Yu tink se di prɔtin dɛn we de na di bɔdi dɔn rɔtin? Wi de tɔk bɔt dis amyloidosis!

Yu de fil bak se yu taya, yu taya, ɛn sɔntɛm yu de lɔs yu wet we yu nɔ go ebul fɔ imajin dis tɛm ya? Sɔntɛnde, smɔl chenj dɛn na wi bɔdi kin mek wi gɛt big big tin dɛn. Tide wi go tɔk bɔt wan sik we kin apin we wan kayn prɔtin na wi bɔdi kray smɔl, nɔ shep fayn, ɛn go de na wi impɔtant ɔgan dɛn. Dis na wetin wi kɔl amyloidosis . Nɔ wɔri, wi go tɔk bɔt dis simpul wan ɛn di we we yu go ɔndastand.

Wetin rili na amyloidosis?

Fɔ tɔk am simpul wan, amyloidosis na wan sik we di amyloid protin dɛm (we na rili abnɔmal protin dɛm) na wi bɔdi misfold, klɔmp togɛda, ɛn mek smɔl smɔl grup dɛm, lɛk fayv dɛm we dɛn kɔl fibril, we de put insay impɔtant ɔgan dɛm lɛk wi at, kidni, ɛn liva. We dɛn du dat, ɛn if dɛn nɔ trit dɛn, dɛn abnɔmal prɔtin fibril ya kin mek wi ɔgan dɛn pwɛl bad bad wan.

Sɔntɛnde, dɛn abnɔmal prɔtin ya kin gɛda na jɔs smɔl say na wan ɔgan. Dɛn kɔl dis lokaliz amyloidosis . Bɔku tɛm dis kin afɛkt wi skin, wan smɔl pat pan di blad, ɔ di say we wi de blo. Bɔt bɔku tɛm dɛn fibril ya kin de na wan ol ɔgan ɔ na difrɛn ɔgan dɛn ɔlsay na di bɔdi. Dɛn kɔl dis sistɛm amyloidosis .

Gud nyus de. Dɔktɔ dɛn kin stɔp di protin dɛn we nɔ de wok we kin mek pɔsin gɛt amyloidosis. insay sכm kayn amyloidosis, wi כwn imyun sistεm kin εp fכ klin dεn protin dεm ya. Dis kin ridyus yu sayn dɛm ɛn ɛp fɔ mek di ɔgan dɛm we gɛt di sik gɛt wɛlbɔdi.

Yu tink se kayn amyloidosis de?

Yɛs, dɔktɔ dɛn kin klas dis sik bay di kayn prɔtin we i gɛt. Di men kayn dɛn we dɛn kin si na:

• AL amyloidosis : Dis na we yu bכdi de mek abnכmal amoun fכ layt chen protin dεm (we na wan mכtalman pat pan di antibodi dεm). dis fibril dεm kin bכku na di at (cardiac amyloidosis) εn di kidni dεm. AL amyloidosis kin afekt yu nerv dεm, skin, εn digεstiv כgan dεm bak. Dis na di kayn amyloidosis we kכmכn pas כl.
• AA amyloidosis : insay dis, di fragmεnt dεm fכ di sεrum A protin de bil insay yu כgan dεm. Dis kin apin if yu gɛt wan sik we de mek yu bɔdi wam fɔ lɔng tɛm, we min se yu gɛt sik we de mek yu bɔdi wam (fɔ ɛgzampul, rεumatoid at, inflammatory bowel disease, ɔr yu gɛt infεkshɔn fɔ lɔng tɛm). Dis kin afɛkt yu kidni, di ɔgan dɛn we de digest, ɔ yu at.
• ATTR amyloidosis: pan dis kכndyushכn, yu liva de mek wan abnכmal amoun fכ di transtayretin protin . dis abnכmal transtayretin protin de gεt dεposit na di at εn sכmtεm na di nεv dεm. sכm tכp dεm kin kכmכt (familial amyloidosis), we כda wan dεm de divεlכp leta in layf as pכsin de ol (wild-type ATTR).

Aw dis sik kin bɔku?

Amyloidosis na rili wan sik we nɔ kin bɔku . Fɔ ɛgzampul, ivin na Amɛrika, dɔktɔ dɛn se na 1,275 to 3,200 nyu pipul dɛn nɔmɔ kin gɛt AL amyloidosis ɛvri ia. So, i nɔto kɔmɔn sik.

Wetin na di sayn dɛm fɔ dis sik?

di simptom dεm fכ amyloidosis kin difrεn frכm pכsin to pכsin, i dipכnt pan di kayn abnכmal protin εn usay di fibril dεm de dכn.

imajin, if dεn protin dεm ya dכn dכn na di at (`(cardiac amyloidosis)`), den di simptom dεm we de apin na wik , i at fכ brith, fεn (dis kin bi sayn fכ abnכmal at ritm) כ at fεil wit swεla na di leg dεm.

כlso, if dεn protin dεm ya de na di kidni dεm (rεnal amyloidosis), simptom dεm lεk f כ swel na di fut εn di lεg dεm εn fכ si bכbul dεm na di urine kin apin.

difrεn kכmכn simptom dεm de we yu kin si pan amyloidosis:

• Fɔ fil taya we yu nɔ go ebul fɔ imajin.
• We yu de lɔs yu wet we yu nɔ gɛt rizin.
• Jɛnɛral wik ɔ swɛt na di an ɛn fut, nɔ ebul fɔ ol sɔntin fayn fayn wan.
• Fɔ fil se yu an nɔ de fil fayn.
• di skin de chenj: Dis min tin dεm lεk di skin de brus izi wan εn pepul spat dεm (purpura) rawnd di yay.

Wetin mek dis amyloidosis kin apin?

amyloidosis kin apin we di protin dεm na wi bכdi kin misfold εn stika. Dɛn kin gɛda togɛda, kin mek grup ɔ fibril, ɛn dɛn kin put dɛn na ɔgan ɛn tisu dɛn. Dɔktɔ dɛn kɔl dis "protein misfolding disorder." di protin dεm we fכ de in כda, insay lכng chen, kin tכn εn di bכdi nכ kin ebul fכ brok dכn fayn fayn wan, we kin mek prכblεm.

Tin dɛm wae kin mek dis sik na:

• jin chenj (mכtεshכn) : Yu kin gεt jin chenj (mכtεshכn) we de mek abnכmal amyloid protin dεm. Ɔ, dɛn jin muteshon ya kin apin insay pɔsin in layf, fɔ rizin dɛn we wi nɔ no.
• Ɔda ɔndalayn mɛdikal kɔndishɔn dɛn: Sɔntɛnde, amyloidosis kin kam bikɔs ɔf wan sɛpret mɛdikal kɔndishɔn. Dis na wetin kin apin na AA amyloidosis. Dis kin mɔs bi pan pipul dɛm wae gɛt lɔng tɛm infɛkshɔn ɔr wae gɛt krɛse sik lɛk rεumatoid at.

Udat dɛn kin gɛt dis sik mɔ? (Di tin dɛn we kin mek pɔsin gɛt prɔblɛm)

difrεn risk fכs dεm de we kin afekt di divεlכpmεnt fכ amyloidosis:

• Ej : Dɛn kin no dis sik mɔ pan pipul dɛm wae ol 60 ia ɔr pas dat .
• Jɛnda : Man dɛn kin gɛt dis sik mɔ.
• Ras : Dɛn dɔn si se blak pipul dɛn na Amɛrika kin gɛt di jɛnɛtik muteshon we de mek di hεriditri fכm fכ `ATTR amyloidosis`. (Na smɔl patikyula data de bɔt dis na wi kɔntri, bɔt dɛn kin se sɔm rays dɛn kin gɛt sɔm kayn pipul dɛn mɔ.)
• Ɔda mεdikal kכndyushכn dεm : We yu gεt krεse inflammatory kכndyushכn de inkrεs di risk fכ divεlכp AA amyloidosis. כlso, bitwin 12% εn 15% pan di pipul dεm we gεt mכltipכl mayloma, we na wan kayn bכdi kεnsar, kin gεt AL amyloidosis.
• Lɔng tɛm dayalaysis : Pipul dɛm wae gɛt krɛse sik wae dɔn de pan dayalaysis fɔ lɔng tɛm kin gɛt sɔm kayn amyloidosis bak.
• Amyloidosis in di famili : Sɔm kayn amyloidosis kin rɔn na famili. Dis min se dɛn kin gɛt dɛn frɔm dɛn prɔpati.

Us prɔblɛm dɛn dis kin mek?

dis amyloid dεposit dεm kin mek di כgan dεm we dεn afekt nכ fכ wok fayn fayn wan. Di prɔblɛm dɛn we kin apin na:

• Di at nɔ de wok fayn ɛn leta di at nɔ de wok fayn.
• Kidni sik ɛn leta di kidni nɔ wok .
• Nyuropathy (we kin mek yu nɔr de fil fayn ɛn wik).

Bɔt mɛmba se if yu go fɛn tritmɛnt wit di rayt mɛdikal tim, yu kin ridyus di chans fɔ gɛt dɛn prɔblɛm ya.

Aw dɛn kin no dis sik kɔrɛkt wan? (Diagnosis) .

Dɔktɔ dɛn kin du bayɔpsi fɔ no di prɔtin we de mek pɔsin gɛt amyloidosis. dis involv fכ tek sכm sכm tisu frכm di כgan we afekt כ frכm ples we dεn fibril ya kin gεt bכku tεm (fכ egzampl, na di fεt we de כnda di skin na yu bכdi כ na yu bon mכro).

Apat frɔm dat, ɔda tɛst dɛn de we yu kin du:

• Blɔd ɛn urine tɛst : Dɛn tɛst ya kin chɛk fɔ si if di prɔtin lɛvɛl nɔ de na yu blɔd ɔ yu urine. Dɛn kin yuz dɛn bak fɔ si aw di ɔgan dɛn we dɛn afɛkt de wok.
• Imej tɛst: Dɛn tɛst ya kin ɛp dɔktɔ dɛn fɔ si di damej we di ɔgan dɛn we gɛt di sik dɔn pwɛl. Dipen pan usay di fibril dɛn de, yu kin nid fɔ du ɛkokadiogram , we de luk di at, MRI , we de sho ditayli pikchɔ dɛn bɔt di ɔgan ɛn tisu dɛn, ɔ ɔda tɛst dɛn.
• Jɛnɛtik tɛst : If yu dɔktɔ sɔspɛkt se yu gɛt amyloidosis bikɔs ɔf wan jin muteshon, dɛn kin du dis tɛst.

Yu tink se stej dɛm de fɔ di sik?

Yɛs, dɔktɔ dɛn kin yuz amyloidosis stej fɔ no aw fa di sik dɔn skata ɛn aw i bad. Difrɛn stej sistɛm de fɔ difrɛn kayn sik. Fɔ stej di sik, yu dɔktɔ kin tink bɔt dɛn tin ya:

• Di kayn we aw di ɔgan dɛn kin pwɛl.
• di bכdi tεst dεm sho di כmכnt כf abnכmal protin we yu kכmpεr wit nכmal amyloid protin.
• Yu simptom dɛm ɛn aw dɛn kin tranga.

I rili impɔtant fɔ tɔk to yu dɔktɔ bɔt di stej we yu amyloidosis de ɛn aw i go afɛkt yu prɔgnosis.

Wetin na di tritmɛnt dɛn we dɛn kin gɛt?

Dɔktɔ dɛn kin manej amyloidosis bay we dɛn de trit di ɔndalayn kɔndishɔn. di tritmεnt kin slo di prכgreshכn fכ amyloidosis εn i kin mek nyu fibril dεm nכ fכm. Mɛrɛsin kin ɛp bak fɔ mek yu nɔ gɛt di sik. insay AL amyloidosis, we di tritmεnt stכp nyu amyloid dεposit fכ fכm, yu imyun sistεm kin klia di wan dεm we dεn dכn כlrεdi de. Risach stil de go bifo fɔ fɛn we fɔ mek di prɔses fɔ klia amyloid frɔm yu ɔgan dɛn bɛtɛ.

Sɔm pan di tritmɛnt dɛm fɔ amyloidosis na:

• Kεmothεrapi : Dis tritmεnt de pwεl di abnכmal plasma sεl dεm we de mek di fכlt layt chen protin dεm we de mek AL amyloidosis. Bɔku pipul dɛn kin tek wan stɛroyd wit di mɛrɛsin dɛn we dɛn kin yuz fɔ mɛn pipul dɛn.
• Targeted therapy : Dis tritmεnt de target spεshal protin dεm, jin dεm, כ tisu dεm we de mek amyloidosis. I gɛt fɔ du wit drɔgs dɛn we de mek di prɔtin dɛn nɔ fol di rɔŋ we.
• Ɔgan transplant : If di kidni, liva, ɔ at dɔn pwɛl te i nɔ ebul fɔ wok fayn igen, dɔktɔ dɛn kin se dɛn fɔ transplant am. Dis kin bi tritmεnt fכ di fכm dεm we dεn kin gεt fכ amyloidosis.

Wetin pɔrsin wae gɛt amyloidosis fɔ wɔri bɔt?

Yu dɔktɔ kin trit yu sayn dɛm, kɔntrol aw di sik de skata, ɛn sɔm tɛm, i kin ivin ɛp fɔ mek di sik nɔ kam bak. Bɔt sɔm kayn amyloidosis, if dɛn nɔ trit am, i kin mek di ɔgan dɛn pwɛl we go mek i day. Na dat mek i rili impɔtant fɔ no di sik kwik ɛn bigin fɔ trit am kwik.

Aw yu want fɔ kia fɔ yusɛf?

Bikɔs sɔm kayn amyloidosis de, nɔr wan saiz-fit-ɔl we de fɔ mɛn di sik. Aks yu dɔktɔ us step dɛn we fayn fɔ yu.

Dis kin inklud:

• Fɔ kia fɔ yu bɔdi bay we yu de it gud it dɛn we gɛt fayn fayn tin dɛn ɛn ɛksesaiz ɔltɛm .
• Yu fɔ put yu maynd wɛlbɔdi fɔs . Aks yu dɔktɔ bɔt sɔpɔt grup fɔ pipul dɛm wae gɛt amyloidosis. E kin bi fayn we fɔ bia wit de strɛs ɛn yu wan wae yu de liv wit dis kayn sik wae nɔr kin bɔrku, ɛn fɔ gɛt kɔnekshɔn wit ɔda pipul dɛm wae de go tru di sem tin lɛk yu.

Ustɛm yu fɔ go to dɔktɔ?

Bikɔs di sayn dɛn we pɔsin kin gɛt kin difrɛn so, i kin at fɔ no ustɛm fɔ go to dɔktɔ. Bɔt in jɔnal, if yu gɛt ɛni sayn we yu nɔ ɔndastand ɛn nɔ go afta sɔm tɛm, yu fɔ rili go to dɔktɔ. I nɔ kin bi amyloidosis, bɔt if na so, di kwik we yu no, na di mɔ i go fayn.

Us kwɛstyɔn dɛn yu fɔ aks di dɔktɔ?

Na sɔm kwɛstyɔn dɛn we yu kin aks yu dɔktɔ:

• Us kayn amyloidosis a gɛt?
• Wetin mek a bin gɛt amyloidosis?
• Us kayn tritmɛnt a nid?
• Wetin na di sayd ɛfɛkt dɛm we di tritmɛnt kin gɛt?
• Wetin na mi prɔgnosis afta tritmɛnt?

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

Amyloidosis na sik we rili tranga bikɔs i kin afɛkt ɔlman difrɛn we. Sɔntɛnde, dɛn kin ebul fɔ kɔntrol am. Ɔda tɛm dɛn, i kin mek pɔsin in layf de pan denja. Dis kin bi tin we kin mek pɔsin kɔnfyus ɛn we kin mek pɔsin tranga. Dɔn bak, bikɔs na sik we nɔ kin apin so ɔltɛm, yu kin fil se yu wangren de we yu nid ɛp mɔ.

Di tin we impɔtant pas ɔl na fɔ mɛmba se nɔto yu wangren de. Yu dɔktɔ kin ɛksplen di bɛst tritmɛnt fɔ yu, i go dipen pan di kayn amyloidosis we yu gɛt. Dɛn kin sho yu bak to tin dɛn ɛn sɔpɔt grup dɛn we go ɛp yu. Yu mɛdikal tim kin gayd yu fɔ fɛn di bɛst tritmɛnt ɛn sɔpɔt we yu nid fɔ fɛt dis sik.

` Amyloidosis, protin dεm, abnכmal protin dεm, כgan dεm we dεn dכn pwεl, at sik, kidni sik, nyurolכjik sik dεm