Yu want fɔ no bak di rayt tin bɔt Mast Sɛl? Lɛ wi tɔk bɔt dis simpul wan!

Sɔntɛm yu nɔ yɛri bɔt di nem ‘Mast Cells’ bifo, nɔto so? Bɔt dɛn tin ya na wan kayn sɛl we rili impɔtant we de protɛkt wi bɔdi. Lɛk smɔl smɔl gad dɛn we de insay wi bɔdi. Bɔt sɔntɛnde, we dɛn gad ya kin gladi tumɔs smɔl, wi kin gɛt prɔblɛm. Tide, lɛ wi tɔk ditayli, rili simpul wan, bɔt wetin na dɛn mast sɛl ya, aw dɛn de wok na wi bɔdi, ɛn us kɔndishɔn dɛn kin mek wi gɛt.

Wetin na Mast Sɛl dɛn?

Fɔ tɔk am simpul wan, mast sɛl na spɛshal sojaman dɛn na wi imyun sistɛm . Dɛn kin mek dɛn na wi bon mɛrɔ . Dɔn dɛn kin travul tru wi blɔd ɛn sidɔm na difrɛn tisu dɛn ɔlsay na di bɔdi. Lɛk sɛntinɛl dɛn we de na difrɛn say dɛn na di kɔntri, dɛn mast sɛl ya de na difrɛn pat dɛn na wi bɔdi, ɛn dɛn rɛdi fɔ protɛkt wi frɔm tin dɛn we de kɔmɔt na do. Dɛn kin fɛt difrɛn infɛkshɔn ɛn ɛp fɔ mek wi bɔdi in ɔgan dɛn wok fayn fayn wan.

Bɔt sɔntɛnde, dɛn mast sɛl ya kin protɛkt dɛnsɛf pasmak ɛn dɛn kin bigin fɔ du tin dɛn we rili nɔ bad fɔ wi. If yu gɛt sizin alɛji ɔ alɛji asma, wan rizin fɔ dis na bikɔs di mast sɛl dɛn de wok. Sɔntɛnde, we di mast sɛl dɛn kin wok, i kin ivin mek pɔsin gɛt siriɔs alɛji we dɛn kɔl anafylaksis . So i impɔtant fɔ no bɔt dis.

Wetin mast sɛl dɛn kin du to wi bɔdi?

di mast sεl dεm de wok lεk wi bכdi in ‘alεt sistεm’ . Dɛn kin protɛkt wi bɔdi frɔm ɔda tin dɛn we kin kam insay wi bɔdi, lɛk di sik dɛn lɛk vayrɔs, baktri ɛn parasayt , ɛn bak pɔyzin lɛk snek pɔyzin ɛn bi pɔyzin. Dɛn kin fɛt bak wit ɛnitin we dɛn tink se go ambɔg dɛn, ilɛksɛf i nɔ bad. Na da tɛm de wi kin gɛt alɛji .

Difrɛn frɔm bɔku ɔda kayn wayt blɔd sɛl dɛn, di mast sɛl dɛn nɔ de pwɛl di sik dɛn we de mek pɔsin sik dairekt wan. Bifo dat, dɛn kin sidɔm wach insay wi tisu dɛn, ɛn wet fɔ mek dɛn sho se sɔntin we bad dɔn kam insay wi bɔdi.

Aw di mast sɛl dɛn kin wok?

Imajin se sɔntin we yu nɔ lɛk, fɔ ɛgzampul, dɔst, pɔlin, ɔ it we yu nɔ lɛk, go insay yu bɔdi. כda spεshal kayn sεl na wi imyun sistεm we dεn kכ l B sεl dεm de no dis invayda. We dɛn dɔn no am, dɛn kin bigin fɔ mek spɛshal prɔtin dɛn we dɛn kɔl antibodi fɔ fɛt am. di spεsifi k antibodi dεm we de prodyuz dis tεm dεn kכl dεm Immunoglobulin E (IgE).Fɔ se.

dis IgE antibodi dεm kin travul kwik kwik wan to εn atak spεsifi k rεsεpכta dεm na di sεf fכ di mast sεl dεm, lεk pusi in klo. di nεks tεm we di sem invayda (e.g. pכlεn, dכst) kam insay di bכdi bak, di IgE we de pan di mast sεl dεm go grap am.

na da tεm de di mast sεl dεm de "aktivet." I tan lɛk se dɛn de ring faya alam.

We di mast sɛl dɛn wok dis we, dɛn kin pul wan kemikal we dɛn kɔl histamin ɛn bɔku ɔda kemikal dɛn we dɛn kin kip insay smɔl smɔl sak dɛn (stɔrɔj ​​granul) insay dɛn sɛl dɛn de wantɛm wantɛm. Dɛn kɔl dis degranulation .

Dɛn histamin ɛn ɔda kemikal ya na dɛn kin mek yu gɛt alɛji. Dɛn tin ya na:

• Wi blɔd vesel dɛn kin big, ɛn wata kin gɛda na di tisu dɛn we de rawnd wi, ɛn dis kin mek wi swel . dis de mek di imyun sεl dεm fכ rכsh kwik kwik wan na di say we di infεkshכn de, kכri di invayda dεm to di limf no dεm fכ pwεl dεm.
• di mכkus (flegm) prodakshכn de inkrεs.
• di smol smol mכsul dεm na wi rεspiretכri trakt εn gεstrointestinal sistεm (intestinal sistεm) de kכntrakt εn tray fכ push bad bad tin dεm kכmכt wit muvmεnt we lεk wev (peristalsis).

Dɛn tin ya kin mek yu skin rɛd, swel, ɛn it. Yu kin gɛt wata we de rɔn na yu nos, yu kin sniz, ɔ yu kin kɔf. Sɔntɛnde, yu kin ivin gɛt dayarɛa ɔ vɔmit. If i rili siriɔs, dis prɔses kin mek di say dɛn we di briz de blo, i kin mek i nɔ izi fɔ blo, ɛn i kin mek di blɔd prɛshɔn go dɔŋ bad bad wan, we kin ivin mek i gɛt siriɔs anafylaksis, we na wan sik we kin mek pɔsin in layf de pan denja.

Mast sel dεm εn homכstasis

apat frכm we i de mek alerji, di mast sεl dεm de εp fכ bεlε difrεn prכsεs dεm na wi bכdi, dat na fכ mεnten wan stet fכ ‘homכstasis’ . Na sɔm ɛgzampul dɛn ya:

• Di blɔd vesel dɛn we de gro.
• Bon dɛn we de gro.
• di growth εn ripa fכ di rεspiretכri trakt sεl dεm.

Usay di mast sɛl dɛn de na wi bɔdi?

We yu kɔmpia am to ɔda kayn wayt blɔd sɛl dɛn, di mast sɛl dɛn nɔ bɔku na wi blɔd. Bɔku tɛm, wi kin gɛt sɔntin we de ambɔg wi bay we wi de blo am, it am, ɔ tru wan wund na wi skin. na dat mek dεn kin fכn mכst sεl dεm mכst insay:

• Insay wi respiratory trakt ɛn di lɔng dɛn .
• wi dijestiv sistεm (GI trakt) (bεlε, intestines).

Apat frɔm dat, dɛn mast sɛl ya de bak rawnd wi blɔd vesel ɛn nerv dɛn.

Wetin na di pat dɛn na di mast sɛl?

if yu tek mast sel, i gεt nyuklios na di sεntrכm, we na di "bren" fכ di sεl. rawnd dis nyukliɔs, bɔku bɔku smɔl smɔl tin dɛn de we tan lɛk sak we dɛn kɔl granul .na insay dεn granul dεm ya we dεn de stכr difrεn kεmikכl mεsenja dεm (mεdiεta dεm) . Dɛn mɛsenja ya na dɛn kin sɛn signal to di bɔdi fɔ ansa we sɔntin we bad kam nia am. Sɔm pan di men wan dɛn we de pan dɛn kemikal ya na:

• Histamine: Wi don tok abaut dis bifo. I de mek di blɔd vesel dɛn big, we de mek di wata ɛn di imyun sɛl dɛn go insay di tisu dɛn. i de kכnstrikt bak di aywe dεm εn di gεstrointestinal trakt, we de mek mכkus fכ εp fכ push di patogens dεm kכmכt.
• di protiz dεm: (Egzampl dεm: triptaz, kaymas, kכbכksipεptidaz A). Protease na wan kayn enzym we de brok di protin dεm. dεn de εp fכ brok dכn di kכnektiv tisu, we de mek di imyun sεl dεm fכ rich di εria izi wan.
• Saytokin/kemokines: dis na sכm sכm protin dεm we de signal כda imyun sεl dεm fכ mek mכr kכpi fכ dεn sεf, fכ mek bכdi vεsul dεm "stika" so dat imyun sεl dεm go transpכt to tisu dεm, εn fכ rikrut sεl dεm fכ klin εn ripa di εria dεm we dεn dכn pwεl.
• Heparin: Dis kin mek blɔd nɔ klɔt, so i kin ɛp fɔ mek di blɔd vesel dɛn opin.

di risepta dεm we de na di mast sεl

di mast sεl dεm gεt bכku difrεn rεsεp כta dεm na dεn sεf. Dis na prɔtin dɛn we gɛt spɛshal shep. lεk aw ki fit lכk, dεn risεptor dεm ya de intarakt wit כda signal protin dεm fכ aktibכt di mast sεl dεm.

pan dεn wan ya, di IgE rεsεpכta we wi bin dכn tכk bכt na in dεn no pas כl. apat frכm dat, di mast sεl dεm gεt rεsεpכta dεm bak fכ כda kayn antibodi dεm (e.g., Immunoglobulin G / IgG) εn fכ dayrekt rεkכgnishכn fכ di patכgens dεm (e.g., Toll-layk rεsεpכta dεm).

Wetin na di kכmכn kכndyushכn dεm we kin kכmכt wit di mast sεl dεm?

Sɔm pan di kɔmɔn tin dɛn we wi kin si we gɛt fɔ du wit mast sɛl na:

• Envayrɔmɛnt alɛji (e.g., dɔst, pɔlin, pet dander) .
• Asma we gɛt asma
• Alɛji fɔ it
• Hɛt Blisters/ Hiv dɛn

Di sik dɛn we nɔ kin bɔku na di mast sɛl

pan tap dat, sεvεra kכndyushכn dεm de we nכ kin apin we kin kכnεkt wit di mast sεl dεm:

• Mast cell activation syndrome (MCAS): Dis na kכndyushכn we, fכ nכ rizin, di simptom dεm fכ alerji כ anafylaksis kin apin bכku tεm.
• sכmtεm di nכmba fכ di mast sεl dεm na di bכdi de inkrεs pasmak (Mastocytosis).
• Hɛridit alfa-triptasemia / famili haypatriptasemia:dis na jεnεtik kכndyushכn we de apin we di bכdi gεt εlevεt lεvεl fכ wan εnzym we dεn kכl triptaz, we di mast sεl dεm de mek. Bɔt bɔrku pipul dɛm wae gɛt dis jenɛtik sik nɔr kin gɛt dis sik.

Wetin na di kɔmɔn sayn dɛm fɔ gɛt mast sɛl sik?

Histamin we de kɔmɔt na di mast sɛl sik kin mek yu gɛt sɔm sayn dɛn lɛk:

• Di skin kin chenj, i kin rɛd, ɔ i kin it.
• Swɛlin (ɛdima) .
• I nɔ kin izi fɔ yu fɔ blo.
• Anafylaksis we kin kam bak .

Us tɛst dɛn kin du fɔ no bɔt dɛn sik ya?

If dɔktɔ tink se yu gɛt di sik we dɛn kɔl mast sɛl, dɛn kin du tɛst dɛn lɛk dis fɔ si if yu mast sɛl dɛn dɔn wok:

• Test fɔ urine.
• Blɔd tɛst dɛn.
• Tɛst fɔ di bon mɛro.
• Test dɛn fɔ di skin.

Dɔktɔ kin du alɛji skin tɛst ɔ blɔd tɛst fɔ no wetin kin mek i gɛt alɛji. Sɔntɛnde, lab kin du jenɛtik tɛst bak fɔ si if yu sik na bikɔs ɔf wan sik we yu gɛt frɔm yu mama ɛn papa.

Wetin na di tritmɛnt dɛm fɔ dis?

Tritmɛnt fɔ mast sɛl sik de dipen pan yu sayn dɛm ɛn wetin de kɔz dɛm. Di tritmɛnt kin inklud:

• Fɔ avɔyd tin dɛn we dɛn no se kin mek pɔsin gɛt alɛji .
• Mɛrɛsin fɔ kɔntrol di sayn dɛm. Dɛn tin ya kin inklud antihistamin , asid ridyus, ɛn leukotriene-modifying mɛrɛsin (e.g., montelukast).
• Mast sel stabiliza dɛn. dis dכg dεm de mek kεmεkal dεm lεk histamin kכmכt frכm di mast sεl dεm.
• Mɛrɛsin fɔ ridyus ɔ trit anafylaksis. Dɛn tin ya na mɛrɛsin dɛn lɛk epinephrine ɛn omalizumab .
• Saytɔriduktiv tɛrapi/kimotɛrapi . Fɔ siriɔs kes dɛm fɔ mastocytosis, sɔmtɛm dɛn kin yuz kemotɛrapi drɔgs we dɛn kin yuz fɔ kil kansa sɛl dɛm.

So, yu tink se mast sɛl dɛn gud ɔ bad?

Bɔku pipul dɛn kin jɔs yɛri bɔt mast sɛl we sɔntin nɔ apin to dɛn, so yu kin tink se mast sɛl na bad tin. Bɔt fɔ tru, dɛn kin ɛp fɔ protɛkt wi bɔdi frɔm bad bad tin dɛn we kin kam insay wi ɛn fɔ mek wi ɔgan dɛn rigul. So, most of di taim, dem gud.

Imajin, sayrin dɛn de blo. Di sikyɔriti tim rich na di say we di aksidɛnt apin. Yu mast sɛl dɛn de mek di alam, ɛn yu imyun sistɛm de rɔn fɔ sev di de. Dɛn na impɔtant pat pan wi bɔdi in difens sistɛm. Bɔt wi kin pe atɛnshɔn mɔ pan di mast sɛl dɛn we dɛn tu zil smɔl fɔ dɛn wok. Bɔt dɛn kin mek wi difens dɛn strɔng bak ɛn ɛp fɔ mek wi blɔd vesel ɛn ɔgan dɛn we de na di bɔdi fayn fayn wan. So, di nɛks tɛm we yu sniz, yu nos we de rɔn, ɔ fil se yu de it smɔl, nɔ fɔgɛt fɔ tɛl yu mast sɛl dɛn tɛnki fɔ we dɛn de wach!

Tin dɛn fɔ mɛmba fɔ sɔm tɛm

So, di mכst imכtant tin fכ mεmba frכm כl dis na dat mast sεl dεm na rili imכtant sכm sכm sεntin dεm na wi imyun sistεm. Dɛn kin protɛkt wi frɔm difrɛn sik dɛn ɛn pɔyzin we de kɔmɔt na do. Bɔt, sɔmtɛm wae dɛn kin tu sɛnsitiv smɔl, dɛn kin riak to tin dɛm wae nɔr rili bad, ɛn mek wi gɛt kɔndishɔn lɛk alɛji.

If yu de gɛt alɛji ɔltɛm, lɛk yu skin we de it, ayv, yu nos we de rɔn, we yu de snis, ɔ we i nɔ izi fɔ blo, di bɛst tin fɔ du na fɔ go to dɔktɔ ɛn gɛt advays ɛn nɔ pe atɛnshɔn to am. Nɔr wɔri, tritmɛnt dɛn de tide wae kin ɛp fɔ kɔntrol bɔrku pan dɛn sik ya.

` Mast sel dεm, imyun sistεm, alerji, histamin, anafylaksis, sεl fכnshכn, simptom dεm