Wi go tɔk bɔt wan sik we nɔ kin bɔku we dɛn kɔl C3G (Complement 3 Glomerulopathy), we kin afɛkt di kidni dɛn?

Sɔntɛnde yu kin gɛt blɔd na yu urine, ɔ yu leg kin swel? Ɔ yu kin fil taya ɔltɛm? Sɔntɛnde, dɛn tin ya kin bi bikɔs ɔf prɔblɛm wit yu kidni. Tide wi go tɔk bɔt wan sik we nɔ kin bɔku bɔt we rili impɔtant we kin afɛkt di kidni dɛm. Dat na C3G (C Tri G) ɔ ``Kɔmplimɛnt 3 Glomerulopathy``.

Wetin na C3G (Kɔmplimɛnt 3 Glomerulopathy)?

Fɔ tɔk am simpul wan, C3G na wan grup fɔ sik dɛn we de afɛkt aw yu kidni dɛn de wok fayn fayn wan. Yu no se di kidni dɛn tan lɛk di tu filta dɛn we de na wi bɔdi. Dɛn men wok na fɔ filta di blɔd, pul dɔti tin dɛn we nɔ nid ɛn wata we pasmak, ɛn mek urine.

"Kכmpliment 3" na spεshal protin we de insay wi bכdi. I rili impɔtant fɔ di imyun sistɛm we de fɛt sik dɛn na wi bɔdi. "Glomerulopathy" na damej pan di glomeruli, we na sכm sכm bכdi we de insay di kidni dεm, we lεk sכm sכm mεsh dεm. Na dɛn glomeruli ya de filta di blɔd.

afta dat C3G na sik we de involv di `kכmpliment 3` protin, we de damej di `glomeruli` εn we de mek di kidni dεm nכ de wok fayn. trade, dat na bifo 2013, dכkta dεm bin de kכl dis ``Mεmbranoproliferativ glomerulonephritis (MPGN) tayp I, II כ III`` כ ``Mesangioproliferative glomerulonephritis``. Bɔt naw dɛn kɔl dis grup fɔ sik dɛn C3G.

Yu tink se kayn C3G de?

Yes, tu men kayn C3G de. di dכkta dεm de disayd dεn tu kayn dεm ya bay we dεn tek sכm sכm pat pan di kidni (wi kכl am `kidney biopsy` ) εn luk am כnda maykroskכp, bay di damej εn inflameshn to di `glomeruli`.

• di sik we dεn kכl dense dεposit (DDD): Fכs dεn bin kכl dis kכndyushכn MPGN tayp II, dεn kin kכl dεn, lεk ribכn dεposit dεm na di glomerular bεsεmεnt mεmbran (GBM), we na di layn fכ di glomeruli. I kin mɔs afɛkt pikin ɛn yɔŋ pipul dɛn we dɔn pas 20 ia.

• `C3 glomerulonephritis` (C3GN): Dɛn bin de kɔl am bifo tɛm `MPGN tayp I` ɔ `III`. Insay dis, di dens dipɔsit dɛm lɛk di wan dɛm we dɛn si na DDD nɔ de si. Dis kin mɔs afɛkt pipul dɛm wae dɔn pas 30 ia.

C3G na sik we nɔ de mɛn?

Yes, C3G na sik we nɔ de mɛn. Dis min se i nɔto sɔntin we go divɛlɔp wantɛm wantɛm ɛn bɛtɛ, ɛn di damej we de pan di kidni dɛn kin bɔku as tɛm de go. So, i rili impɔtant fɔ tek tɛm wit dis.

Aw kɔmɔn dis C3G?

Dis na rili sik we nɔ kin apin so ɔltɛm.Dɔktɔ dɛn se dis kin apin to lɛk tu to tri pipul dɛn pan ɛvri ɔndrɛd tawzin. So sɔntɛm yu nɔ go dɔn yɛri bɔku tin bɔt am. Bɔt pan ɔl we i nɔ kin bɔku, i impɔtant fɔ no bɔt am.

Wetin na di sayn dɛm fɔ C3G sik?

Naw lɛ wi si wetin na di sayn dɛm fɔ dis C3G sik. Dɛn tu kayn ya gɛt sɔm tin dɛn we kɔmɔn, we impɔtant fɔ no:

• Blɔd we de na di urine ( hematuria ): Sɔntɛnde di urine kin tan lɛk rɛd, ɔ i kin bi smɔl we yu kin si ɔnda maykroskɔp nɔmɔ.
• di protin we pasmak na di urine (proteinuria): Dis kin mek di urine tan lεk fכm.
• Fɔ pas smɔl urine pas aw i fɔ pas (oliguria).
• di protin lεvεl dεm we de dכn na di bכdi (hypoalbuminemia).
• Swɛlin (ɛdima): Ɛspɛshali na di an, anklɛ, ɛn fut. Imajin, if yu wek na mɔnin ɛn yu fut fil swel, i kin bi sɔntin lɛk dis.
• Ay blɔd prɛshɔn (haypa prɛshɔn).
• Infεkshכn dεm we de kam bak.
• Fɔ fil taya bad bad wan (`Fatigue`): Nɔto jɔs taya, bɔt na filin fɔ taya ilɛksɛf yu slip.
• Sɔm pipul dɛn kin gɛt tin dɛn lɛk gaut .

Dɛn tu sayn ya kin mek yu kidni nɔ wok fayn . If yu kidni nɔ wok fayn, dat kin mek yu gɛt sɔm sayn dɛn bak lɛk:

• Ɔltɛm i kin taya.
• Nɔs, fɔ vɔmit.
• I nɔ izi fɔ mek pɔsin disayd fɔ du sɔntin, i nɔ gɛt op igen.
• Di bɔdi we de swel.
• fכ pas mכr urine pas aw i kin bi (dεn kin si dis sכmtεm di fכs stej dεm we di kidni dεm de fεl).

Apat frɔm di kidni dɛm, C3G kin mek ɔda sayn dɛm bak. Dɛn tin ya na:

• di prכblεm dεm we yu de si: yu kin si fayn bikoz fכ di akyumyuleshכn fכ di protin εn kalsiכm dεposit dεm (drusen), spεshal wan na di makula.
• Lipodystrophy: Dis na di kכndyushכn we di fεt de lכs na sכm pat dεm na di bכdi (especially di fes εn di limb dεm).

Wetin mek dɛn mek dis C3G?

Okay, naw mek wi si wai dis C3G de fom. Dis na tin we kɔmplikt smɔl, bɔt a go ɛksplen am simpul wan. dis kin apin we di ``kכmpliment sistεm`` na wi bכdi nכ de wok fayn fayn wan. dis ``kכmpliment sistεm`` na kכlekshכn fכ di protin dεm we de insay wi bכdi. Dis na pat pan wi imyun sistɛm. Dis kin ɛp fɔ fɛt tin dɛn lɛk baktri ɛn vayrɔs we de kɔmɔt na do.

wetin kin apin to pכsin we gεt C3G na dat dis `kכmpliment sistεm` de aktibכt tu mכch, כ aut כf kכntrol. afta dat di `kכmpliment 3 (C3)` protin de gεt dεmεj. dis damej C3 protin fragmεnt dεm de stכk insay di `glomeruli`. afta dat i kin at fכ di `glomeruli` fכ filta bכdi εn mek urine. If dɛn nɔ trit am, dis damej kin kɔntinyu ɛn mek di kidni nɔ wok fayn.

Mɔs tɛm, i kin at fɔ pinpoint di ɛksaktɔl rizin we mek dis ``kɔmplimɛnt sistɛm'' kin go haywire. Bɔt sɔntɛnde:

• C3G kin divεlכp bikoz fכ chenj dεm na wi jin dεm (mכtεshכn dεm na di jin dεm we riliyt to di kompliment sistεm, lεk ``C3`` εn ``CFH``).
• wan bכdi sik we dεn kכl ``Monoclonal gammopathy`` kin indaykt dεm bak di kidni dεm, i kin disrupt di fכnshכn fכ di ``kכmpliment`` sistεm, εn i kin mek C3G fכm. dis ``monoclonal gammopathy`` na wan kכndyushכn we de afekt di plasma sεl dεm na wi bon mכro.
• di mεdikal risach dεm de sכspεkt se sכmtin we dεn kכl ``autoantibodies'' kin ple wan rol bak. ``autoantibodies'' na protin dεm we wi כwn imyun sistεm de mek we de mistek atak wi כwn hεlty tisu dεm. כltu, nכ inof risεch de fכ se fכ sכri se dεn ``autoantibodies'' dεm ya na di kכz fכ C3G.

Udat dis C3G sik kin afɛkt pas ɔlman?

Dis C3G sik kin kam pan ɛnibɔdi. I kin afɛkt man ɛn uman ikwal. Di avrej ej fɔ no di sik na lɛk 23 ia. Bɔt di `DDD` tayp we wi bin dɔn tɔk bɔt kin apia we i yɔŋ pas di `C3GN` tayp.

Wetin na di poshubul komplikashɔn dɛm fɔ C3G?

Di men ɛn denja kɔmplikeshɔn na dat lɛk 50% pan di pipul dɛm we gɛt C3G, ɔ wan pan tu pipul dɛm, go gɛt kidni fayl insay 10 ia afta dɛn dɔn no se dɛn gɛt di sik. Dis na wetin wi ɔl fɔ fred pas ɔl.

Aw dɛn kin no se pɔsin gɛt C3G sik?

Dɔktɔ go du bɔku tɛst fɔ chɛk yu kidni dɛn wɛlbɔdi ɛn aw dɛn de wok fayn. Dɛn tin ya kin bi:

• Blɔd tɛst: Dɛn kin tek smɔl blɔd sɛmpul frɔm wan vein na yu an ɛn di lab kin chɛk fɔ si if yu kɔmplimɛnt protin dɛn nɔmal ɔ if bɔku west prɔdak dɛn (e.g. kriaytinin) de na yu blɔd.
• `Estimated Glomerular Filtration Rate (eGFR): Dis na tεst we de mכsu aw yu kidni dεm de filta yu bכdi, bay di כmכnt כf `sεrum kriatinin` כ `cystatin C` insay bכdi sεmpl. Dis kin gi yu gud aidia bɔt aw yu kidni dɛn de wok fayn fayn wan.
• Urinalysis: Yu go nid fɔ pis insay spɛshal kɔp ɛn gi di sampul to yu dɔktɔ. di lab go chɛk fɔ protin ɔ blɔd na di urine, we yu kin si ɔnda maykroskɔp nɔmɔ.
• Kidni bayɔpsi: Dis na wetindi bεst we fכ difinitivli no di C3G sik na tru bayopsi. Insay dis, dɔktɔ kin tek wan smɔl tisu frɔm yu kidni bay we i de yuz fayn nidul ɔ smɔl say we dɛn kɔt am ɛn tɛst am na lab. if dis sεmpl gεt pat dεm pan di C3 protin we dεn dכn pwεl na yu glomeruli, i kin bi C3G sik. Dis bayɔpsi kin tɛl yu bak us kayn C3G yu gɛt (DDD ɔ C3GN), bay we yu gɛt dɛn sɔlid dipɔsit dɛn de ɔ yu nɔ gɛt.

Yu tink se dɛn kin wɛl C3G ɔltogɛda?

I sɔri fɔ no se naw, no mɛrɛsin nɔ de fɔ C3G sik. Bɔt nɔr wɔri, dɔktɔ ɛn risach pipul dɛm de kɔntinyu fɔ stɔdi dis sik ɛn dɛn de wok fɔ fɛn nyu tritmɛnt. Wi op se bɛtɛ tritmɛnt go kam tumara bambay.

Wetin na di tritmɛnt dɛm fɔ C3G?

Naw, no patikyula tritmɛnt nɔ de we di U.S. Food and Drug Administration (FDA) dɔn gri fɔ fɔ C3G. Bɔt dɔktɔ dɛn kin gi dɛn difrɛn tritmɛnt dɛn ɛn sɔpɔt kia fɔ mek di C3G nɔ go bifo kwik kwik wan, fɔ kɔntrol di sik dɛn, ɛn fɔ mek di kidni nɔ pwɛl. Dɛn tin ya na:

• bכdi prεshכn mεdikeshכn dεm: mεdikeshכn dεm lεk angiotensin-converting enzyme (ACE) inhibitor dεm εn angiotensin II rεsεptכr blכk dεm (ARB) de ridyus di prεshכn insay di glomeruli. dis de ridyus di protin we de insay di urine εn i de ridyus di strεs we de pan di kidni dεm.
• Di mɛrɛsin dɛn we de mek yu nɔ gɛt bɔku kɔlɔstrel: Yu dɔktɔ kin gi yu mɛrɛsin lɛk statin fɔ mek yu gɛt bɔku kɔlɔstrel ɛn fɔ mek yu kidni nɔ pwɛl.
• Di chenj we yu de it: Wan dɔktɔ we de mɛn yu rεnal go ɛp yu fɔ mek wan it plan we go fayn fɔ yu ɛn ɛp yu fɔ gɛt wɛl bɔdi wet. If yu nɔ it sɔl (sɔdiɔm), sɛtyuret fat, ɛn kɔlɔstrel, dat kin ɛp fɔ mek yu nɔ gɛt bɔku prɔblɛm wit yu kidni.
• Kכtikostεroyd: dεn kכl dεm bak "stεroyd," dεn ya na anti-inflammatory dεm we de wok bay we dεn de stכp di imyun sistεm fכ atak yu glomeruli.
• Eculizumab: Dis na wan monoklɔnal antibodi drɔg we dɛn kin yuz fɔ trit di sik dɛn we nɔ kin apin na di blɔd we nɔ kin apin so ɔltɛm. i kin εp fכ impruv di kidni fכ wok bay we i de ridyus di protin na di urine εn inkrεs di glomerular filtration rate in sכm C3G pasεnshכn dεm.
• Dayalaysis: Dɛn kin se lɛk 50% pan di pipul dɛn we gɛt C3G kin gɛt kidni we nɔ de wok fayn. Dayalaysis na we di kidni dɛn nɔ de wok fayn, ɛn di wok we di kidni dɛn fɔ du (klin di blɔd, pul di dɔti tin dɛn, ɛn di wata we pasmak) na we dɛn de du am wit di ɛp fɔ mashin.
• Kidni transplant: Dis na ɔda tritmɛnt fɔ kidni we nɔ de wok fayn. Dɔktɔ we de du ɔpreshɔn kin pul yu kidni we nɔ de wok fayn ɛn put wan wɛlbɔdi kidni we pɔsin we gi yu di kidni gɛt.

If yu gɛt ɛni wan pan di `DDD` ɔ `C3GN` ɛn yu gɛt `monoclonal gammopathy` bak, yu dɔktɔ go rikɔmɛnd fɔ du ɔda tɛst fɔ chɛk fɔ ɔda ɔndalayn kɔndishɔn dɛn.

Wetin na de luk fɔ C3G sik?

Na lɛk af pan di wan dɛn we gɛt C3G kin gɛt di kidni we nɔ de wok fayn insay 10 ia afta dɛn dɔn no se dɛn gɛt di sik. Naw, no mɛrɛsin nɔ de fɔ mek pɔsin in kidni nɔ wok fayn. Bɔt if dɛn no di sik kɔrɛkt wan ɛn trit yu kwik kwik wan, yu go ebul fɔ liv lɔng ɛn gɛt wɛlbɔdi ɛn yu nɔ go gɛt big chenj. So, i impɔtant fɔ mek yu nɔ gɛt wanwɔd ɛn fala yu dɔktɔ in advays.

Yu tink se dɛn kin ebul fɔ avɔyd C3G sik?

I sɔri fɔ no se naw, no we nɔ de fɔ mek wi nɔ gɛt C3G sik, bikɔs bɔku tɛm na tin dɛn we wi nɔ ebul fɔ kɔntrol kin mek i sik.

Aw a kin kia fɔ misɛf?

If yu gɛt C3G, yu dɔktɔ go mek di bɛst tritmɛnt plan fɔ yu. Dis kin inklud mɛrɛsin, sɔpɔt fɔ kia fɔ yu, ɛn chenj di we aw yu de liv yu layf. Yu tritmɛnt plan kin gɛt dɛn tin ya, ɛn i impɔtant fɔ tek tɛm fala dɛn tin ya:

• Tek yu mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu. Nɔ mis wan de.
• Chenj yu it, mɔ fɔ ridyus sɔl, ɔyl, ɛn shuga, ɛn it mɔ frut ɛn vɛjitebul.
• Nɔ yuz nɔ-stɛroyd anti-inflammatory drugs (NSAID) (e.g., pen kil lɛk ibuprofen ɛn diclofenac) we yu nɔ gɛt dɔktɔ advays, bikɔs dɛn kin pwɛl di kidni dɛn ɛn mek di kidni dɛn nɔ wok kwik kwik wan.
• Fɔ kia fɔ yu maynd wɛlbɔdi. We yu gɛt dis kayn sik we nɔ kin apin so ɔltɛm, dat kin mek yu fil se yu wangren de ɛn yu kin fred. Dɔn bak, fɔ no se C3G kin mek yu kidni nɔ wok fayn, dat kin mek yu gɛt pwɛl hat. Tɔk to yu dɔktɔ bɔt yu maynd wɛl bɔdi ɛn aks fɔ advays ɛn tritmɛnt if nid de. Aks yu dɔktɔ bɔt sɔpɔt grup fɔ pipul dɛn we gɛt C3G. Fɔ mit ɔda pipul dɛm wae gɛt C3G kin ɛp fɔ ridyus yu wan ɛn sheb ɛkspiriɛns.

Ustɛm a fɔ go to dɔktɔ?

If yu gɛt sayn dɛn fɔ C3G, mɔ we yu gɛt chenj na yu urine (blɔd, fom, smɔl), swel, ɔ taya pasmak, go to dɔktɔ wantɛm wantɛm. Dɛn tin ya kin bi sayn fɔ sho se yu kidni nɔ de wok fayn.

If dɛn no se yu gɛt C3G, yu dɔktɔ go rifer yu to spɛshal pɔsin we gɛt kidni sik (nɛfrɔlɔjis). Na in go bi di wan we go gi yu di bɛst tritmɛnt plan.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

We yu go to dɔktɔ, nɔ shem fɔ aks kwɛstyɔn dɛn lɛk dɛn wan ya:

• Aw a go no fɔ tru if a gɛt C3G?
• If a nɔ gɛt C3G, us ɔda sik a go gɛt?
• Us kayn C3G a gɛt (DDD ɔ C3GN)?
• Us tritmɛnt dɛn yu kin kɔmɛnt fɔ mi? Ɛni bad bad tin dɛn de we kin apin to am?
• Us chenj dɛn a fɔ mek na di it we a de it?
• Yu tink se mi kidni dɛn go fel? Wetin a go du fɔ mek dat nɔ apin?
• A kin go to dɔktɔ we de mɛn di nefrɔlɔjis?

Fɔ dɔn, a fɔ se...

C3G na wan sik we nɔ kin bɔku, we kɔmpleks we kin afɛkt di smɔl smɔl filta yunit dɛn na di kidni dɛn. If yu gɛt C3G, yu kin gɛt chenj na yu urine, yu kin swel, yu jɔyn dɛn kin pen, yu nɔ kin si fayn, ɛn yu kin taya.

Yu kin gɛt difrɛn kayn filin as yu de aksept dis diagnosis ɛn ajɔst to aw C3G go afɛkt yu layf. Nɔ wɔri, nɔto yu wan de. Gi yusɛf tɛm ɛn ples fɔ lan bɔt C3G ɛn yu tritmɛnt opshɔn dɛm. We yu lan bɔt di tin dɛn we yu go ebul fɔ du ɛn wetin yu fɔ ɛkspɛkt, dat go ɛp yu fɔ dil wit aw yu de fil di kayn we we go mek yu gɛt wɛlbɔdi ɛn we go mek yu gɛt bɔku tin dɛn fɔ du. Dɔktɔ dɛn de fɔ gi infɔmeshɔn ɛn gayd. If yu gɛt ɛni kwɛstyɔn, nid advays ɔ sɔpɔt, tɔk to dɛn. Mɛmba se if yu no di sik kwik kwik wan ɛn gɛt di rayt tritmɛnt, yu go ebul fɔ kɔntrol dis sik ɛn liv gud layf.

` C3G, kidni sik, kompliment 3, glomerulopathy, kidni fεil, urine protin, dayalysis