Yu dɔn ɛva it it we gɛt bɔku ɔyl, lɛk biryani, ɔ sɔntin lɛk spaysi kari wit kokonat milk, ɔ wan fish we gɛt ɔyl? We yu dɔn it, yu tink se, "O, dat dɔn inof, mi bɛlɛ dɔn ful-ɔp." Yu dɔn ɛva wɔnda udat rili tɛl yu bren se yu bɛlɛ ful-ɔp ɛn yu fɔ stɔp fɔ it? Wan pan di impɔtant wok dɛm we dis ɔmon de du we wi de tɔk bɔt tide na kɔlesistɔkinin. Fɔ tɔk am simpul wan, i tan lɛk wan rili impɔtant manija na wi dijestiv sistɛm.
Fɔ tɔk am simpul wan, wetin na kɔlesistɔkinin?
Cholecystokinin na wan ɔmon we de wok as pat pan wi dijestiv sistɛm. Ɔmon na kemikal mɛsenja we de mek na wan ples na wi bɔdi, we de travul tru di blɔd, ɛn kɛr mɛsej go na ɔda say. Lɛk pɔsin we de wok na post. dis cholecystokinin, כ CCK fכ sכt, na wi bכdi de kכmכt afta wi it, we dεn digεst da it de.
I kin mɔ na wi smɔl intestinal we dɛn kin mek ɛn kɔmɔt . bכt di amazing tin na, dis CCK כmon de insay wi bren εn sεntri nεv sεstem bak. Bɔt dɔktɔ dɛn stil de tray fɔ no bɔku tin bɔt aw i de wok de. Sɔntɛnde dɛn kin kɔl am bak pankrɛozaymin . Bɔt di nem we dɛn kin yuz mɔ na kɔlesistɔkinin.
Aw dis CCK ɔmon kin bigin fɔ kɔmɔt na di bɔdi?
Imajin se yu de it it. Dat it de fɔs go insay di bɛlɛ. afta sכm tεm dεn dכn digεst na di bεlε, da it de go dכn go insay di fכs pat pan di sכmכl intestin. Wi kin kɔl am di duodenum .
Na de di rial wok bigin. if yu don it it we rich wit protin (e.g. mit, fish, eg, lentil) εn fεt (e.g. כyl, kokonat milk, bכta), wan spεshal tכp sεl na di wכl dεm na di duodenum (we dεn kכl 'I-sεl') "de no" dεn protin dεm εn fεt dεm ya. I tan lɛk se gad de si spɛshal gɔst.
we dεn no di protin εn fεt dis we, dεn sεl dεm ya kin mek di כmon CCK kwik kwik wan εn kכmכt na wi bכdi. Dat na di ‘signal’ fɔ mek CCK bigin fɔ wok.
Wetin na di men tin dɛm we kin apin insay di bɔdi bikɔs ɔf di CCK ɔmon?
Wans CCK de insay di blɔd, i nɔ jɔs de sidɔm de. I tan lɛk se na manija fɔ di wan ol dijestiv sistɛm, we de du bɔku wok dɛn wan tɛm. Dis na tin we rili wɔndaful. Lɛ wi si wetin i bi.
| Di wok we di CCK ɔmon de du | Wan simpul ɛksplen |
|---|---|
| Di gal blad we de kɔntrakt | CCK go signal di gal blad, "Okay, naw yu go swɛt ɔl di bayl we yu gɛt insay di smɔl intestin." di wכd 'cholecystokinin' rili min "fכ muv di gal blad." dis bayl na in de εp wi fכ digεst di fεt we wi de it. |
| Stimulating di pankrias | di sem tεm, CCK de sεnd mεsej bak to di pankrias, se, "Sεnd yu pankrεas εnzym dεm naw." dis εnzym dεm de brok dכn di protin dεm εn fεt dεm to sכm sכm sכm pat dεm so dat di bכdi go tek dεm. |
| Kɔntrol di gastric ɛmti we de ɛmti | we dis digεstכn prכsεs de go bifo na di sכmכl intestin, di CCK de tεl di bεlε se, "Wεt wan minit, nכ sεnd mכr it te dis it dεn digεst." I tan lɛk se trafik polis ɔfisa de kɔntrol trafik. dis de mek di digεstכn prכsεs tek di rayt tεm. |
| Di apɛtit we de go dɔŋ (we yu de fil ful) . | Dis na wetin wi kin fil bɔku tɛm. CCK de mek wi fil ful pan tu we. Wan pan dɛn na bay we dɛn de mek di bɛlɛ fil lɛk se in bɔdi ful-ɔp. di כda wan na bay we i de mek di vagal nεv dεm na di bεlε wכl dεm, we de sεnd signal to di bren we se, "If, a ful." |
| fכ mek di intestinal muvmεnt (peristalsis) . | fכ finish, CCK de εp bak fכ initiate peristalsis, di mכsul kכntrikshכn dεm we lεk wev we nid fכ muv di it we dεn digεst dכn di intestines. |
di ifekt dεm we CCK gεt pan di bren εn di nεv sεstem
Apat frɔm di dijeshɔn, risach dɔn sho se CCK kin afɛkt wi maynd stet bak. Speshal, wae yu de wɔri ɛn de panik.I tan lɛk se CCK gɛt fɔ du wit wɔri hat. Stɔdi dɔn sho se we di CCK lɛvɛl go ɔp na di bren kin mek pɔsin wɔri mɔ ɛn mɔ. Dɛn de du mɔ risach bɔt dis.
Us mɛdikal kɔndishɔn dɛn kin gɛt fɔ du wit CCK?
Dɔktɔ dɛn dɔn si se pipul dɛn we gɛt sɔm kayn mɛrɛsin kin gɛt smɔl CCK. Bɔt dɛn nɔr dɔn klia yet if dis na wan tin wae de mek pɔrsin gɛt dis sik ɔr na sayn fɔ de sik.
- Gastroparesis: pan dis kכndyushכn, di bεlε mכsul dεm nכ de wok fayn, we de mek di it de delay fכ muv frכm di bεlε to di sכmכl intestכn. di lכw lεvεl dεm fכ CCK kin involv.
- Biliary Dyskinesia: Dis na we di gal blad nɔ de kɔntrakt fayn ɛn i de rilis bayl. dis kin bi biכs di gal blad nכ de rεspכnd fayn to CCK.
- Wae yu de wɔri ɛn fat: Sɔm pipul dɛn gɛt difrɛn kayn jɛnɛtiks we de chenj di we aw di CCK ɔmon de tɔk to di bren. Dis kin mek chenj na di apɛtit kɔntrol signal ɔ di wɔri kɔntrol signal.
Di rilayshɔn bitwin CCK ɛn fɔ fat pasmak
Dis na impɔtant tɔpik fɔ bɔku pipul dɛn. Sayɛnsman dɛn de du bɔku risach bɔt di rilayshɔn bitwin CCK ɛn fɔ fat.
Sɔm stεdi dεn sho se pipul dεm we gεt spεshal jεnεtik vεryכnt kin gεt 60% inkrεs risk fכ fכ fat.
dεn dכn fכnshכn bak se sכm pipul dεm we fat nכ kin gεt bכku sεnsitiviti to di "ful" signal we di כmon CCK de sεnd. Dis min se pan ɔl we dɛn ful-ɔp, dɛn bren nɔ go ebul fɔ no am kɔrɛkt wan. Dis kin mek dɛn it mɔ pas wetin dɛn nid. CCK ɛn wan ɔda ɔmon we dɛn kɔl lɛptin de wok togɛda fɔ kɔntrol wi angri ɛn ful signal.
Wetin na di Kɔlesistɔkinin Tɛst?
Sɔntɛnde, if yu dɔktɔ tink se yu gal blad nɔ de wok fayn, i kin ɔda fɔ mek dɛn du spɛshal tɛst fɔ si if i de wok fayn. Dis na we dɛn kin du di CCK tɛst.
Dɛn kin du dis togɛda wit HIDA skan . HIDA skan na spɛshal skan we de luk aw tin dɛn lɛk wi gal blad ɛn bayl dakt dɛn de wok.
Na dis na aw fɔ du am:
1. Tracer Injection: Fɔs, wan tɛknishian go injekt wan rili smɔl redioaktiv tin (tracer) insay yu vein. Nɔ wɔri, dis nɔr de ambɔg di bɔdi. Dis tin de travul tru di blɔd ɛn gɛda na yu liva ɛn gal blad.
2. Fɔs skan:Dɔn, dɛn kin yuz kɔmpyuta skan fɔ tek sɔm pikchɔ dɛn bɔt yu gal blad.
3. CCK injεkshכn: Nεks כp na di mכst imכtant pat. If di dɔktɔ want fɔ si wetin kin apin we yu gal blad kɔntrakt, dɛn go injɛkt yu smɔl smɔl ɔmon CCK tru wan vein.
4. Di sɛkɔn skan: Afta di CCK injɛkshɔn, wetin de apin na di sem tin lɛk we yu it it we gɛt fat. Dat min se yu gal blad de bigin fɔ kɔntrakt. Da tɛm de, dɛn kin tek ɔda siriɔs pikchɔ dɛn.
We di dɔktɔ kɔmpia dɛn pikchɔ ya, i go ebul fɔ no ustɛm yu gal blad de wok fayn, if i de pul di bayl fayn fayn wan, ɛn if ɛnitin de we dɔn blok.
Dɛn kin yuz CCK fɔ mɛn pipul dɛn?
Naw, dɛn nɔ de yuz di CCK ɔmon dairekt wan as tritmɛnt fɔ ɛni mɛdikal kɔndishɔn. Bɔt i dɔn rili impɔtant fɔ fɛn ɛn tɛst nyu mɛrɛsin dɛn.
Fɔ ɛgzampul:
- Drugs fɔ lɛf fɔ it: Bikɔs CCK gɛt di abiliti fɔ no se pɔsin ful-ɔp, di wan dɛn we de stɔdi bɔt dis de tray fɔ mek mɛrɛsin dɛn we de mek pɔsin nɔ want fɔ it we go falamakata da prɔses de.
- Tritmɛnt fɔ wɔri: Wan patikyula pat pan CCK (CCK-4) kin mek mɔtalman wɔri ɛn panik ɔnda kɔndishɔn we dɛn kin kɔntrol. Sayɛnsman dɛn kin yuz dis we fɔ tɛst if nyu mɛrɛsin dɛn we dɛn dɔn mek fɔ mek pipul dɛn nɔ wɔri bɛtɛ, wok fayn.
So, CCK nɔto jɔs ɔda ɔmon na wi bɔdi. Na wan wɔndaful kemikal mɛsenja we de afɛkt bɔku tin dɛn, frɔm wi dijestiv sistɛm to wi maynd wɛlbɔdi, ɛn bɔku ɔda tin dɛn de fɔ no tumara bambay.
Mɛsej we dɛn kin kɛr go na os
- Cholecystokinin (CCK) na wan imכtant כmon we di sכmכl intestin de mek we de εp fכ digεst di protin dεm εn fεt dεm we wi de it.
- dis de mek di gal blad εn pankrias wok, i de rilis bayl εn εnzym dεm we nid fכ digεst.
- dis CCK כmon na in de gi di bren di mכst imכtant signal we de tεl wi se, "Wi ful, wi dכn it inof." Dis rili impɔtant fɔ kɔntrol di wet.
- Dɛn kin yuz CCK bak fɔ du mɛdikal tɛst, lɛk di HIDA skan, we de chɛk aw di gal blad de wok.
- Sayɛnsman dɛm stil de du risach bɔt di rilayshɔn bitwin CCK ɛn tin dɛm lɛk fɔ fat ɛn wɔri. If yu gɛt ɛnitin fɔ wɔri bɔt dis, i go fayn fɔ mek yu tɔk to yu dɔktɔ.
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