Wi go tɔk bɔt dis ‘klia sɛl’ kayn kansa we de divɛlɔp na di kidni (Clear Cell Renal Cell Carcinoma - ccRCC) tide?

Di kidni na wan pan di impɔtant pat dɛn na wi bɔdi. Dɛn tu smɔl ɔgan ya we de filta wi blɔd ɛvride ɛn pul tin dɛn we nɔ nid as urine tan lɛk tu filta dɛn na wi bɔdi. Bɔt dɛn kidni ya kin gɛt difrɛn sik dɛn bak. Tide wi go tɔk bɔt wan kayn kidni kansa we siriɔs smɔl, bɔt i rili impɔtant fɔ no bɔt. dis na `(Klir Sεl Rεnal Sεl Karεn)`, in sכt `(ccRCC)`.

Wetin na ‘klia sɛl rεnal sɛl kansa’ (ccRCC)?

Fɔ tɔk am simpul wan, dis `(Clear Cell Renal Cell Carcinoma - ccRCC)` na wan sɔbtayp fɔ kidni kansa. we wi de tכk bכt kidni kεnsar, wi kin jεnarali se `(Renal Cell Carcinoma - RCC)`. Dis `(ccRCC)` na wan pan in kayn dɛn.

Yu no se wi kidni dɛn gɛt smɔl smɔl chanɛl dɛn insay dɛn, lɛk filta? Dɛn wan ya kin filta di dɔti tin dɛn we de insay di blɔd ɛn pas dɛn as urine. Dis kansa kin bigin na di sɛl dɛn we de layn dɛn chanɛl dɛn de. dis `(ccRCC)` sεl dεm de divayd εn mכltiply kwik kwik wan, we de fכm wan כ mכr tכmכro dεm. Bɔku tɛm, i kin afɛkt wan kidni, bɔt sɔntɛnde i kin afɛkt ɔl tu di kidni dɛn.

Wetin na di sayn dɛm fɔ dis sik?

Bɔrku tɛm, na di fɔs stej dɛm fɔ dis `(ccRCC)`, nɔr big simptom nɔ de. Na dat de mek pɔsin fred smɔl. Bikɔs yu nɔ go ivin no se yu gɛt di sik. Bɔt as di sik de go bifo, yu kin gɛt tin dɛn lɛk:

• Blɔd we de na di urine. Sɔntɛnde, di urine kin bi rɛd, pink, ɔ brawn. Dɔktɔ dɛn kin kɔl dis ``hematuria''.
• Taya na di filin fɔ taya pasmak, ilɛksɛf yu slip bɔku. Yu kin fil taya ɔl di de.
• Fiva we kin kam fɔ natin. If yu jɔs gɛt fiva we yu nɔ gɛt ɛni ɔda sik, dat na sɔntin bak fɔ pe atɛnshɔn to.
• I kin fil lɛk wan lump we yu kin fil na di kidni we afɛkt .
• Flank pen na pen na di sayd na di kidni . Dis pen kin de ɔltɛm ɔr kin kam ɛn go.
• We yu de lɔs yu wet we yu nɔ ɛksplen. If yu jɔs de lɔs yu wet we yu nɔ de it ɔ ɛksesaiz, dat na sɔntin we yu fɔ luk insay.

Wetin mek dis `(ccRCC)` kin apin? Wetin na di tin dɛn we kin mek i apin?

fכ bi כnεst, dεn nכ no di εksakεt kכz fכ mכst kidni kεnsar, inklud dis `(ccRCC)` . Bɔt dɛn dɔn si se sɔm tin dɛn kin mek pɔsin gɛt am mɔ ɛn mɔ. Lɛ wi si wetin dɛn bi?

• Yuz tin dɛn we dɛn mek wit tabak : Dis nɔ min jɔs fɔ smok bɔt fɔ vap bak. Di bad bad kemikal dɛn we de insay tabak kin pwɛl di kidni dɛn.
• Body Mass Index (BMI) ova 25 : Fɔ tɔk am simpul wan, fɔ bi ɔvawej/fat. If pɔsin fat, i kin mek in ɔmon chenj ɛn ɔda prɔblɛm dɛn we kin mek i gɛt kansa mɔ.
• Ay blɔd prɛshɔn (hay blɔd prɛshɔn): Dis na we yu blɔd prɛshɔn de go ɔp. Dis risk kin apin bikɔs ay blɔd prɛshɔn kin pwɛl di kidni dɛm.
• Fɔ gɛt dayalaysis bikɔs ɔf di kidni sik we dɔn de fɔ lɔng tɛm : Pipul dɛn we de du dayalaysis kin gɛt risk bak fɔ gɛt kidni kansa.
• Fɔ gɛt sɔm pɔyzin kemikal dɛn na di wokples : Fɔ ɛgzampul, di wan dɛn we de pan sɔlvɛnt lɛk triklɔroɛtilin, asbest, ɛn kadmiɔm dɛnsɛf kin gɛt mɔ prɔblɛm.
• Yuz mɛrɛsin fɔ mɛn pen fɔ lɔng tɛm : Sɔm mɛrɛsin dɛn we de mek yu fil pen, lɛk asetaminofɛn (Tylenol®), nɔ fayn fɔ yu if yu de tek dɛn ɔltɛm ɔ yu tek am pasmak.

Udat kin divɛlɔp dis `(ccRCC)` pas ɔlman?

fכ tru, enibodi kin divεlכp dis kכndyushכn, we dεn kכl ``(ccRCC)``. Bɔt dɛn dɔn si se man dɛn kin gɛt dis sik tu tɛm pas uman dɛn . Dɔn bak, i kin bɔku pan pipul dɛn we ol bitwin 50 ɛn 70 ia.

Di American Cancer Society bin tɔk se ɛvri ia pas 81,000 pipul dɛn na Amɛrika kin gɛt kansa na dɛn kidni. Fɔ dɛn wan ya, di kayn kansa na di kidni we kin bɔku pas ɔl na in dɛn kɔl ccRCC .

Na dis sik we dɛn kɔl `(ccRCC)` na frɔm in mama ɛn papa?

If yu gɛt blɔd fambul we gɛt rεnal sɛl kansa, yu kin gɛt smɔl risk fɔ gɛt kidni kansa. Bɔt, dɔktɔ dɛn stil nɔ shɔ wetin mek.

Sɔm pipul dɛn gɛt jɛnɛtik kɔndishɔn we de mek dɛn gɛt mɔ chans fɔ gɛt ccRCC. Wan ɛgzampul na di sik we dɛn kɔl Von Hippel-Landau (VHL).

insay dεn kayn tin ya, wan jεnεtik mכtεshכn we de pas dכn tru jεnereshכn de mek sist εn tכmכro fכm na difrεn pat dεm na di bכdi. Bɔku tɛm, dɛn tumbu ya nɔ kin gɛt kansa. Bɔt pipul dɛn na dɛn famili ya kin gɛt ccRCC bɔku tɛm, ɛn i kin gɛt bak we dɛn yɔŋ pas aw i fɔ gɛt.

If dɛn no se yu gɛt ccRCC we yu yɔŋ, ɔ if yu gɛt bɔku bɔku tumbu dɛn, yu dɔktɔ kin tɛl yu fɔ du yu jenɛtik tɛst .

Aw dɛn kin no dis `(ccRCC)` sik?

As wi bin dɔn tɔk, bɔku tɛm, kidni kansa nɔ kin gɛt bɛtɛ sayn dɛn we i kin bigin. Na dat mek bɔku tɛm dɔktɔ dɛn kin fɛn kidni tumbu we dɛn de luk fɔ ɔda sik dɛn. Fɔ ɛgzampul, dɛn kin no wan kidni tumbu bay chans we dɛn de du MRI ɔ CT skan fɔ luk fɔ kidni ston.

Imej tɛst lɛk dis kin no if tumbu de. Bɔt i nɔ kin izi fɔ no fɔ tru frɔm skan nɔmɔ if di tumbu nɔ fayn ɔ i bad.

Fɔ mek dɛn no di sik kɔrɛkt wan , na dɔktɔDɛn kin du di kidni bayɔpsi, ɔ dɛn kin se dɛn fɔ du ɔpreshɔn fɔ pul di tumbu.

If dɛn pul di tumbu tru ɔpreshɔn, dɛn kin tek di tisu frɔm di tumbu ɛn tɛst fɔ si if i gɛt kansa. di rizulεt dεn de yuz fכ no if na kεnsar εn if na wan tכp we dεn kכl ``ccRCC''.

I sɔprayz fɔ no se na 4 pan 10 smɔl smɔl kidni tɔŋ dɛn nɔmɔ, we nɔ rich 4 sɛntimita in saiz, kin bi benign tumor, lɛk rεnal ɔnkosaytoma.

Wetin na di stej dɛm fɔ (ccRCC) kansa?

afta dεn no se i gεt `(ccRCC)`, di dכkta de disayd di ``kansa stej`` . Dat min se dɛn kin luk di sayz we di tumbu gɛt ɛn if i dɔn skata to ɔda pat dɛn na di bɔdi.

Fכ men kayn Klia Sεl Rεnal Sεl Karsinoma de.

• Di smɔl chans we yu gɛt, na di mɔ di kansa nɔ go rili bad.

Di dɔktɔ go tɔk to yu bɔt dɛn tin ya:

• Us stej yu kansa de insay.
• Wetin na di risk fɔ mek i go to ɔda pat dɛn na di bɔdi?
• Wetin na di nɛks tin dɛn we yu fɔ du ?

Wetin na di tritmɛnt dɛm fɔ `(ccRCC)`?

Bɔrku tɛm, di tritmɛnt opshɔn dɛm kin dipen pan if di kansa dɔn spre pas di kidni. Okay, mek wi si.

If di kansa nɔ bin dɔn pas di kidni:

If na so i bi, dɛn kin du tritmɛnt lɛk dis:

• Ɔpreshɔn - Nɛfrɛktɔmi : Ɔpreshɔn de pul di pat pan di kidni nɔmɔ we gɛt kansa. Dɛn kɔl dis pat pan di nɛfrɛktomi. Ɔda we de fɔ pul di wan ol kidni. Dɛn kɔl dis radikal nɛfrɛktɔmi.
• Ablative therapies : Dɛn tritmɛnt ya kin yuz wan we fɔ pwɛl di kansa sɛl dɛn bay we dɛn kin put nidul tru di skin. Difrɛn we dɛn de fɔ du dis. fכ egzampl, dεn kin pwεl di kεnsar sεl dεm bay we dεn yuz fכ kol pasmak (cryoablation) כ fכ wam pasmak (thermal ablation).

If di kansa dɔn skata, ɔ i gɛt bɔku risk fɔ prɛd:

If dɛn kayn tin ya apin, di tritmɛnt we dɛn kin pik na:

• Immunotherapy : Dis kin min fɔ mek yu bɔdi in yon imyun sistɛm pwɛl fɔ pwɛl di kansa sɛl dɛn. Di mɛrɛsin dɛn we dɛn kin yuz fɔ dis na pembrolizumab (Keytruda®) ɔ nivolumab (Opdivo®).
• Targeted therapy : Dis tritmɛnt de wok bay we i de stɔp di growth ɛn multiplication of cancer cells. Di mɛrɛsin dɛn we dɛn kin yuz fɔ dis na axitinib (Inlyta®) ɛn kabozantinib (Cabometyx®).

`(ccRCC)` na siriɔs, fast-spred kansa?

lεk כl כda kayn `(karsinoma), dis `(Klir Sεl Rεnal Sεl Karsinoma)` kin spre (mεtastasayz) to כda pat dεm na di bכdi. Fɔ trit kansa we dɔn skata dis kayn we (mɛtastatik kansa) kin at smɔl.

we yu kכmpεr am wit כda kayn kidni kεnsar, ``(ccRCC)`` kin bi mכr agresiv εn i kin tεnd fכ spre kwik kwik wan .

di rεnal sεl kansa kin spre mכst na dεn say dεm ya:

• Di limf no dɛm
• Lɔng
• di adrenal gland dεm (we de oba di kidni dεm) .
• Liva
• Bren
• Bɔn dɛn

Aw fast (ccRCC) kansa kin gro?

di growth rεt fכ Klia Sεl Rεnal Sεl Karsinoma kin difrεn bכku. Wan stɔdi sho se dɛn kin gro ɛnisay frɔm 0.2 to 6.5 sɛntimita (0.07 to 2.5 inch) insay wan ia. di avrej growth rεt na lεk 2.13 sεntimita (0.83 inch) pan ia.

Wetin na di sɔvayv rit fɔ `(ccRCC)`?

in jεnarכl, di fayv ia sכvayv rεt fכ (ccRCC) de bitwin 50% εn 69% .

Bɔt di chans fɔ mek dis wɛl bɔdi de dipen pan di sayz we yu tumbu gɛt. in jεnarכl, di tritmεnt nכ kin bכku fכ big tכmכro dεm כ if di `(ccRCC)` dכn spre to כda pat dεm na di bכdi. na dεn kayn kes dεm ya, if big tכmכro de כ if di kansa dכn spre, di fayv ia rεt we de liv kin bi lεk 10%. Na dat mek i impɔtant fɔ no am kwik ɛn bigin fɔ trit am kwik.

Aw a fɔ kia fɔ misɛf?

Na nɔmal tin fɔ fil difrɛn kayn filin we yu kam fɔ no se yu gɛt Klia Sɛl Rɛnal Sɛl Karsinɔma. Yu kin fil difrɛn tin dɛn lɛk fɔ fred, fɔ vɛks, fɔ fil bad, fɔ wɔri, ɛn fɔ fil bad.

Bɔrku pipul kin gɛt fridɔm bay wae dɛn kin lan bɔrku tin bɔt (ccRCC) ɛn aks fɔ ɛp frɔm di wan dɛm wae dɛn lɛk. I fayn bak fɔ jɔyn (ccRCC) sɔpɔt grup dɛm we kin ɔndastand ɛksaktɔli wetin yu de go tru.

I rili impɔtant bak fɔ trɔst yu mɛdikal tim. Aks dɛm ɛni kwɛstyɔn wae yu gɛt bɔt di tritmɛnt opshɔn dɛm ɛn aw fɔ wɛl.

Na sɔm ɔda we dɛn we yu go ebul fɔ kia fɔ yusɛf:

• Tek ɔl di mɛrɛsin dɛn we dɔktɔ dɛn tɛl yu fɔ tek jɔs lɛk aw dɛn tɛl yu fɔ tek .
• Nɔ fɔ tan lɛk tin bay we yu it tin dɛn we gɛt bɔku prɔtin ɛn kalori.
• Slip fayn fayn wan as yu ebul.
• Tray fɔ kɔntrol strɛs tru tin dɛm lɛk fɔ brith dip, fɔ tink gud wan, yoga, art tɛrapi, ɔr tin dɛm wae de mek yu fil fayn lɛk pazl.
• As yu bɔdi gɛt trɛnk.Fɔ du tin dɛn we yu de du fɔ mek yu bɔdi wok.

Ustɛm a fɔ go to dɔktɔ?

If yu gɛt ɛni wan pan dɛn sik ya, go to dɔktɔ wantɛm wantɛm:

• If blɔd de na di urine.
• If yu gɛt wan lump ɔ pen na yu an we nɔ de go .
• If yu gɛt fiva we yu nɔ ɛksplen ɔ yu de lɔs yu wet .

If dɛn dɔn ɔlrɛdi gɛt tritmɛnt fɔ (ccRCC), tɔk to yu dɔktɔ wantɛm wantɛm if yu gɛt nyu sik ɔ if yu sik de wɔs . Dɛn kin tɛl yu aw fɔ kɔntrol yu sik, chenj yu mɛrɛsin doz, ɔr kin tɛl yu fɔ tek nyu tritmɛnt. Wan impɔtant pat pan yu tritmɛnt na fɔ gɛt wɛl bɔdi as yu ebul.

Us kwɛstyɔn dɛn a fɔ aks di dɔktɔ?

I fayn fɔ aks yu dɔktɔ kwɛstyɔn dɛn lɛk dɛn wan ya:

• "Wetin na di bɛst tritmɛnt fɔ mi?"
• "Wetin na di sayd ifekt dɛm fɔ di tritmɛnt we yu kin rɛkɔmɛnd?"
• "A de pan risk fɔ gɛt mɛtastas kansa?"
• "Aw a go ridyus di risk fɔ spre dis `(ccRCC)`?"
• "Ɛnibɔdi de na mi blɔd famili we de pan risk fɔ gɛt `(ccRCC)`?"
• "Eni simptom de fo komplikashon we a shud bi espeshali aware of?"

Dɛn kwɛstyɔn ya na jɔs fɔ ɛp yu. Nɔ shem fɔ aks yu dɔktɔ ɛnitin we yu gɛt na yu maynd, ilɛksɛf i smɔl. I rili impɔtant fɔ mek yu ɔndastand ɔltin klia wan.

Wetin na di difrɛns bitwin ‘klia sɛl’ ɛn ‘papillary’ kidni kansa?

dis dεm na `(Klir Sεl Rεnal Kכrεs)` εn `(Papillary Renal Sεl Karεn)`. Di sayn dɛm fɔ dɛn tu tin ya rili fiba. Di tritmɛnt dɛn bak rili fiba.

Di men difrɛns na aw dɛn kansa sɛl ya de luk we dɛn si dɛn ɔnda maykroskɔp.

• di papil kεnsar sεl dεm de sho lεk lכng, tכn, lεk finga dεm we de gro.
• `(ccRCC)` di kεnsar sεl dεm de luk lεk klia bכbul dεm.

Na lɛk wan pan ɛvri 10 pipul dɛm wae gɛt rεnal sɛl kansa gɛt di papillary tayp.

Fɔ dɔn, sɔm tin dɛn fɔ mɛmba (Take-Home Message) .

A ɔndastand aw i kin tranga fɔ no se yu gɛt kansa. Filin lɛk fɔ fred, sɔri, vɛks, kɔnfyushɔn, ɛn fɔ de yu wan kin kam pan yu wan tɛm. Sɔntɛm yu kin fil ɔl dɛn tin ya wan tɛm. Ɔ, yu kin fil se yu nɔr gɛt ɛnitin fɔ du wit yu filin as yu de tray fɔ bia wit dis diagnosis. Ɔndastand se ɛnitin we yu de fil, na nɔmal tin.

Klia Sεl Rεnal Sεl Kεnsar (ccRCC) na di kayn kεnsar we de kכmכn pas ɔl na di kidni. I kin gro fast ɛn i kin agresiv pas ɔda kayn kidni kansa.

Yu gɛt bɔku prɔblɛm dɛn, ɛn yu nid fɔ tɔk to pɔsin bɔt aw yu de tink ɛn aw yu de fil.Nɔ ɛva shem fɔ aks fɔ ɛp frɔm yu dɔktɔ ɛn abop pan yu sɔpɔt sistɛm (famili, padi dɛm).

Dis kin tranga fɔ waka, bɔt tek am wan stɛp wan wan, ɛn du gud to yusɛf. Mɛmba se if yu no am kwik ɛn trit yu kwik, dat kin mek big difrɛns. Nɔto yu wan de.

` Kidni kansa, ccRCC, Klia Sεl Rεnal Sεl Kansa, kidni sik, kansa simptom, kansa tritmεnt, kidni hεlth