Yu bin no bɔt dis sik we kin afɛkt yu lɔng ɛn kidni di sem tɛm? Lɛ wi tɔk bɔt Goodpasture Syndrome!

Sɔntɛnde, yu kin kɔf ɔltɛm? Sɔntɛnde, da kɔf de kin briŋ smɔl blɔd? Ɔ yu fil lɛk se yu gɛt prɔblɛm fɔ blo, ɔ yu jɔs taya ɛn yu nɔ gɛt bɛtɛ urine? Dɛn tin ya kin bi sayn dɛn fɔ sɔntin we rili siriɔs. Tide wi go tɔk bɔt wan kayn tin we nɔ kin apin so ɔltɛm, bɔt wan we yu fɔ no bɔt.

Wetin na Gudpaschɔ Sindrom?

Fɔ tɔk am simpul wan, Goodpasture Syndrome na wan sik we nɔ kin apin so ɔltɛm bɔt we kin mek pɔsin in layf pan denja . "Autoimmune" min se di difεns sistεm na wi bכdi, di imyun sistεm, de mistek bigin fכ atak wi כwn hεlty sεl dεm εn tisu dεm.

Insay dis sik, wi imyun sistɛm kin atak wan prɔtin we dɛn kɔl kolagen. Kɔlagen tan lɛk bildin blɔk na wi bɔdi. Kɔlɔjen de ɛp fɔ mek wi skin, mɔsul dɛn, tɛndon dɛn, ligamɛnt dɛn, ɛn bon dɛn strɔng.

So, if yu gɛt Goodpasture syndrome, sɔm pan di protin dɛm we yu bɔdi de mek, wi kin kɔl dɛm antibodi, go ɛn atak di kolagen na yu lɔng ɛn kidni. We dis apin, inflamɛns kin bigin na dɛn say dɛn de, ɛn da tisu de kin bigin fɔ brok smɔl smɔl. If dɛn nɔ trit dis, dis kin mek di kidni dɛn inflamɛns bad bad wan (glomerulonephritis), we kin mek di kidni dɛn nɔ wok fayn. Yu kin bigin fɔ blɔd bɔku bɔku wan bak frɔm di lɔng dɛn (pulmonary hemorrhage). Bɔku tɛm, di men tin we kin mek pɔsin day bikɔs ɔf dis sik na we i de blɔd na in lɔng.

Wan ɔda nem fɔ dis na:

• Anti-glomerular bεsmεnt mεmbran (anti-GBM) sik
• Gudpaschɔ sik

Aw kɔmɔn tin dis?

Dis na sik we nɔ kin apin so ɔltɛm . Dɔktɔ dɛn se na wan to tu nyu pipul dɛn nɔmɔ kin gɛt dis sik pan ɛvri 100,000 pipul dɛn ɛvri ia. So yu kin imajin aw i nɔ kin bɔku.

Wetin na di sayn dɛm we de sho se yu gɛt dis sik?

Gudpaschɔ sεndrכm na `(pulmonary-rεnal)` kכndishכn. Dis min se di lכng εn di kidni dεm de afekt di sem tεm. Bɔrku tɛm, di fɔs sayn dɛm wae kin apun kin gɛt fɔ du wit di lɔng dɛm. Dɛn tin ya na:

• I nɔ izi fɔ blo (dyspnea): Nɔto jɔs we yu de klaym stej, bɔt ivin we yu de rɛst.
• Chɛst pen : Chɛst pen we yu de blo ɔ kɔf.
• Kɔf : Na kɔf we kin kɔntinyu fɔ kɔf, we kin mek pɔsin fil pen sɔntɛnde.
• Nɔys de kɔmɔt na di chɛst we yu de blo : I kin bi sawnd we de grɔmbul, lɛk se sɔntin dɔn stɔp insay di chɛst.
• A kin fil se a taya bad bad wan.`(fatigue)`: Na filin fɔ bi so wik dat yu nɔ ebul fɔ du ɛnitin.
• Nɔs blɔd (epistaxis).
• Kɔf blɔd : Dis na sayn we de mek bɔku pipul dɛn fred ɛn i nid fɔ go to dɔktɔ wantɛm wantɛm.
• Pallor : Di skin kin tɔn pale bikɔs blɔd nɔ de.

Di sik dɛn we gɛt fɔ du wit di kidni kin apin bak leta. Dɛn tin ya na:

• Di rɛd blɔd sɛl dɛn we de na di blɔd we de go dɔŋ, dat na, anemia .
• Blɔd we de na di urine (hematuria): Di urine kin tɔn rɛd ɔ dak brawn.
• Les urine output pas aw i kin bi.
• Di ay blɔd prɛshɔn .
• Nɔs ɛn vɔmit : Dis kin apin bak we yu nɔ want fɔ it.

Wetin kin mek dis apin?

di gudpasture sεndrכm de apin we di antibodi dεm we wi imyun sistεm de prodyuz de atak di kolagen we de insay di glomerular basement membrane (GBM) insay di kidni dεm. Dis GBM na pat pan di glomeruli, we na di smɔl smɔl blɔd-filta yunit dɛn na wi kidni. dis antibodi dεm de atak bak di kolagen we de insay di ay sak dεm na di lכng dεm. Dis kin mek di lכng tisu dεm de pwεl, we de mek di bכdi bכn εn i kin mek i at fכ brith.

dεn nכ no yet bכku bכku wan wetin mek di imyun sistεm de atak in yon kolagen. I pɔsibul se di tin dɛn we de arawnd wi ɛn di jin dɛn we wi gɛt kin gɛt fɔ du wit di sik. Stɔdi dɔn sho se pipul dɛn we gɛt dis sik gɛt strɔng asosieshɔn wit wan jɛnɛtik mak we dɛn kɔl Human Leukocyte Antigen (HLA) DR15. dis na protin we de εp di imyun sistεm fכ difrεnt bitwin wi כwn tisu dεm εn fכrin tin dεm.

Sɔmtɛm, dis sik kin kam afta pɔrsin gɛt infekshɔn, lɛk kol ɔr flu. Dɔn bak, yu:

• If yu de smok .
• If yu inhal drɔgs lɛk kɔkɛyn .
• Di risk fɔ gɛt dis sik kin bɔku if yu gɛt mɛtal dɔst ɔ haydrokabon kemikal lɛk mitin ɛn prɔpan.

Udat dis de afɛkt mɔ?

Gudpaschɔ sindrom kin apin pan ɛni ej, bɔt i kin mɔs pan yɔŋ pipul dɛm, bitwin tɛn ɛn tati ia, ɛn afta dat bak pan pipul dɛm wae dɔn pas 60 ɛn 70 ia.

Aw dɛn kin du di diagnosis?

We yu go to dɔktɔ, dɛn go aks yu bɔt di sik dɛn we yu gɛt ɛn du ɛgzam fɔ yu bɔdi. Apat frɔm dat, dɛn kin du dɛn tɛst ya bak fɔ no if pɔsin gɛt di sik we dɛn kɔl Goodpasture syndrome:

• Blɔd tɛst : Dɛn tin ya de chɛk yu ɛstimat glomerular filtration rate (eGFR), we de mɛzhɔ aw yu kidni dɛn de wok fayn fayn wan.
• Test fɔ yu urineUrinalysis: Dis de chɛk fɔ blɔd na yu urine ɔ di ay protin lɛvɛl (proteinuria).
• Imej tɛst : Dɛn kin du ɛkstrem rayt ɔ CT skan na di chɛst fɔ chɛk fɔ si if di lɔng dɛn dɔn pwɛl.
• Bronchoscopy : Insay dis prosidur, dɔktɔ kin put wan tin, lɔng tiub (bronchoscope) wit kamɛra ɛn layt we dɛn tay tru yu nos ɔ mɔt fɔ chɛk if i dɔn pwɛl insay yu lɔng.
• Kidni bayɔpsi : Insay dis, dɛn kin tek wan smɔl pat pan di tisu frɔm di kidni ɛn chɛk am ɔnda maykroskɔp fɔ kɔnfɔm if di sik we de na di kidni de.

Yu tink se dɛn kin mɛn di sik we dɛn kɔl Goodpasture syndrome?

Yɛs, dis kin wɛl if dɛn no di sik kɔrɛkt wan ɛn bigin tritmɛnt kwik kwik wan.

Aw dɛn kin trit am?

Di tritmɛnt fɔ Goodpasture syndrome kin difrɛn difrɛn wan bay aw di sik siriɔs. If de sik nɔr tu tranga, dɔktɔ kin gi yu mɛrɛsin lɛk:

• Kɔtikosterɔyd : Fɔ ɛgzampul, mɛrɛsin dɛn lɛk prɛdnison. Dɛn tin ya kin ɛp fɔ stɔp di blɔd we de kɔmɔt na di lɔng dɛn.
• Immunosuppressant drugs : Drug dɛm lɛk sayklofosfamid. Dɛn tin ya kin mek yu imyun sistɛm nɔ atak in yon tisu dɛn.
• Di mɛrɛsin dɛn we de mek di blɔd prɛshɔn go dɔŋ (antihypertensives): Dɛn tin ya kin ɛp fɔ kɔntrol di blɔd prɛshɔn ɛn fɔ mek di kidni dɛn nɔ pwɛl.

Apat frɔm dat, dɔktɔ dɛn kin yuz wan tritmɛnt bak we dɛn kɔl plasmapheresis . Dis min se yu fɔ tek blɔd frɔm wan vein na yu an tru nidul, ɛn separet di wata pat na di blɔd we dɛn kɔl plasma frɔm di blɔd sɛl dɛn. di bad bad anti-GBM antibodi dεm de insay dis plasma. Dɔn dɛn kin pul di plasma, ɛn dɛn kin ad plasma we pɔsin we gɛt wɛlbɔdi gɛt bak to yu blɔd sɛl dɛn ɛn gi yu bak. Fɔ tɔk am simpul wan, i de pul di bad bad antibodi dɛn na yu bɔdi.

Aw lɔng e kin tek fɔ wɛl afta dɛn dɔn trit am?

Yu go gɛt fɔ tek di mɛrɛsin dɛn we de mek yu bɔdi nɔ gɛt bɛtɛ wɛlbɔdi fɔ lɛk 6 to 12 mɔnt. Bɔrku tɛm, yu kin gɛt fɔ du plasmapheresis ɛvride fɔ sɔm wiks.

Wetin go apin afta dat?

If dɛn nɔ trit am, Goodpasture syndrome kin mek yu layf de pan denja fɔ mek yu blɔd kɔmɔt na yu lɔng ɛn yu kidni nɔ de wok fayn. Bɔt if dɛn no di sik kwik kwik wan ɛn bigin fɔ trit am, bɔku tɛm di tin we kin apin kin fayn. yu bכdi de כnli prodyuz dεn harmful antibodi dεm fכ sכm tεm – frכm fכ wik to lεk tu ia. Rilaps ɔ rikɔrɛshɔn nɔ kin rili apin.

Di mɔs siriɔs kɔmplikeshɔn fɔ dis na we di kidni nɔ de wok fayn. If dat apin, dɛn nid fɔ gɛt dayalaysis tritmɛnt fɔ filta di blɔd.I nid fɔ transplant di kidni.

Wetin a gɛt fɔ tɔk bɔt mi layf?

Na lɛk 80% pan di pipul dɛm wae gɛt Goodpasture syndrome gɛt fayv ia sɔvayv rɛt wae na 80%. Dat na if dɛn no di sik kwik kwik wan ɛn trit am fayn.

Yu tink se dɛn go ebul fɔ stɔp dis?

Sɔntɛm i nɔ go pɔsibul fɔ mek dɛn nɔ du am kpatakpata. Bɔt yu kin ridyus di prɔblɛm we yu gɛt if yu avɔyd sɔm tin dɛn:

• Haydrokabɔn, we min tin dɛn lɛk mitin, prɔpan, petrol, kerosin, ɛn tar.
• Dɔst we dɛn mek wit mɛtal.
• Kɔkɛyn.
• Di tin dɛn we dɛn kin yuz fɔ mek yu ia kɔlɔ.

Aw a go tek kia ɔf misɛf?

If yu gɛt Goodpasture syndrome, i fayn fɔ du dɛn tin ya:

• Lɛf fɔ smok kpatakpata. Nɔ de na ples usay ɔda pipul dɛn de smok (i.e. avɔyd fɔ de na `sɛkɔnd smok`).
• Ɛnjɔy fɔ du bɔku bɔku tin dɛn fɔ at le 30 minit ɛvride.
• Tray fɔ ridyus strɛs .

Ustɛm a fɔ go to dɔktɔ?

If yu kɔf blɔd, i nɔ izi fɔ yu fɔ blo, yu nɔ de pis bɛtɛ, ɔ yu gɛt ɛni ɔda sayn dɛn we wi dɔn tɔk bɔt, go to dɔktɔ wantɛm wantɛm. If yu no am kwik, dat kin mek yu gɛt chans fɔ wɛl bad bad wan. If dɛn nɔ trit am, i kin mek di kidni pwɛl sote go ɛn ivin gɛt prɔblɛm wit in lɔng we kin kil pɔsin.

Us kwɛstyɔn dɛn yu fɔ aks di dɔktɔ?

We yu go to dɔktɔ, yu kin aks dɛn kwɛstyɔn ya:

• Aw a go no fɔ tru if a gɛt Goodpasture Syndrome?
• Aw siriɔs mi sik de?
• Us tritmɛnt dɛn yu kin advays?
• Wetin a go du fɔ kia fɔ mi kidni dɛn?
• A fɔ go to dɔktɔ we de mɛn mi bɔdi ɔ dɔktɔ we de mɛn mi pulmon?
• Yu kin tɛl mi bɔt wan sɔpɔt grup we de ɛp pipul dɛn we gɛt dis sik?

Wetin na di tri men tin dɛm (Triad) fɔ Gudpasture syndrome?

Insay mεdikal, ``triad'' de tכk bכt tri men simptom dεm we de dεskrεb wan mεdikal kכndyushכn. Di tri men sayn dɛm fɔ Goodpasture Syndrome na:

• Blɔd we de kɔmɔt na di lɔng dɛn.
• di inflameshn na di kidni dεm de inkrεs kwik kwik wan.
• di prεsεns fכ dεn antibodi dεm we dεn kכl ``anti-GBM antibodies'' insay di bכdi.

We pɔsin gɛt dis sik, i kin rili mek i fil bad ɛn i kin mek pɔsin in wan, mɔ bikɔs dɛn nɔ no yet di rayt tin we kin mek i gɛt dis sik. I kin ambɔg di tin dɛn we yu de du ɛvride, ɛn yu kin ivin nid fɔ chenj yu wok if yu de wok wit mɛtal paoda, petrol, ɔ tar.

Fɔ dɔn, wetin fɔ mɛmba

So, Goodpasture Syndrome na tin wae yu fɔ frayd, bɔt if yu no de sik kwik kwik wan, go to dɔktɔ kwik kwik wan, ɛn bigin fɔ trit yu, yu kin gɛt bɔrku gud rizulyt. Yu fɔ no bɔt di chenj dɛn we de apin na yu bɔdi. If yu fil sɔntin we strenj, i impɔtant fɔ go to dɔktɔ ɛn yu nɔ fɔ tek am se na smɔl tin. Nɔto yu wan de, ɛn dɔktɔ dɛn kin ɛp yu.

` Gudpaschɔ sindrom, Anti-GBM sik, pulmonary hemorrhage, kidni sik, ɔtoimyun sik, i nɔ izi fɔ blo, blɔd na di urine