Wetin na dɛn tכmכro dεm ya we de fכm insay yu bכdi, insay yu bayl dakt dεm? Mek wi tok abaut Klatskin Tumors!

Yu dɔn ɛva fil lɛk se yu yay de tɔn yɔlɔ wit bɛlɛ we de at? Ɔ sɔntɛm yu jɔs de fil lɛk se yu de lɔs yu wet? Dis na tin wae wi nɔr kin pe atɛnshɔn to sɔmtɛm, bɔt dɛn kin bi sayn fɔ sɔm sik dɛm wae nɔr kin bɔrku. Tide wi go tɔk bɔt wan sik we siriɔs smɔl, bɔt i rili impɔtant fɔ no bɔt. Dat na wan sik we dɛn kɔl Klatskin Tumor .

Wetin na Klatskin Tumɔs?

Fɔ tɔk am simpul wan, dɛn Klatskin tɔŋ ya na wan kayn kansa tɔŋ we de divɛlɔp na di bayl dakt dɛn we de na do na wi liva. Tink bɔt dis, wi liva de mek wan wata we dɛn kɔl bayl, we de ɛp fɔ digest. dis bayl de fכlכ tru sכm sכm chεnal dεm εn i de jכyn tכgeda fכ mek di men bayl dakt. patikyular, dεn tכmכro dεm ya kin fכm mכst na di εria we dεn kכl ‘hilum’, usay di rayt εn lεft bayl dakt dεm we de kכmכt frכm di liva de jכyn fכ fכm di men bayl dakt. Dɔktɔ dɛn kin kɔl dis bak ‘Hilar Cholangiocarcinoma’ . If dɛn no dɛn tumbu ya ɛn trit dɛn kwik, chans de fɔ mek dɛn wɛl. Tin dɛm lɛk ɔpreshɔn ɛn liva transplant na di men tritmɛnt dɛm. Tritmɛnt dɛn de bak fɔ ridyus di sayn dɛm. Dɛn de du risach bak bɔt nyu tritmɛnt dɛn.

Aw dis nɔ kin apin so ɔltɛm?

Dis na tin we nɔ kin apin so ɔltɛm . Dɛn se na lɛk wan pan ɛvri ɔndrɛd tawzin pipul dɛn kin gɛt dis sik. Dat min se nɔto sik we de ambɔg bɔku pipul dɛn.

Wetin na di sayn dɛm fɔ Klatskin Tumor?

so, we dεn bayl dakt tכmכro dεm ya fכm, dεn de blכk di fכ fכm di bayl frכm di gal blad. Na da tɛm de difrɛn sayn dɛn kin sho. Dɛn tin ya kin apin smɔl smɔl, so sɔntɛnde wi nɔ kin notis dɛn.

• Bɛlɛ pen: Na di bɛlɛ pen we kin de ɔltɛm, sɔm tɛm dɛn kin mek i wɔs, mɔ na di ɔp rayt say na di bɛlɛ.
• Taya: Na filin fɔ taya pasmak we nɔ de go ivin afta yu dɔn slip fayn.
• Nɔs: Na fɔ fil lɛk se yu sik, sɔntɛm yu kin ivin vɔmit.
• We yu de lɔs yu wet: Fɔ lɔs yu wet fɔ no rizin ɛn we yu nɔ de it.
• Janda: Di wayt pat na di yay ɛn di skin kin yɔlɔ. dis kin apin we di bayl nɔ de dray fayn fayn wan, we kin mek wan yɔlɔ tin we dɛn kɔl bilirubin gɛda na di blɔd. Yurin kin tɔn dak yɔlɔ ɛn di stɔl kin tɔn wayt pale.
• Itchy skin: Sɔm pipul dɛn kin gɛt it ɔlsay na dɛn bɔdi, we na prɔblɛm bak we gɛt fɔ du wit bayl.

Dɛn sik ya kin tranga fɔ liv wit, so nɔr shem fɔ go to dɔktɔ. Di tin we impɔtant pas ɔl na fɔ fɛn di rizin kwik kwik wan.

Wetin na di tin dɛn we kin mek pɔsin gɛt Klatskin Tumor?

Di wan dɛn we de stɔdi bɔt dis nɔ dɔn no yet di rayt tin we kin mek dɛn bɔdi wam dɛn bɔdi ya.. Bɔt na dis na wetin kin apin: Dɛn tɔŋ ya kin mek we wan chenj na di jɛnɛtiks (myuteshɔn) apin na di nɔmal sɛl dɛn na wi bɔdi, we kin mek dɛn sɛl dɛn de sheb nɔmal wan ɛn bɔku we wi nɔ ebul fɔ kɔntrol.

Bɔt dɛn dɔn si sɔm tin dɛn we kin mek pɔsin gɛt dis sik mɔ ɛn mɔ. Dat min se, tin dεm lεk sכm sik dεm εn jεnεtik chenj dεm we kin apin afta wi bכn.

Sɔm tin dɛm wae kin mek dis risk bɔku na:

• Alcohol use disorder: Ɔlman no se rɔm nɔr fayn fɔ di liva. If yu drink bɔku rɔm fɔ lɔng tɛm, dat kin pwɛl yu liva ɛn i kin mek yu gɛt dis kayn kansa.
• Galston dεm (Choldocholithiasis): Ston dεm we de blכk di bayl dakt dεm kin mek di inflameshn fכ lכng tεm εn di sεl dεm chenj.
• Kronik pankrias: Di pankrias kin inflamesh fɔ lɔng tɛm.
• Klonorchiasis: Dis na infεkshכn we wan Chaynish liva fluk parasayt kin kכz. dis parasayt de liv na di bayl dakt dεm εn i de mek i damej fכ lכng tεm.
• Primary sclerosing cholangitis (PSC): Dis na wan sik we di bayl dakt dɛn kin inflam, skata, ɛn smɔl. Dis na kכndyushכn bak we de rili inkrεs di risk fכ Klatskin tכmכro.
• Sɔm vayrɔs: di liva we di vayrɔs kin mek, mɔ di epataytis B ɛn epataytis C, kin gɛt dis sik bak.
• Ej: Pipul wae dɔn pas 50 ia kin gɛt bɔrku risk.
• Dɛn kin tink bak se if pɔsin fat ɛn gɛt dayabitis, dat kin mek i gɛt mɔ prɔblɛm to sɔm mak.

Us prɔblɛm dɛn dis kin mek?

Dis sik kin mek yu gɛt siriɔs prɔblɛm dɛn .

• Blɔd klɔt: Kansa kin go na big blɔd vesel ɛn mek blɔd klɔt.
• εkstrahεpatik kכlestasis: Dis kin apin we wan big bayl dakt we de na do na di liva de blok bay wan tכmכro. Dis kin mek di jaundice wɔs.
• kansa we de mεtastas: dεn Klatskin tכmכro dεm ya kin kכmכt frכm di bayl dakt dεm we de na do na di liva to di liva insεf, di lכng dεm, bon dεm, limf no dεm, εn כda pat dεm na di bכdi.

Aw dɛn kin no se pɔsin gɛt Klatskin Tumor?

If yu gɛt dɛn sik ya, di fɔs tin we yu dɔktɔ go du na fɔ chɛk yu gud gud wan. Ɛspɛshali yu bɛlɛ. Dɛn go chɛk fɔ si if yu bɛlɛ dɔn swel, i gɛt ɛni lumps, ɔ i de pen we yu tɔch am. Dɛn go chɛk bak fɔ si if yu skin ɛn yu yay yɔlɔ.

Dɔn, dɛn kin du blɔd tɛst, imej tɛst, ɛn ɔda tin dɛn fɔ si ɛksaktɔli wetin de apin to di bayl dakt dɛn. Dɛn kin du tɛst bak pan dɛn jɛnɛtiks fɔ luk fɔ chenj dɛn na dɛn jɛnɛtiks.

Blɔd tɛst dɛn

• Di mak dɛn we de mek di tumbu:Dɛn tin ya kin luk sɔm tin dɛn we de na di blɔd we kin bi sayn fɔ se pɔsin gɛt Klatskin tɔŋ. fכ egzampl, dεn de luk di lεvεl fכ wan tin we dεn kכl k כbhaydret antijen (CA) 19-9 . If di lɛvɛl fɔ dis rili ay, i kin bi sayn fɔ dis sik. Bɔt nɔto ɔlman we gɛt dis lɛvɛl gɛt kansa, ɛn i kin bɔku bak fɔ ɔda rizin dɛn.
• di tεst dεm fכ di liva fכ wok: dεn ya inklud bilirubin tεst εn tεst fכ chεk fכ εlevεt liva εnzym dεm. dis kin gi yu aidia if di liva dεn dכn pwεl כ if di bayl fכ fכlכ dεn blכk.

Test dɛn fɔ tek imej

Dɛn tɛst ya kin tek pikchɔ fɔ di insay pat na di bɔdi. Sɔm imej tɛst dɛn kin tek bak wan tisu sɛmpul (bayɔpsi) ɛn mek wan mɛdikal patɔlɔjis chɛk am. Dis na wetin go sho if na kansa ɔ nɔto kansa.

• Ultrasound scan: Dis na simpul tɛst we dɛn kin du fɔs.
• CT (CT - Computed Tomography) Scan: Dis kin tek pikchɔ dɛn we klia.
• MRI (Magnetic Resonance Imaging): Dis kin tek pikchɔ dɛn bak we rili klia ɛn we gɛt ditayli.
• ERCP (Endoscopic Retrograde Cholangiopancreatography): Insay dis prɔsidyu, dɛn kin put ɛndoskɔp (wan tin tiub we gɛt kamɛra) tru di mɔt, tru di bɛlɛ, ɛn insay di bayl dakt dɛn. Dɛn kin tek sɛmpul dɛn frɔm de, ɛn dɛn kin put stent na di say we dɛn dɔn blok fɔ ɛp di bayl fɔ flɔ.
• MRCP (Magnetic Resonance Cholangiopancreatography): Dis tan lεk MRI, bכt dεn kin du am spεshal fכ luk di bayl dakt dεm εn di pankrεas dakt dεm. Dɛn nɔ de put natin na di bɔdi fɔ dis.

Stej dɛn we kansa kin gɛt

If dɛn no se yu gɛt dis sik, yu dɔktɔ go no di stej we di kansa de (kansa stej) . Dis impɔtant fɔ plan tritmɛnt ɛn fɔ no di prɔgnosis afta tritmɛnt.

di kεnsar stej dεm dεn kin kכl dεm bay di sayz fכ di tכmכro (T), if di kεnsar dכn spre to limf no dεm (N), εn if i dכn spre to di fa fa כgan dεm (M - mεtastasized). Sɔntɛnde, dɛn kin tink bak bɔt aw di kansa sɛl dɛn de apia ɔnda maykroskɔp (kansa gred) .

di stej dεm fכ di Klatskin tכmכro dεm na jכs lεk dis:

• Stej 0: di tכmכro de כnli insay di insay layεr dεm na di bayl dakt. I nɔ dɔn spre to dip layers, limf no dɛm, ɔ ɔda pat dɛm na di bɔdi.
• Stej I: Di kansa de na di wכl na di bayl dakt, bכt i nכ spre ausayd di bayl dakt.
• Stej II: di tכmכro dכn spre to fεt tisu we de nia כ di liva tisu we de nia.
• Stej IIIA: Di kansa dɔn spre to branch dɛm na wan pan di men blɔd vesel dɛm na di liva (rayt ɔ lɛft).
• Stej IIIB: di tכmכro dכn spre to di tu say dεm na di men blכd vεsεl dεm na di liva, כ to כda bayl dakt dεm na wan say na di liva εn to wan men blכd vεsεl na di כda say.
• Stej IIIC: Di kansa dɔn spre to wan to tri limf no dɛm we de nia.
• Stej IVA: di tכmכro dכn spre to fכ כ mכr limf no dεm.
• Stej IVB: Naw di kansa dɔn go fa fa say dɛn na di lɔng, bon, ɔ liva.

Wetin na di tritmɛnt dɛm fɔ Klatskin Tumor?

Di tritmɛnt we dɛn kin pik kin dipen pan bɔku tin dɛn, lɛk aw yu sik, di stej we di kansa gɛt, ɛn yu ɔl yu wɛlbɔdi. Bɔt bɔku tɛm, ɔpreshɔn na di fɔs ɛn kɔmɔn tritmɛnt fɔ dis sik.

Difrɛn kayn ɔpreshɔn dɛn de:

• biliary drainage: Dɛn kin du dis fɔ pul di bayl we pasmak we dɔn gɛda na di liva. Dis kin ridyus di sayn dɛm lɛk janda. Dis kin bi tru ERCP wit stent ɔ wit ɛksternal tiub.
• εkstend εpatektכmi: Fכ pipul dεm we gεt εli stej tכmכro, εpatektכmi kin pul pat pan di liva, bayl dakt, gal blad, εn limf no dεm we de nia.
• Liva transplant: Di wangren we fɔ mɛn dis sik ɔltogɛda na fɔ pul di kansa tɔŋ(dɛn). Dis kin nid fɔ pul di wan ol liva ɛn du liva transplant. Dis nɔ pɔsibul fɔ ɔlman, ɛn i nid fɔ fit fɔ tek pat.

Apat frɔm ɔpreshɔn, ɔ if dɛn nɔ ebul fɔ du ɔpreshɔn, dɔktɔ dɛn kin yuz wan tritmɛnt we dɛn kɔl kemoradiation . Dis na wan kɔmbaynshɔn fɔ kemotɛrapi ɛn redyushɔn tɛrapi . Dɛn tritmɛnt ya kin kil di kansa sɛl dɛn ɔ kɔntrol dɛn growth.

Naw tu nyu tritmɛnt dɛn de fɔ di mɛtastas squamous cell tumors:

• Imyun tεrapi: fכ egzampl, dεn dεm we dεn kכl ‘immune checkpoint inhibitors’ . Dɛn tin ya kin wok bay we dɛn kin ɛp yu yon imyun sistɛm fɔ fɛt kansa.
• Tεrapi we dεn tכk bכt: Drug dεm lεk fibroblast growth factor rεsεptכr (FGFR) inhibito dεm כ IDH inhibito dεm . FGFR inhibito dεm de stכp di kεnsar sεl dεm fכ gro εn kil dεm. IDH inhibito dεm de blכk wan abnכmal protin we de afekt nכmal sεl growth. Dɛn tin ya nɔ kin wok fɔ ɔlman, ɛn dɛn kin jɔs gi dɛn to pipul dɛn we gɛt sɔm chenj dɛn na dɛn jɛnɛtiks na dɛn kansa sɛl dɛn.

Kɔmplikɛshɔn ɛn sayd ɛfɛkt dɛn we di tritmɛnt kin gɛt

Epatectomies ɛn liva transplant na big ɔpreshɔn, ɛn as a so, dɛn kin gɛt bɔku prɔblɛm dɛn.

• Ascites: Fכ wata we de kכmכt na di bכdi.
• di bayl lik: We dɛn de du ɔpreshɔn pan di liva, di bayl dakt dɛn na di liva kin pwɛl, we kin mek di bayl we pasmak lik insay di liva.
• Dip vein thrombosis (DVT): na di fכmeshכn fכ wan bכdi we de kכlכt na di dip vein dεm na di bכdi afta dεn du di כpεrayshכn.
• Infεkshכn: Infεkshכn kin apin na di say we dεn du di כpεrayshכn, na di urinary tract, כ na di lכng.
• Kidni we nɔ de wok fayn: Sɔntɛnde, we dɛn du ɔpreshɔn pan di liva, i kin afɛkt di kidni dɛn ɛn mek dɛn stɔp fɔ wok.
• Liva fεil: Dis kin apin if dεn pul pat pan di liva (hεpatectomy).
• Ɔgan rijɛkt: Di bɔdi kin rijɛkt liva we dɛn transplant.

Di kɔmɔn sayd ɛfɛkt dɛn we redyushɔn tɛrapi ɛn kemotɛrapi kin gɛt na:

• Taya.
• Di ia we de lɔs.
• Nɔs ɛn vɔmit.
• Sɔl dɛn na yu mɔt.
• Rɔnbɛlɛ.
• Anemia we nɔ gɛt bɛtɛ blɔd.

Dɔktɔ dɛn kin gi advays ɛn mɛrɛsin bak fɔ mɛn dɛn bad bad tin ya.

Wetin na di rεt wae de liv fכ Klatskin Tumor?

We yu yɛri bɔt sik lɛk dis, wan pan di fɔs kwɛstyɔn dɛn we kin kam na yu maynd na wetin na di ‘survival rate’. Dis de tɔk bɔt di pasɛnt we pipul dɛn we gɛt wan patikyula kayn kansa stil de alayv fayv ia afta dɛn dɔn no se dɛn gɛt am.

Di Nashɔnal Kɛnsa Instityut (NCI) na Amɛrika kin gɛda dɛn kayn data ya. pan ɔl we no patikyula data nɔ de fɔ di Klatskin tɔŋ dɛm, data de fɔ ɔl kayn bayl dakt kansa we de divɛlɔp ausayd di liva. akɔdin to dis, ɔltogɛda, 9% pan di pipul dɛm we gɛt ɛkstrahɛpatik bayl dakt kansa de alayv fayv ia afta dɛn dɔn no se dɛn gɛt am.

Bɔt we yu de tink bɔt dɛn statystik ya, yu fɔ mɛmba tu tin dɛn:

• Dis na jɔs ɛstimat: dɛn de bay wetin ɔda pipul dɛn dɔn ɛkspiriɛns. Di tin we de apin to yu kin difrɛn bad bad wan. Fɔ ɛgzampul, yu ɔl wɛl bɔdi, yu ej, di stej we yu gɛt kansa, ɛn aw yu de du tritmɛnt kin afɛkt dɛn rit ya.
• Dɛn nɔmba ya na istri: Dɛn de sho di tin dɛn we bin dɔn apin i nɔ tu te yet, nɔto di tin dɛn we de apin naw. Dɛn kin mɛzhɔ dɛn rit ya ɛvri fayv ia. So di impak we nyu tritmɛnt dɛn gɛt nɔ de sho pan dis.

Di impɔtant tin na dat dɛn statystik ya nɔ de tɛl di wan ol stori. Ɔlman difrɛn, ɛn di tritmɛnt dɛn de bɛtɛ ɔltɛm. I fayn fɔ tɔk to yu dɔktɔ bɔt dis ɛn aks dɛn wetin dis infɔmeshɔn min fɔ yu. I impɔtant fɔ kɔntinyu fɔ gɛt op ɛn fɔ gɛt gud tin dɛn fɔ du.

Aw a go tek kia ɔf misɛf?

Fɔ kip yu kwaliti layf afta yu dɔn no dis sik, tritmɛnt, ɛn wɛl na di bɛst tin we yu kin du fɔ yusɛf. Na sɔm advays dɛn ya:

• It gud gud wan:It tin we balans ɛn we gɛt fayn fayn tin dɛn fɔ it. It mɔ tin dɛn we nɔ gɛt bɛtɛ bɔdi, vɛjitebul, frut, ɛn ɔl gren. Kɔnsul yu dɔktɔ ɔ pɔsin we sabi bɔt it fɔ advays.
• Nɔ no di lay lay tin: Bikɔs dis na sik we nɔ kin apin so ɔltɛm, yu nɔ go no bɔku tin bɔt am. We yu de luk fɔ infɔmeshɔn na di Intanɛt kin mek yu kɔnfyus ɛn mek yu fred. Bɔt fɔ no na pawa . Na di say dɛn nɔmɔ we yu kin abop pan fɔ gɛt infɔmeshɔn. Du yu bɛst fɔ du risach bɔt di tru tin dɛn, ɛn aks yu mɛdikal tim ɛni kwɛstyɔn ɔ tin we de mɔna yu.
• Sɔpɔt yu maynd wɛl bɔdi: Wit kansa wae nɔr kin bɔrku lɛk dis, e kin tek yu maynd wɛl bɔdi, bikɔs bɔrku tɛm i kin nid ɔpreshɔn ɛn tritmɛnt fɔ lɔng tɛm. Na nɔmal tin fɔ fil bad, fred, ɛn wɔri. Aks yu mɛdikal tim bɔt program ɛn advays wae kin ɛp wit dis. Tɔk to yu fambul ɛn padi dɛn.
• Tink bɔt di program dɛm fɔ sev frɔm kansa: Dɛn tin ya de tɔk mɔ bɔt wɛl bɔdi, wɛl bɔdi, ɛn kwaliti layf wae yu de liv wit kansa.
• Aks bɔt palliativ kia: Palliative care na tritmɛnt wae nɔr kin ebul fɔ mɛn di sik, bɔt kin ɛp fɔ kɔntrol di sik ɛn impruv kwaliti layf. Paliativ kia fɔ bayl dakt kansa kin ɛp fɔ mek yu nɔ fil fayn, fɔ mek yu nɔ fil pen, ɛn fɔ mek di bayl flɔ na say dɛn we di tumbu de blok am.

Ustɛm a fɔ go to di dɔktɔ?

If dɛn dɔn no se yu gɛt Klatskin tumor, kɔntinyu fɔ tɔk to yu dɔktɔ ɔltɛm.

• Aks yu dɔktɔ wetin chenj (we de wɔs pan di sik, nyu sayn dɛm) fɔ ɛkspɛkt.
• If di sayn dɛn lɛk pen, nɔs, ɛn vɔmit de wɔs, ɔ if nyu sayn dɛn de sho , tɛl yu dɔktɔ wantɛm wantɛm .
• If di sayd ɛfɛkt dɛm we di tritmɛnt kin gɛt bad bad wan, tɛl dɛn bɔt am.
• Yu dɔktɔ gɛt tritmɛnt fɔ ɛp fɔ ridyus di sayn dɛm wae de afɛkt yu ɛvride layf ɛn kwaliti layf.

Us kwɛstyɔn dɛn a fɔ aks di dɔktɔ?

Yu go dɔn rid bɔku tin bɔt Klatskin tumor ɛn yu gɛt kwɛstyɔn bɔt yu kɔndishɔn. Rayt dɛn kwɛstyɔn ya we yu go si yu dɔktɔ.

• Aw yu no se a gɛt dis kayn kansa?
• Wetin na di stej we pɔsin kin gɛt kansa? Wetin i min?
• Us tritmɛnt opshɔn dɛn a gɛt? Wetin na di gud ɛn bad tin dɛn we ɛni wan pan dɛn gɛt?
• Yu tink se kɔmplit mɛrɛsin de fɔ dis?
• Aw mi layf go tan lɛk afta dɛn dɔn trit mi?
• Ɛni klinik trial dɛn de we a fɔ tink bɔt?
• A nid fɔ chenj di we aw a de it ɛn di we aw a de liv mi layf?
• Usay mi ɛn mi famili go gɛt ɛp fɔ bia wit dis prɔblɛm?

Fɔ dɔn, mɛmba...

Klatskin tumor (hilar cholangiocarcinoma) na rili chalenj, siriɔs sik.No kweshon de se na sik. Na nɔmal tin fɔ mek yu fil fred we yu yɛri am. Bɔt, data lɛk aw pɔrsin de liv nɔr de tɛl di ɔl stori bɔt dis sik. Na sik wae dɛn kin trit pasmak, ɛn sɔm pipul dɛm wae de stɔdi bɔt dis de du klinik trial fɔ nyu tritmɛnt dɛm.

If yu gɛt dis sik, yu mɛdikal tim kin ɛp yu fɔ kɔntrol yu sayn dɛm ɛn di tritmɛnt sayd ɛfɛkt dɛm. Dɛn go gladi bak fɔ gi yu advays bak bɔt aw fɔ du klinik trial dɛn we yu go want fɔ tink bɔt. Nɔ ɛva giv ɔp op. Di tin we impɔtant pas ɔl na fɔ tɛl yu ɛn fala yu dɔktɔ in advays.

` Klatskin Tumor, Hilar Cholangiocarcinoma, Bayl Dakt Kansa, Liva Kansa, Yɔlɔ Fiva, Jandis, Kansa Simptom, Kansa Tritmɛnt