Yu gɛt tumɔs gastrin na yu bɛlɛ? Lɛ wi tɔk bɔt (Hypergastrinemia)!

Bɔku tɛm yu kin fil se yu bɛlɛ nɔ kin fayn, yu kin ful-ɔp, ɔ yu kin fil ɔda prɔblɛm dɛn we yu kin gɛt we yu de digest? sכmtεm di rizin fכ dis kin bi biכs di lεvεl fכ wan כmon we dεn kכl `(Gastrin)` we dεn prodyuz na yu bכdi hכy pas nכmal. Tide, wi go tɔk bɔt dis kɔndishɔn we dɛn kɔl `(Hypergastrinemia)` ditayli ɛn rili simpul.

Wetin na `(Hypergastrinemia)`? Lɛ wi ɔndastand gud gud wan!

Fɔ tɔk am simpul wan, `(Hypergastrinemia)` min se di lɛvɛl fɔ `(Gastrin)`, we na ɔmon we de ɛp wi bɔdi fɔ dayjɛst it, ay pas aw i nid. dis `(Gastrin)` כmon de mek bay wan spεshal tכp sεl we de na di bεlε wכl na di lכw pat pan wi bεlε, dat na nia di sכmכl intestin. Wi kin kɔl dis `(G sɛl)`.

naw luk, dis `(Gastrin)` כmon na in de tεl wi bεlε, "Okay, naw sekret asid." dis bכdi asid, dat na `(gastric acid), rili imכtant fכ wi. biכs, dis bכdi asid de εp wi fכ digεst di it we wi de it εn fכ abzכp di nyutriεnt dεm we de insay da it de, fכ egzampl `(amino asid)` εn protin dεm.

Bɔt wetin kin apin wit `(Hypergastrinemia)` kin kɔmplikt smɔl. sכmtεm i kin mek di bכdi asid tu bכku (`hyperchlorhydria`), εn כda tεm dεm i kin mek di bכdi asid tu sכm (`hypochlorhydria`). So aw `(Hypergastrinemia)` de afɛkt yu dipen pan ɔda mɛrɛsin wae yu gɛt, ɔpreshɔn wae yu dɔn gɛt, ɛn mɛrɛsin wae yu de tek.

Udat kin gɛt dis sik?

infakt, dis kכndyushכn we dεn kכl ``Hypergastrinemia'' kin apin to εnibodi, i nכ mata di ej כ jεnda. So, i fayn fɔ lɛ wi ɔl no bɔt dis.

Wetin na di tin dɛm we kin mek pɔsin gɛt `(Hypergastrinemia)`?

bכku tin dεm kin de fכ dis kכndyushכn, inklud ``Hypergastrinemia.'' Sכm tin dεm kin mek di bεlε asid prodyushכn dכn, כda wan dεm de mek di bεlε asid prodyushכn bכku. Lɛ wi luk di tu wan bay wan.

Di tin dɛn we kin mek di bɛlɛ asid nɔ bɔku

we ``Hypergastrinemia`` de apin, di nכmal prodakshכn fכ di bכdi asid kin dכn bikoz fכ dεn rizin dεm ya:

• Antasid fɔ at bɔn ɔ GERD (Gastroesophageal Reflux Disease): If yu de yuz dɛn kayn mɛrɛsin ya ɔltɛm , dat kin bi bak wan kɔz.
• Chronic atrophic gastritis: Dis na we di bɛlɛ wɔl kin wik smɔl smɔl ɛn i kin inflam as tɛm de go.
• Kolorektal kansa: Dis kin afɛkt bak.
• `(H. pylori)` infεkshכn: `(Helicobacter pylori)` na baktri we kin liv na di bεlε. Dis infεkshכn na di kכz dεm bak fכ `(Hypergastrinemia).`
• Kidni fεil: Dis kכndyushכn kin apin we di kidni dεm nכ de wok fayn fayn wan.
• Yuz fɔ Protɔn Pɔmp Inhibitɔ (PPI): .Fɔ yuz PPI mɛrɛsin fɔ lɔng tɛm (lɛk omeprazole) fɔ gastritis, asid riflɔks, indijɛshɔn, ɔ peptik ɔlsa sik bak na wan men tin we kin mek pɔsin gɛt sik.
• Vagotomy: Dis kin min fɔ pul wan pat pan di vagus nerve. dis nεv de kכmכt frכm di bren to di bεlε εn i de kכri signal to di at εn di dijestiv sistεm. Hypergastrinemia kin apin afta dis ɔpreshɔn.

Di tin dɛn we kin mek di bɛlɛ asid bɔku

Naw lɛ wi luk wetin kin mek di bɛlɛ asid bɔku (Hypergastrinemia):

• Antral G-sεl haypaplasia (pseudo-Zollinger-Ellison syndrome / Ps-ZES): Dis na wan kכndyushכn we nכ kin apin. i sכm kayn we lεk Zollinger-Ellison syndrome, bכt nכ tכmכro dεm we de prodyuz gastrin de na di pankrias כ di fכs pat pan di sכmכl intestin (duodenum).
• di gastric outlet obstruction: Dis kכndyushכn kin apin we di pasej we de kכmכt na di bεlε to di sכmכl intestכn dεn blכk. Tink bɔt am lɛk wata paip we dɔn lɔk.
• Multiple endocrine neoplasia type-1 (MEN-1): Dis kכndyushכn de mek nyuroεndokrin tכmכro dεm de divεlכp na di adrenal gland dεm, tayroyd gland dεm, כ paratayroyd gland dεm.
• Ritained antrum syndrome: Dis kכndyushכn kin apin if dεn lεf sכm sכm pat pan di lכw pat pan di bεlε (di antrum) afta dεn dכn כpεrayshכn fכ pul di tכmכro כ trit כlsa.
• Zollinger-Ellison syndrome (ZES): Dis na wan sik we di tכmכro dεm de prodyuz di כmon gastrin pasmak. Dis kכndyushכn (ZES) kin mek yu bכdi כlsa.

Wetin na di sayn dɛm fɔ di sik `(Hypergastrinemia)`?

If yu gɛt `(Hypergastrinemia)`, yu kin gɛt sɔm kayn sik lɛk:

• Bɛlɛ pen: Yu kin gɛt bɛlɛ pen ɔltɛm.
• Kronik dayarɛa: Dayrɛa we kin te fɔ sɔm dez.
• Pankrias tכmכro dεm: Dis kin bi kansa כ benign tכmכro.
• Ɔlsa na di bɛlɛ: Sɔl we kin apin wit inflamɛns na di bɛlɛ.
• Sivεr εsophagitis: Sivεr inflameshn εn pen na di εsophagus.

Aw dɔktɔ dɛn kin no bɔt dis sik?

Fɔ mek dɔktɔ dɛn no di rayt we fɔ no ɔmɔs asid yu bɛlɛ de mek. Dɛn kin mɛzhɔ bak di lɛvɛl we di gastrin de na yu blɔd.

• Bifo dis tɛst, yu dɔktɔ go tɛl yu fɔ fast (nɔ fɔ it) fɔ sɔm tɛm .
• Dɔn bak, if yu na ``(PPI)`` yuza, .Yu go gɛt fɔ stɔp fɔ tek da mɛrɛsin de lɛk wan wik bifo di tɛst.
• Dɔn, dɛn kin tek wan sɛmpul pan yu blɔd ɛn chɛk yu Gastrin lɛvɛl. Sɔntɛnde, dɛn kin tek dɛn blɔd sɛmpul ya bɔku tɛm insay di de, fɔ sɔm dez, fɔ si if yu Gastrin lɛvɛl chenj.

If yu dɔktɔ tink se yu gɛt haypa gastrinemia, dɛn kin tɛl yu fɔ du ɔda tɛst fɔ no ɔda tin dɛn we de apin. Dɛn tin ya na:

• sekrit stimulashכn tεst: Dis min fכ gi yu wan כmon we dεn kכl sekretin, we di fכs pat pan yu sכmכl intestin (duodenum) de mek. If yu gastrin lɛvɛl go ɔp wantɛm wantɛm, i kin bi sayn fɔ Zollinger-Ellison syndrome.
• bכdi pH tεst: Dis de chεk di asid lεvεl dεm na yu bεlε. if di pH less dan 2, i kin bi sayn bak fכ Zollinger-Ellison syndrome.

Aw dɛn kin trit Hypergastrinemia?

Di tritmɛnt fɔ hypergastrinemia dipen pan di kɔz.

• Kכlon kεnsar, εsophageal obstruction, kidni sik, εn kכndyushכn dεm lεk `(MEN-1)` εn `(ZES)`: We dεn trit dεn kכndyushכn ya (bכku tεm tru כpεrayshכn), di simptom dεm fכ `(Hypergastrinemia)` dεn kin sכlv bak.
• Atrophic gastritis (ACG) ɛn H. pylori infεkshɔn: Dɛn kin trit dɛn sik ya wit antibayɔtik.
• Proton-pump inhibitors (PPI): If yu de tek PPI, di hypergastrinemia go ɔltɛm sɔlv insay fayv to sɛvin dez afta yu dɔn stɔp di mɛrɛsin.
• Ritained antrum syndrome: we yu pul di antral tisu we de na di lכw pat pan di bכdi i kin ridyus di εkstra bכdi asid we de prodyuz.

De tin wae impɔtant pas ɔl na fɔ tɔk to yu dɔktɔ bɔt di bɛst tritmɛnt fɔ yu sik.

A kin ridyus di risk fɔ `(Hypergastrinemia)`?

If yu de yuz antisid ɔ PPI fɔ lɔng tɛm, risk de fɔ mek yu gɛt aypagastrinemia. So, e fayn fɔ tɔk to yu dɔktɔ bɔt aw fɔ kɔntrol dis prɔblɛm.

If a gɛt `(Hypergastrinemia)`, wetin a kin ɛkspɛkt? Wetin kin apin if dɛn nɔ trit am?

If dɛn nɔ trit di haypa gastrinemia fayn, di bɔdi in gastrin lɛvɛl kin stil ay. Risach pipul dɛn tink se dis kin mek di kansa sɛl dɛn gro. Fɔ ɛgzampul:

• Blɔd kansa: lɛk lukimiya, limfoma, ɛn mɔltipɛl mayloma.
• Kansa na di εsophageal
• Kansa na di pankrias

כlso, fכ lכng tεm `(Hypergastrinemia)` kin mek yu bכdi tכmכro `(gastric carcinoids)` כ `gastric adenocarcinoma`. Tu kayn `(gastric carcinoids)` de:

• Tayp I gastric carcinoids: Dɛn wan ya gɛt fɔ du wit di kɔndishɔn we dɛn kɔl kronik atrofik gastritis.
• I kin apin mɔ pan uman dɛn.
• Yu kin si am na bɔku say dɛn na di bɛlɛ.
• Di chans fɔ gɛt kansa nɔ bɔku.
• Tayp II gastric carcinoids: Dɛn wan ya gɛt fɔ du wit di kɔndishɔn dɛn we nem ZES ɛn MEN-1.
• I kin apin to man ɛn uman.
• Yu kin si am na bɔku say dɛn na di bɛlɛ.
• Sɔmtɛm i kin tɔn to kansa (bitwin 7% ɛn 12%).

Wetin na de luk fɔ pɔrsin wae gɛt `(Hypergastrinemia)`?

di fכs hεlth stet fכ pכsin we gεt ``Hypergastrinemia`` de dipכnt pan sεvεra tin dεm:

• Di tin we kin mek pɔsin gɛt dis sik.
• Jɛnɛtiks.
• Wɛlbɔdi istri.
• Di we aw pɔsin de liv in layf.

Bɔt if dɛn trit dɛn fayn, pipul dɛn we gɛt ``Hypergastrinemia'' kin liv aktif, nɔmal layf.

A gɛt `(Hypergastrinemia)`, aw a go tek kia ɔf misɛf?

If yu de tek antisid ɔ PPI fɔ lɔng tɛm, i impɔtant fɔ mek yu de chɛk yu mɛrɛsin ɔltɛm. Kɔnsul yu dɔktɔ fɔ advays.

Ustɛm a fɔ go to dɔktɔ?

If yu gɛt ɛni wan pan dɛn nyu sik ya, ɔ if yu fil lɛk se yu sik dɛn we yu dɔn gɛt de wɔs, mek shɔ se yu go to dɔktɔ ɛn mek dɛn chɛk yu ful wan.

Tin dɛn fɔ mɛmba fɔ sɔm tɛm

Okay den, lɛ wi jɔs mɛmba wetin wi bin tɔk bɔt:

• Hypergastrinemia na we di ɔmon gastrin we de na di bɔdi de bɔku.
• dis כmon (Gastrin) de afekt di asid lεvεl dεm na di bεlε (asid kin inkrεs כ dכn).
• Bɔku rizin kin de – tin dɛn lɛk `(PPI)`/kɔntinyu fɔ yuz antisid, `(H. pylori)` infɛkshɔn, gastritis, `(Zollinger-Ellison syndrome)`.
• dכkta dεn kin no dis bay we dεn de tεst di lεvεl fכ ``Gastrin''.
• Di tritmɛnt de bays pan di ɔndalayn kɔz.
• Nɔ ignore de symptoms, as dɛn kin divɛlɔp to tumor ɛn kansa if dɛn nɔ trit dɛn! Go to dɔktɔ wantɛm wantɛm.

A op se yu si dis infɔmeshɔn yusful. Stay wit wɛlbɔdi!

` Haypagastrinemia, Gastrin, Bɛlɛ asid, Dijeshɔn, Zollinger-Ellison sindrom, H. pylori, PPI, Gastritis, Bɛlɛ inflameshɔn