj qaum, qhov muag, raum, lub txiav, thiab cov qog adrenal.

Thaum somatostatin raug tsim ntau dhau, kev tsim ntau lwm yam tshuaj hormones endocrine raug txo qis heev. Cov tsos mob ntawm qhov no tuaj yeem zoo ib yam li cov tsos mob ntawm ntau lwm yam kab mob. Yog li ntawd, qee zaum nws yuav nyuaj rau kev kuaj mob hu ua somatostatinoma kom raug.

Qhov tseem ceeb yog tias cov teeb meem ntsig txog somatostatin no tsis tshua muaj , txhais tau tias feem ntau cov neeg tsis muaj dab tsi txhawj txog.

Tsis tas li ntawd xwb, muaj ob peb daim ntawv tshaj tawm txog cov theem somatostatin qis dua li qub hauv lub cev ntawm ib tus neeg.

Cov kev kuaj twg kuaj xyuas cov qib somatostatin?

Vim tias cov teeb meem ntsig txog somatostatin tsis tshua muaj, cov kws kho mob feem ntau tsis kuaj txhua tus neeg cov somatostatin. Txawm li cas los xij, yog tias muaj kev xav tias muaj ib qho mob qog nqaij hlav uas tsim cov somatostatin ntau dhau hu ua somatostatinoma, raws li tau hais ua ntej, kev kuaj ntshav hu ua somatostatin-like-immunoreactivity (SLI) yog siv los txheeb xyuas nws.

Thaum twg kuv yuav tsum mus ntsib kws kho mob txog kuv cov somatostatin?

Feem ntau koj tsis tas yuav txhawj txog koj cov somatostatin theem, vim tias muaj ob peb yam teeb meem cuam tshuam nrog qhov no.

Txawm li cas los xij, yog tias ib tug neeg hauv tsev neeg (niam txiv lossis kwv tij neej tsa) tau kuaj pom tias muaj mob xws li ntau yam mob qog nqaij hlav endocrine hom 1 (MEN hom 1), neurofibromatosis hom 1 (NF1), lossis mob Von Hippel-Lindau, nws yog ib qho tseem ceeb uas yuav tsum qhia rau koj tus kws kho mob. Vim tias cov no yog cov mob uas tau txais los ntawm noob caj ces, koj kuj tseem yuav muaj feem yuav mob somatostatinoma. Koj tus kws kho mob mam li ua qhov kev kuaj mob kom pom tias koj puas muaj mob.

Tej yam tseem ceeb tshaj plaws uas yuav tsum nco ntsoov (Cov Lus Coj Mus Tsev)

Zoo, yog li, ntawm no yog cov yam tseem ceeb tshaj plaws uas koj yuav tsum nco ntsoov los ntawm qhov peb tau tham txog hnub no:

• Somatostatin yog ib qho tshuaj hormones 'master' uas ua lub luag haujlwm tseem ceeb heev hauv peb lub cev, tswj lwm cov tshuaj hormones.
• Nws feem ntau tswj cov yam xws li kev tsim cov tshuaj hormones, kev ua haujlwm ntawm lub cev zom zaub mov, thiab kev faib cov cell sai sai.
• Cov teeb meem nrog somatostatin feem ntau tsis tshua muaj.Qhov teeb meem tseem ceeb yog ib qho qog nqaij hlav tsis tshua muaj hu ua somatostatinoma.
• Yog tias muaj leej twg hauv koj tsev neeg muaj cov mob caj ces xws li MEN hom 1, NF1, lossis kab mob Von Hippel-Lindau , nrog koj tus kws kho mob tham txog qhov ntawd.
• Tsis txhob ntshai qhov no yam tsis muaj qab hau. Nws yog ib qho tseem ceeb uas yuav tsum paub txog cov kab ke zoo kawg no hauv peb lub cev.

Yog li ntawd, somatostatin yog ib yam tshuaj uas ntsiag to, tab sis tseem ceeb heev, hauv peb lub cev. Tsuav nws ua nws txoj haujlwm kom raug, peb tsis muaj dab tsi yuav ntshai!

` Somatostatin, Somatostatin, Hormone, Pancreas, Hypothalamus, Digestive System, Somatostatinoma, Somatostatinoma, GHIH, Endocrine System, Cancer