Yu mama, papa, ɔ pɔsin we yu sabi kin fɔgɛt mɔ ɛn mɔ? Fɔ fɔgɛt smɔl tin lɛk usai yu ki de ɔr pɔrsin in nem kin bi wan fɔs sayn fɔ Alzaima sik. Pan ɔl we dɛn nɔ stil gɛt mɛrɛsin fɔ dis siriɔs sik, di US FDA (Food and Drug Administration) dɔn gri fɔ mek wan nyu mɛrɛsin we go mek di sik nɔ go bifo kwik kwik wan. Dis na rili big op fɔ di wan dɛn we sik ɔlsay na di wɔl. So mek wi tok likl mo abaut dis nyu drug, Leqembi.
Wetin na dis nyu mɛrɛsin we dɛn kɔl Leqembi?
Di fɔs tin fɔ ɔndastand na dat dis nɔto mɛrɛsin fɔ Alzaima sik. Bɔt i kin ɛp. I kin mek di sik slo. Risach dɔn sho se i kin slo di sik fɔ go bifo bay lɛk 27% fɔ 18 mɔnt.
Naw yu go de tink se, ‘I go rili mek difrɛns?’ Yɛs, i go mɔs bi. Jɔs tink, pɔsin we de tek dis mɛrɛsin go ebul fɔ liv 5 mɔnt mɔ we nɔ gɛt di sik dɛn we de wɔs pas pɔsin we nɔ de tek di mɛrɛsin, ɛn i go ebul fɔ du in yon wok, gladi wit in famili, go si granpikin we gradyuet... Aw valyu da ɛkstra tɛm de fɔ du tin dɛn lɛk dis? Da tɛm de na di big bɛnifit we dis mɛrɛsin de gi.
Bɔt i impɔtant fɔ mɛmba dis: Dɛn kin rɛkɔmɛnd Leqembi fɔ pipul dɛm nɔmɔ we de na di fɔs stej fɔ Alzaima sik , we min di wan dɛm wae de sho se dɛn nɔr de tink fayn. E nɔr go woke fɔ pɔrsin wae gɛt mɔr advans sik.
Aw dis mɛrɛsin de wok?
Fɔ ɔndastand dis, lɛ wi tek wan smɔl ɛgzampul. Insay di bren fɔ di wan dɛn we gɛt Alzaima, dɛn kin put wan prɔtin we dɛn nɔ want we dɛn kɔl amyloid plaques . I tan lɛk dɔti we kin stɔp na wata paip ɛn smɔl smɔl i kin stɔp na di paip. bikɔs dεn protin dεm ya de dכn, di kכmyunikeshn bitwin di bren sεl dεm de ambɔg, εn di sεl dεm de bigin day sכmtεm. Dis na di rizin we mek di mɛmori kin lɔs ɛn di we aw pɔsin de biev kin chenj.
Dis drɔg we dɛn kɔl Leqembi de tɔch ɛn pul di amyloid plek dɛn we dɔn bil na di bren. I de pan wan klas ɔf drɔgs we dɛn kɔl monoklɔnal antibodi. Dɛn kin gi dis mɛrɛsin to di pɔsin tu tɛm insay di mɔnt tru wan IV infushɔn.
Lɛ wi luk sɔm impɔtant tin dɛn bɔt dis mɛrɛsin na tebul.
| Wan shɔt sɔmari bɔt Leqembi (lecanemab) . | |
|---|---|
| Tayp fɔ mɛrɛsin | Wan monoklɔnal antibodi tayp drɔg. |
| Udat i fayn fɔ? | Na fɔ pipul dɛm nɔmɔ we de na di fɔs stej dɛm fɔ Alzaima, wit smɔl smɔl kɔgnitiv impairment. |
| Men advantej | Di sik we de prɛd kin slo bay lɛk 27% insay 18 mɔnt. |
| Aw fɔ gi | Dɛn kin gi am tru wan vein (IV infusion) tu tɛm insay di mɔnt. |
| Di limit we impɔtant pas ɔl | Dis nɔ de mɛn di sik. I nɔ gɛt ɛni yus fɔ di wan dɛn we dɔn ɔlrɛdi de pan di sik bad bad wan. |
Risk de fɔ yuz dis?
Yɛs. Lɛk ɔl di mɛrɛsin dɛn, dis wan gɛt sɔm prɔblɛm dɛn ɛn sɔm sayd ɛfɛkt dɛn. Infakt, di FDA dɔn gi "blak bɔks wɔnin" fɔ dis mɛrɛsin, we na di ays lɛvɛl fɔ wɔnin fɔ sef . Di rizin fɔ dat na wan kɔndishɔn we dɛn kɔl ARIA.
Wetin na ARIA?
ARIA na shɔt fɔ Amyloid-Related Imaging Abnormalities. Fɔ tɔk am simpul wan, dis mɛrɛsin kin mek sɔm pipul dɛn gɛt swel na dɛn bren ɔ dɛn kin gɛt smɔl smɔl blɔd (maycrobleeds) . Pan ɔl we dɛn tin ya nɔ kin siriɔs, sɔntɛnde dɛn kin mek pɔsin in layf de pan denja.
- APOE4 jin: Pipul dεm we gεt tu kכpi fכ di APOE4 jin mכtεshכn de pan hכy risk fכ divεlכp dis ARIA kכndishכn pas כda wan dεm.
- Blɔd Tin dɛn: Wan ɔda tin we rili impɔtant na dat dɔktɔ dɛn kin wɔn yu tranga wan se yu nɔ fɔ yuz dis mɛrɛsin fɔ pɔsin we de tek blɔd tin dɛn. Bikɔs if yu du dat, chans de fɔ mek smɔl blɔd tɔn to big blɔd we go mek yu layf de pan denja (macro-bleed). Sɔntɛnde, dis kin mek i gɛt sik, dɛn kin put am na ɔspitul, ɔ ivin day.
So, bifo yu bigin dis mɛrɛsin, i impɔtant fɔ tɔk klia wan bɔt ɔl dɛn prɔblɛm ya wit yu dɔktɔ, du di tɛst dɛn we yu nid, ɛn kɔnfirm if dis fayn fɔ yu.
So wetin a fɔ du?
If yu, we de rid dis atikul, gɛt ivin smɔl saspek se yu ɔ pɔsin we de nia yu gɛt di fɔs sayn dɛm fɔ Alzaima, di bɛst tin fɔ du na fɔ go to dɔktɔ we yu nɔ de te ɛn gɛt kɔrɛkt diagnosis.
Bikɔs as wi bin dɔn tɔk, drɔgs lɛk Leqembi kin jɔs yusful na di fɔs stej dɛm fɔ di sik. If yu delay, yu kin mis di chans fɔ gɛt tritmɛnt. Dɔn bak, bɔku tɛm, nyu mɛrɛsin dɛn lɛk dis kin dia. So i fayn fɔ tɔk to yu dɔktɔ bɔt dat bifo yu bigin fɔ trit yu.
Masta sabi bukman dɛn biliv se i nɔ go te igen, dɛn go gɛt tritmɛnt dɛn we go ebul fɔ no ɛn protɛkt di sik bifo pipul dɛn sho ɛni sayn. Jɔs lɛk aw wi kin no ɛn trit brɔst kansa ɛn prɔstat kansa kwik, wan de wi go ebul fɔ no ɛn protɛkt Alzaima sik kwik kwik wan. Te da tɛm de, drɔgs lɛk Leqembi de gi big op fɔ wi ɔl.
Mɛsej we dɛn kin kɛr go na os
- Leqembi nɔto mɛrɛsin fɔ Alzaima sik. I kin jɔs slo di sik fɔ go bifo we i bigin.
- Dis drɔg de wok bay we i de pul di bad bad amyloid plek dɛm we de gɛda na di bren.
- Risk de fɔ gɛt siriɔs sayd ɛfɛkt lɛk bren swel ɔ smɔl blɔd (ARIA), so i impɔtant fɔ tɔk bɔt ɔl di risk dɛn wit dɔktɔ.
- Dis mɛrɛsin nɔ fayn fɔ di wan dɛn we de tek mɛrɛsin we de mek dɛn blɔd tan ɔ di wan dɛn we gɛt siriɔs sik.
- If yu ɔ pɔsin we de nia yu gɛt prɔblɛm wit yu maynd, go to dɔktɔ fɔ advays yu nɔ go te. I impɔtant fɔ no di sik kwik kwik wan fɔ tritmɛnt.
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