Yu kin tɔsti ɔltɛm ɛn pis lɛk twɛnti tɛm insay di de bak? Dis na Arginine Vasopressin Disɔda / Dayabitis Insipidus?

Yusɛf gɛt tɔsti we yu nɔ go ebul fɔ bia? Yu fil se yu nɔ go ebul fɔ drink bɛtɛ wata? Yu fɔ go bak na di bafa bɔku tɛm insay di de, sɔntɛnde ivin wan ɔ tu tɛm insay di awa? If yu fɔ grap na nɛt fɔ pis we yu nɔ slip fayn, dis nɔto sɔntin we yu fɔ tek am layt. Tide wi go tɔk bɔt wan sik wae nɔr kin bɔrku bɔt wae dɛn kin trit wae de sho di sem kayn sik. Bifo dis tɛm, dɛn bin de kɔl dis ‘Diabetes Insipidus’.

Wetin na Arginine Vasopressin Disɔda?

Fɔ tɔk am simpul wan, dis sik na we yu bɔdi de mek bɔku bɔku urine. Dis min se yu bɔdi nɔ ebul fɔ kip inof wata. Di men rizin fɔ dis na prɔblɛm wit wan ɔmon we dɛn kɔl Arginine Vasopressin (AVP) . Dɔktɔ dɛn kin kɔl dis ɔmon bak ``AVP`` di Antidiuretic Hormone (ADH) . dis ``AVP`` כmon de ple wan rili imכtant rol fכ kip di amoun fכ wata na di bכdi bεlε tru wi kidni dεm.

Tu men kayn tin dɛn de we kin apin:

1. AVP dεfisiεns (AVP-D): Dis na we yu bכdi nכ de prodyuz inof כmon AVP.

2. AVP rεsistεns (AVP-R): Dis na we yu kidni dεm nכ de rεspכnd fayn to di כmon AVP. Dis min se pan ɔl we di ɔmon de, di kidni dɛn nɔ de yuz am.

Wetin na di sayn dɛm fɔ dis sik?

Di men simptom dɛm fɔ AVP dɛfisiɛns ɛn AVP rɛsistɛns na:

• Yu nid fɔ pis bɔku tɛm: Wan men sayn fɔ dis na fɔ gɛt fɔ grap fɔ pis nɔto jɔs na de bɔt bak na nɛt (Nocturia) .
• Fɔ pas bɔku bɔku layt kɔlɔ ɔ wata urine: Nɔmal wan, pɔsin kin pas bitwin 1 ɛn 3 lita urine ɛvride. Bɔt pɔsin we gɛt dis sik kin pas 20 lita urine ɛvride. Imajin aw dat na bɔku tin!
• Tɔsti pasmak (Polydipsia): Fɔ fil lɛk se yu nɔ de stɔp yu tɔsti ilɛksɛf yu drink bɔku wata.

Dɛn sayn ya na strɔng sayn fɔ sho se sɔmtin nɔ de wok fayn na yu bɔdi. I rili impɔtant fɔ go to dɔktɔ kwik kwik wan.

Aw dɛn sik ya kin afɛkt yɔŋ pikin dɛn?

If dis sik apin to yɔŋ pikin dɛm, di sayn dɛm kin difrɛn smɔl. Sɔm pan dɛn na:

• Di wata we de kɔmɔt na di bɔdi bad bad wan .
• Banbɛlɛ.
• Fɔ vɔmit.
• Fiva we kin kam ɔltɛm.
• Fɔ sho se yu gɛt abit we rili de vɛks ɛn we de mek yu vɛks.
• Growth faltering / Fɔ nɔ ebul fɔ go bifo.

If bebi ɔ yɔŋ pikin dɛn gɛt dɛn sik ya, i fɔ rili go to dɔktɔ wantɛm wantɛm.

Wetin mek dɛn arginin vasopressin dizayd ya kin apin?

Di rizin dɛn kin difrɛn, i kin dipen pan di kayn we we wi bin dɔn tɔk bɔt.

Di tin dɛn we kin mek di AVP nɔ de `(AVP-D)`

Fɔs dɛn bin de kɔl dis sɛntral dayabitis insipidus , dis kin apin bikɔs di ɔmon we dɛn kɔl arginine vasopressin (AVP) nɔ de. Dis na di kayn we we pipul dɛn kin gɛt mɔ.

Dis kin bi bikɔs ɔf:

• di damej pan di haypothalamus כ pituitary gland (dεn na imכtant pat dεm na di bren we de kכntro di כmon dεm). Dis damej kin apin bikɔs ɔf ɔpreshɔn ɔ injuri na in ed.
• Sכm jεnεtik vεryushכn dεm (Inherited gene variation) .
• Fɔmeshɔn fɔ di tɔŋ dɛn .
• Inflameshɔn / Granulomas we kin kam bikɔs ɔf sɔm mɛdikal kɔndishɔn, lɛk sarkoidosis ɔ TB.
• Sɔntɛnde, dɛn nɔ kin fɛn di kɔz (idiopathic) . Dis min se pan lɛk af pan di wan dɛn we sik, dɛn nɔ no di tin we kin mek i sik.

Di tin dɛn we kin mek pɔsin nɔ gɛt AVP (AVP-R) .

Fɔs, dɛn bin de kɔl dis kayn nɛfrojɛnik dayabitis insipidus . insay dis kes, di pituitary gland de prodyuz di כmon AVP, bכt di kidni dεm nכ de rεspכnd to am fayn.

Bɔku rizin dɛn de fɔ dis:

• Sɔm chenj dɛn we kin apin na di jɛnɛtiks.
• Di urinary tract we dɔn blok .
• Yuz sɔm mɛrɛsin dɛn fɔ lɔng tɛm , mɔ di litiɔm .
• Di kalsiɔm lɛvɛl we de na di blɔd de go ɔp (Hypercalcemia) .
• di potashכm lεvεl dεm we lכw na di bכdi (Hypokalemia) .

Wan spɛshal kayn we kin apin we uman gɛt bɛlɛ

dis dεn kכl dis Jεstashכnal Arginin Vasoprεsin Dizכrd (gAVP-d) . Dis nɔ kin apin so ɔltɛm. we uman bεlε, di plasεnta de mek tu mכch εnzym we de brok di כmon AVP.

Yu kin gɛt dis sik, fɔ sɔm rizin :

• If yu de kɛr twins ɔ mɔ pikin dɛn .
• If yu gɛt wan sik we de afɛkt di we aw yu liva de wok, lɛk prɛeklampsia ɔ HELLP syndrome .

di gud nyus na dat dis `gAVP-d` kכndishכn kin go tu to tri wik afta i bכn.

Wetin na de prɔblɛm wae kin kam wit dis sik?

di men komplikashכn fכ AVP-D εn AVP-R na dihaydreshכn , we na di lכs fכ di wata εn ilektrolayt dεm we di bכdi nid fכ wok.

Bɔku tɛm yu kin kɔntrol di we aw yu de urine bay we yu drink mɔ wata pas aw yu nid, bɔt if yu nɔ du dat, yu kin gɛt wata kwik kwik wan.

We yu nɔ gɛt wata na yu bɔdi, dat kin mek yu layf de pan denja. If yu gɛt sɔm sayn dɛn we de sho se yu nɔ gɛt wata na yu bɔdi, lɛk yu ed de tɔn, yu nɔs, ɔ yu taya pasmak, go na di ɔspitul we de nia yu kwik kwik wan.

Aw dɔktɔ dɛn kin no dis?

Bikɔs di sayn dɛm we de sho se pɔsin de tɔsti ɔltɛm ɛn we i de pis kin bi bak wit ɔda kɔmɔn tin dɛm, dɔktɔ dɛn kin fɔs rul ɔda tin dɛm we dɛn de no se i gɛt `AVP-D` ɔ `AVP-R`. If yu gɛt dɛn sik ya, yu dɔktɔ go tɛl yu fɔ du bɔku tɛst dɛn.

We yu de no dis kכndyushכn, i nid fכ no if na `AVP-D` כ `AVP-R` εn wetin na di kכz.

Test dɛn fɔ no if pɔsin gɛt di sik

• Wata prɛvɛshɔn tɛst: Dis na di we we pɔsin kin abop pan fɔ no AVP-D ɔ AVP-R. Dɛn go de wach yu gud gud wan we dɛn de du dis tɛst, bikɔs dis kin mek yu nɔ gɛt wata na yu bɔdi. Dis tɛst min se yu nɔ fɔ drink ɛni wata fɔ sɔm awa ɛn si aw yu bɔdi de ansa. If yu gɛt dis sik, yu go kɔntinyu fɔ pas bɔku bɔku wata we gɛt layt kɔlɔ urine. If yu nɔ gɛt dis sik, yu go jɔs pas smɔl kɔnsɛntret, dak yɔlɔ urine.
• Kɔpɛptin blɔd tɛst: Kɔpɛptin na bayprodukt fɔ di ɔmon AVP.
• Blɔd glukɔs tɛst: Dɛn kin du dis fɔ chɛk fɔ si if pɔsin gɛt dayabitis, we insɛf gɛt di sem kayn sayn dɛn.
• Urinalysis: dis de tεst di osmolality ( kכnsantreshכn fכ di urine) εn di kεtכn dεm na di urine.
• imej tεst dεm lεk MRI skan (MRI - Magnetic Resonance Imaging): dεn kin du dis fכ si if eni damej de pan di pituitary gland כ haypothalamus.

Aw dɛn kin trit dɛn `AVP-D` ɛn `AVP-R` ya?

Tritmɛnt dipen pan if yu gɛt `AVP-D` ɔ `AVP-R`. I nɔ mata aw dɛn trit yu, i impɔtant fɔ drink bɔku wata fɔ mek yu nɔ gɛt wata na yu bɔdi.

AVP-D (Dɛfisiɛns) Tritmɛnt

Desmopressin na di men tritmɛnt fɔ AVP-D. Na drɔg we de wok di sem we lɛk di ɔmon AVP. Dɛn kin tek am difrɛn we dɛn (e.g., as sprɛy na yu nos, as pil).

sכmtεm dεn kin yus dεsmoprεsin fכ di rare bεlε kכndishכn ``(gAVP-d)''. Bɔt sɔntɛnde we uman gɛt bɛlɛ, i kin kɔntrol am bay we i drink mɔ wata.

AVP-R (Rɛsistɛns) Tritmɛnt

Trit `AVP-R` na smɔl kɔmplikɛt. Sɔntɛnde, dɛn kin nid fɔ yuz difrɛn we dɛn togɛda. Fɔ ɛgzampul:

• Thiazide diuretiks we dɛn kin yuz fɔ mek wata(Pan ɔl we dɛn tin ya na wan kayn mɛrɛsin we de mek pɔsin ebul fɔ pis, dɛn kin wok difrɛn we na dis kayn tin)
• Nɔn-stɛroyd anti-inflammatory drɔgs (NSAID) .

If di `AVP-R` kɔndishɔn na wan mɛrɛsin we yu de tek, yu dɔktɔ kin ebul fɔ trit di sik bay we i chenj yu to ɔda mɛrɛsin.

Ustɛm a fɔ go to dɔktɔ?

If yu gɛt `AVP-D` ɔ `AVP-R`, i rili impɔtant fɔ go to yu dɔktɔ ɔltɛm fɔ advays. Dis we ya, yu dɔktɔ kin du tɛst fɔ wach yu sik ɛn mek shɔ se yu tritmɛnt de wok fayn fayn wan.

Yu go si se i go fayn fɔ aks yu dɔktɔ dɛn kwɛstyɔn ya:

• A gɛt `AVP-D` ɔ `AVP-R`?
• Wetin na di rizin fɔ dis?
• Dis na krεse (lכng tεm) kכndyushכn כ na tεmporari kכndyushכn?
• Us tritmɛnt opshɔn dɛn a gɛt?
• Ɔmɔs wata a fɔ drink fɔ wan de?
• Wetin bak a go du fɔ mek a ebul fɔ sɔlv dis prɔblɛm?
• Mi famili sɛf de pan denja fɔ gɛt arginine vasopressin disɔda?

Wetin a kin ɛkspɛkt if a gɛt `AVP-D` ɔ `AVP-R`?

Di autluk (autkam) fɔ `AVP-D` ɛn `AVP-R` kɔndishɔn dɛn na jɔs gud. If yu tek di rayt tritmɛnt ɛn drink bɔku wata, yu nɔ fɔ gɛt ɛni siriɔs prɔblɛm.

Bɔt dɛn pipul ya kin gɛt bɔku prɔblɛm dɛn:

• Bebi dɛn
• Pipul dɛn we dɔn pas 65 ia
• Pipul wae gɛt sɔm kayn mɛntɛl hεlth kכndyushכn ɔr divεlכpmεnt disabiliti

Dɛn pipul ya kin gɛt prɔblɛm fɔ no se dɛn tɔsti, ɔ dɛn nɔ kin ebul fɔ tek akshɔn pan am.

Wetin mek dɛn nɔ kɔl dis ‘Diabetes Insipidus’ naw?

Insay 2022, sɔm mɛdikal ɔganayzeshɔn dɛn disayd fɔ chenj di nem `Diabetes Insipidus` to `Arginine Vasopressin Deficiency` ɛn `Arginine Vasopressin Resistance`. Di men rizin fɔ dis na di kɔnfyushɔn we di wɔd `dayabitis` bin mek ɛn di bad bad wɛlbɔdi ifɛkt dɛn we i bin de mek.

We bɔku pipul dɛn jɔs se "dayabitis", dɛn min dayabitis mɛlitus . Na bikɔs di shuga we de na di blɔd bɔku. I gɛt sɔm sayn dɛn bak lɛk fɔ tɔsti ɔltɛm ɛn fɔ pis. כltu, i bכku pas di kכndishכn dεm `AVP-D` εn `AVP-R` (dεn bin de kכl am fכs `Diabetes Insipidus`). Dɔn bak, di tritmɛnt fɔ dayabitis mɛlitus difrɛn frɔm di tritmɛnt fɔ `AVP-D` ɛn `AVP-R`.

Di wɔd "diabetes" kɔmɔt frɔm di Grik wɔd "diabetesine," we min "fɔ pas tru." Dɛn kin yuz da nem de bikɔs, lɛk dayabitis, wata kin pas na di bɔdi tumɔs kwik, ɛn na dat kin apin pan dɛn sik ya we dɛn kɔl arginin vasopressin.

Fɔ dɔn, a fɔ tɛl una... (Tek-Home Message)

If yu gɛt `AVP-D` (arginine vasopressin deficiency) ɔ `AVP-R` (arginine vasopressin resistance), yu kin fil lɛk se yu de spɛn bɔku pan yu layf na di bafa, nɔ ebul fɔ stɔp yu tɔsti ilɛksɛf yu drink bɔku wata. Bɔt di gud nyus na dat, dɛn kin ebul fɔ kɔntrol dɛn tin ya.

Yu dɔktɔ go mek wan tritmɛnt plan we go wok fɔ yu, ɛn i go tɛl yu bak ɔmɔs wata yu nid fɔ drink fɔ wan de fɔ mek yu gɛt wata. Nɔ panik. Gɛt yu dɔktɔ in sɔpɔt ɛn gayd. Mɛmba se dis nɔto "dayabitis." Na dat mek i impɔtant fɔ gɛt di rayt diagnosis ɛn tritmɛnt. Yu nɔ de yu wan, de no mɔ, ɛn kɔntinyu fɔ strɔng.

` Arginine Vasopressin Disɔda, Dayabitis Insipidus, AVP, ADH, Tɔsti pasmak, Yurineshɔn ɔltɛm, we yu nɔ gɛt wata na yu bɔdi, Polidipsia, Nocturia, Desmopressin, Kidni, Ɔmon