Wetin na Sεstεmik Mastosaytכsis (SM)? Mek wi lan bɔt di mɛrɛsin Ayvakit.

Yu dɔktɔ dɔn tɛl yu se yu gɛt wan sik we nɔ kin apin so ɔltɛm we dɛn kɔl Systemic Mastocytosis ? Yu kin fil smɔl fɔ fred ɛn wɔri we yu yɛri dat. I rili nɔmal. Bɔt nɔ wɔri. Naw, rili gud ɛn fayn tritmɛnt dɛn de fɔ dɛn kayn sik ya. Tide wi go tɔk bɔt di mɛrɛsin Ayvakit (avapritinib) we dɛn bin gi yu. Lɛ wi ɔndastand ɔltin bɔt dis sik ɛn di mɛrɛsin simpul ɛn klia wan.

Wetin na di ɛksaktɔli Sistɛm Mastosaytɔsis (SM)?

fכ sכmtεm, Sistem Mastocytosis na wan kכndishכn we nכ kin apin we wan kayn sεl we dεn kכl ‘mast sεl dεm’ na wi bכdi de gro pasmak. Dɛn mast sɛl ya na pat pan wi imyun sistɛm. Laik wi kontri difens fos. we sכmtin we fכrin go insay di bכdi, dεn sεl dεm ya de aktibכt εn de rilis kεmikכl dεm lεk ‘histamine’.

Imajin se we mɔskito bit yu, di say kin it ɛn rɛd, nɔto so? Na dat kin apin bikɔs ɔf dis histamin. bכt pan pכsin we gεt Systemic Mastocytosis, dεn mast sεl dεm ya de kכmכt insay wan we we dεn nכ kכntro na di bכdi. Dɛn kin gɛda na di skin, di bon mɛro, ɔ di ɔgan dɛn we de insay lɛk di liva ɛn di splin. Bikɔs ɔf dis, di bɔdi kin gɛt alɛji, lɛk fɔ it, fɔ rɛd in skin, fɔ at na in bɛlɛ, ɛn fɔ gɛt diziz, fɔ no rizin.

di wכd "sistεmik" min se i kin afekt di כl bכdi, nכto jכs wan εria. Bɔrku difrɛn kayn dis sik de, frɔm wae nɔr kin bɔrku, wae de gro sloslo (indolent) to wae dɔn go bifo, wae gɛt kansa.

Aw a go no if Ayvakit rayt fɔ mi?

Yu dɔktɔ go du sɔm tɛst fɔ no uskayn kayn Systemic Mastocytosis yu gɛt. Di rizɔlt fɔ dɛn tɛst dɛn de ɛn di sayn dɛm we yu gɛt go sho if Ayvakit rayt fɔ yu. Ayvakit naw dεn apruv fכ trit sεvεra tכp dεm fכ Sεstεmik Mastosaytosis pan big pipul dεm.

Aw dis Ayvakit mɛrɛsin de wok pan di bɔdi?

Ayvakit na mεdisin we de pan wan grup we dεn kכl ‘kinase inhibitors’. kinase na wan kayn εnzym protin we de εp fכ sεnd signal bitwin sεl dεm na wi bכdi. dis signal dεm rili imכtant fכ tin dεm lεk di sεl dεm we de gro εn divεlכpmεnt.

bכku pipul dεm we gεt Systemic Mastocytosis gεt mכtεshכn na wan protin we dεn kכl KIT we de insay mast sεl dεm . dis mכtεshכn de mek di KIT protin de ova aktv, we de mek di mast sεl dεm de gro we dεn nכ de kכntro.

di Ayvakit d כg de tכk bכt εksakכt da mכtayt KIT protin de εn i de stכp am fכ fכnshכn.. Lɛk fɔ mek wan tawa we de gi di rɔng signal nɔ tɔk natin. Dis kin mek di mast sɛl dɛn nɔ bɔku pasmak, i kin mek di sik nɔ bɔku, ɛn i kin kɔntrol di ɔgan dɛn we kin pwɛl.

Aw a fɔ yuz Ayvakit pils?

Ayvakit na wan pil. Di tin we impɔtant pas ɔl we yu de tek am na fɔ tek am ɛmti bɛlɛ . Dat min se yu fɔ tek am at le wan awa bifo yu it, ɔ tu awa afta yu it. Na da tɛm de di bɔdi kin tek di mɛrɛsin fayn fayn wan.

Di dos dɛm we dɛn kin gi na dɛn wan ya:

• Fɔ Advans Sistɛm Mastitis TOS (AdvSM): 200mg wan tɛm ɛvride.
• Fכ Indolent Sεstεmik Mastosaytosis (ISM): 25mg wan tεm evri de.

Bɔrku tɛm, dis na tritmɛnt fɔ lɔng tɛm. Yu dɔktɔ go tɛl yu fɔ kɔntinyu fɔ tek di mɛrɛsin te yu gɛt gud rizɔlt frɔm am ɛn nɔr de gɛt ɛni siriɔs sayd ɛfɛkt. If yu gɛt ɛni bad bad tin we kin apin to yu, yu dɔktɔ kin disayd fɔ ridyus di doz, stɔp am fɔ sɔm tɛm, ɔ stɔp am kpatakpata.

Wetin risach se bɔt di sakrifays we Ayvakit dɔn mek?

Infɔmeshɔn de bɔt tri klinik trayal dɛn we dɛn dɔn du fɔ chɛk di ɛfifikɛshɔn ɛn sef fɔ di Ayvakit drɔg.

Fɔ AdvSM (siv): Insay di tu stɔdi dɛm, EXPLORER ɛn PATHFINDER, 57% pan di pipul dɛm we tek Ayvakit, ɔ pas af, bin gɛt ridɔkshɔn pan di simptom dɛm ɛn sɔm rikavari fɔ wok na di ɔgan dɛm we dɛn afɛkt. Af pan di wan dɛn we sho di rizɔlt bin kɔntinyu fɔ gɛt da impɔtant tin de fɔ 38 mɔnt, ɔ pas 3 ia.

Fɔ ISM (mild type): Insay di PIONEER stɔdi, di wan dɛn we tek Ayvakit bin gɛt signifyant less symptoms (lɛk it, bɛlɛ pen, ɛn taya) pas di wan dɛn we tek plasɛbo. Dis min se dis drɔg dɔn gi bɔku rilif fɔ impɔtant kwaliti layf.

dis stכdi dεm sho se Ayvakit na rili ifektiv tritmεnt opshכn fכ Sεstεmik Mastosaytosis. Bɔt mɛmba se i nɔ de mɛn di sik ɔltogɛda, ɛn di tin dɛn we go apin nɔ go bi di sem fɔ ɔlman.

Prɔblɛm kin de wit ɔda mɛrɛsin dɛn? (Drug Intarakshɔn) .

Yes, Ayvakit kin intarakt wit sɔm mɛrɛsin dɛn. εspεshali dεn wan dεm we de afekt di εnzym CYP3A na wi liva. Sɔm mɛrɛsin dɛn kin mek di Ayvakit lɛvɛl go ɔp na di bɔdi ɛn mek di sayd ɛfɛkt dɛn go ɔp, ɔda mɛrɛsin dɛn kin mek di Ayvakit lɛvɛl go dɔŋ ɛn mek i nɔ wok fayn.

So, mek shɔ se yu tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek (mɛrɛsin fɔ ɔda sik, vaytamɛn, tradishɔnal mɛrɛsin, sɔpɔtmɛnt). Dɔn i kin chɛk fɔ ɛni prɔblɛm ɛn if nid de, chenj yu ɔda mɛrɛsin dɛn ɔ chenj di doz fɔ Ayvakit.

Dɔn bak, if yu de tek tin dɛn we de mek yu blɔd tan lɛk warfarin (Coumadin, Jantoven) , yu risk fɔ mek yu blɔd kɔmɔt na yu bren frɔm Ayvakit kin go ɔp smɔl. So, yu dɔktɔ go de wach yu gud gud wan if yu de tek dɛn kayn mɛrɛsin ya.

Aw fɔ gɛt Ayvakit mɛrɛsin?

Ayvakit na mɛrɛsin we dɛn kin gi pɔsin nɔmɔ, bɔku tɛm na dɔktɔ we de mɛn blɔd ɔ we de mɛn kansa kin gi am.

Dis nɔto mɛrɛsin we yu kin gɛt na famasi ɔltɛm . I de na wan ‘spɛshal famasi’. We yu dɔktɔ dɔn sɛn di mɛrɛsin to da spɛshal famasi de, dɛn kin ship di mɛrɛsin to yu os ɔ na yu dɔktɔ in ɔfis.