Yu dɔn yɛri bɔt dis siriɔs blɔd kansa? (Acute Promyelocytic Leukemia - APL) Lɛ wi tɔk ditayli!

Yu dɔn ɛva fil taya bad bad wan wantɛm wantɛm, yu gɛt sɔm brus dɛn, ɔ yu gɛt blɔd we de kɔmɔt na yu gam ɔltɛm? Pan ɔl we wi nɔ kin pe atɛnshɔn tumɔs to dɛn tin ya, na smɔl tɛm dɛn kin bi sayn fɔ wan sik we rili siriɔs, lɛk Acute Promyelocytic Leukemia (APL) . So, nɔ wɔri, tide wi go tɔk bɔt dis blɔd kansa we dɛn kɔl APL insay klia ɛn simpul we.

Wetin na akyu promaylosaytik lukimiya (APL)?

Fɔ tɔk am simpul wan, APL na wan kayn blɔd kansa we nɔ kin bɔku . I rili de pan wan big grup we gɛt lukimiya we dɛn kɔl Acute Myeloid Leukemia . Di men ples we dɛn kin mek blɔd na wi bɔdi na di bon mɛro . na ya insay dis bon mכro, biכs fכ wan jεnεtik chenj, dat na, jεnεtik mכtεshכn , abnכmal wayt blכd sεl dεm de bigin fכ fכm. dis abnכmal sεl dεm de sheb εn bכku kwik kwik wan we dεn nכ de kכntrכl εn dεn de spre כlsay na di bon mכro. Sɔntɛnde, dɔktɔ dɛn kin kɔl dis APL lukimiya, ɔ M3-lukimiya .

APL na siriɔs kɔndishɔn. I kin kam wantɛm wantɛm ɛn wɔs kwik kwik wan. If yu blɔd bɔku pasmak na di men tin we kin mek yu gɛt dis sik. Bɔt gud nyus de! Wit nyu tritmɛnt dɛm, lɛk kemotɛrapi ɛn nyu mɛrɛsin dɛm we nɔto kemotɛrapi, dɔktɔ dɛn kin ebul fɔ kɔntrol APL ɛn bɔku tɛm dɛn kin mɛn am kpatakpata.

Aw dis sik kin bɔku?

APL na rili sik we nɔ kin bɔku . Fɔ ɛgzampul, na kɔntri lɛk Amɛrika, na lɛk 30,000 pipul dɛn nɔmɔ dɛn kin gɛt dis sik ɛvri ia. Bɔrku tɛm, dɛn kin no APL pan pipul dɛm wae dɔn pas 30 ia .

Wetin na di sayn dɛm fɔ APL?

APL simptom dɛn kin apin we yu bon mɛro nɔ ebul fɔ mek wɛlbɔdi rɛd blɔd sɛl , wayt blɔd sɛl, ɛn pletlɛt lɛk aw i nɔmal. dis rεdukshכn pan כl dεn kayn bכdi sεl dεm ya dεn kכl am pancytopenia . We dis kin apin, yu kin gɛt siriɔs sayn dɛn lɛk anemia , prɔblɛm wit blɔd bikɔs blɔd de klɔt , ɛn sik dɛn we yu kin gɛt ɔltɛm.

Ɔda kɔmɔn APL simptom dɛm na:

• fכ fil f כ taya pasmak εn taya biכs fכ di rεd bכdi sεl dεm we de dכn (i.e. anemia).
• Infεkshכn dεm we kin kam bכku tεm bikoz fכ di lכw wayt blכd sεl dεm we de fכt sik. Tin dɛm lɛk fiva ɛn kol kin apin ɔltɛm.
• Bikɔs di mɛtabolism na yu bɔdi de aksɛleret ɛn di ɛnaji we de kɔmɔt na it de bɔn kwik kwik wan, .We yu nɔ bin want fɔ lɔs yu wet.

Di sayn dɛn we de sho se pɔsin de blɔd

Pɔsin we gɛt APL gɛt smɔl nɔmba pan di pletlɛt ɛn tin dɛn we de mek di blɔd klɔt we de ɛp di blɔd fɔ klɔt. Yu no, na di pletlɛt dɛn de ɛp fɔ stɔp ɔ ridyus di blɔd. So, we dɛn tin ya smɔl, di prɔblɛm kin bigin.

Na sɔm sayn dɛm fɔ blɔd we APL kin mek:

• Blɔd kin apin ɛnisay na di bɔdi. Fɔ ɛgzampul, blɔd we de kɔmɔt na di gam , we de blɔd na dɛn nos ɔltɛm , ɛn pan uman dɛn, we dɛn de gɛt bɔku blɔd we dɛn de gɛt we dɛn de gɛt mɔnt .
• Blɔd kin gɛda ɔnda di skin ɛn mek pɔsin gɛt brus na difrɛn say dɛn na di bɔdi . Ivin we pɔsin kɔt smɔl, i kin mek i gɛt big brus.
• Sɔntɛnde , blɔd kin kɔmɔt insay di bren (intracranial hemorrhage) . If dis apin, yu kin gɛt prɔblɛm fɔ muv yu an ɛn fut, yu kin gɛt siriɔs ed pen, ɛn yu kin gɛt chenj na yu yay. Dis na imejensi!
• If yu stɔl blak ɔ gɛt blɔd strek, i kin bi bikɔs ɔf blɔd we de kɔmɔt na di dijestiv sistɛm (gaystrointestinal bleeding) .

Wetin kin mek pɔsin gɛt APL?

Dis sik kin kam bikɔs tu jin dɛn we de kɔntrol aw wi blɔd sɛl dɛn de mek we de kam togɛda fɔ mek wan jin we nɔ de wok we dɛn kɔl PML-RARa . Di impɔtant tin na dat, dis chenj we yu de chenj yu jɛnɛtiks nɔto sɔntin we yu gɛt frɔm yu mama ɛn papa . I kin apin randomly, min fɔ no rizin, insay yu layf. Masta sabi pipul dɛn stil nɔ no bɛtɛ bɛtɛ wan wetin kin mek dis chenj na di jɛnɛtiks.

dis mכtεshכn de mek di wayt blכd sεl dεm gro we dεn nכ de kכntrol, insted fכ divεlכp fayn, εn insted fכ fכm wayt blכd sεl dεm we nכ machכ (promyelocytes) . Dɛn sɛl dɛn ya we nɔ machɔ kin ful-ɔp di bon mɛro, ɛn dɛn kin krawd di ples fɔ gɛt wɛlbɔdi blɔd sɛl ɛn pletlɛt dɛn.

Wetin na di kɔmplikɛshɔn dɛm we APL kin gɛt?

APL na wan sik we de mek pɔsin in layf de pan denja. Dis na bikɔs di blɔd we de kɔmɔt pasmak we kin apin kin bi denja kwik kwik wan. If yu nɔ ebul fɔ stɔp fɔ blɔd we yu kɔt ivin smɔl, if yu gɛt bɔku blɔd na yu stɔl ɔ yu urine we yu de go tɔylɛt, ɔ if yu nɔ ebul fɔ stɔp fɔ blɔd na yu gam, yu fɔ go to dɔktɔ ɔ go na ɔspitul imejensi rum wantɛm wantɛm .

Mɛmba se: If yu gɛt blɔd we yu nɔ ebul fɔ kɔntrol, nɔ ɛva ignore am. Fɔ trit yu kwik kwik wan na di men tin.

Aw dɛn kin no se pɔsin gɛt APL?

Bɔku tɛm, dɔktɔ dɛn kin du bɔku tɛst fɔ no if yu gɛt dis sik.

• Kɔmplit Blɔd Kɔnt (CBC): APL de mek wayt blɔd sɛl dɛn we nɔ de wok fayn fɔ mek. CBC tɛst kin luk di difrɛn kayn blɔd sɛl dɛn ɛn di nɔmba fɔ di pletlɛt dɛn we de na wan sɛmpul na yu blɔd.
• Pɛriferal Blɔd Smia:Insay dis, dɛn kin tek blɔd sɛmpul ɛn chɛk am ɔnda maykroskɔp. Dɔn, dɛn kin luk if bɔku smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl. Dɛn tin ya na di kwaliti dɛn we APL gɛt.
• Bone Marrow Biopsy: Insay dis tɛst, dɛn kin tek smɔl sampul pan yu bon marrow ɛn chɛk in sɛl dɛn.
• Flow Cytometry: insay dis tεst, di patכlayz dεm de luk fכ patεn dεm fכ spεsifi k protin dεm na di sεf fכ di abnכmal sεl dεm. Dɛn patɛns ya kin kɔnfɔm APL.
• Polymerase Chain Reaction (PCR) test: dis tεst kin kכrekt fכ no if di abnכmal jin (PML-RARa) we de mek APL de.
• Saytojenεtiks: dis de tεst fכ spεshal chenj dεm na di kromozom dεm na di abnכmal sεl dεm. Fɔ fɛn dɛn chenj ya na di men we fɔ kɔnfɔm di diagnosis fɔ APL.

Dɔktɔ dɛn kin klas APL as lɔw risk ɔ ay risk bay yu wayt blɔd sɛl kɔnt. Pipul wae gɛt APL wae gɛt ay risk kin gɛt kansa bak ɔr kin gɛt am bak .

Aw dɛn kin trit APL?

Dɛn kin trit APL wit wan kɔmbaynshɔn fɔ sɛl difrɛns ɛjɛn , kemotɛrapi, ɛn targeted tɛrapi . Infakt, frɔm we dɛn dɔn fɛn dɛn tritmɛnt ya insay di 1980 dɛm, dis sik we dɛn bin de tink se go kil pɔsin, dɔn bi sik naw we pɔsin kin mɛn. Dis na big big tin we dɛn dɔn du!

difrεns sεl dεm na dεn nכn-kεmothεrapi dεm we de εp di abnכmal, immature wayt bכdi sεl dεm fכ difrεnt to nכmal, machכ wayt blכd sεl dεm. Dɛn drɔgs ya we nɔto kimotɛrapi, we dɛn rayt dɔŋ ya, dɔn mek dɛn gɛt mɔ pas 95% rɛmishɔn ɛn kɔrej rɛt.

• כl-trans-rεtinoik asid (ATRA) , כ tretinoin (Vesanoid ®) – Dis na wan fכm fכ vaytam in A.
• Arsenic trioxide (ATO) – Dis na wan kayn asɛnik.

If yu dɔktɔ sɔspɛkt se yu gɛt APL, dɛn kin stat yu pan ATRA ivin bifo ɔda tɛst dɛn kɔnfyus di sik. Dis na bikɔs if yu bigin tritmɛnt kwik, dat kin mek yu nɔ gɛt blɔd we go mek yu day.

Stej dɛm fɔ APL tritmɛnt

Dɛn kin du di tritmɛnt insay tri pat: Induction, Consolidation, ɛn Maintenance. Di tritmɛnt kin difrɛn difrɛn wan dipen pan di lɛvɛl we di risk de.

• Di fɔs stej (Indukshɔn): .di men gol fכ dis fכs na fכ kil inof lukimiya sεl dεm fכ put yu APL insay rεmishכn . Rimishɔn min se yu nɔ gɛt ɛni sayn ɛn yu nɔ go ebul fɔ fɛn ɛni sayn fɔ lukimiya pan tɛst. Dɛn kin du dis bay we dɛn de yuz mɛrɛsin dɛn we nɔto kemotɛrapi, kemotɛrapi, ɛn tritmɛnt dɛn we dɛn kin yuz fɔ mɛn pipul dɛn. Insay dis tɛm, yu go nid fɔ de na ɔspitul, bɔku tɛm fɔ 4 to 6 wiks.
• Kɔnsolidɛshɔn faz: Yu ɔnkɔlɔjis kin kɔl dis bak ‘pɔst-rɛmishɔn tɛrapi’. Dis tritmɛnt de kip di APL insay rɛmishɔn ɛn kɔntinyu fɔ kil ɛni lukimiya sɛl we lɛf. Dis na di sem mɛrɛsin we dɛn bin de yuz di fɔs tɛm. Dis tritmɛnt kin las fɔ lɛk et mɔnt, ɛn dɛn kin trit am ɛvri tu mɔnt. Yu kin gɛt 4 wik tritmɛnt ɛn afta dat yu kin gɛt 4 wik ɔf. Dɛn kin gi dis mɛrɛsin as pil ɔ as tritmɛnt we dɛn kin put insay di bɛlɛ (IV) .
• Mentɛnans faz: Dis na tritmɛnt we de kɔntinyu, bɔt dɛn kin gi di mɛrɛsin pan smɔl doz pas di fɔs ɛn stebilizayshɔn faz. Dɛn kin gi dis mentenɛns tritmɛnt fɔ lɛk wan ia so.

Yu dɔktɔ we de mɛn yu kansa kin gi yu sɔpɔt tritmɛnt bak , lɛk fɔ gi yu blɔd, wit dis tritmɛnt.

Di prɔblɛm dɛn we kin apin we pɔsin de trit am

Di prɔblɛm we kin apin pas ɔl, ɛn we kin rili siriɔs, na in dɛn kɔl difrɛns sindrom . Dis na grup we gɛt siriɔs riakshɔn to APL mɛrɛsin. Dɛn riakshɔn ya kin apin insay di fɔs tri wiks we dɛn bigin fɔ trit am. Di sayn dɛm kin bi smɔl ɔr kin tranga. Sɔm pan dɛn na:

• Kɔf.
• Ekstra wata we de rawnd yu at ɛn yu lɔng (pleural effusion) .
• Renal we nɔ de wok fayn .
• Lɔw blɔd prɛshɔn (haypɔtɛnshɔn) .
• Di ɔksijɛn we de na di blɔd we de go dɔŋ (hypoxemia) .
• I nɔ izi fɔ blo (dyspnea) .
• Swɛlin/ inflamɛns na yu an, yu leg, ɛn nɛk.
• Fiva we kin kam witout rizin.
• We yu de gɛt mɔ wet fɔ natin.

If yu gɛt dis difrɛns, yu dɔktɔ kin stɔp yu tritmɛnt fɔ sɔm tɛm. Dɛn kin yuz ɔda mɛrɛsin dɛn bak lɛk haydroksiyuria fɔ mek yu wayt blɔd sɛl nɔ bɔku.

Wetin pɔsin we gɛt APL kin ɛkspɛkt?

Jɛnɛral wan, di prɔgnosis fɔ di sik kin fayn.. Pan ɔl we ɔlman in sityueshɔn difrɛn, stɔdi dɔn sho se bitwin 90% ɛn 95% pan pipul dɛm wae gɛt APL kin go na rɛmishɔn. Bɔt, APL kin kam bak afta dɛn dɔn trit am. Bitwin 5% ɛn 10% pan pipul dɛm go gɛt di sik bak, bɔku tɛm insay di fɔs tri ia afta dɛn dɔn trit am. Dɔn dɛn go nid ɔda tritmɛnt ɔ difrɛn tritmɛnt.

Di nɔmba fɔ pipul dɛn we nɔ day

Bikɔs APL na sik we nɔ kin bɔku, wetin wi no bɔt di rit we pipul dɛn kin liv kin kɔmɔt frɔm klinik trial dɛn we gɛt fɔ du wit APL pasɛnt dɛn we nɔ gɛt bɔku prɔblɛm ɛn we gɛt bɔku prɔblɛm.

Wan analisis sho se 99% pan di lɔw risk APL pasɛnt dɛn de alayv 4 ia afta dɛn dɔn trit dɛn. Wan ɔda analisis fɔ di APL pasɛnt dɛn we gɛt ay risk sho se 86% de alayv fayv ia afta dɛn dɔn trit dɛn. Dis na rili fayn tin dɛn we kin apin!

Aw a kin kia fɔ misɛf?

Bikɔs APL kin kam bak, i rili impɔtant fɔ mek yu si yu dɔktɔ di rayt tɛm (fɔl-ɔp apɔntinmɛnt) .

Yu go gɛt mɛdikal chɛk-ap ɛvri mɔnt ɔ tu mɔnt fɔ di fɔs ia afta yu dɔn gɛt tritmɛnt. Afta di fɔs ia, yu go nid fɔ go to yu dɔktɔ lɛk ɛvri tri to 4 mɔnt fɔ di nɛks tu ia. dεn kin du tεst dεm lεk CBC, PCR, εn bon mכro bayopsi na dεn visit dεm ya.

Ustɛm a fɔ go na di imejensi rum?

APL kin kam bak afta dɛn dɔn trit am, ɛn di sik kin wɔs kwik kwik wan. If yu de na rɛmishɔn frɔm APL, go na di imejensi rum wantɛm if yu gɛt ɛni wan pan dɛn tin ya:

• If yu de blɔd we yu nɔ ebul fɔ kɔntrol .
• If yu bigin fɔ swel wantɛm wantɛm wit pen na yu leg ɔ yu bɛlɛ we de dɔŋ .

Fɔ dɔn, wan impɔtant mɛsej

Acute promyelocytic leukemia (APL) na wan blɔd kansa we nɔ kin bɔku ɛn we dɛn bin de tek as sik we kin kil pɔsin, bɔt naw i dɔn bi sik we pɔsin kin mɛn bikɔs ɔf di advans tritmɛnt dɛn.

Bɔt dis stil na siriɔs sik. If dɛn nɔ no di sik ɛn trit am kwik, i kin mek pɔsin in layf de pan denja . So, if yu gɛt sɔm sayn dɛn lɛk fɔ blɔd we yu nɔ ebul fɔ kɔntrol, nɔ ɛva ignore am. Di tin we impɔtant pas ɔl na fɔ go to dɔktɔ ɛn gɛt diagnosis kwik kwik wan. Nɔ fred, gɛt maynd, bikɔs naw gud tritmɛnt dɛn de fɔ dis!

` Lukimiya, APL, Blɔd Kansa, Blɔd Kansa, Bɔn Mɛro, Anemia, ATRA, Kimotɛrapi, Akyu Promyelocytic Lukiemia, M3-Lukemia, PML-RARa, Blɔd