Koj puas muaj pob nyob ze koj cov pob qij txha? Cia peb tham txog Tumoral Calcinosis!

Puas muaj tej lub sij hawm koj xav tias koj muaj ib lub pob los yog ib qho chaw tawv nyob hauv qab daim tawv nqaij ze ntawm ib qho pob qij txha xws li koj lub luj tshib, xub pwg, los yog hauv caug? Tej zaum nws yuav tsis mob thaum koj nias rau nws, tab sis nws yuav loj me ntsis. Nws yog ib qho ib txwm muaj uas yuav ntshai me ntsis thaum koj pom ib yam dab tsi zoo li no. Tab sis tsis yog txhua lub pob no yog mob qog noj ntshav txaus ntshai. Hnub no peb yuav tham txog ib qho mob uas qhia cov tsos mob no, tab sis tsis yog mob qog noj ntshav, thiab nws yog qhov tsawg me ntsis tab sis tseem ceeb kom paub txog. Ntawd yog 'Tumoral Calcinosis' .

Tumoral Calcinosis yog dab tsi?

Hais yooj yim xwb, tumoral calcinosis yog ib qho mob caj ces . Qhov no yog thaum koj cov ntshav muaj cov tshuaj hu ua phosphate siab dhau. Phosphate yog ib qho khoom me me uas muaj hluav taws xob, lossis ion, uas muaj cov phosphorus minerals. Yog li, rau ib tus neeg uas muaj tumoral calcinosis, ob qho tib si phosphorus thiab calcium sib sau ua ke hauv lub cev, ua rau muaj cov pob ua rau hauv qab daim tawv nqaij, tshwj xeeb tshaj yog nyob ib puag ncig cov pob qij txha.

Ob qho tib si phosphorus thiab calcium yog qhov tseem ceeb rau peb lub cev kom tsim cov hniav thiab pob txha noj qab haus huv thiab muaj zog. Tab sis thaum lawv siab dhau, cov qog tsis yog mob qog noj ntshav (benign), uas yog, tsis txaus ntshai, tab sis zoo li qog nqaij hlav, pib tsim nyob rau hauv cov nqaij. Qhov no yog qhov peb hu ua tumoral calcinosis.

Puas muaj lwm lub npe rau qhov no?

Yog lawm, lub npe kho mob tag nrho rau tus mob no yog 'Hyperphosphatemic Familial Tumoral Calcinosis' (HFTC) . Lub npe ntev me ntsis, puas yog? Qee tus kws kho mob kuj hu nws ua 'Teutschlaender kab mob'. Qhov ntawd yog kev nco txog Otto Teutschlaender, tus kws kho mob German uas tau kawm txog tus kab mob no txij li xyoo 1930 txog 1950.

Lub npe kho mob ntev no txhais li cas?

Peb puas yuav muab lub npe no faib ua tej daim me me thiab nkag siab? Qhov ntawd yuav yooj yim dua.

• Hyperphosphatemic: Qhov no txhais tau hais tias cov phosphate theem hauv cov ntshav siab.
• Tsev neeg: Qhov no txhais tau tias qhov no yog ib qho mob uas khiav hauv tsev neeg thiab yog los ntawm noob caj noob ces.
• Mob qog: Lo lus no siv vim tias cov qog no zoo li cov qog mob qog.
• Calcinosis: Qhov no txhais tau hais tias calcium tau tso rau hauv cov nqaij ntawm koj cov leeg thiab cov leeg nqaij.

Koj puas nkag siab lub ntsiab lus ntawm lub npe ntev ntawd tam sim no?

Tumoral Calcinosis cuam tshuam li cas rau lub cev?

Cov pob no, hu ua tumoral calcinosis , feem ntau tsim nyob rau hauv qab daim tawv nqaij, ze ntawm cov pob qij txha . Lawv tuaj yeem tsim ntau dua ib qho pob qij txha, tab sis lawv kuj tuaj yeem tsim ntau qhov pob qij txha. Qhov chaw feem ntau yog:

• Cov pob qij txha ntawm lub duav
• Lub luj tshib
• Xub pwg
• Hauv qab
• Cov pob qij txha ntawm lub dab teg
• Cov kab mob ntsig txog tus txha caj qaum
• Thaj chaw ntawm lub puab tsaig

Tus mob no feem ntau tshwm sim li cas?

Cov kws kho mob tsis paub tseeb tias muaj pes tsawg tus neeg muaj tus mob no. Vim tias nws yog ib qho mob tsis tshua muaj , nws feem ntau tshwm sim rau cov neeg African thiab Middle East. Nws tuaj yeem cuam tshuam rau txiv neej thiab poj niam.

Cov hom mob Tumoral Calcinosis tseem ceeb yog dab tsi?

Hom mob no feem ntau yog Hyperphosphatemic Familial Tumoral Calcinosis, uas peb tau tham ua ntej lawm. Tsis tas li ntawd xwb, tseem muaj lwm hom mob uas tsis tshua muaj:

• Hyperphosphatemia-hyperostosis syndrome (HHS): Qhov no yog ib qho mob uas ua rau pob txha loj hlob ntau dhau thiab ua rau muaj cov pob txha uas tsis yog mob qog noj ntshav.
• Normophosphatemic tumoral calcinosis: Hom no feem ntau pom muaj nyob rau hauv cov neeg uas muaj mob raum tsis ua haujlwm. Nws tuaj yeem ua rau muaj mob hu ua hyperparathyroidism, uas yog lub qog parathyroid ua haujlwm ntau dhau.

Dab tsi ua rau muaj Tumoral Calcinosis?

Kab mob qog nqaij hlav calcinosis yog ib qho teeb meem metabolic uas tau txais los ntawm noob caj noob ces . Kwv yees li ib feem peb ntawm cov neeg uas muaj tus mob no muaj kev hloov pauv, lossis kev hloov pauv, hauv lawv cov noob caj noob ces FGF23. Cov noob caj noob ces FGF23 pab peb cov pob txha tsim cov protein hu ua fibroblast growth factor (FGF) 23. Ib txhia neeg kuj muaj tus mob no vim muaj kev hloov pauv hauv cov noob caj noob ces GALNT3 thiab KL. Cov noob caj noob ces no tswj kev tsim cov FGF23. Cov neeg uas muaj cov noob caj noob ces nomophosphatemic tumor calcinosis muaj kev hloov pauv hauv cov noob caj noob ces SAMD9.

Feem ntau, cov protein 'FGF23' qhia peb lub raum tias yuav tsum nqus cov phosphate ntau npaum li cas los ntawm cov ntshav. Tab sis thaum muaj kev hloov pauv ntawm cov noob caj ces, cov txheej txheem no mus tsis zoo. Tom qab ntawd lub raum rov nqus cov phosphate ntau dua li lawv yuav tsum tau ua. Feem ntau, lub raum tso cov phosphate ntau dhau hauv cov zis. Tab sis hauv cov qog nqaij hlav calcinosis, cov phosphate no khi rau calcium thiab tsim cov qog nqaij hlav hauv cov nqaij mos.

Leej twg muaj feem yuav muaj tus mob no?

Tumorous calcinosis yog ib yam kab mob autosomal recessive . Qhov no nyuaj me ntsis rau kev nkag siab, tab sis hais yooj yim xwb, yog koj xav kom muaj tus kab mob no, koj yuav tsum tau txais cov noob caj noob ces hloov pauv los ntawm koj niam koj txiv ob leeg. Koj niam koj txiv tuaj yeem yog cov neeg nqa cov noob caj noob ces hloov pauv, tab sis lawv yuav tsis muaj tus kab mob no.

Yog tias ob leeg niam txiv yog tus nqa kab mob, txhua tus ntawm lawv cov menyuam muaj cov hauv qab no:

• Muaj 1 ntawm 4 tus neeg uas yuav tsis muaj cov noob caj noob ces uas hloov pauv lawm (tsis muaj kev pheej hmoo ntawm kev mob).
• Muaj 1 ntawm 4 tus neeg uas yuav muaj mob qog nqaij hlav (tumoral calcinosis).
• Muaj 1 ntawm 2 tus neeg uas yuav yog tus nqa kab mob uas tsis kis tus kab mob.

Cov tsos mob ntawm Tumoral Calcinosis yog dab tsi?

Qhov mob no ua rau muaj cov pob ntawm ntau qhov loj sib txawv los tsim ze ntawm ib lossis ntau lub pob qij txha. Cov pob no feem ntau tshwm sim thaum yau lossis thaum hluas . Txawm li cas los xij, lawv kuj tuaj yeem tshwm sim rau cov menyuam mos thiab cov neeg laus. Qee zaum, tsuas yog ob peb lub pob tshwm sim hauv ib lub neej. Lossis, ntau lub pob yuav tshwm sim tag nrho ib zaug.

Tej zaum koj yuav muaj cov tsos mob zoo li no:

• Nyuaj siab txav lossis khoov cov pob qij txha uas raug mob kom zoo.
• Cov pob tawv, tsis mob (qee cov pob yuav mob me ntsis thaum kov).
• Mob pob txha thiab leeg.

Yuav kuaj mob li cas yog tias muaj Tumoral Calcinosis?

Tus kws kho pob txha yog tus kws kho mob uas tshwj xeeb hauv cov teeb meem pob txha thiab pob qij txha. Nws yuav kuaj koj thiab nug txog koj cov tsos mob. Tom qab ntawd nws yuav ua ib lossis ntau dua cov duab X-ray hauv qab no los nrhiav cov qog no thiab lwm yam teeb meem pob txha:

• Kev kuaj mob X-ray `(X-ray)`
• Kev kuaj CT
• Kev kuaj MRI (MRI)

Muaj lwm yam mob dab tsi uas qhia tau tias muaj cov tsos mob zoo sib xws rau Tumoral Calcinosis?

Qhov no tseem ceeb heev. Vim tias nws yog ib qho tseem ceeb kom tau txais kev kuaj mob kom raug . Qhov laj thawj yog tias muaj lwm yam mob uas qhia cov tsos mob zoo sib xws, tab sis hnyav dua. Qee qhov ntawm cov mob no yog:

• Cov qog nqaij mos zoo thiab cov qog nqaij mos phem
• Calcific myonecrosis (mob qog ntawm cov calcium uas tso rau hauv cov leeg nqaij ceg)
• Calcific tendonitis (calcific tendonitis) (cov calcium uas tso rau hauv cov leeg nqaij)
• Calcinosis circumscripta (calcium deposits nyob rau hauv daim tawv nqaij thiab cov nqaij ntawm tes thiab taw)
• Calcinosis ntawm kev ua haujlwm tsis zoo ntawm lub raum (lub raum) (calcium tso rau hauv cov neeg uas tau ntxuav ntshav)
• Calcinosis universalis (kev tso cov ntsev calcium hauv daim tawv nqaij, cov nqaij, cov leeg, thiab cov leeg)
• Cov kab mob ntawm cov nqaij sib txuas
• Mob pob qij txha
• Myositis ossificans (cov leeg nqaij hloov mus ua pob txha)
• Osteosarcoma thiab sarcoma (mob qog nqaij hlav pob txha)
• Synovial chondromatosis (cov pob txha mos hauv cov pob qij txha)

Koj puas pom? Txawm hais tias cov tsos mob zoo sib xws los, qhov ua rau muaj qhov teeb meem no kuj txawv heev. Yog vim li ntawd nws thiaj li tseem ceeb heev uas yuav tsum nrhiav seb muaj dab tsi tshwm sim.

Cov kev kho mob uas tsis yog phais yog dab tsi?

Koj tus kws kho mob yuav txo cov phosphate hauv koj cov ntshav.Tej zaum yuav muaj kws kho mob sau ntawv kom noj cov tshuaj uas khi phosphate. Thaum cov tshuaj no sib xyaw nrog cov tshuaj hu ua acetazolamide (feem ntau siv rau kev qaug dab peg thiab glaucoma), lawv tuaj yeem thaiv lub cev kom tsis txhob nqus tau phosphorus. Tej zaum koj yuav tsum noj zaub mov uas muaj phosphorus tsawg .

Kev noj zaub mov uas muaj phosphorus tsawg yog dab tsi?

Yog koj muaj mob qog nqaij hlav calcinosis, koj tus kws kho mob yuav pom zoo kom noj zaub mov uas muaj phosphorus tsawg. Phosphorus muaj nyob rau hauv nqaij, ntses, thiab cov khoom noj mis nyuj. Phosphorus kuj tseem ntxiv rau lwm yam khoom noj ua ib yam khoom tiv thaiv lossis ua kom tsw qab.

Sim txo cov khoom noj thiab dej haus uas muaj phosphorus ntau, xws li:

• Npias, colas, tshuaj yej txias thiab dej haus chocolate.
• Cov ntau yam chocolate thiab caramel.
• Cov khoom noj uas muaj mis nyuj (mis nyuj, cheese, ice cream, cov yogurt uas tsis yog Greek, cov kua zaub creamy).
• Cov khoom noj hauv dej xws li cov oysters thiab cov sardines, thiab cov plab hnyuv sab hauv xws li nqaij nyuj thiab siab qaib.
• Cov nqaij ua tiav (hot dogs, nqaij noj su, bacon, sausages).
• Cov khoom ua los ntawm oat bran.

Nws yog qhov zoo tshaj plaws los tham nrog koj tus kws kho mob lossis tus kws noj zaub mov txog qhov no kom paub ntau ntxiv.

Cov kev kho mob phais yog dab tsi?

Tej zaum koj yuav tau phais kom tshem tawm cov qog uas loj dhau ua haujlwm tsis tau zoo. Txawm li cas los xij, cov qog no yuav loj dua rov qab los . Koj tus kws kho mob kuj tseem yuav coj ib qho qauv ntawm cov nqaij uas raug tshem tawm thiab ua qhov biopsy los xyuas kom meej qhov kev kuaj mob.

Cov teeb meem uas yuav tshwm sim ntawm Tumoral Calcinosis yog dab tsi?

Tsis tshua muaj, qhov mob no tuaj yeem cuam tshuam rau koj cov hlab ntsha lossis lub hlwb, ua rau koj muaj feem yuav muaj teeb meem kev noj qab haus huv loj xws li mob plawv thiab mob hlwb.

Tsis tas li ntawd xwb, tus mob no kuj tseem tuaj yeem ua rau muaj cov hauv qab no:

• Corneal calcifications lossis angioid streaks (liab streaks) hauv cornea ntawm lub qhov muag.
• Teeb meem hniav.
• Kev loj hlob ntawm pob txha ntau dhau (hyperostosis).
• Mob o ntawm cov pob txha ntev (diaphysis) hauv koj ob txhais ceg lossis caj npab.

Puas tiv thaiv tau qhov mob Tumoral Calcinosis?

Yog tias koj thiab koj tus khub ob leeg muaj kev hloov pauv ntawm cov noob caj noob ces uas ua rau muaj qog nqaij hlav calcinosis, koj tuaj yeem tham nrog tus kws pab tswv yim txog noob caj noob ces txog txoj hauv kev los txo qhov kev pheej hmoo ntawm koj cov menyuam yuav tau txais kev hloov pauv ntawd. Ib txhia neeg xaiv ib txoj kev kho mob hu ua Preimplantation Genetic Diagnosis (PGD) . Qhov no suav nrog kev txheeb xyuas cov qe menyuam uas tsis muaj kev hloov pauv ntawd. Koj tus kws kho mob mam li siv ib txoj kev kho mob hu ua In Vitro Fertilization (IVF) los hloov cov qe menyuam noj qab haus huv mus rau hauv tus poj niam lub cev xeeb tub. Nrog rau txoj kev kho mob no, koj tus menyuam yuav tsis tau txais kev hloov pauv ntawm cov noob caj noob ces uas ua rau muaj kab mob.

Yuav ua li cas rau ib tus neeg uas muaj Tumoral Calcinosis?

Feem ntau cov neeg uas muaj mob qog nqaij hlav (tumoral calcinosis) ua neej nyob puv npo thiab nquag ua ub ua no . Tus mob no tsis tshua ua rau muaj teeb meem kev noj qab haus huv loj. Txawm li cas los xij, koj yuav tsum mus ntsib koj tus kws kho mob tsis tu ncua kom paub seb puas rov qab muaj mob dua.

Kuv yuav tsum mus ntsib kws kho mob thaum twg?

Mus ntsib kws kho mob yog tias koj muaj cov tsos mob no:

• Txo qhov kev txav mus los hauv ib qho pob qij txha.
• Mob pob qij txha, mob pob txha, lossis mob nqaij.
• Qhov tsos ntawm ib lub qog lossis ib lub pob hauv qab daim tawv nqaij.

Kuv yuav tsum nug kuv tus kws kho mob li cas?

Koj tuaj yeem nug cov lus nug ntawm tus kws kho mob zoo li no:

• Vim li cas kuv thiaj li muaj mob qog nqaij hlav calcinosis?
• Kev kho mob zoo tshaj plaws rau kuv yog dab tsi?
• Kuv puas yuav tsum tau phais?
• Kuv yuav tsum txo cov khoom noj dab tsi?
• Kuv puas yuav tsum txhawj xeeb txog cov teeb meem?
• Puas yuav tsum kuaj xyuas kuv tsev neeg cov noob caj noob ces tas?

Puas yog Tumoral Calcinosis yog Cancer?

Txawm hais tias muaj lo lus "tumoral" nyob rau hauv lub npe, cov qog nqaij hlav uas tshwm sim los ntawm tumoral calcinosis tsis yog mob qog noj ntshav tiag tiag . Tsis muaj kev pheej hmoo ntawm cov qog nqaij hlav no ua rau mob qog noj ntshav. Yog li ntawd, tsis txhob txhawj txog nws.

Muaj tseeb tiag, cov qog nqaij hlav hauv qab daim tawv nqaij vim yog tumoral calcinosis tuaj yeem ua rau tsis xis nyob thiab ntshai me ntsis. Tab sis rau feem ntau ntawm cov neeg, cov qog nqaij hlav no tsis ua rau muaj teeb meem loj. Cov tshuaj tuaj yeem txo cov phosphorus hauv cov ntshav. Koj tus kws kho mob kuj tseem yuav pom zoo kom koj mus ntsib kws noj haus kom pab koj noj cov zaub mov uas muaj phosphorus tsawg. Yog tias koj muaj mob hauv koj cov pob qij txha, pob txha, lossis cov leeg uas txwv koj txoj kev txav mus los, qhia rau koj tus kws kho mob. Txawm hais tias cov qog nqaij hlav tuaj yeem raug tshem tawm nrog kev phais, nco ntsoov tias lawv tuaj yeem rov qab los.

Cov Lus Qhia Txog Kev Nqa Mus Tsev (Yam Yuav Tsum Nco Ntsoov)

Zoo, yog li cia peb rov hais dua cov ntsiab lus tseem ceeb tshaj plaws uas peb tau tham hnub no txog Tumoral Calcinosis:

• Qhov no yog ib qho mob uas tsis tshua muaj, uas yog los ntawm noob caj ces. Yog tias cov phosphate ntau ntxiv hauv cov ntshav ua rau lawv sib xyaw nrog calcium los ua cov pob ze ntawm cov pob qij txha.
• Cov qog no tsis yog mob qog noj ntshav .
• Cov no feem ntau tsis mob, tab sis tuaj yeem cuam tshuam rau kev txav mus los ntawm cov pob qij txha.
• Kev kho mob suav nrog cov tshuaj txo cov phosphate, kev noj zaub mov uas muaj phosphorus tsawg, thiab, yog tias tsim nyog, phais mob.
• Yog koj pom ib lub pob zoo li no, tsis txhob ntshai thiab nrhiav kev pab kho mob. Kev kuaj mob kom raug yog qhov tseem ceeb heev.
• Muaj ntau tus neeg nyob lub neej ib txwm muaj, ua neej nquag nrog tus mob no.

Yog li ntawd, yog tias koj lossis ib tus neeg koj paub muaj cov tsos mob no, nws yog qhov zoo tshaj plaws mus ntsib kws kho mob kom tau txais kev qhia.

Cov qog nqaij hlav calcinosis, cov pob qij txha cysts, phosphate, calcium, cov kab mob caj ces, cov pob tawv nqaij, cov kab mob pob txha