Yu dɔn ɛva yɛri bɔt kansa na yu famili? Ɔ yɔŋ pɔsin we gɛt kansa we kin ambɔg ol pipul dɛn? Sɔntɛnde, rizin kin de biɛn dɛn tin ya we wi nɔ no. Na dat wi go tɔk bɔt tide, wan rare jenɛtik kɔndishɔn we de rɔn na famili ɛn i kin rili inkrisayz di risk fɔ gɛt kansa. Dɛn kɔl am Li-Fraumeni Sindrom.
Fɔ tɔk am simpul wan, wetin na Li-Fraumeni Syndrome?
Dis na wan sik we nɔ kin apin we pɔsin kin gɛt we i kam pan jɛnɛtiks. Na bikɔs wan pan di jin dɛn we de na wi bɔdi chenj chenj. Dis chenj na yu jɛnɛtiks kin rili mek yu ɛn yu famili gɛt wan ɔ mɔ kayn kansa.
Tink bɔt dis: Pɔsin we gɛt dis sik kin gɛt 90% chans fɔ gɛt kansa we i ol 60. Ɛn, lɛk af pan dɛn pipul ya kin gɛt kansa bifo dɛn rich 40. Mɔtalman, uman dɛn we gɛt Li-Fraumeni Syndrome kin gɛt lɛk 100% chans fɔ gɛt bɔdi kansa insay dɛn layf.
Dis kin tan lɛk se i de mek pɔsin fred smɔl. Bɔt di impɔtant tin na dat, pan ɔl we wi nɔ go ebul fɔ avɔyd dis sik, bay we wi kin gɛt kansa skrinin kwik ɛn ɔltɛm ɛn gɛt di tritmɛnt we wi nid , wi kin rili stɔp di impak we i kin gɛt pan wi layf.
Aw dis sik kin kɔmɔn?
Li-Fraumeni Syndrome na wan sik wae nɔr kin bɔrku. Risach pipul dɛn dɔn jɔs fɛn lɛk 1,000 famili dɛn ɔlsay na di wɔl we gɛt dis chenj we dɛn chenj dɛn jɛnɛtiks. So nid nɔ de fɔ fred am fɔ natin.
Wetin na di sayn dɛm wae de sho se yu gɛt Li-Fraumeni Syndrome?
Di spɛshal tin ya na dat, nɔr patikyula sayn nɔr de wae gɛt fɔ du wit di sik wae dɛn kɔl Li-Fraumeni Syndrome. Dat min se pɔrsin wae gɛt dis sik nɔr kin si ɛni chenj na do.
So aw yu no dis? Di men sayn fɔ dis sik na we sɔm kayn kansa kin apin we i yɔŋ . So, de sayn dɛm wae yu go gɛt go dipen pan di kayn kansa wae yu gɛt. Fɔ ɛgzampul, bren kansa go sho sɔm sayn dɛn we gɛt fɔ du wit dat, ɛn bɔdi kansa go sho sɔm sayn dɛn we gɛt fɔ du wit dat.
Us kayn kansa kin gɛt fɔ du wit dis sik?
Mɔ pas tɛn kayn kansa dɛn dɔn gɛt fɔ du wit Li-Fraumeni Syndrome. Sɔm kansa kin so kɔmɔn pan pipul dɛm wae gɛt dis sik dat dɛn kin kɔl dɛm "kɔr kansa." Lɛ wi tek wan luk pan wetin dɛn bi.
| Kansa kategori | Tɔk bɔt |
|---|---|
| Kɔr Kansa dɛn | |
| Sarkoma dɛn | kansa dεm we de apin na di bon dεm (Osteosarcoma) εn sכft tisu dεm (Soft Tissue Sarcoma). |
| Brɔst Kansa | Uman dɛm wae gɛt dis sik kin gɛt dis sik na dɛn layf. |
| Bren Kansa | Dis inklud difrɛn kayn dɛn lɛk Gliomas, Choroid Plexus Carcinoma, ɛn Medulloblastoma. |
| Adrenokɔrtikɛl Karsinɔma | Wan kansa we de divεlכp na di כta layt na di adrenal gland dεm, we de oba wi kidni dεm. |
| Lukimiya | Dis inklud akyu lukimiya, we na wan kansa we de na di blɔd sɛl dɛn. |
| Ɔda kansa dɛn we nɔ kin gɛt fɔ du wit am | |
| Kɔlɔn kansa, Kidni kansa, Limfoma, Lɔng kansa, Ovarian kansa, Pankrias kansa, Prɔstat kansa, Skin kansa, Bɛlɛ kansa, Tɛstikul kansa, Tayrɔyd kansa. | |
Wetin mek dis tin kin apin?
Fɔ ɔndastand wetin mek dis de apin, wi nid fɔ no bɔt wan smɔl gad we de na wi bɔdi. Wi gɛt wan jin we dɛn kɔl TP53 . I tan lɛk "guardian angel" na wi bɔdi. di men wok we dis jin de du na fכ mek di sεl dεm na wi bכdi nכ gro di nכmal wan εn we wi nכ de kכntro εn bi tכmכro.
di protin we dis TP53 jin mek dεn kכl am di P53 protin. Dis na wetin rili de du da gad wok de.
Naw, wetin kin apin to pɔsin we gɛt Li-Fraumeni Syndrome na dat chenj, ɔ muteshon de na di jin we de protɛkt am we dɛn kɔl TP53 . wetin de apin na di jin nכ ebul fכ prodyuz di P53 protin we de wok fayn fayn wan. We dis jin we de protɛkt di bɔdi dɔn lɔs, di sɛl dɛn kin bigin fɔ sheb we dɛn nɔ ebul fɔ kɔntrol. Na dat kin divɛlɔp to kansa.
כltu, pikin kin gεt dis TP53 jin we nכ de wok fayn frכm in mama εn papa. Dɛn kɔl dis wan Ɔtosɔmal Dɔminant Pɔtn . Fɔ tɔk am simpul wan, ilɛksɛf na wan mama ɔ papa nɔmɔ gɛt dis jin we nɔ fayn, ilɛksɛf na di mama ɔ di papa, di pikin kin stil gɛt dis sik ɛn i kin gɛt kansa mɔ ɛn mɔ .
Bɔt, na smɔl tɛm nɔmɔ, dis chenj na di jɛnɛtiks kin apin na pɔsin in bɔdi we nɔr gɛt ɛnibɔdi na di famili we gɛt dis sik. Dɛn kɔl dis wan De Novo Mutation.
Aw dɛn kin no dis sik?
Dɔktɔ dɛn kin yuz jenɛtik tɛst fɔ no di sik. Bɔt bifo dɛn du dat, dɛn go tek tɛm luk yu ɛn yu famili in mɛdikal istri. Bɔku rizin dɛn de we mek dɔktɔ kin tink se i gɛt Li-Fraumeni Syndrome:
- If dɛn dɔn no se yu gɛt sarkoma kansa bifo yu ol 45 ia.
- If wan pan yu fɔs digri fambul dɛm (mama ɛn papa, brɔda ɛn sista, pikin dɛm) dɔn gɛt ɛni kansa bifo i ol 45 ia.
- If dɛn dɔn no se ɛni wan pan yu fambul dɛn we de na yu sɛkɔn digri (grani ɛn granpa, anti, ɔnkul, neba, nius) gɛt ɛni kansa bifo i ol 45 ia.
If dɛn mit wan ɔ mɔ pan dɛn tin ya, di dɔktɔ kin sɛn yu fɔ mek dɛn du yu jenɛtik tɛst.
If dɛn no se yu gɛt dis sik, di nɛks tin we impɔtant pas ɔl na fɔ wok pan wan schedule fɔ chɛk yu kansa. If yu de go to yu dɔktɔ ɔltɛm ɛn du tɛst, dɛn kin no ɛni kansa we kin apin ɛn trit am kwik kwik wan .
Aw dɛn kin trit am?
Nɔ patikyula tritmɛnt nɔ de fɔ di jenɛtik kɔndishɔn we dɛn kɔl Li-Fraumeni Syndrome. Dɔktɔ dɛn kin trit di kansa dɛn we kin kam bikɔs ɔf dis sik. Di tritmɛnt dɛn kin rili fiba di wan dɛn we dɛn kin gi pɔsin we nɔ gɛt dis sik. Dɛn tin ya na ɔpreshɔn ɛn kemotɛrapi.
Bɔt wan rili impɔtant ɛksɛpshɔn de ya.
Pipul wae gɛt Li-Fraumeni Syndrome kin rili fil fɔ gɛt raytin. So, risk de fɔ mek nyu kansa dɛn kam wit redyushɔn tɛrapi. Fɔ dis rizin, yu dɔktɔ go tray fɔ avɔyd ɔ nɔ tek bɔku raytin tritmɛnt if yu gɛt kansa.
Wetin yu fɔ ɛkspɛkt we yu de liv wit dis sik?
We yu no se yu gɛt Li-Fraumeni Syndrome, dat min se yu ɛn yu famili nid fɔ wok pan wan schedule fɔ chɛk yu kansa ɔltɛm. Risach dɔn sho se we dɛn de chɛk dɛn ɔltɛm , dat kin rili mek di chans fɔ sev layf pan dɛn pipul ya .
Dɛn tɛst schedule ya difrɛn fɔ pikin ɛn big pipul dɛn. Di tin dɛn we de kam biɛn ya na jɔs wan ɛgzampul. Yu dɔktɔ go mek wan schedule we go fayn fɔ yu.
| Grup we dɛn ol | Taym gap | Test dɛn we dɛn fɔ du |
|---|---|---|
| Fɔ pikin dɛn (we ol 18 ia) . | ||
| I go rich 18 ia yet | Ɛvri 3-4 mɔnt | Wan kɔmplit fizik ɛgzamin ɛn wan abdominal ɔltra saund skan. |
| Wan tɛm ɛvri ia | Wan bren MRI skan ɛn wan ol bɔdi MRI skan. | |
| Fɔ big pipul dɛn | ||
| Big pipul dɛn | Ɛvri 6 mɔnt | Mek dɔktɔ ɛgzam yu brɔst (frɔm 20-25 ia). |
| Wan tɛm ɛvri ia | Fyzikal egzamin, brɔst MRI, bren ɛn ful bɔdi MRI, abdominal ɛn pelvik ɔltrasɔund skan, ful skin ɛgzamin fɔ skin kansa. | |
| Ɛvri 2-3 ia | Kolonoskopi ɛn Ɔpa Ɛndoskopi tɛst dɛn. | |
Yu nɔ tink se dɛn go ebul fɔ stɔp dis tin?
No we nɔ de fɔ mek dɛn nɔ gɛt di jenɛtik kɔndishɔn we dɛn kɔl Li-Fraumeni Syndrome. Na sɔntin we kin kam wit wi jin dɛn. Bɔt yu kin avɔyd tin dɛn we de mek yu gɛt kansa mɔ ɛn mɔ.
- Nɔ smok kpatakpata.
- Nɔ drink rɔm pasmak .
- We yu de go na do na di san, nɔ de na do fɔ lɔng tɛm we yu nɔ gɛt ɛnitin fɔ protɛkt yu lɛk tin we de protɛkt yu frɔm di san .
Sɔm uman dɛn kin gɛt ɔpreshɔn fɔ pul dɛn tu bɔdi bifo kansa bigin fɔ mek dɛn nɔ gɛt bɔku kansa na dɛn bɔdi. Dɛn kɔl dis prɔfylaktik mastektomi .
Ivin wit ɔl dɛn tin ya fɔ tek tɛm, pɔsin we gɛt dis sik kin stil gɛt kansa. Na dat mek di bɛst tin fɔ du na fɔ gɛt skrinin ɔltɛm ɛn fɔ kech kansa kwik if i apin.
Aw yu de kia fɔ yusɛf ɛn yu famili?
Fɔ liv wit wan sik lɛk dis fɔ ɔl yu layf kin tranga pan yu bɔdi ɛn maynd.
1. Nɔ mis di skrinin: Fɔ fala di tɛm we yu dɔn rɛkɔmɛnd fɔ chɛk di kansa ɛksaktɔli.
2. Famili planin: If yu de plan fɔ bɔn pikin, i rili impɔtant fɔ tɔk to pɔsin we de advays yu bɔt yu jɛnɛtiks. Yu nid fɔ ɔndastand di prɔblɛm we kin apin we pɔsin pas dis jin we nɔ fayn to pikin.
3. Mental helt: Nɔ kɛr dis lod yu wan. Go to ɛp frɔm pɔsin we de gi advays bɔt mɛntɛl hεlth we gɛt ɛkspiriɛns fɔ wok wit pipul dɛm wae gɛt kansa ɔr pipul dɛm wae gɛt krɛse sik. Aks yu dɔktɔ bɔt sɔpɔt grup dɛn lɛk dɛn wan ya.
If yu notis ɛni chenj we nɔ kɔmɔn na yu bɔdi, lɛk pen ɔ lump, nɔ ignore am, tink se, "Dis fɔ bi nɔmal tin." Nɔ wet te yu du di nɛks tɛst, bɔt go to yu dɔktɔ wantɛm wantɛm .
Mɛsej we dɛn kin kɛr go na os
- Li-Fraumeni Syndrome na wan rare, inhɛrit jɛnɛtik kɔndishɔn we kin rili inkrisayz di risk fɔ gɛt kansa.
- Nɔr sayn nɔr de wae gɛt fɔ du wit dis sik insɛf. De sayn dɛm kin kam wit de kansa wae kin kam wit am.
- Pan ɔl we dɛn nɔ go ebul fɔ avɔyd dis sik, fɔ chɛk kansa ɔltɛm ɛn kwik kwik wan kin mek di chans fɔ sev pipul dɛn layf bɔku.
- If yu gɛt dis sik, i impɔtant fɔ avɔyd fɔ tek redyushɔn tɛrapi. Yu dɔktɔ go mɔs no bɔt dis.
- Bikɔs dis na tin we pɔsin kin gɛt frɔm in mama ɛn papa, i impɔtant fɔ mek yu go to dɔktɔ bɔt aw fɔ rifer ɔda pipul dɛn na yu famili fɔ mek dɛn go tɛst yu jɛnɛtiks.
- Jɔs lɛk aw bɔdi wɛl bɔdi, maynd wɛl bɔdi bak impɔtant pasmak pan dis joyn. Nɔ shem fɔ go fɛn ɛp if yu nid am.
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