Yu de tɔsti ɔltɛm, yu de pis ɔltɛm? Dis na Sɛntral Dayabitis Insipidus (CDI)? Mek wi tok!

Yu kin gɛt wata dayarɛa bak ɔl di de? I nɔ mata ɔmɔs wata yu drink, i nɔ de apin? Yu fɔ grap bɔku tɛm bak, sɔntɛnde na nɛt, fɔ pis? Ivin we yu du dat, yu kin pas bɔku layt kɔlɔ ɛn wata urine? Dɔn dis kin impɔtant to yu. Wi kin kɔl dis kɔndishɔn Sɛntral Dayabitis Insipidus, ɔ `Sɛntral Dayabitis Insipidus (CDI)`. Pan ɔl we i gɛt "dayabitis" na in nem, dis nɔto di dayabitis mɛlit we wi ɔl no. Lɛ wi tɔk bɔt dis ditayli.

Wetin na Sɛntral Dayabitis Insipidus (CDI)?

Fɔ tɔk am simpul wan, `Sɛntral Dayabitis Insipidus (CDI)` na wan sik we nɔ kin apin so ɔltɛm. Wetin kin apin na dat yu bɔdi nɔ gɛt di Antidiuretic Hormone (ADH) , we sɔm pipul dɛn kin kɔl Vasopressin . Dis ADH ɔmon de ɛp fɔ kɔntrol di wata we de na wi bɔdi. we dis כmon dכn sכmtεm, di kidni dεm kin bigin fכ kכl mכr wata lεk urine. So, yu kin pis bɔku ɛn fil se yu dɔn blo bad bad wan.

Dis ADH ɔmon na di haypothalamus we de na wi bren de mek am. Bɔt dɛn kin kip am ɛn pul am we ɔda smɔl gland we de na di bren , we na di pituitary gland , nid am. So, if eni damej de pan di haypothalamus כ pituitary gland, CDI kin divεlכp.

If yu gɛt CDI, if yu nɔ drink inof wata fɔ tek di ples fɔ di wata we yu de lɔs tru urine, yu kin gɛt dɛhydrated . Dis rili denja.

Sɔm pipul dɛn kin gɛt wan kayn CDI we kin rili bad, we min se di ADH ɔmon nɔ de wok fayn. Dɛn kɔl dis `kɔmplit CDI`. כda wan dεm kin gεt fכm we nכ sכmtεm, we min se di ADH כmon de wok to sכm tεm. Dɛn kɔl dis `partial CDI`.

Di tin we impɔtant pas ɔl na, we yu yɛri di nem `Diabetes Insipidus`, nɔ kɔnfyus am wit `Diabetes Mellitus`. Dɛn tu tin ya gɛt di wɔd `dayabitis` bikɔs dɛn tu tin ya gɛt di sem sayn fɔ tɔsti pasmak ɛn fɔ pis bɔku tɛm. Di wɔd `diabetes` kɔmɔt frɔm di Grik wɔd `diabainein`. I min `fɔ pas tru`. Jɔs lɛk aw wata kin pas na di bɔdi kwik kwik wan ɛn kɔmɔt na di bɔdi lɛk urine.

Fo men kayn `Dayabetes Insipidus` de:

• `Sɛntral Dayabitis Insipidus (CDI)` - Dis na di kayn we we wi de tɔk bɔt pas ɔl.
• Nephrogenic Diabetes Insipidus - di kidni dεm nכ de rεspכnd to ADH.
• `Dipsogenic Diabetes Insipidus` - Bikɔs ɔf wan saykolojik urge fɔ drink pasmak wata.
• `Gestational Diabetes Insipidus` - na wan tεmporari kכndyushכn we de apin we uman bεlε.

Wetin na dis ADH (antidiuretic hormone)?

ADH, ɔ vasopressin, na, lɛk aw wi bin dɔn tɔk, wan ɔmon we yu haypothalamus de mek ɛn we yu pituitary gland de kip ɛn pul am. Ɔmon dɛnDɛn tan lɛk kemikal mɛsenja dɛn we de kɔdinɛt di difrɛn tin dɛn we wi bɔdi de du. Dɛn tin ya kin travul tru di blɔd ɛn kɛr mɛsej to wi ɔgan dɛn, mɔsul dɛn, ɛn ɔda tisu dɛn. Dɛn sayn ya de tɛl di bɔdi wetin fɔ du ɛn ustɛm fɔ du am.

di haypothalamus na di pat pan wi bren we de kכntro di wok we di כtonom nεv sεstem εn di pituitary gland de du. i de mek ADH εn i de sεnd am to di pituitary gland fכ stכr εn rilis we nid de.

di pituitary gland na wan sכmכl gland we de na di bכs pat na di bren, jכs dכn di haypothalamus. na pat pan wi εndokrin sistεm. I wok na fɔ mek, kip, ɛn pul bɔku impɔtant ɔmon dɛn. ADH de stכr εn rilis bay di posita pituitary gland.

ADH kin kɔntrol mɔ ɔmɔs wata wi kidni dɛn kin tek bak insay wi bɔdi we dɛn de filta dɔti tin dɛn we de kɔmɔt na wi blɔd, ɛn dis kin mek di wata balans na di bɔdi. Nɔmal wan, we yu nɔ gɛt wata ɔ yu blɔd prɛshɔn smɔl, yu bɔdi kin mek ɛn pul mɔ ADH. dis de gi signal fכ di kidni dεm fכ "kip di wata na yu bכdi, nכ fכ kכl am na di urine."

so, insay CDI, di haypothalamus nכ de prodyuz inof ADH, כ di pituitary gland nכ de rilis inof ADH. Dis na di rizin we mek bɔku bɔku urine kin de bɔku tɛm.

Wetin na di difrɛns bitwin Sɛntral Dayabitis Insipidus (CDI) ɛn Nɛfrojɛnik Dayabitis Insipidus?

Di sayn dɛm fɔ ɔl tu di sik dɛm na di sem: fɔ pis pasmak ɛn fɔ it wata pasmak. Di difrɛns de pan di tin we kin mek dɛn tu sik ya ɛn aw dɛn kin trit dɛn.

Nephrogenic Diabetes Insipidus kin apin we yu pituitary gland de rilis inof ADH, bɔt yu kidni dɛn nɔ de ansa fayn. Dis min se yu kidni nɔ kin ebul fɔ kip wata. Bɔku rizin dɛn de fɔ dis:

• Sɔm mɛrɛsin dɛn, fɔ ɛgzampul, litiɔm ɛn tɛtrasayklin .
• Di potashɔm we de na di blɔd we smɔl (Hypokalemia) .
• Di kalsiɔm lɛvɛl we de na di blɔd de go ɔp (Hypercalcemia) .
• Urinary tract we nɔ de wok fayn.

Sɛntral Dayabitis Insipidus (CDI) kin kam bikɔs di haypothalamus ɔ pituitary gland nɔ de wok fayn, we nɔ de mek inof ADH. I kin bi bikɔs di haypothalamus ɔ di pituitary gland dɔn pwɛl. Dis damej kin kam bikɔs ɔf tin dɛm lɛk ed injury, ɔpreshɔn, inflamation, ɔ tumor.

Udat kin gɛt CDI? Aw i kɔmɔn?

Sɛntral Dayabitis Insipidus (CDI) kin kam pan ɛni ej, bɔt i kin izi fɔ bigin bitwin 10 ɛn 20 ia .

CDI na wan sik wae nɔr kin bɔrku, wae kin afɛkt lɛk wan pan ɛvri 25,000 pipul dɛm .

Wetin na di sayn dɛm fɔ CDI?

Di men sayn dɛm fɔ `Sɛntral Dayabitis Insipidus (CDI)` na:

• Fɔ pis bɔku tɛm, ivin na nɛt.
• Fɔ pas bɔku bɔku layt kɔlɔ ɔ klia urine ɛvri tɛm.
• Fɔ fil taya bad bad wan ɛn tɔsti , so drink wata ɔltɛm.

Pan ɔl we nɔmal pɔsin kin pul lɛk wan to tu lita urine pan wan de, pɔsin we gɛt CDI kin pul lɛk 19 lita (20 kwata) urine fɔ wan de ! Imajin aw dat na bɔku tin!

Di simptom dɛm na yɔŋ bebi dɛm

Yכŋ pikin dεm we gεt CDI kin sho bak sכmtεm dεm lεk dis:

• I nɔ kin rɛst ɔltɛm ɛn i kin vɛks bad bad wan.
• Letargy we pɔsin kin taya.
• Fɔ vɔmit.
• Banbɛlɛ.
• Fiva.

Di sayn dɛn we de sho se yu nɔ gɛt wata na yu bɔdi

If dɛn nɔ trit CDI, ɔ if pɔsin we gɛt CDI nɔ drink bɛtɛ wata, di wata kin kɔmɔt na in bɔdi kwik kwik wan. Di sayn dɛm we de sho se yu nɔ gɛt wata na yu bɔdi na:

• Diziz, fil lɛk yu ed layt.
• Taya.
• Dray mɔt, lip, yay.
• I nɔ izi fɔ du simpul wok dɛn na yu maynd.
• Vɔmit.
• Fɔ mek pɔsin nɔ ebul fɔ du natin.

If yu tɔsti pasmak ɛn yu de pis bɔku tɛm ɛn/ɔ sayn dɛn fɔ se yu nɔ gɛt wata na yu bɔdi, i rili impɔtant fɔ go na ɔspitul kwik kwik wan. Pan ɔl we CDI nɔ kin bɔku, nɔto di wangren tin we kin mek pɔsin gɛt dɛn sik ya. Fɔ tɔsti pasmak ɛn fɔ pis bɔku tɛm na strɔng sayn dɛn we de sho se sɔntin nɔ de wok fayn na yu bɔdi ɛn yu nid fɔ go to dɔktɔ.

Wetin na di tin dɛn we kin mek pɔsin gɛt Sɛntral Dayabitis Insipidus (CDI)?

Di men tin we kin mek pɔsin gɛt Sɛntral Dayabitis Insipidus (CDI) na we di ɔmon ADH nɔ de kɔmplit ɔ sɔm pat pan am. dis dεfichεshכn kin kכz fכ di damej pan yu haypothalamus, pituitary gland, כ di tisu we kכnεkt di tu (pituitary stalk). Sɔm patikyula tin dɛn we kin mek pɔsin gɛt dis sik na:

• Damej to di haypothalamus ɔ pituitary gland bikɔs ɔf ɔpreshɔn.
• di damej pan di haypothalamus כ pituitary gland bikoz fכ di ed injuri, spεshal wan di basal sכkul fraktכs.
• Inflameshɔn (granulomas) we kin kam wit sik dɛn lɛk sarcoidosis ɔ tuberculosis .
• Tumɔs dɛn lɛk kraniopharyngioma ɔ germinoma .
• Langerhans cell histiocytosis (dis na sik we nɔ kin apin so ɔltɛm we kin mek di tisu dɛn pwɛl ɔ skata na wan ɔ mɔ eria na di bɔdi).
• wan inhεrit jεnεtik mכtεshכn pan kromozom 20 (dis na rili, rili rεs - lεs dan 100 kes dεm dεn ripot insay di mεdikal litεrachכ).

Insay lɛk wan pat pan tri pan di wan dɛn we gɛt CDI, dɔktɔ dɛn nɔ kin ebul fɔ fɛn di rayt tin we mek i apin. Dɛn kɔl dis idiopatik sɛntral dayabitis insipidus (CDI).Risach pipul dɛm tink se sɔm kes dɛm fɔ idiopathic CDI kin bi bikɔs ɔf ɔtoimyun factor dɛm. Insay ɔtoimyun kɔndishɔn, yu bɔdi in imyun sistɛm kin bigin fɔ atak di wɛlbɔdi tisu. insay dis kayn we, di imyun sistεm kin mek antibodi dεm כ limfosayt dεm we de atak di sεl dεm we de mek ADH.

CDI kin apin bak as pat pan big sεndrכm כ kכndyushכn, lεk Wolfram sεndrכm ( wan kכndyushכn we dεn kin gεt bכdi) εn septo-optic dysplasia (wan dizayd we nכ kin apin we di bren de divεlכp kwik kwik wan).

Aw yu go no if yu gɛt CDI? (Diagnosis) .

Bikɔs ɔda tin dɛn bak kin mek pɔsin tɔsti ɛn pis bɔku tɛm, lɛk dayabitis, i impɔtant fɔ pul ɔda tin dɛn we de apin we yu de no se yu gɛt sɛntral dayabitis insipidus (CDI). So, if yu gɛt dɛn sik ya, yu dɔktɔ kin du bɔku tɛst dɛn.

Fɔ no bɔt CDI kin inklud bak fɔ no wetin kin mek i gɛt am.

Us tɛst dɛn kin yuz fɔ no if pɔsin gɛt CDI?

Di tɛst we pɔsin nɔ gɛt wata na di we we simpul ɛn we pɔsin kin abop pan fɔ no if pɔsin gɛt CDI. If yu dɔktɔ tɛl yu fɔ du dis tɛst, dɛn go mek shɔ se dɛn de wach yu gud gud wan we dɛn de du di tɛst, bikɔs i kin mek yu nɔ gɛt wata na yu bɔdi.

Dis tɛst involv fɔ go witout ɛni wata fɔ sɔm awa ɛn si aw yu bɔdi de ansa. If yu gɛt CDI, yu go kɔntinyu fɔ pas bɔku bɔku wata (dilute), layt kɔlɔ urine, ivin we yu nɔmal fɔ pas smɔl dak yɔlɔ, kɔnsɛntret urine.

Yu dɔktɔ kin ɔda dɛn tɛst ya bak fɔ ɛp fɔ no if yu gɛt CDI ɛn fɔ pul ɔda tin dɛn we de apin:

• Wan blɔd tɛst fɔ chɛk di lɛvɛl we ADH (antidiuretic hormone) de na di blɔd.
• Blɔd tɛst fɔ chɛk di glukɔs lɛvɛl fɔ mek dɛn nɔ gɛt dayabitis.
• urinalysis fכ chεk di kכnsantreshכn (osmolality) fכ di urine εn/כ fכ chεk fכ kεtכn, we kin sho se yu gεt dayabitis.
• Fɔ no aw yu kidni dɛn de ansa, dɛn go gi yu wan injɛkshɔn we gɛt sɛntetik ADH. Pipul dɛm wae gɛt Nephrogenic Diabetes Insipidus nɔr de rεspכnd to sεntetik ADH bikɔs dεn kidni dεm nɔr de rεsist di ifekt dεm we ADH de gi. Na di ɔda say, pipul dɛn we gɛt CDI kin ansa to sintetik ADH.
• Yu kin yuz imej tɛst lɛk MRI (Magnetic Resonance Imaging) fɔ no if yu pituitary gland ɔ haypothalamus dɔn pwɛl, ɛn if na so, wetin na di kɔz.

Wetin na di tritmɛnt dɛm fɔ CDI?

di tritmεnt fכ CDI dipכnt pan di siriכs we di ADH כmon dεfichεns de.

Yu gɛt wan kɔmplit CDI.If na so, desmopressin na di fɔs layn tritmɛnt. Dis na mɛrɛsin we de wok lɛk di ɔmon ADH. Yu kin tek desmopressin as injɛkshɔn, as pil, ɔ as sprɛy na yu nos.

If yu gɛt pat pan CDI , we min se natura ADH stil de wok to sɔm mak, yu dɔktɔ kin gi yu ɔda mɛrɛsin dɛn, lɛk hydrochlorothiazide (HCTZ) .

As tritmɛnt fɔ yɔŋ bebi dɛn we gɛt CDI, dɛn kin gi fɔmula ɔ mama in milk we dɛn dɔn dil wit wata ɛn gi am wit haydroklorotiazayd.

Ɛni sayd ɛfɛkt de we Desmopressin kin gɛt?

Desmopressin na jɔs wan mɛrɛsin we rili sef wit smɔl sayd ɛfɛkt dɛn. Di sayd ɛfɛkt dɛn we pɔsin kin gɛt na:

• Ed de at.
• Bɛlɛ de pen.
• Vɔmit.
• Nasal kɔnjɛshɔn ɔ di nos we de rɔn .
• Nɔs blɔd de kɔmɔt.

If yu tek bɔku desmopressin, ɔ if yu drink bɔku wata we yu de tek am, yu bɔdi kin kip bɔku wata. Dis kin mek yu gɛt sɔm kayn sik lɛk:

• Ed de at.
• Diziz we pɔsin kin gɛt.
• Fɔ blo.
• Sɔl (sɔdiɔm) we smɔl na di blɔd (Hyponatremia) .

Di sayn dɛm fɔ Hyponatremia:

• Wan ed we kin at bad bad wan ɔ we kin de fɔ lɔng tɛm.
• Kɔnfyus.
• Nɔs ɛn vɔmit.

If yu gɛt sayn dɛm fɔ hyponatremia, yu fɔ kɔl 911 ɔ go na di imejensi rum we de nia yu kwik kwik wan.

Aw pɔsin we gɛt CDI go ebul fɔ manej dis?

If yu gɛt CDI, apat frɔm mɛrɛsin, i rili impɔtant fɔ drink wata ɔltɛm fɔ mek yu nɔ gɛt wata na yu bɔdi.

I impɔtant bak fɔ go to yu dɔktɔ ɔltɛm fɔ mek shɔ se yu tritmɛnt de wok fayn ɛn di doz fɔ di mɛrɛsin we dɛn gi yu kɔrɛkt.

Wetin na di risk factor dɛm fɔ divɛlɔp CDI?

Bɔt i sɔri fɔ no se, bɔku pan di kes dɛm we dɛn kin gɛt Sɛntral Dayabitis Insipidus (CDI) nɔ kin ebul fɔ avɔyd. Risk factor dɛm fɔ divɛlɔp CDI inklud:

• Dɛn kin du ɔpreshɔn pan di bren.
• Fɔ gɛt famili histri bɔt dayabitis insipidus ɛn/ɔ Wolfram sindrom.
• Di wund dɛn we pɔsin kin gɛt na in ed.
• Infεkshכn dεm na di bren.

Wetin na di wɛlbɔdi stet fɔ pɔsin we gɛt CDI? (Prɔgnosis) .

Di prɔgnosis fɔ pɔsin we gɛt `Sɛntral Dayabitis Insipidus (CDI)` kin jɔs fayn, ɛn if dɛn trit am fayn ɛn it inof wata, i nɔ kin mek big prɔblɛm.

Bɔt yɔŋ pikin dɛn, ol pipul dɛn, ɛn di wan dɛn we gɛt prɔblɛm wit dɛn maynd kin gɛt prɔblɛm ɛn day bikɔs i nɔ kin izi fɔ dɛn fɔ no se dɛn tɔsti ɔ fɔ du sɔntin.

Wetin na di prɔblɛm dɛn we kin apin we pɔsin gɛt Sɛntral Dayabitis Insipidus (CDI)?

Di men kɔmplikɛshɔn fɔ CDI naDi wata we nɔ de na di bɔdi . Dis min se yu bɔdi de lɔs inof wata ɛn ilɛktrɔlayt fɔ wok fayn fayn wan. If yu gɛt CDI, yu kin ebul fɔ manej di bɔku bɔku wata we yu de lɔs na yu urine bay we yu de drink bɔku wata. Bɔt if yu nɔ du dat, yu kin gɛt wata kwik kwik wan.

If yu nɔ gɛt wata na yu bɔdi, dat kin mek yu gɛt prɔblɛm, ɛn i kin ivin mek yu layf de pan denja. If yu gɛt sɔm sayn dɛn we de sho se yu nɔ gɛt wata na yu bɔdi, lɛk yu ed de tɔn, yu nɔs, ɛn yu nɔ de taya, go na di ɔspitul we de nia yu kwik kwik wan.

If dɛn nɔ trit CDI pan yɔŋ bebi dɛn , we dɛn nɔ gɛt wata na dɛn bɔdi bɔku tɛm i kin mek dɛn gɛt prɔblɛm dɛn lɛk:

• Di sik dɛn we kin mek pɔsin sik.
• Bren we dɔn pwɛl.
• Divɛlɔpmɛnt dilɛys.
• Stunted growth.

If dɛn nɔ trit CDI pan pikin ɛn big pipul, kɔmplikeshɔn dɛn lɛk:

• Di at we nɔ de bit ɔltɛm (Aritmia) .
• Fiva.
• di dray we di skin εn di mכkus mεmbran dεm (e.g. insay di mכt, di nos).
• Di sik dɛn we kin mek pɔsin sik.
• Kɔma.

Di big pipul dɛn we gɛt CDI kin gɛt wan sik we dɛn kɔl ɔrthostatic hypotension , we na we dɛn blɔd prɛshɔn kin go dɔŋ wantɛm wantɛm we dɛn tinap ɔ sidɔm. Dis kin mek yu ed de tɔn ɔ yu nɔr no natin fɔ sɔm tɛm.

Ustɛm yu fɔ go to dɔktɔ?

If yu gɛt Sɛntral Dayabitis Insipidus (CDI), i impɔtant fɔ go to yu dɔktɔ ɔltɛm fɔ wach yu kɔndishɔn ɛn mek shɔ se yu tritmɛnt de wok. If yu gɛt ɛni sayn we de wɔri yu, mek shɔ se yu tɛl yu dɔktɔ.

If yu gɛt sɔm sayn dɛn we de sho se yu nɔ gɛt bɛtɛ wata na yu bɔdi, lɛk fɔ kɔnfyus ɔ yu nɔs, go na di imejensi rum we de nia yu kwik kwik wan.

Kwɛstyɔn dɛn we yu fɔ aks yu dɔktɔ

If dɛn dɔn no se yu gɛt Sɛntral Dayabitis Insipidus (CDI), i go fayn fɔ aks yu dɔktɔ dɛn kwɛstyɔn ya:

• Wetin mek a bin gɛt CDI?
• Mi CDI kɔndishɔn na fɔ lɔng tɛm ɔ fɔ shɔt tɛm?
• Us tritmɛnt opshɔn dɛn a gɛt?
• Wetin na di bɛnifit ɛn bad tin dɛn we difrɛn tritmɛnt dɛn kin gɛt?
• Ɔmɔs wata a fɔ drink fɔ wan de?
• Wetin bak a go du fɔ mek a ebul fɔ kɔntrol mi sik?
• Mi famili mɛmba dɛn de pan denja fɔ gɛt CDI?

Fɔ dɔn, di tin we impɔtant pas ɔl (Take-Home Message) .

Sɛntral Dayabitis Insipidus (CDI) na wan sik we nɔ kin bɔku bɔt we kin rili siriɔs. Di gud nyus na dat, dɛn kin trit am ɛn manej am.If yu gɛt CDI, i impɔtant fɔ go to yu dɔktɔ ɔltɛm fɔ mek shɔ se yu tritmɛnt de wok fayn fayn wan. If yu gɛt ɛni kwɛstyɔn bɔt yu sik, nɔr frayd fɔ aks yu dɔktɔ. Dɛn de fɔ ɛp yu fɔ kɔntrol yu sik. Nɔ fɔgɛt fɔ drink bɔku wata, i rili impɔtant!

` Sɛntral Dayabitis Insipidus, CDI, ADH, kidni, ɔmon, we yu de pis pasmak, we yu tɔsti pasmak