Yu want fɔ no bak bɔt Hairy Cell Leukemia? Mek wi tok!

Yu kin fil taya ɔltɛm? Ɔ yu kin gɛt kol ɛn infɛkshɔn ɔltɛm? Sɔntɛnde, dɛn kin tek dɛn tin ya as nɔmal tin, bɔt i nɔ kin rili bi sayn fɔ ɔda tin. Tide wi go tɔk bɔt wan blɔd kansa we nɔ kin bɔku bɔt we rili impɔtant we rili impɔtant fɔ no bɔt. Dɛn kɔl am "Hairy Cell Leukemia".

Wetin na dis "Hairy Cell Leukemia"?

Fɔ tɔk am simpul wan, dis na wan kayn kansa we kin bigin na di blɔd. Wi gɛt wan pat na wi bɔdi we dɛn kɔl bon mɛro. Na frɔm da bon mɛro de mek di kayn sɛl dɛn we de na wi blɔd. pan dεn ya, di B-sεl dεm (dεn kכl dεm bak `B limfosayt`) na wan kayn wayt bכdi sεl. Dɛn men wok na fɔ fɛt di jem dɛn we de kam insay wi bɔdi ɛn protɛkt wi frɔm sik dɛn.

so, insay dis kכndishכn we dεn kכl `Hairy Cell Leukemia`, wetin de apin na dat yu bon mכro de prodyuz abn כmal B-sεl dεm . We yu luk dɛn nɔmal sɛl ya ɔnda maykroskɔp, yu go si se dɛn gɛt smɔl smɔl tin dɛn we tan lɛk ia we de kɔmɔt pan dɛn. na dat mek dεn kכl dis sik ``hayry cell leukemia'' biכs fכ dat ``hary'' apinεns. Na di wan dɛn we de stɔdi bɔt di sik dɛn we de chɛk di sɛl dɛn ɔnda maykroskɔp kin no am.

Wetin mek dis kin apin? Wetin kin apin to di bɔdi?

Pan ɔl we dɛn nɔ no yet bɛtɛ bɛtɛ wan wetin mek dis kin apin, sɔm tin dɛn de we kin apin to di bɔdi we dis sik kin apin. Imajin se yu gɛt vegjetabul gadin, ɛn wetin go apin if gras gro we yu nɔ ebul fɔ kɔntrol? Di gud vegjetabul dɛn kin lɔs ples ɛn nɔ kin gro fayn, nɔto so? Na dat de apin na ya bak.

• di bon mכro ifekt dεm: dεn abnכmal B-sεl dεm de bigin fכ bכku na di bon mכro, lεk gras. Dat de mek i nɔ ebul fɔ mek wayt blɔd sɛl dɛn, rɛd blɔd sɛl dɛn, ɛn pletlɛt dɛn (sɛl dɛn we de ɛp fɔ mek blɔd klɔt) we gɛt wɛlbɔdi.
• di limf no dεm εn di splin de swel: dεn abnכmal sεl dεm ya na wi limf no dεm εn splin de bigin fכ sheb εn bכku, we de mek dεn כgan dεm de swel.
• Di tin dɛn we kin apin to di liva: Sɔntɛnde, dɛn nɔmal sɛl ya kin spre to di liva tru di blɔd ɛn pwɛl am. dis kin mek wata kכmכt na di bכdi (wan kכndyushכn we dεn kכl `ascites`).

Yu tink se dis kɔmɔn?

`Hairy Cell Leukemia` na wan sik we nɔ kin bɔku . Ivin na kɔntri lɛk Amɛrika, i kin apin to lɛk wan pan ɔl wan ɔndrɛd tawzin pipul dɛn. Dɛn kin tɔk bak se dis sik kin bɔku smɔl pan wayt pipul dɛn pas ɔda etnik grup dɛn.

Wetin na di sayn dɛm we de sho se yu gɛt dis sik?

Sɔmtɛm pipul dɛm wae gɛt `Hairy Cell Leukemia` nɔr kin gɛt ɛni sayn . Bɔt we di sayn dɛn kin sho, dɛn kin sho tin dɛn lɛk:

• Taya: Dis taya kin apin bikɔs di rεd bכdi sεl lεvεl dεm de dכn (anemia).
• Fiva ɛn infekshɔn dɛn we kin kam bɔku tɛm:Bikɔs di wayt blɔd sɛl dɛn we gɛt wɛlbɔdi we de fɛt di infɛkshɔn nɔ bɔku, i kin izi fɔ mek pɔsin kol ɔltɛm ɛn i kin gɛt siriɔs infɛkshɔn.
• di lεft lכw bכdi pen: We di abnכmal sεl dεm na di splin de kכmכt εn mek di splin swel, yu kin fil pen na di lεft lכw bכdi εria. Di splin kin big ɛn mek yu fil ful, ɛn yu kin fil ful ivin afta yu it smɔl. Yu kin lɔs yu wet bak we yu nɔ tray.
• Pen na di rayt bɛlɛ we de dɔŋ: If di liva dɔn big, yu kin fil pen na di rayt say.
• I nɔ izi fɔ blo: Dis na ɔda sayn we de sho se pɔsin nɔ gɛt bɛtɛ blɔd.
• di limf no dεm we swεla: Lump dεm we nכ de fil kin apia na di nεk, di armpit dεm, εn di bεlε.
• Brus ɔ blɔd we nɔ kɔmɔn: Bikɔs di bon mɛrɔ nɔ de mek inof pletlɛt, we de ɛp fɔ mek blɔd klɔt, ivin di smɔl smɔl brus ɛn blɔd kin apin.

Impɔtant: If yu gɛt wan ɔ mɔ pan dɛn sik ya, dat nɔ min se yu gɛt Hairy Cell Leukemia. Bɔt if dɛn sik ya kɔntinyu, i go fayn fɔ mek yu go to dɔktɔ.

Wetin na di tin dɛn we kin mek i apin? Ɛnitin de we kin mek pɔsin gɛt prɔblɛm?

Masta sabi pipul dɛn stil nɔ no di rayt tin we kin mek pɔsin gɛt Hairy Cell Leukemia. Bɔt, risach dɔn sho se lɛk 90% pan di pipul dɛm wae gɛt dis sik gɛt wan jɛnɛtik muteshon. I kin afɛkt wan jin we dɛn kɔl BRAF. Dis jin de ɛp di sɛl dɛn fɔ gro. So, we i chenj, di nɔmal sɛl dɛn kin bigin fɔ gro ɛn bɔku we dɛn nɔ ebul fɔ kɔntrol. Dis chenj na di jɛnɛtiks kin apin afta dɛn bɔn wi. Bɔt, i stil nɔ klia wetin de mek da chenj de.

Bɔt dɛn dɔn no sɔm tin dɛn we kin mek pɔsin gɛt dis sik mɔ ɛn mɔ:

• Ej: Dis sik kin mɔs afɛkt pipul dɛm wae ol bitwin 40 ɛn 70. De avrej ej wae dɛn kin no bɔt dis sik na lɛk 58 ia.
• Jɛnda: Dis sik kin bɔku pan man pas uman.
• Ejen Ɔrɛnj ɛksposhɔn: Risach pipul dɛn biliv se link de bitwin dis kemikal ɛn kronik B-sɛl lukimiya ɛn limfoma (inklud hairy cell leukemia).

Us prɔblɛm dɛn dis kin mek?

Hairy Cell Leukemia kin mek di nɔmba fɔ di wayt blɔd sɛl dɛn na yu bɔdi we de fɛt di infɛkshɔn go dɔŋ bad bad wan, ɛn dis kin mek yu gɛt mɔ sik . Dɛn tin ya kin bi baktri, vayral, ɔ fɛns infɛkshɔn. Sɔntɛnde, dɛn infɛkshɔn ya kin mek pɔsin in layf de pan denja.

Smɔl chans de bak fɔ gɛt sɛkɔn kayn kansa bɔku ia afta dɛn dɔn no bɔt am ɛn trit am. Fɔ ɛgzampul, stɔdi dɛm wae bin fala pipul dɛm wae bin dɔn gɛt saksesful tritmɛnt fɔ `Hairy Cell Leukemia` fɔ 10-20 ia dɔn ripɔt kes dɛm wae sɔm pipul dɛm gɛt ɔda kansa.

Aw dɛn kin no dis sik?

We yu go to dɔktɔ, i go aks yu bɔt tin dɛn lɛk ustɛm yu sik bigin ɛn if yu kin gɛt infɛkshɔn ɔltɛm. I go aks bak bɔt yu mɛdikal istri. Dɔn, dɛn go du ɛgzam fɔ dɛn bɔdi. Dɛn kin chɛk yu limf no dɛm, splin, ɛn liva bak fɔ si if yu swel.

Dɔn, dɛn kin sɛn yu to dɔktɔ we de mɛn yu blɔd ɔ dɔktɔ we de mɛn kansa fɔ mek dɛn du ɔda tɛst fɔ no if yu gɛt di sik. Dɛn tɛst ya kin bi:

• kכmplit bכdi kכnt (CBC) εn difrεns: Dis de mכsu di nכmba fכ di rεd εn wayt bכdi sεl dεm, εn di pletlet dεm. di difrεns de mכsu di nכmba fכ difrεn kayn wayt bכdi sεl dεm.
• di pεrifεral bכdi smεl: di patכlayz dεm de luk pan bכdi sεmpl כnda maykroskכp fכ luk fכ abnכmal sεl dεm wit "hεr" lεk protrushכn.
• di bon mכro aspirashכn εn bon mכro bayopsi: dεn tεst dεm ya kin no di sεl dεm we nכ nכmal na di bon mכro.
• CT skan (Kכmpyuta tכmografi - `CT` skan): `CT` skan kin tek ditayl pikchכ dεm fכ di insay pat pan di bכdi. dis kin yus fכ si di sayz fכ di splin, liva, εn limf no dεm, כ fכ ultrasound fכ di bכdi.
• Flɔ saytometri: Dis de chɛk di blɔd ɛn bon mɛro fɔ si if dɛn gɛt sɛl dɛn we nɔ de wok lɛk di ia sɛl dɛn. I de chɛk bak di sayz, shep fɔ di sɛl dɛn, ɛn di prɛzɛns fɔ di tumor mak dɛn. di tכmכro mak dεm kin bi protin dεm we di kεnsar sεl dεm de mek.

Aw dɛn kin trit am?

If yu gɛt infekshɔn, yu go nid fɔ trit am fɔs. afta dat, dεn go stat כda tritmεnt dεm fכ kכntrכl di simptom dεm fכ `Hairy Cell Leukemia`. Bɔt, lɛk aw wi bin dɔn tɔk bifo tɛm, nɔto ɔlman go gɛt di sayn dɛn. Fɔ dɛn kayn pipul ya, yu dɔktɔ we de mɛn yu blɔd ɔ kansa kin tɛl yu wan we we dɛn kɔl aktif sɔvɛlayshɔn . If sɔm sayn dɛn de, dɛn kin gi yu mɛrɛsin.

Aktiv Sɔvɛlayshɔn

Hairy Cell Leukemia na wan sik we de gro sloslo . I kin tek sɔm ia fɔ mek di sayn dɛn de sho. Bikɔs di tritmɛnt fɔ kansa kin mek yu gɛt sayd ɛfɛkt ɛn kɔmplikeshɔn, if yu nɔ gɛt ɛni sayn, yu dɔktɔ kin disayd fɔ delay fɔ stat di tritmɛnt te di sayn dɛn sho.

We dɛn de du aktif sɔvɛlayshɔn, yu go si yu dɔktɔ ɛvri tri to siks mɔnt. Insay dɛn visit dɛn de:

• Dɛn go aks bɔt yu jenɛral wɛlbɔdi, mɔ if yu fil taya pas aw yu kin fil.
• Dɛn go du wan fyzikal ɛgzamin fɔ chɛk if di liva ɛn di splin dɔn swel.
• Dɛn kin ɔda fɔ mek dɛn du blɔd tɛst fɔ chɛk di lɛvɛl we di blɔd sɛl dɛn ɛn di pletlɛt dɛn de.

E kin tranga smɔl pan aw pɔrsin de fil fɔ wet fɔ di sayn dɛm fɔ sho bifo yu bigin tritmɛnt. Bɔt yu dɔktɔ go ɔndastand aw yu de fil ɛn ɛksplen wetin mek i fayn fɔ mek yu de wach yu.

Mɛrɛsin we dɛn kin gi

Di men tritmɛnt fɔ pipul dɛn we gɛt hairy cell leukemia na kemotɛrapi . Di mɛrɛsin dɛn we dɛn kin yuz mɔ fɔ mɛn kansa na Cladribine (Leustatin®) ɔ Pentostatin (Nipent®).

If kemotɛrapi nɔ wok, ɔ if di sik kam bak, ɔda tritmɛnt dɛn de:

• Immunotherapy: `Rituximab (Rituxan®)` na `monoclonal antibody` tritmɛnt we dɛn kin yuz fɔ `Hairy Cell Leukemia`. Dɛn kin gi am as fɔs tritmɛnt wit kemotɛrapi ɔ if di sik kam bak. כda imyuno tεrapi na `Rεkombinεnt Intεrfεron Alfa-2b (Intron A®)`.
• Targeted therapy: Fɔ rilaps Hairy Cell Leukemia, dɛn kin yuz drɔgs we dɛn kɔl Rituximab ɛn Moxetumomab pasudotox (Lumoxiti®) (dis na wan kayn antibodi-drug conjugate).
• Splenectomy: Na sכmtεm, dεn kin rεkomεnd dis כpεrayshכn if mεdikal tritmεnt lεk kemothεrapi nכ de εp εn di spεlin kכntinyu fכ swel biכs fכ di abnכmal sεl dεm na di splin.

Ɛni bad tin de we di tritmɛnt kin du?

Lɛk ɛni tritmɛnt fɔ kansa, i kin gɛt bad bad tin dɛn. Mɔtalman, kemotɛrapi drɔgs fɔ hairy cell leukemia kin mek pɔsin gɛt infɛkshɔn we kin mek pɔsin in layf de pan denja . Yu dɔktɔ go ɛksplen to yu wetin yu kin du fɔ mek yu nɔ gɛt di sik ɛn wetin chenj na yu bɔdi we kin bi sayn fɔ se yu gɛt di sik.

Wetin yu kin ɛkspɛkt we yu de liv wit dis sik?

Naw, no mɛrɛsin nɔ de fɔ Hairy Cell Leukemia. Bɔt risach dɔn sho se tritmɛnt, inklud kemotɛrapi, kin mek di sik nɔr de igen fɔ 10 ia ɔ mɔ . Rimishɔn min se yu nɔ gɛt ɛni sayn fɔ di sik ɛn yu nɔ go ebul fɔ si ɛni sayn fɔ di sik pan tɛst. Wan stɔdi we dɛn bin du fɔ stɔdi bɔt di tin dɛn we pipul dɛn we gɛt Hairy Cell Leukemia kin gɛt, sho se afta dɛn dɔn trit dɛn, dɛn kin liv lɔng lɛk pipul dɛn we nɔ gɛt dis sik.

Bɔt, hairy cell leukemia kin kam bak sɔm ia afta di fɔs tritmɛnt. Bɔt if dat apin, tritmɛnt dɛn de we kin mek di sik nɔ kam bak.

Bɔrku pipul dɛn nid mɛrɛsin ɛn sɔpɔt fɔ ɔl dɛn layf, bikɔs dɔktɔ dɛn nid fɔ wach fɔ si if dɛn gɛt dis sik bak. Ivin if yu gɛt di sik bɔt nɔr gɛt ɛni sayn, yu go nid fɔ gɛt tɛst ɛn fɔ fala am ɛvri tri to siks mɔnt afta dɛn dɔn no se yu gɛt dis sik.

Wetin na di rit we pɔsin kin wɛl?

Di Lukiemia ɛn Limfoma Sɔsayti se 90% pan di pipul dɛn we dɛn trit wit di kemotɛrapi drɔg we dɛn kɔl Cladribine, de alayv fayv ia afta dɛn dɔn trit dɛn. Bɔt, yu prɔgnosis — wetin kin apin afta tritmɛnt — kin dipen pan bɔku tin dɛn . Yu ej, ɔl yu wɛl bɔdi, di sayn dɛm wae yu gɛt, ɛn aw yu bɔdi de ansa to tritmɛnt ɔl de ɛp. If yu gɛt ɛni kwɛstyɔn bɔt dis, aks yu dɔktɔ.

Aw a fɔ kia fɔ mi wɛlbɔdi biznɛs?

Hairy Cell Leukemia de mek di risk fɔ gɛt infɛkshɔn we de mek pɔsin in layf de pan denja. Yu kin mek yu imyun sistɛm strɔng ɛn protɛkt yusɛf frɔm infɛkshɔn . Na sɔm advays dɛn ya:

• It fayn it: Tin dɛn lɛk frut, vɛjitebul, prɔtin we nɔ gɛt bɛtɛ bɔdi, ɛn ɔl di tin dɛn we yu kin it kin ɛp di imyun sistɛm fɔ wok.
• Ɛksesaiz ɛvride: Fɔ de aktif ɛvride i fayn fɔ bɔku tin dɛn na yu wɛlbɔdi, ivin yu imyun sistɛm.
• Slip inof: If yu nɔ slip fayn, dat kin mek yu imyun sistɛm nɔ wok fayn.
• Gɛt yu vaysin dɛn di rayt tɛm: Vaysin de tren yu bɔdi fɔ fɛt di jem dɛn we de mek yu gɛt sik. Tɔk to yu dɔktɔ bɔt us vaysin yu nid ɛn ustɛm fɔ gɛt dɛn.

Ustɛm yu fɔ go to dɔktɔ?

Hairy Cell Leukemia ɛn di tritmɛnt we dɛn kin gi yu kin mek yu gɛt siriɔs sik dɛn we kin mek yu layf de pan denja. Si dɔktɔ wantɛm wantɛm if yu gɛt dɛn sik ya:

• Fiva we pas 38 digri sɛlshiɔs (100.4 digri F) ɛn we nɔ de go dɔŋ.
• Trot we kin at we kin te fɔ pas sɔm dez ɔ we kin wɔs.
• Bɛlɛ pen we nɔ de go ɔ we de wɔs.

Sɔma ɛn Fɔ dɔn (Tek-Home Message) .

Sɔntɛm yu dɔn de fil taya pas aw yu kin fil fɔ natin. Ɔ sɔntɛm yu dɔn de tink bɔt wan sik we de mek yu nɔ ebul fɔ blo pan ɔl we yu dɔn de tek ɔl di mɛrɛsin. Naw tɛst dɔn sho se yu gɛt wan blɔd kansa we nɔ kin bɔku we dɛn kɔl `Hairy Cell Leukemia`, we nɔ kin mɛn atɔl wit tritmɛnt.

Bɔt nɔ wɔri . Tritmɛnt de wae kin kip de sik ɔnda kɔntrol fɔ lɔng lɔng tɛm wae nɔr gɛt sɔm kayn sik. Fɔ lɔng tɛm `rɛmishɔn` min se yu wɛlbɔdi tim go de wach yu wɛlbɔdi fɔ di res ɔf yu layf. εn, if Hairy Cell Leukemia dכn kam bak, di risach dεm de kכntinyu fכ luk fכ we fכ put di kכndyushכn bak insay `rεmishכn`.

Tin dɛn de we yu kin du na yu pat. Fɔ ɛgzampul, tritmɛnt fɔ kansa kin mek yu gɛt mɔ sik. Aks yu dɔktɔ bɔt di vaysin ɛn ɔda tin dɛn we yu kin du fɔ ridyus yu risk fɔ gɛt di sik.Nɔto yu wan, dɔktɔ ɛn wɛlbɔdi wokman dɛn de fɔ ɛp yu pan dis joyn.

` Hairy Cell Lukimiya, lukimiya, blɔd kansa, B sɛl, bon mɛro, splin, simptom dɛm