Wetin na Aldosterone? Lɛ wi no aw i kin afɛkt yu blɔd prɛshɔn!

Yu dɔn ɛva yɛri bɔt Aldosterone? Sɔntɛm yu dɔktɔ dɔn tɔk bɔt am, ɔ sɔntɛm yu dɔn yɛri di nem we yu de tɔk bɔt yu blɔd prɛshɔn. Na tru tru wan smɔl bɔt rili impɔtant ɔmon na wi bɔdi. I de ɛp fɔ mek di sɔdiɔm ɛn potashɔm we de na wi bɔdi fayn ɛn i de mek wi blɔd prɛshɔn nɔ de chenj. So, mek wi tok abaut Aldosterone tide fo simpul we we yu go andastan, okay?

Wetin na aldosterone? Usay i kɔmɔt?

Fɔ tɔk am simpul wan, Aldosterone na ɔmon we yu adrenal gland dɛn de mek . Yu no wetin na dɛn adrenal gland ya? Dɛn na tu smɔl smɔl gland dɛn we tan lɛk triangul ɛn we tan lɛk smɔl hat dɛn we de ɔp yu kidni dɛn. Dɛn na pat pan wi ɛndokrin sistɛm . Dɛn gland ya kin mek bɔku ɔmon dɛn we impɔtant to wi bɔdi.

Ɔmon dɛn tan lɛk kemikal mɛsenja dɛn we de kɔdinɛt di wok we wi bɔdi de du. Dɛn kin travul tru di blɔd ɛn tɛl di ɔgan dɛn, di mɔsul dɛn, ɛn ɔda tisu dɛn wetin fɔ du ɛn ustɛm fɔ du am.

Naw, dis ɔmon , Aldosterone, de manej di lɛvɛl dɛn we sɔdiɔm ɛn potashɔm de na yu blɔd. Dɛn kɔl dɛn sɔdiɔm ɛn potashɔm ya ilɛktrɔlayt . Dɛn tin ya de ɛp fɔ mek di wata we de na di bɔdi balans ɛn ɛp di nerv ɛn mɔsul dɛn fɔ wok fayn fayn wan. כlso, Aldosterone de kכntro di כmכnt כf wata we di kidni dεm de tek bak. Dis kin mek di blɔd bɔku ɛn i kin afɛkt di blɔd prɛshɔn.

So, ilɛksɛf yu aldosterone lɛvɛl smɔl ɔ ay, i kin afɛkt yu wɛlbɔdi.

Us savis aldosterone de gi wi bɔdi?

Di men wok we aldosterone de du na fɔ ɛp fɔ mek yu blɔd prɛshɔn fayn. I de ɛp fɔ du dis impɔtant wok pan bɔku we dɛn:

• Aldosterone de signal ɔgan dɛm lɛk yu kidni ɛn kɔlon fɔ mek di sodium we dɛn ad to yu blɔd go ɔp ɔ fɔ mek di potashɔm we de kɔmɔt na yu urine go ɔp.
• We di sodium lɛvɛl go ɔp dis we, di bɔdi kin bigin fɔ kip wata, we kin mek di blɔd bɔku.

Ɔl dis impɔtant, we blɔd prɛshɔn smɔl, fɔ mek i kam bak to wɛlbɔdi lɛvɛl.

indaykt wan, aldosterone de εp bak fכ mεnten di pH (i.e. asid-bεys bεlε) εn εlektrolayt lεvεl dεm na yu bכdi.

Aw dɛn kin kɔntrol di aldosterone lɛvɛl? Lɛ wi tek tɛm luk am gud gud wan!

Aldosterone na pat pan wan kɔmpleks nɛtwɔk we gɛt ɔmon, ɛnzaym, protin, ɛn riakshɔn we dɛn kɔl Renin-Angiotensin-Aldosterone System (RAAS) . Na in mɔ de kɔntrol blɔd prɛshɔn.

Tink bɔt dis as stɛp bay stɛp:

1. Fɔs, we yu blɔd prɛshɔn go dɔŋ , wan ɛnzaym we dɛn kɔl renin kin kɔmɔt na yu blɔd frɔm yu kidni.

2. Dis renin de go ɛn brok wan prɔtin we dɛn kɔl angiotensinogen , we dɛn mek na yu liva. wan pan di pies dεm na angiotensin I. Dis nכ de aktif da tεm de, we min se i nכ de gεt bכku ifekt.

3. afta dat, di Angiotensin-Converting Enzyme (ACE) we de kכmכt na yu lכng de kam insay εn brok dis Angiotensin I insay mכr pat dεm. Wan pan dɛn pat dɛn de na di aktif ɔmon we dɛn kɔl Angiotensin II .

4. Dis na di say we Angiotensin II de du di impɔtant wok:

• Wan na fɔ mek di blɔd prɛshɔn go ɔp bay we i de mek di mɔsul wɔl dɛn na di smɔl smɔl blɔd vesel dɛn (arterioles) kɔntrakt.
• di כda wan na dat i de "signal" yu adrenal gland dεm fכ rilis aldosterone.
• I kin tɛl yu bak se yu pituitary gland fɔ pul Antidiuretic Hormone (ADH) , we dɛn kin kɔl bak Vasopressin .

5. So, Aldosterone εn ADH de wok togeda fכ tεl di kidni dεm fכ kip sכdiכm na di bכdi. Aldosterone de mek di kidni dεm kכl potashכm insay di urine. We di sɔdiɔm we de na di blɔd go ɔp, wata de kɔntinyu fɔ de na di bɔdi. Dis kin mek di blɔd bɔku ɛn di blɔd prɛshɔn go ɔp.

dis na aw di Renin-Angiotensin-Aldosterone System de komplit. Yu ɔndastand da prɔses de?

Dis sistεm kin wok bak bay כda כmon dεm lεk kכ tikostεroyd , εstrojen, εn tayroyd כmon dεm .

If prɔblɛm de wit ɛni pat pan dis sistɛm, i kin afɛkt yu blɔd prɛshɔn ɛn sɔdiɔm ɛn potashɔm lɛvɛl. Bɔt i impɔtant fɔ mɛmba se bɔku ɔda tin dɛn kin afɛkt yu blɔd prɛshɔn, lɛk ay kɔlɔstrel, jɛnɛtiks, ɛn sɔm mɛrɛsin dɛn.

Aw fɔ chɛk di aldosterone lɛvɛl?

Di men tɛst we dɔktɔ dɛn kin yuz fɔ chɛk fɔ gɛt prɔblɛm dɛn we gɛt fɔ du wit aldosterone na di Aldosterone: Renin Ratio Test . Bikɔs di renin ɛn aldosterone gɛt tayt padi biznɛs, dis tɛst kin no if di prɔblɛm na jɔs prɔblɛm wit di aldosterone prodakshɔn ɛn wok, ɔ if prɔblɛm de wit di renin-angiotensin sistɛm insɛf.

Fɔ dis Aldosterone: Renin Ratio Test, dɛn kin tek blɔd sɛmpul frɔm wan vein na yu an.

Dɔktɔ dɛn kin mɛzhɔ bak jɔs di aldosterone we de na yu blɔd ɛn/ɔ yu urine.

Sɔntɛnde, yu dɔktɔ kin ɔda fɔ mek dɛn du tɛst fɔ put kateshɔn fɔ tek blɔd sɛmpul frɔm wan vein na yu kidni (fɔ renin) ɔ wan vein na yu adrenal gland (fɔ aldosterone). Dis na tɛst we dɛn kin du na ɔspitul bay wan spɛshal trenin we de mɛn raydiɔlɔjis.

Wetin na di nɔmal lɛvɛl dɛn fɔ aldosterone?

di nכmal valyu dεm fכ di aldosterone lεvεl kin difrεn sכmtεm frכm wan labכtכri to כda wan. So, mek shɔ se yu chɛk di nɔmal rɛnj na yu lab ripɔt, ɔ aks yu dɔktɔ if yu gɛt ɛni kwɛstyɔn bɔt yu rizɔlt.

di nכmal rεnj fכ di aldosterone lεvεl dεm na di bכdi de difrεn wit di ej. in jεnarכl, di nכmal lεvεl dεm na dεn wan ya:

• fכ bεlε pikin dεm we ol 1 to 12 mכnt: 5.8 – 110.0 nanogram pan wan dεsilita (ng/dL) .
• Fɔ pikin dɛn we ol 1 to 5 ia: < 36.0 ng/dL
• Fɔ pikin dɛn we ol 6 to 9 ia: < 24.0 ng/dL
• Fɔ pikin dɛn we ol 10 to 11 ia: < 15.0 ng/dL
• Fɔ pikin dɛn we ol 12 to 14 ia: < 22.0 ng/dL
• Fɔ yɔŋ pipul dɛn we ol 15 to 17 ia: 3.0 – 32.0 ng/dL
• Adult dεm we ol 18 to 99 ia: 3.1 – 35.4 ng/dL

we yu luk di aldosterone lεvεl dεm insay 24 awa urine tεst, di nכmal rεnj de bitwin 3 – 25 maykrogram pan 24 awa (3 – 25 mcg/24 awa).

Wetin kin apin if di aldosterone lɛvɛl go ɔp?

we di aldosterone lεvεl hכy pas nכmal, wi kin kכl am hyperaldosteronism .

Di men tin we kin mek dis apin na Primary Aldosteronism , we dɛn kin kɔl bak Conn’s syndrome . Dis kכndyushכn de kכz fכ wan tכmכro we nכ de kεnsar ( benign) we kin kכmכt na wan pan yu adrenal gland dεm.dis kin mek di gland de mek mכr aldosterone pas aw i fכ mek. we di aldosterone lεvεl inkrεs, di sכdiכm lεvεl de inkrεs ( hypernatremia ) εn di potashכm lεvεl de dכn ( hypokalemia ). Dis kin mek di ilɛktrɔlayt nɔ balans.

Di sayn dɛn we de sho se pɔsin gɛt bɔku aldosterone

insay di kes fכ praymar aldosteronism, dat na we di aldosterone lεvεl dεm de εlevεt, di simptom dεm lεk:

• Ay blɔd prɛshɔn (Hypertension) .
• Ed de at
• Di mɔsul dɛn wik , mɔ if di potashɔm lɛvɛl rili smɔl
• Fɔ tɔsti pasmak ɛn fɔ pis bɔku tɛm

If yu gɛt dɛn sik ya, i rili impɔtant fɔ go to dɔktɔ wantɛm wantɛm.

Wetin kin apin if di aldosterone lɛvɛl go dɔŋ?

we di aldosterone lεvεl dεm dכn lכs pas nכmal, wi kin kכl am haypoaldosteronism . Dis na we pɔsin nɔ gɛt aldosterone, ɔ i nɔ de wok fayn. we di aldosterone lεvεl dכn lכw, di sכdiכm lεvεl de dכn ( hyponatremia ), di potashכm lεvεl de inkrεs ( hyperkalemia ), εn di bכdi de prodyuz tu mכch asid ( mεtabolik acidosis ).

Bɔku tin dɛn de we kin mek pɔsin gɛt haypoaldosteronism:

• Di sik we dɛn kɔl Addison: Dis na sik we nɔ kin apin so ɔltɛm. Dɛn kin kɔl am bak Primary Adrenal Insufficiency . Na sik we pɔsin kin gɛt we i de fɛt insɛf . dis min se yu yon imyun sistεm de atak di כta pat (kכtεks) na di adrenal gland dεm. Dɛn ɔl tu di ɔmon dɛn we dɛn kɔl aldosterone ɛn cortisol de kɔmɔt de. dis kin mek di lεvεl fכ di tu כmon dεm dכn dכn.
• Congenital Adrenal Hyperplasia (CAH): Dis na wan grup we gɛt sik dɛn we de ambɔg di adrenal gland dɛn. Pipul dεm we gεt CAH dεn bכn wit dεfichεshכn pan sכm εnzym dεm we dεn nid fכ mek כmon dεm we di adrenal gland dεm de prodyuz.
• Sɔm wɛlbɔdi prɔblɛm dɛn: Pipul dɛn we gɛt dayabitis, kidni sik, lid pɔyzin, ɔ siriɔs mɛrɛsin kin gɛt hypoaldosteronism.
• Sɔm mɛrɛsin dɛn: Nɔn-stɛroyd anti-inflammatory drɔgs (NSAID) , ƐparinDis sik kin kam bak bikɔs ɔf mɛrɛsin wae dɛn kin gi fɔ trit at sik.

Di sayn dɛn we de sho se di aldosterone nɔ bɔku

in jεnarכl, di lכw aldostεron lεvεl (Hypoaldosteronism) kin mek yu gεt simptom dεm lεk:

• Lɔw blɔd prɛshɔn (Hypotension) .
• Di mɔsul dɛn we wik
• Vɔmit
• Di at we de blo
• Di at bit we nɔ de bit ɔltɛm (Aritmia) .

Dipen pan de kɔz fɔ yu hypoaldosteronism, yu kin gɛt ɔda sayn dɛm. Fɔ ɛgzampul, insay di sik we dɛn kɔl Addison, we di kɔtisol nɔ bɔku, dat kin mek di skin chenj (lɛk di say dɛn we dak ɛn di say dɛn we di skin kin fold) ɛn di shuga we de na di blɔd nɔ kin bɔku ( hypoglycemia ).

If yu gɛt ɛni wan pan dɛn sayn ya, go to yu dɔktɔ wantɛm wantɛm.

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

Aldosterone na ɔmon we impɔtant fɔ kɔntrol blɔd prɛshɔn. If yu gɛt prɔblɛm fɔ mek yu gɛt wɛlbɔdi blɔd prɛshɔn ɛn yu gɛt chenj dɛn bak na yu blɔd potashɔm lɛvɛl, i fayn fɔ tɔk to yu dɔktɔ bɔt ɔda we dɛn fɔ kɔntrol blɔd prɛshɔn ɛn ɔda tɛst dɛn. Dɔn i kin ɔda fɔ mek dɛn du tɛst fɔ si if yu simptom dɛn na bikɔs ɔf di abnɔmal aldosterone lɛvɛl.

A op se dis infɔmeshɔn go yusful to yu! Stay wit wɛlbɔdi!

` Aldosterone, Aldosterone, Hɔmɔn, Blɔd Prɛshɔn, Adrenal Gland dɛn, Sɔdiɔm, Potashɔm